‘Indirect’ challenges from science to clinical practice

References

• Joos GF, O'Connor B, Anderson SD, Chung F, Cockcroft DW, Dahlen B, etal. Indirect airway challenges. Eur Respir J. 2003; 21: 1050–68.
   PubMed Web of Science ®Google Scholar
• Anderson SD, Brannan JD. Methods for ‘indirect’ challenge tests including exercise, eucapnic voluntary hyperpnea and hypertonic aerosols. Clin Rev Allergy Immunol. 2003; 24: 63–90.
   Web of Science ®Google Scholar
• Jones RS, Buston MH, Wharton MW. The effect of exercise on ventilatory function in the child with asthma. Brit J Dis Chest. 1962; 56: 78–86.
   PubMedGoogle Scholar
• Jones RS, Wharton MJ, Buston MH. The place of physical exercise and bronchodilator drugs in the assessment of the asthmatic child. Arch Dis Childh. 1963; 38: 539–45.
   PubMed Web of Science ®Google Scholar
• McNeill RS, Nairn JR, Millar JS, Ingram CG. Exercise-induced asthma. Q J Med. 1966; 35: 55–67.
   PubMedGoogle Scholar
• Sly RM, Heimlich EM, Busser RJ, Strick L. Exercise-induced bronchospasm: effect of adrenergic or cholinergic blockade. J Allergy. 1967; 40: 93–9.
   PubMedGoogle Scholar
• Fisher HK, Holton P, Buxton RSJ, Nadel JA. Mechanism of exercise-induced bronchoconstriction. Am Rev Resp Dis. 1970; 101: 885–96.
   PubMed Web of Science ®Google Scholar
• Cox JS. Disodium cromoglycate (FPL 670) (‘Intal’): a specific inhibitor of reaginic antibody-antigen mechanisms. Nature. 1967; 216: 1328–9.
   PubMed Web of Science ®Google Scholar
• Altounyan REC. Inhibition of experimental asthma by a new compound, disodium cromoglycate. Acta Allerg. 1967; 22: 487.
   Google Scholar
• Pepys J, Hargreave FE, Chan M, McCarthy DS. Inhibitory effects of disodium cromoglycate on allergen-inhalation tests. Lancet. 1968; 2: 134–8.
   PubMed Web of Science ®Google Scholar
• Davies SE. Effect of disodium cromoglycate on exercise-induced asthma. Br Med J. 1968; 3: 593–4.
   PubMed Web of Science ®Google Scholar
• Poppius H, Muttari A, Kreus KE, Karronen O, Viljanen A. Exercise asthma and disodium cromoglycate. Brit Med J. 1970; 4: 337–9.
   PubMedGoogle Scholar
• Pierson WE, Bierman CW, Stamm SJ. Cycloergometer-induced bronchospasm. J Allergy. 1969; 43: 136–44.
   Google Scholar
• Godfrey S, Silverman M, Anderson SD. Problems of interpreting exercise-induced asthma. J Allergy Clin Immunol. 1973; 52: 199–209.
   PubMed Web of Science ®Google Scholar
• Cropp GJ. Grading, time course, and incidence of exercise-induced airway obstruction and hyperinflation in asthmatic children. Pediatrics. 1975; 56(5 pt-2 suppl): 868–79.
   PubMed Web of Science ®Google Scholar
• Cropp GJA. Relative sensitivity of different pulmonary function tests in the evaluation of exercise-induced asthma. Pediatrics. 1975; 56(5 Pt 2): 860S–7S.
   Web of Science ®Google Scholar
• Eggleston PA, Bierman CW, Pierson WE, Stamm SJ, Van Arsdel PP Jr. . A double blind trial of the effect of cromolyn sodium on exercise-induced bronchospasm. J Allergy Clin Immunol. 1972; 50: 57–63.
   PubMed Web of Science ®Google Scholar
• Fitch KD, Morton AR. Specificity of exercise in exercise-induced asthma. Br Med J. 1971; 4: 577–81.
   PubMed Web of Science ®Google Scholar
• Anderson SD, Connolly N, Godfrey S. Comparison of bronchoconstriction induced by cycling and running. Thorax. 1971; 26: 396–401.
   PubMed Web of Science ®Google Scholar
• Wright BM, McKerrow CB. Maximum forced expiratory flow rate as a measure of ventilatory capacity: with a description of a new portable instrument for measuring it. Br Med J. 1959; 2: 1041–6.
   PubMed Web of Science ®Google Scholar
• Silverman M, Anderson SD. Standardization of exercise tests in asthmatic children. Arch Dis Childh. 1972; 47: 882–9.
   PubMed Web of Science ®Google Scholar
• Silverman M, Andrea T. Time course of effect of disodium cromoglycate on exercise-induced asthma. Arch Dis Childh. 1972; 47: 419–22.
   PubMed Web of Science ®Google Scholar
• Silverman M, Turner-Warwick M. Exercise-induced asthma: response to disodium cromoglycate in skin-test positive and skin-test negative subjects. Clin Allergy. 1972; 2: 137–42.
   Google Scholar
• Bierman CW, Kawabori I, Pierson WE. Incidence of exercise-induced asthma in children. Pediatrics. 1975; 56(5 Part 2): 847–50.
   Web of Science ®Google Scholar
• Cropp GJ. The exercise bronchoprovocation test: standardization of procedures and evaluation of response. J Allergy Clin Immunol. 1979; 64(6 pt 2): 627–33.
   Web of Science ®Google Scholar
• Godfrey S, Silverman M, Anderson SD. The use of the treadmill for assessing exercise-induced asthma and the effect of varying the severity and the duration of exercise. Paediatrics. 1975; 56(5 Pt 2): 893S–8S.
   Web of Science ®Google Scholar
• Eggleston PA. The cycloergometer as a system for studying exercise-induced asthma. Pediatrics. 1975; 56(5 Part 2): 899–903.
   Web of Science ®Google Scholar
• Pierson WE, Bierman CW. Free running test for exercise -induced bronchoconstriction. Pediatrics. 1975; 56(5 Part 2): 890–2.
   Web of Science ®Google Scholar
• Kattan M, Thomas CM, Keens TG, Mellis CM, Levison H. The response to exercise in normal and asthmatic children. J Pediatr. 1978; 92: 718–21.
   PubMed Web of Science ®Google Scholar
• Anderson SD, Silverman M, Konig P, Godfrey S. Exercise-induced asthma. A Review. Br J Dis Chest. 1975; 69: 1–39.
   PubMedGoogle Scholar
• Eggleston PA, Rosenthal RR, Anderson SD, Anderton R, Bierman CW, Bleecker ER, etal. Guidelines for the methodology of exercise challenge testing of asthmatics. J Allergy Clin Immunol. 1979; 64: 642–5.
   PubMed Web of Science ®Google Scholar
• Eggleston PA. Laboratory evaluation of exercise-induced asthma: methodologic considerations. J Allergy Clin Immunol. 1979; 64: 604S–8S.
   Web of Science ®Google Scholar
• Fitch KD, Morton AR, Blanksby BA. Effects of swimming training on children with asthma. Arch Dis Child. 1976; 51: 190–4.
   PubMed Web of Science ®Google Scholar
• Weinstein RE, Anderson JA, Kvale P, Sweet LC. Effects of humidification on exercise induced asthma (EIA). J Allergy Clin Immunol. 1976; 57: A250–1.
   Web of Science ®Google Scholar
• Bar-Or O, Neuman I, Dotan R. Effects of dry and humid climates on exercise-induced asthma in children and preadolescents. J Allergy Clin Immunol. 1977; 60: 163–8.
   PubMed Web of Science ®Google Scholar
• Chen WY, Horton DJ. Heat and water loss from the airways and exercise-induced asthma. Respiration. 1977; 34: 305–13.
   PubMed Web of Science ®Google Scholar
• Strauss RH, McFadden ER, Ingram RH, Deal EC, Jaeger JJ, Stearns D. Influence of heat and humidity on the airway obstruction induced by exercise in asthma. J Clin Invest. 1978; 61: 433–40.
   PubMed Web of Science ®Google Scholar
• Anderson SD, Daviskas E, Schoeffel RE, Unger SF. Prevention of severe exercise-induced asthma with hot humid air. Lancet. 1979; 2: 629.
   PubMed Web of Science ®Google Scholar
• Strauss RH, McFadden ER Jr. , Ingram RH Jr. , Jaeger JJ. Enhancement of exercise-induced asthma by cold air. N Engl J Med. 1977; 297: 743–7.
   PubMed Web of Science ®Google Scholar
• Deal EC, McFadden ER, Ingram RH, Strauss RH, Jaeger JJ. Role of respiratory heat exchange in production of exercise-induced asthma. J Appl Physiol Respir Environ Exerc Physiol. 1979; 46: 467–75.
   PubMed Web of Science ®Google Scholar
• Deal EC, McFadden ER, Ingram RH, Jaeger JJ. Hyperpnea and heat flux: initial reaction sequence in exercise-induced asthma. J Appl Physiol Respir Environ Exerc Physiol. 1979; 46: 476–83.
   PubMed Web of Science ®Google Scholar
• Anderson SD, Schoeffel RE, Follet R, Perry CP, Daviskas E, Kendall M. Sensitivity to heat and water loss at rest and during exercise in asthmatic patients. Eur J Respir Dis. 1982; 63: 459–71.
   PubMedGoogle Scholar
• Schoeffel RE, Anderson SD, Altounyan RE. Bronchial hyperreactivity in response to inhalation of ultrasonically nebulised solutions of distilled water and saline. Br Med J. 1981; 283: 1285–7.
   PubMed Web of Science ®Google Scholar
• Aitken ML, Marini JJ. Effect of heat delivery and extraction on airway conductance in normal and in asthmatic subjects. Am Rev Respir Dis. 1985; 131: 357–61.
   PubMed Web of Science ®Google Scholar
• Hahn A, Anderson SD, Morton AR, Black JL, Fitch KD. A re-interpretation of the effect of temperature and water content of the inspired air in exercise-induced asthma. Am Rev Respir Dis. 1984; 130: 575–9.
   PubMed Web of Science ®Google Scholar
• Anderson SD. Is there a unifying hypothesis for exercise-induced asthma?. J Allergy Clin Immunol. 1984; 73(5 Part 2): 660–5.
   Web of Science ®Google Scholar
• Anderson SD, Schoeffel RE, Black JL, Daviskas E. Airway cooling as the stimulus to exercise-induced asthma – a re-evaluation. Eur J Respir Dis. 1985; 67: 20–30.
   PubMedGoogle Scholar
• Eschenbacher WL, Sheppard D. Respiratory heat loss is not the sole stimulus for bronchoconstriction induced by isocapnic hyperpnea with dry air. Am Rev Respir Dis. 1985; 131: 894–901.
   PubMed Web of Science ®Google Scholar
• Anderson SD, Daviskas E. Weiler J. Pathophysiology of exercise-induced asthma: role of respiratory water loss. Allergic and respiratory disease in sports medicine. 1997; New York: Marcel Dekker. 87–114.
   Google Scholar
• Togias AG, Proud D, Lichenstein LM, Adams GK, Norman PS, Kagey-Sobotka A, etal. The osmolality of nasal secretions increases when inflammatory mediators are released in response to inhalation of cold, dry air. Am Rev Respir Dis. 1988; 137: 625–9.
   Google Scholar
• Daviskas E, Gonda I, Anderson SD. Local airway heat and water vapour losses. Respiration Physiology. 1991; 84: 115–32.
   Google Scholar
• McFadden ER, Lenner KA, Strohl KP. Postexertional airway rewarming and thermally induced asthma. J Clin Invest. 1986; 78: 18–25.
   PubMed Web of Science ®Google Scholar
• Anderson SD, Holzer K. Exercise-induced asthma: is it the right diagnosis in elite athletes?. J Allergy Clin Immunol. 2000; 106: 419–28.
   PubMed Web of Science ®Google Scholar
• Anderson SD, Daviskas E. The mechanism of exercise-induced asthma is … . J Allergy Clin Immunol. 2000; 106: 453–9.
   PubMed Web of Science ®Google Scholar
• Anderson SD, Daviskas E. The airway microvasculature and exercise-induced asthma. Thorax. 1992; 47: 748–52.
   PubMed Web of Science ®Google Scholar
• Anderson SD, Daviskas E, Smith CM. Exercise-induced asthma: a difference in opinion regarding the stimulus. Allergy Proc. 1989; 10: 215–26.
   PubMedGoogle Scholar
• Smith CM, Anderson SD, Walsh S, McElrea M. An investigation of the effects of heat and water exchange in the recovery period after exercise in children with asthma. Am Rev Respir Dis. 1989; 140: 598–605.
   Google Scholar
• Sterk PJ, Fabbri LM, Quanjer PH, Cockcroft DW, O'Byrne PM, Anderson SD, etal. Airway responsiveness: standardized challenge testing with pharmacological, physical and sensitizing stimuli in adults. Eur Respir J. 1993; 6(Suppl 16): 53–83.
   PubMed Web of Science ®Google Scholar
• Folgering H, Palange P, Anderson S. Clinical exercise testing with reference to lung diseases: indications and protocols. Eur Respir Mon. 1997; 6: 51–71.
   Google Scholar
• Crapo RO, Casaburi R, Coates AL, Enright PL, Hankinson JL, Irvin CG, etal. Guidelines for methacholine and exercise challenge testing – 1999. Am J Respir Crit Care Med. 2000; 161: 309–29.
   PubMed Web of Science ®Google Scholar
• Anderson SD, Lambert S, Brannan JD, Wood RJ, Koskela H, Morton AR, etal. Laboratory protocol for exercise asthma to evaluate salbutamol given by two devices. Med Sci Sports Exerc. 2001; 33: 893–900.
   PubMed Web of Science ®Google Scholar
• Haby MM, Anderson SD, Peat JK, Mellis CM, Toelle BG, Woolcock AJ. An exercise challenge protocol for epidemiological studies of asthma in children: comparison with histamine challenge. Eur Respir J. 1994; 7: 43–9.
   PubMed Web of Science ®Google Scholar
• Haby MM, Peat JK, Mellis CM, Anderson SD, Woolcock AJ. An exercise challenge for epidemiological studies of childhood asthma: validity and repeatability. Eur Respir J. 1995; 8: 729–36.
   PubMed Web of Science ®Google Scholar
• Godfrey S, Springer C, Bar-Yishay E, Avital A. Cut-off points defining normal and asthmatic bronchial reactivity to exercise and inhalation challenges in children and young adults. Eur Respir J. 1999; 14: 659–68.
   PubMed Web of Science ®Google Scholar
• Custovic A, Arifhodzic N, Robinson A, Woodcock A. Exercise testing revisited. The response to exercise in normal and atopic children. Chest. 1994; 105: 1127–32.
   PubMed Web of Science ®Google Scholar
• Freed AN, Anderson SD. Kay AB. Exercise-induced bronchoconstriction. Human models. Allergy & allergic diseases. 2008; Oxford: Blackwell Scientific Publications. 808–22.
   Google Scholar
• Parsons JP, Hallstrand TS, Mastronade JG, Kaminsky DA, Rundell K, Hull J, etal. An official American Thoracic Society clinical practice guideline: exercise-induced bronchoconstriction. Am J Respir Crit Care Med. 2013; 187: 1016–27.
   PubMed Web of Science ®Google Scholar
• Rundell KW, Wilber RL, Szmedra L, Jenkinson DM, Mayers LB, Im J. Exercise-induced asthma screening of elite athletes: field vs laboratory exercise challenge. Med Sci Sports Exerc. 2000; 32: 309–16.
   PubMed Web of Science ®Google Scholar
• Carlsen KH, Engh G, Mørk M. Exercise induced bronchoconstriction depends on exercise load. Respir Med. 2000; 94: 750–5.
   PubMed Web of Science ®Google Scholar
• Vilozni D, Bentur L, Efrati O, Barak A, Szeinberg A, Shoseyov D, etal. Exercise challenge test in 3–6 year old asthmatic children. Chest. 2007; 132: 497–503.
   PubMed Web of Science ®Google Scholar
• Anderson SD, Pearlman DS, Rundell KW, Perry CP, Boushey H, Sorkness CA, etal. Reproducibility of the airway response to an exercise protocol standardized for intensity, duration, and inspired air conditions, in subjects with symptoms suggestive of asthma. Respir Res. 2010; 11: 120.
   PubMed Web of Science ®Google Scholar
• Van Leeuwen JC, Driessen JMM, de Jongh FHC, Anderson SD, Thio BJ. Measuring breakthrough exercise-induced bronchoconstriction in young asthmatic children using a jumping castle. J Allergy Clin Immunol. 2013; 131: 1427–9.
   PubMed Web of Science ®Google Scholar
• Carlsen KH, Anderson SD, Bjermer L, Bonini S, Brusasco V, Canonica W, etal. Exercise-induced asthma, respiratory and allergic disorders in elite athletes: epidemiology, mechanisms and diagnosis: part I of the report from the Joint Task Force of the European Respiratory Society (ERS) and the European Academy of Allergy and Clinical Immunology (EAACI) in cooperation with GA2LEN. Allergy. 2008; 63: 387–403.
   PubMed Web of Science ®Google Scholar
• Weiler JM, Anderson SD, Randolph C, Bonini S, Craig T, Randolph C, etal. Pathogenesis, prevalence, diagnosis, and management of exercise-induced bronchoconstriction: a practice parameter. Ann Allergy Asthma Clin Immunol. 2010; 105(6 suppl): S1–S47.
   PubMedGoogle Scholar
• Chan-Yeung MMW, Vyas MN, Grzybowski S. Exercise-induced asthma. Am Rev Respir Dis. 1971; 104: 915–23.
   Google Scholar
• Zeballos RJ, Shturman-Ellstein R, McNally JF Jr. , Hirsch JE, Souhrada JF. The role of hyperventilation in exercise-induced bronchoconstriction. Am Rev Respir Dis. 1978; 118: 877–84.
   PubMed Web of Science ®Google Scholar
• Kilham H, Tooley M, Silverman M. Running, walking and hyperventilation causing asthma in children. Thorax. 1979; 34: 582–6.
   PubMed Web of Science ®Google Scholar
• Kivity S, Souhrada JF, Melzer E. A dose-response-like relationship between minute ventilation and exercise-induced bronchoconstriction in young asthmatic patients. Eur J Respir Dis. 1980; 61: 342–6.
   Google Scholar
• Kivity S, Souhrada JF. Hyperpnea: the common stimulus for bronchospasm in asthma during exercise and voluntary isocapnic hyperpnea. Respiration. 1980; 40: 169–77.
   PubMed Web of Science ®Google Scholar
• O'Byrne PM, Ryan G, Morris M, McCormack D, Jones NL, Morse JL, etal. Asthma induced by cold air and its relation to nonspecific bronchial hyperresponsiveness to methacholine. Am Rev Respir Dis. 1982; 125: 281–5.
   PubMed Web of Science ®Google Scholar
• Latimer KM, Roberts R, Morris MM, Hargreave FE. Inhibition by sodium cromoglycate of bronchoconstriction stimulated by respiratory heat loss: comparison of pressurised aerosol and powder. Thorax. 1984; 39: 277–81.
   Web of Science ®Google Scholar
• Aquilina AT. Comparison of airway reactivity induced by histamine, methacholine, and isocapnic hyperventilation in normal and asthmatic subjects. Thorax. 1983; 38(10): 766–70.
   Web of Science ®Google Scholar
• Weiss JW, Rossing TH, McFadden ER, Ingram RH. Relationship between bronchial responsiveness to hyperventilation with cold air and methacholine in asthma. J Allergy Clin Immunol. 1983; 72: 140–4.
   Web of Science ®Google Scholar
• Tessier P, Cartier A, L'Archeveque J, Ghezzo J, Martin RR, Malo J-L. Within- and between-day reproducibility of isocapnic cold air challenges in subjects with asthma. J Allergy Clin Immunol. 1986; 78(3 Pt 1): 379–87.
   Web of Science ®Google Scholar
• Zach M, Polgar G, Kump H, Kroisel P. Cold air challenge of airway hyperreactivity in children: practical application and theoretical aspects. Pediatr Res. 1984; 18: 469–78.
   PubMed Web of Science ®Google Scholar
• Varga E-M, Eber E, Zach MS. Cold air challenge for measuring airway reactivity in children: lack of a late asthmatic reaction. Lung. 1990; 168: 267–72.
   Web of Science ®Google Scholar
• Nicolai T, Mutius EV, Reitmeir P, Wjst M. Reactivity to cold-air hyperventilation in normal and in asthmatic children in a survey of 5,697 schoolchildren in southern Bavaria. Am Rev Respir Dis. 1993; 147: 565–72.
   PubMed Web of Science ®Google Scholar
• Nielsen KG, Bisgaard H. Lung function response to cold air challenge in asthmatic and healthy children of 2–5 years of age. Am J Respir Crit Care Med. 2000; 161: 1805–9.
   Web of Science ®Google Scholar
• Rosenthal RR. Simplified eucapnic voluntary hyperventilation. J Allergy Clin Immunol. 1984; 73: 676–85.
   Web of Science ®Google Scholar
• Phillips YY, Jaeger JJ, Laube BL, Rosenthal RR. Eucapnic voluntary hyperventilation of compressed gas mixture. A simple system for bronchial challenge by respiratory heat loss. Am Rev Respir Dis. 1985; 131: 31–5.
   PubMedGoogle Scholar
• Hurwitz KM, Argyros GJ, Roach JM, Eliasson AH, Phillips YY. Interpretation of eucapnic voluntary hyperventilation in the diagnosis of asthma. Chest. 1995; 108: 1240–5.
   PubMed Web of Science ®Google Scholar
• Argyros GJ, Roach JM, Hurwitz KM, Eliasson AH, Phillips YY. Eucapnic voluntary hyperventilation as a bronchoprovocation technique. Development of a standardized dosing schedule in asthmatics. Chest. 1996; 109: 1520–4.
   PubMed Web of Science ®Google Scholar
• Argyros GJ, Roach JM, Hurwitz KM, Eliasson AH, Phillips YY. The refractory period after eucapnic voluntary hyperventilation challenge and its effect on challenge technique. Chest. 1995; 108: 419–24.
   Web of Science ®Google Scholar
• Eliasson AH, Phillips YY, Rajagopal KR, Howard RS. Sensitivity and specificity of bronchial provocation testing. An evaluation of four techniques in exercise-induced bronchospasm. Chest. 1992; 102: 347–55.
   PubMed Web of Science ®Google Scholar
• Anderson SD, Argyros GJ, Magnussen H, Holzer K. Provocation by eucapnic voluntary hyperpnoea to identify exercise induced bronchoconstriction. Br J Sports Med. 2001; 35: 344–7.
   PubMed Web of Science ®Google Scholar
• Anderson SD, Fitch K, Perry CP, Sue-Chu M, Crapo R, McKenzie D, etal. Responses to bronchial challenge submitted for approval to use inhaled beta2 agonists prior to an event at the 2002 Winter Olympics. J Allergy Clin Immunol. 2003; 111: 44–9.
   Web of Science ®Google Scholar
• Anderson SD, Kippelen P. The best physiological test to use, when evaluating asthma and sport- from a respiratory physiologist's point of view. LungeForum. 2004; 14(3) : 6–13.
   Google Scholar
• Dickinson J. Screening elite winter athletes for exercise induced asthma: a comparison of three challenge methods. Brit J Sports Med. 2006; 40: 179–82.
   PubMed Web of Science ®Google Scholar
• Dickinson J, McConnell A, Whyte G. Diagnosis of exercise-induced bronchoconstriction: eucapnic voluntary hyperpnoea challenges identify previously undiagnosed elite athletes with exercise-induced bronchoconstriction. Br J Sports Med. 2010; 45(14): 1126–31.
   Web of Science ®Google Scholar
• Fitch KD, Sue-Chu M, Anderson SD, Boulet L-P, Hancox RJ, McKenzie DC, etal. Asthma and the elite athlete: summary of the International Olympic Committee's Consensus Conference, Lausanne, Switzerland, January 22–24, 2008. J Allergy Clin Immunol. 2008; 122: 254–60.
   PubMed Web of Science ®Google Scholar
• Smith CM, Anderson SD, Seale JP. The duration of action of the combination of fenoterol hydrobromide and ipratropium bromide in protecting against asthma provoked by hyperpnea. Chest. 1988; 94: 709–17.
   Web of Science ®Google Scholar
• Rodwell LT, Anderson SD, du Toit J, Seale JP. Different effects of inhaled amiloride and furosemide on airway responsiveness to dry air challenge in asthmatic subjects. Eur Respir J. 1993; 6: 855–61.
   PubMed Web of Science ®Google Scholar
• Brannan JD, Koskela H, Anderson SD, Chew N. Responsiveness to mannitol in asthmatic subjects. Am J Respir Crit Care Med. 1998; 158: 1120–6.
   PubMed Web of Science ®Google Scholar
• Brummel NE, Mastronarde JG, Rittinger D, Philips G, Parsons JP. The clinical utility of eucapnic voluntary hyperventilation testing for the diagnosis of exercise-induced bronchospasm. J Asthma. 2009; 46: 683–6.
   PubMed Web of Science ®Google Scholar
• Parsons JP, Kaeding C, Phillips G, Jarjoura D, Wadley G, Mastronarde JG. Prevalence of exercise-induced bronchospasm in a cohort of varsity college athletes. Med Sci Sports Exerc. 2007; 39: 1487–92.
   PubMed Web of Science ®Google Scholar
• Allegra L, Bianco S. Non-specific broncho-reactivity obtained with an ultrasonic aerosol of distilled water. Eur J Respir Dis. 1980; 61(Suppl 106): 41–9.
   Google Scholar
• Salvato G. Mast cells in bronchial connective tissue of man: their modification in asthma and after treatment with histamine liberator 48/80. Int Arch Allergy. 1961; 18: 348–58.
   Web of Science ®Google Scholar
• Patterson R, McKenna JM, Suszko IM, Solliday NH, Pruzansky JJ, Roberts M, etal. Living histamine containing cells from the bronchial lumes of humans. J Clin Invest. 1977; 59: 217–25.
   PubMed Web of Science ®Google Scholar
• Kaliner M, Austen KF. Cyclic AMP, ATP and reversed anaphylactic histamine release from rat mast cells. J Immunology. 1974; 112: 664–74.
   PubMed Web of Science ®Google Scholar
• Findlay SR, Dvorak AM, Kagey-Sobotka A, Lichtenstein LM. Hyperosmolar triggering of histamine release from human basophils. J Clin Invest. 1981; 67: 1604–13.
   PubMed Web of Science ®Google Scholar
• Anderson SD, Schoeffel RE, Finney M. Evaluation of ultrasonically nebulised solutions as a provocation in patients with asthma. Thorax. 1983; 38: 284–91.
   PubMed Web of Science ®Google Scholar
• Anderson SD, Schoeffel RE. A method for documenting bronchial hyperresponsiveness using ultrasonically nebulized water. Pract Cardiol. 1984; 10: 69–88.
   Google Scholar
• Anderson SD. Bronchial challenge by ultrasonically nebulized aerosols. Clin Rev Allergy. 1985; 3: 427–39.
   PubMedGoogle Scholar
• Anderson SD, Schoeffel RE. Hargreave FE, Woolcock AJ. The inhalation of ultrasonically nebulized aerosols as a provocation test for asthma. Airway responsiveness: measurement and interpretation. 1985; 39–50. Mississauga, Ontario: Astra Pharmaceuticals Canada Ltd.
   Google Scholar
• Mattoli S, Foresi A, Corbo GM, Valente S, Ciappi G. The effect of indomethacin on the refractory period occurring after the inhalation of ultrasonically nebulized distilled water. J Allergy Clin Immunol. 1987; 79: 678–83.
   Web of Science ®Google Scholar
• Foresi A, Pelucchi A, Mastropasqua B, Cavigioli G, Carlesi RM, Marazzini L. Effect of inhaled furosemide and torasemide on bronchial response to ultrasonically nebulized distilled water in asthmatic subjects. Am Rev Respir Dis. 1992; 146: 364–8.
   PubMed Web of Science ®Google Scholar
• Groot CA, Lammers JW, Molema J, Festen J, van Herwaarden CL. Effect of inhaled beclomethasone and nedocromil sodium on bronchial hyperresponsiveness to histamine and distilled water. Eur Respir J. 1992; 5: 1075–82.
   Web of Science ®Google Scholar
• Mattoli S, Foresi A, Corbo GM, Valente S, Patalano F, Ciappi G. Increase in bronchial responsiveness to methacholine and late asthmatic response after the inhalation of ultrasonically nebulized distilled water. Chest. 1986; 90: 726–32.
   Web of Science ®Google Scholar
• Smith CM, Anderson SD, Black JL. Methacholine responsiveness increases after ultrasonically nebulized water, but not after ultrasonically nebulized hypertonic saline. J Allergy Clin Immunol. 1987; 79: 85–92.
   Web of Science ®Google Scholar
• Kivity S, Poterman R, Schwarz Y, Soferman R, Topilsky M. Changes in sensitivity to methacholine after inhalation with distilled water: the role of the bronchoconstrictive response. Eur Respir J. 1995; 8: 253–6.
   PubMed Web of Science ®Google Scholar
• Eschenbacher WL, Boushey HA, Sheppard D. Alteration in osmolarity of inhaled aerosols cause bronchoconstriction and cough, but absence of a permeant anion causes cough alone. Am Rev Respir Dis. 1984; 129: 211–5.
   PubMed Web of Science ®Google Scholar
• Weibel ER. Morphometry of the human lung. 1963; Berlin: Springer.
   Google Scholar
• Anderson SD, Daviskas E. McFadden ER. Airway drying and exercise induced asthma. Exercise induced asthma – lung biology in health and disease. 1999; New York: Marcel Dekker. p. 77–113.
   Google Scholar
• Anderson SD, Smith CM, Rodwell LT, du Toit JI, Riedler J, Robertson CF. Spector S. The use of non-isotonic aerosols for evaluating bronchial hyperresponsiveness. Provocation challenge procedures. 1995; New York: Marcel Dekker. p. 249–78.
   Google Scholar
• Anderson SD, Smith CM. Spector S. The use of nonisotonic aerosols for evaluating bronchial hyperresponsiveness. Provocative challenge procedures. 1989; New York: Futura, Mount Kisco. 227–52.
   Google Scholar
• Smith CM, Anderson SD. Inhalation provocation tests using non-isotonic aerosols. J Allergy Clin Immunol. 1989; 84(5 Pt 1): 781–90.
   PubMed Web of Science ®Google Scholar
• Smith CM, Anderson SD. Hyperosmolarity as the stimulus to asthma induced by hyperventilation?. J Allergy Clin Immunol. 1986; 77: 729–36.
   PubMed Web of Science ®Google Scholar
• Smith CM, Anderson SD. A comparison between the airway response to isocapnic hyperventilation and hypertonic saline in subjects with asthma. Eur Respir J. 1989; 2: 36–43.
   PubMed Web of Science ®Google Scholar
• Smith CM, Anderson SD. Inhalational challenge using hypertonic saline in asthmatic subjects: a comparison with responses to hyperpnoea, methacholine and water. Eur Respir J. 1990; 3: 144–51.
   PubMed Web of Science ®Google Scholar
• Gibson PG, Saltos N, Borgas T. Airway mast cells and eosinophils correlate with clinical severity and airway hyperresponsiveness in corticosteroid-treated asthma. J Allergy Clin Immunol. 2000; 105: 752–9.
   PubMed Web of Science ®Google Scholar
• Rodwell LT, Anderson SD, Seale JP. Inhaled steroids modify bronchial responses to hyperosmolar saline. Eur Respir J. 1992; 5: 953–62.
   Web of Science ®Google Scholar
• Anderson SD, Dutoit JI, Rodwell LT, Jenkins CR. Acute effect of sodium cromoglycate on airway narrowing induced by 4.5-percent saline aerosol – outcome before and during treatment with aerosol corticosteroids in patients with asthma. Chest. 1994; 105: 673–80.
   PubMed Web of Science ®Google Scholar
• Anderson SD. Indirect challenge tests: airway hyperresponsiveness in asthma: its measurement and clinical significance. Chest. 2010; 138(2 Suppl): 25S–30S.
   PubMed Web of Science ®Google Scholar
• Iredale MJ, Wanklyn SAR, Phillips IP, Krauz T, Ind PW. Non-invasive assessment of bronchial inflammation in asthma: no correlation between eosinophilia of induced sputum and bronchial responsiveness to inhaled hypertonic saline. Clin Exp Allergy. 1994; 24: 940–5.
   PubMed Web of Science ®Google Scholar
• Anderson SD, Gibson P. Barnes PJ, Grunstein MM, Leff A, Woolcock AJ. The use of aerosols of hypertonic saline and distilled water (fog). 1997; Asthma. New York: Raven Press. 1135–50.
   Google Scholar
• Anderson SD, Brannan J, Trevillion L, Young IH. Lung function and bronchial provocation tests for intending divers with a history of asthma. SPUMS J. 1995; 25: 233–48.
   Google Scholar
• Freed R, Anderson SD, Wyndham J. The use of bronchial provocation tests for identifying asthma. A review of the problems for occupational assessment and a proposal for a new direction. ADF Health. 2002; 3: 77–85.
   Google Scholar
• Rabone S, Phoon WO, Anderson SD, Wan KC, Seneviratne M, Gutierrez L, etal. Hypertonic saline challenge in an adult epidemiological field survey. Occup Med. 1996; 46: 177–85.
   Google Scholar
• Riedler J, Reade T, Dalton M, Holst DI, Robertson CF. Hypertonic saline challenge in an epidemiological survey of asthma in children. Am J Respir Crit Care Med. 1994; 150(6 Pt 1): 1632–9.
   PubMed Web of Science ®Google Scholar
• Riedler J, Robertson CF. Effect of tidal volume on the output and particle size distribution of hypertonic saline from an ultrasonic nebuliser. Eur Respir J. 1994; 7: 998–1002.
   PubMed Web of Science ®Google Scholar
• Riedler J, Reade T, Robertson CF. Repeatability of response to hypertonic saline aerosol in children with mild to severe asthma. Pediatr Pulmonol. 1994; 18: 330–6.
   Web of Science ®Google Scholar
• Riedler J, Gamper A, Eder W, Oberfeld G. Prevalence of bronchial hyperresponsiveness to 4.5% saline and its relation to asthma and allergy symptoms in Austrian children. Eur Respir J. 1998; 11: 355–60.
   PubMed Web of Science ®Google Scholar
• de Meer G, Postma DS, Janssen NA, de Jongste JC, Brunekreef B. Bronchial hyper-responsiveness to hypertonic saline and blood eosinophilic markers in 8–13 year old school children. Clin Exp Allergy. 2004; 34: 1226–31.
   PubMed Web of Science ®Google Scholar
• Anderson SD, Spring J, Moore B, Rodwell LT, Spalding N, Gonda I, etal. The effect of inhaling a dry powder of sodium chloride on the airways of asthmatic subjects. Eur Respir J. 1997; 10: 2465–73.
   PubMed Web of Science ®Google Scholar
• Anderson SD, Brannan J, Spring J, Spalding N, Rodwell LT, Chan K, etal. A new method for bronchial-provocation testing in asthmatic subjects using a dry powder of mannitol. Am J Respir Crit Care Med. 1997; 156(3 Pt 1): 758–65.
   PubMed Web of Science ®Google Scholar
• Eggleston PA, Kagey-Sobotka A, Schleimer RP, Lichtenstein LM. Interaction between hyperosmolar and IgE-mediated histamine release from basophils and mast cells. Am Rev Respir Dis. 1984; 130: 86–91.
   PubMed Web of Science ®Google Scholar
• Eggleston PA, Kagey-Sobotka A, Lichtenstein LM. A comparison of the osmotic activation of basophils and human lung mast cells. Am Rev Respir Dis. 1987; 135: 1043–8.
   PubMed Web of Science ®Google Scholar
• Flint KC, Leung KBP, Pearce FL, Hudspith BN, Brostoff J, Johnson NM. The hyperosmolar release of histamine from bronchoalveolar mast cells and its inhibition by sodium cromoglycate. Thorax. 1985; 40(9): 717.
   Web of Science ®Google Scholar
• Brannan JD, Koskela H, Anderson SD, Chan H-K. Budesonide reduces sensitivity and reactivity to inhaled mannitol in asthmatic subjects. Respirology. 2002; 7: 37–44.
   PubMed Web of Science ®Google Scholar
• Holzer K, Anderson SD, Chan H-K, Douglass J. Mannitol as a challenge test to identify exercise-induced bronchoconstriction in elite athletes. Am J Respir Crit Care Med. 2003; 167: 534–47.
   PubMed Web of Science ®Google Scholar
• Subbarao P, Brannan JD, Ho B, Anderson SD, Chan H-K, Coates AL. Inhaled mannitol identifies methacholine-responsive children with active asthma. Pediatr Pulmonol. 2000; 29: 291–8.
   PubMed Web of Science ®Google Scholar
• Leuppi JD, Salome CM, Jenkins CR, Koskela H, Brannan JD, Anderson SD, etal. Markers of airway inflammation and airway hyperresponsiveness in patients with well-controlled asthma. Eur Respir J. 2001; 18: 444–50.
   PubMed Web of Science ®Google Scholar
• Leuppi JD, Salome CM, Jenkins CR, Anderson SD, Xuan W, Marks GB, etal. Predictive markers of asthma exacerbations during stepwise dose-reduction of inhaled corticosteroids. Am J Respir Crit Care Med. 2001; 163: 406–12.
   PubMed Web of Science ®Google Scholar
• Brannan JD, Anderson SD, Gomes K, King GG, Chan H-K, Seale JP. Fexofenadine decreases sensitivity to and montelukast improves recovery from inhaled mannitol. Am J Respir Crit Care Med. 2001; 163: 1420–5.
   PubMed Web of Science ®Google Scholar
• Koskela HO, Hyvarinen L, Brannan JD, Chan HK, Anderson SD. Sensitivity and validity of three bronchial provocation tests to demonstrate the effect of inhaled corticosteroids in asthma. Chest. 2003; 124: 1341–9.
   PubMed Web of Science ®Google Scholar
• Brannan JD, Anderson SD, Perry CP, Freed-Martens R, Lassig AR, Charlton B. The safety and efficacy of inhaled dry powder mannitol as a bronchial provocation test for airway hyperresponsiveness: a phase 3 comparison study with hypertonic (4.5%) saline. Respir Res. 2005; 6: 144.
   PubMed Web of Science ®Google Scholar
• Anderson SD, Charlton B, Weiler JM, Nichols S, Spector SL, Pearlman DS, etal. Comparison of mannitol and methacholine to predict exercise-induced bronchoconstriction and a clinical diagnosis of asthma. Respir Res. 2009; 10: 4.
   PubMed Web of Science ®Google Scholar
• Brannan JD, Perry CP, Anderson SD. Mannitol (AridolTM) test results in asthmatic adults receiving inhaled corticosteroids. J Allergy Clin Immunol. 2013; 131: 906–7.
   PubMed Web of Science ®Google Scholar
• GINA. Strategy for asthma management and prevention. 2015. chapter 1(5). Available from: http://wwwginasthma/org/local/uploads/files/GINA_Report2015_Trackedpdf.
   Google Scholar
• Kersten ET, Driessen JM, van der Berg JD, Thio BJ. Mannitol and exercise challenge tests in asthmatic children. Pediatr Pulmonol. 2009; 44: 655–61.
   PubMed Web of Science ®Google Scholar
• Barben J, Roberts M, Chew N, Carlin JB, Robertson CF. Repeatability of bronchial responsiveness to mannitol dry powder in children with asthma. Pediatr Pulmonol. 2003; 36: 490–4.
   PubMed Web of Science ®Google Scholar
• Barben J, Kuehni C, Strippoli M-P, Schiller B, Hammer J, Trachsel D. Mannitol dry powder challenge in comparison with exercise-testing in children. Pediatric Pulmonol. 2011; 46: 842–8.
   PubMed Web of Science ®Google Scholar
• Sverrild A, Porsbjerg C, Thomsen SF, Backer V. Diagnostic properties of inhaled mannitol in the diagnosis of asthma: a population study. J Allergy Clin Immunol. 2009; 124: 928–32.
   PubMed Web of Science ®Google Scholar
• Backer V, Sverrild A, Ulrik CS, Bodtger U, Seersholm N, Porsbjerg C. Diagnostic work-up in patients with possible asthma referred to a university hospital. Eur Clin Respir J. 2015; 2: 27768.
   PubMed Web of Science ®Google Scholar
• Porsbjerg C, Lund TK, Pedersen L, Backer V. Inflammatory subtypes in asthma are related to airway hyperresponsiveness to mannitol and exhaled NO. J Asthma. 2009; 46: 606–12.
   PubMed Web of Science ®Google Scholar
• Anderson WJ, Lipworth BJ. Relationship of mannitol challenge to methacholine challenge and inflammatory markers in persistent asthmatics receiving inhaled corticosteroids. Lung. 2012; 190: 513–21.
   PubMed Web of Science ®Google Scholar
• Clearie KL, Jackson CM, Fardon TC, Williamson PA, Vaidyanathan S, Burns P, etal. Supervised step-down of inhaled corticosteroids in the community-an observational study. Respir Med. 2011; 105: 558–65.
   Web of Science ®Google Scholar
• Lipworth BJ, Short PM, Williamson PA, Clearie KL, Fardon TC, Jackson CM. A randomized primary care trial of steroid titration against mannitol in persistent asthma: STAMINA trial. Chest. 2012; 141: 607–15.
   PubMed Web of Science ®Google Scholar
• Henriksen JM, Dahl R. Effects of inhaled budesonide alone and in combination with low-dose terbutaline in children with exercise-induced asthma. Am Rev Respir Dis. 1983; 128: 993–7.
   PubMed Web of Science ®Google Scholar
• Henriksen JM. Effect of inhalation of corticosteroids on exercise induced asthma: randomised double blind crossover study of budesonide in asthmatic children. Brit Med J. 1985; 291: 248–9.
   Google Scholar
• Vathenen AS, Knox AJ, Wisniewski A, Tattersfield AE. Effect of inhaled budesonide on bronchial reactivity to histamine, exercise, and eucapnic dry air hyperventilation in patients with asthma. Thorax. 1991; 46: 811–6.
   PubMed Web of Science ®Google Scholar
• Pedersen S, Hansen OR. Budesonide treatment of moderate and severe asthma in children: a dose-response study. J Allergy Clin Immunol. 1995; 95(1 Pt 1): 29–33.
   PubMed Web of Science ®Google Scholar
• Jonasson G, Carlsen KH, Hultquist C. Low-dose budesonide improves exercise-induced bronchospasm in schoolchildren. Pediatr Allergy Immunol. 2000; 11: 120–5.
   PubMed Web of Science ®Google Scholar
• du Toit JI, Anderson SD, Jenkins CR, Woolcock AJ, Rodwell LT. Airway responsiveness in asthma: bronchial challenge with histamine and 4.5% sodium chloride before and after budesonide. Allergy Asthma Proc. 1997; 18: 7–14.
   PubMed Web of Science ®Google Scholar
• Aldridge RE, Hancox RJ, Robin Taylor D, Cowan JO, Winn MC, Frampton CM, etal. Effects of terbutaline and budesonide on sputum cells and bronchial hyperresponsiveness in asthma. Am J Respir Crit Care Med. 2000; 161: 1459–64.
   PubMed Web of Science ®Google Scholar
• Hofstra WB, Neijens HJ, Duiverman EJ, Kouwenberg JM, Mulder PG, Kuethe MC, etal. Dose-response over time to inhaled fluticasone propionate: treatment of exercise- and methacholine-induced bronchoconstriction in children with asthma. Pediatr Pulmonol. 2000; 29: 415–23.
   PubMed Web of Science ®Google Scholar
• Subbarao P, Duong M, Adelroth E, Otis J, Obminski G, Inman M, etal. Effect of ciclesonide dose and duration of therapy on exercise-induced bronchoconstriction in patients with asthma. J Allergy Clin Immunol. 2006; 117: 1008–13.
   PubMed Web of Science ®Google Scholar
• Israel E, Dermarkarian R, Rosenberg M, Sperling R, Taylor G, Rubin P, etal. The effects of a 5-lipoxygenase inhibitor on asthma induced by cold, dry air. N Engl J Med. 1990; 323: 1740–4.
   PubMed Web of Science ®Google Scholar
• Meltzer SS, Hasday JD, Cohn J, Bleecker ER. Inhibition of exercise-induced bronchospasm by zileuton: a 5-lipoxygenase inhibitor. Am J Respir Crit Care Med. 1996; 153: 931–5.
   PubMed Web of Science ®Google Scholar
• Leff JA, Busse WW, Pearlman D, Bronsky EA, Kemp J, Hendeles L, etal. Montelukast, a leukotriene-receptor antagonist, for the treatment of mild asthma and exercise-induced bronchoconstriction. N Engl J Med. 1998; 339: 147–52.
   PubMed Web of Science ®Google Scholar
• Coreno A, Skowronski M, Kotaur C, McFadden ER. Comparative effects of long-acting b2-agonists, leukotriene antagonists, and a 5-lipoxygenase inhibitor on exercise-induced asthma. J Allergy Clin Immunol. 2000; 106: 500–6.
   PubMed Web of Science ®Google Scholar
• Edelman JM, Turpin JA, Bronsky EA, Grossman J, Kemp JP, Ghannam AF, etal. Oral montelukast compared with inhaled salmeterol to prevent exercise-induced bronchoconstriction. A randomized, double-blind trial. Exercise Study Group. Ann Intern Med. 2000; 132: 97–104.
   Web of Science ®Google Scholar
• Rundell K, Spiering BA, Baumann JM, Evans TM. Effects of montelukast on airway narrowing from eucapnic voluntary hyperventilation and cold air exercise. Br J Sports Med. 2005; 39: 232–6.
   PubMed Web of Science ®Google Scholar
• Reiss TF, Hill JB, Harman E, Zhang J, Tanaka WK, Bronsky E, etal. Increased urinary excretion of LTE4 after exercise and attenuation of exercise-induced bronchospasm by montelukast, a cysteinyl leukotriene receptor antagonist. Thorax. 1997; 52: 1030–5.
   PubMed Web of Science ®Google Scholar
• O'Sullivan S, Roquet A, Dahlén B, Larsen F, Eklund A, Kumlin M, etal. Evidence for mast cell activation during exercise-induced bronchoconstriction. Eur Respir J. 1998; 12: 345–50.
   PubMed Web of Science ®Google Scholar
• Brannan JD, Gulliksson M, Anderson SD, Chew N, Kumlin M. Evidence of mast cell activation and leukotriene release after mannitol inhalation. Eur Respir J. 2003; 22: 491–6.
   PubMed Web of Science ®Google Scholar
• Misso NLA, Aggarwal S, Phelps S, Beard R, Thompson PJ. Urinary leukotriene E4 and 9a,11b,-prostaglandin F2 concentrations in mild, moderate and severe asthma, and in healthy subjects. Clin Exp Allergy. 2004; 34: 624–31.
   PubMed Web of Science ®Google Scholar
• Brannan JD, Gulliksson M, Anderson SD, Chew N, Seale JP, Kumlin M. Inhibition of mast cell PGD2 release protects against mannitol-induced airway narrowing. Eur Respir J. 2006; 27: 944–50.
   PubMed Web of Science ®Google Scholar
• Hallstrand TS, Moody MW, Wurfel MM, Schwartz LB, Henderson WR, Aitken ML. Inflammatory basis of exercise-induced bronchoconstriction. Am J Respir Crit Care Med. 2005; 172: 679–86.
   PubMed Web of Science ®Google Scholar
• Kippelen P, Larsson J, Anderson SD, Brannan JD, Dahlen B, Dahlen SE. Effect of sodium cromoglycate on mast cell mediators during hyperpnea in athletes. Med Sci Sports Exerc. 2010; 42: 1853–60.
   PubMed Web of Science ®Google Scholar
• Kippelen P, Larsson J, Anderson SD, Brannan JD, Delin I, Dahlen B, etal. Acute effects of beclomethasone on hyperpnea-induced bronchoconstriction. Med Sci Sports Exerc. 2010; 42: 273–80.
   Web of Science ®Google Scholar
• Chan-Yeung M. The effect of Sch 1000 and disodium cromoglycate on exercise-induced asthma. Chest. 1977; 71: 320–3.
   PubMed Web of Science ®Google Scholar
• Tullett WM, Tan KM, Wall RT, Patel KR. Dose-response effect of sodium cromoglycate pressurised aerosol in exercise induced asthma. Thorax. 1985; 40: 41–4.
   PubMed Web of Science ®Google Scholar
• Juniper EF, Kline PA, Morris MM, Hargreave FE. Airway constriction by isocapnic hyperventilation of cold, dry air: comparison of magnitude and duration of protection by nedocromil sodium and sodium cromoglycate. Clin Allergy. 1987; 17: 523–8.
   PubMedGoogle Scholar
• Boulet L-P, Turcotte H, Tennina S. Comparative efficacy of salbutamol, ipratropium and cromoglycate in the prevention of bronchospasm induced by exercise and hyperosmolar challenges. J Allergy Clin Immunol. 1989; 83: 882–7.
   PubMed Web of Science ®Google Scholar
• Edmunds A, Tooley M, Godfrey S. The refractory period after exercise-induced asthma: its duration and relation to the severity of exercise. Am Rev Respir Dis. 1978; 117: 247–54.
   PubMed Web of Science ®Google Scholar
• Schoeffel RE, Anderson SD, Gillam I, Lindsay DA. Multiple exercise and histamine challenge in asthmatic patients. Thorax. 1980; 35: 164–70.
   Web of Science ®Google Scholar
• Wilson NM, Barnes PJ, Vickers H, Silverman M. Hyperventilation-induced asthma: evidence for two mechanisms. Thorax. 1982; 37: 657–62.
   Web of Science ®Google Scholar
• Rosenthal RR, Laube BL, Hood DB, Norman PS. Analysis of refractory period after exercise and eucapnic voluntary hyperventilation challenge. Am Rev Respir Dis. 1990; 141: 368–72.
   Google Scholar
• Belcher NG, Rees PJ, Clark TJM, Lee TH. A comparison of the refractory periods induced by hypertonic airway challenge and exercise in bronchial asthma. Am Rev Respir Dis. 1987; 135: 822–5.
   Google Scholar
• Larsson J, Perry CP, Anderson SD, Brannan JD, Dahlen S-E, Dahlen B. The occurrence of refractoriness and mast cell mediator release following mannitol-induced bronchoconstriction. J Appl Physiol. 2011; 110: 1029–35.
   PubMed Web of Science ®Google Scholar