A clear urban–rural gradient of allergic rhinitis in a population-based study in Northern Europe

References

• Brooks C, Pearce N, Douwes J. The hygiene hypothesis in allergy and asthma: an update. Curr Opin Allergy Clin Immunol. 2013; 13: 70–7.
   PubMed Web of Science ®Google Scholar
• Braun-Fahrlander C. Mikrobielles Umfeld und allergische Erkrankungen im Kindesalter. Ther Umsch. 2013; 70: 714–19. [In German].
   Google Scholar
• Bornelöv S, Sääf A, Melén E, Bergström A, Torabi Moghadam B, Pulkkinen V, etal. Rule-based models of the interplay between genetic and environmental factors in childhood allergy. PLoS One. 2013; 8: 1–12.
   Web of Science ®Google Scholar
• Linneberg A, Dam Petersen K, Hahn-Pedersen J, Hammerby E, Serup-Hansen N, Boxall N. Burden of allergic respiratory disease: a systematic review. Clin Mol Allergy. 2016; 14: 12.
   PubMedGoogle Scholar
• Meltzer EO, Bukstein DA. The economic impact of allergic rhinitis and current guidelines for treatment. Ann Allergy Asthma Immunol. 2011; 106: 12–6.
   PubMed Web of Science ®Google Scholar
• Riedler J, Eder W, Oberfeld G, Schreuer M. Austrian children living on a farm have less hay fever, asthma and allergic sensitization. Clin Exp Allergy. 2000; 30: 194–200.
   PubMed Web of Science ®Google Scholar
• Braun-Fahrländer C, Gassner M, Grize L, Neu U, Sennhauser FH, Varonier HS, etal. Prevalence of hay fever and allergic sensitization in farmer's children and their peers living in the same rural community. SCARPOL team. Swiss Study on Childhood Allergy and Respiratory Symptoms with Respect to Air Pollution. Clin Exp Allergy. 1999; 29: 28–34.
   PubMed Web of Science ®Google Scholar
• Von Ehrenstein O, Von Mutius E, Illi S, Baumann L, Bohm O, Von Kries R. Reduced risk of hay fever and asthma among children of farmers. Clin Exp Allergy. 2000; 30: 187–93.
   PubMed Web of Science ®Google Scholar
• Nicolaou N, Siddique N, Custovic A. Allergic disease in urban and rural populations: increasing prevalence with increasing urbanization. Allergy. 2005; 60: 1357–60.
   PubMed Web of Science ®Google Scholar
• Ege M, Mayer M, Normand A, Genuneit J, William O, Braun-Fahrländer C, etal. Exposure to enviromental microorganisms and childhood asthma. N Engl J Med. 2011; 364: 701–9.
   PubMed Web of Science ®Google Scholar
• Elholm G, Linneberg A, Husemoen LLN, Omland Ø, Grønager PM, Sigsgaard T, etal. The Danish urban-rural gradient of allergic sensitization and disease in adults. Clin Exp Allergy. 2016; 46: 103–11.
   PubMed Web of Science ®Google Scholar
• Eriksson J, Ekerljung L, Lötvall J, Pullerits T, Wennergren G, Rönmark E, etal. Growing up on a farm leads to lifelong protection against allergic rhinitis. Allergy. 2010; 65: 1397–403.
   PubMed Web of Science ®Google Scholar
• Kilpelaine M, Terh E, Helenius H, Koskenvuo M. Farm environment in childhood prevents the development of allergies. Clin Exp Allergy. 2000; 30: 201–8.
   Web of Science ®Google Scholar
• Campbell B, Raherison C, Lodge CJ, Lowe AJ, Gislason T, Heinrich J, etal. The effects of growing up on a farm on adult lung function and allergic phenotypes: an international population-based study. Thorax. 2016. [Epub ahead of print]
   Web of Science ®Google Scholar
• Omenaas E, Svanes C, Janson C, Toren K, Jogi R, Gislason T, etal. What can we learn about asthma and allergy from the follow-up of the RHINE and the ECRHS studies?. Clin Respir J. 2008; 2(Suppl 1): 45–52.
   PubMed Web of Science ®Google Scholar
• Burney PG, Luczynska C, Chinn S, Jarvis D. The European community respiratory health survey. Eur Respir J. 1994; 7: 954–60.
   PubMed Web of Science ®Google Scholar
• Johannessen A, Verlato G, Benediktsdottir B, Forsberg B, Franklin K, Gislason T, etal. Longterm follow-up in European respiratory health studies – patterns and implications. BMC Pulm Med. 2014; 14: 63.
   Web of Science ®Google Scholar
• Timm S, Svanes C, Janson C, Sigsgaard T, Johannessen A, Gislason T, etal. Place of upbringing in early childhood as related to inflammatory bowel diseases in adulthood: a population-based cohort study in Northern Europe. Eur J Epidemiol. 2014; 29: 429–37.
   PubMed Web of Science ®Google Scholar
• Timm S, Frydenberg M, Janson C, Campbell B, Forsberg B, Gislason T, etal. The urban-rural gradient in asthma: a population-based study in Northern Europe. Int J Environ Res Public Health. 2016; 13: 93–107.
   Web of Science ®Google Scholar
• MacNeill SJ, Sozanska B, Danielewicz H, Debinska A, Kosmeda A, Boznanski A, etal. Asthma and allergies: is the farming environment (still) protective in Poland? The GABRIEL Advanced Studies. Allergy. 2013; 68: 771–9.
   PubMed Web of Science ®Google Scholar
• Olivieri M, Heinrich J, Schlünssen V, Antó J, Forsberg B, Janson C, etal. The risk of respiratory symptoms on allergen exposure increases with increasing specific IgE levels. Allergy. 2016; 6: 859–68.
   Google Scholar
• Bodtger U, Poulsen LK, Linneberg A. Rhinitis symptoms and IgE sensitization as risk factors for development of later allergic rhinitis in adults. Allergy. 2006; 61: 712–6.
   Web of Science ®Google Scholar
• Toren K, Gislason T, Omenaas E, Jogi R, Forsberg B, Nystrom L, etal. A prospective study of asthma incidence and its predictors: the RHINE study. Eur Respir J. 2004; 24: 942–6.
   PubMed Web of Science ®Google Scholar
• Douwes J, Travier N, Huang K, Cheng S, McKenzie J, Le Gros G, etal. Lifelong farm exposure may strongly reduce the risk of asthma in adults. Allergy. 2007; 62: 1158–65.
   PubMed Web of Science ®Google Scholar
• Elholm G, Schlünssen V, Doekes G, Basinas I, Bibby BM, Hjort C, etal. Become a farmer and avoid new allergic sensitization: adult farming exposures protect against new-onset atopic sensitization. J Allergy Clin Immunol. 2013; 132: 1239–41.
   Web of Science ®Google Scholar
• Bowatte G, Lodge C, Lowe AJ, Erbas B, Perret J, Abramson MJ, etal. The influence of childhood traffic-related air pollution exposure on asthma, allergy and sensitization: a systematic review and a meta-analysis of birth cohort studies. Allergy. 2015; 70: 245–56.
   PubMed Web of Science ®Google Scholar
• Chiarella SE, Fernandez R, Avila PC. The genes and the environment in nasal allergy. Curr Opin Allergy Clin Immunol. 2015; 15: 440–5.
   Web of Science ®Google Scholar
• Eduard W, Schlünssen V, Sigsgaard T, Omland Ø, Pearce N, Douwes J. Can selection explain the protective effects of farming on asthma?. Ann Agr Environ Med. 2015; 22: 467–9.
   Web of Science ®Google Scholar
• Bråbäck L, Hjem A, Rasmussen F. Selective migration to a healthy worker effect in the farming population. J Clin Epidemiol. 2006; 59: 102–5.
   PubMed Web of Science ®Google Scholar
• Riedler J. Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey. J Am Med Assoc. 2001; 286: 1129–33.
   Google Scholar
• Horak F, Studnicka M, Gartner C, Veiter A, Tauber E, Urbanek R, etal. Parental farming protects children against atopy: longitudinal evidence involving skin prick tests. Clin Exp Allergy. 2002; 32: 1155–9.
   PubMed Web of Science ®Google Scholar
• Horak E, Morass B, Ulmer H, Genuneit J, Braun-Fahrländer C, von Mutius E. Prevalence of wheezing and atopic diseases in Austrian schoolchildren in conjunction with urban, rural or farm residence. Wien Klin Wochenschr. 2014; 126: 532–6.
   Web of Science ®Google Scholar
• Strachan DP. Hay fever, hygiene, and household size. Br Med J. 1989; 299: 1259–60.
   PubMed Web of Science ®Google Scholar
• Karmaus W, Botezan C. Does a higher number of siblings protect against the development of allergy and asthma?. A review. J Epidemiol Community Health. 2002; 56: 209–17.
   PubMed Web of Science ®Google Scholar
• Leynaert B, Neukirch C, Jarvis D, Chinn S, Burney P, Neukirch F. Does living on a farm during childhood protect against asthma, allergic rhinitis, and atopy in adulthood?. Am J Respir Crit Care Med. 2001; 164: 1829–34.
   PubMed Web of Science ®Google Scholar
• Gassner-Bachmann M, Wüthrich B. Bauernkinder leiden selten an Heuschnupfen und asthma. Dtsch Med Wochenschr. 2000; 125: 924–31. [In German].
   PubMed Web of Science ®Google Scholar
• Matheson MC, Dharmage SC, Abramson MJ, Walters EH, Sunyer J, de Marco R, etal. Early-life risk factors and incidence of rhinitis: results from the European community respiratory health study. An international population-based cohort study. J Allergy Clin Immunol. 2011; 128: 816–23.
   PubMed Web of Science ®Google Scholar
• Genuneit J, Strachan DP, Büchele G, Weber J, Loss G, Sozanska B, etal. The combined effects of family size and farm exposure on childhood hay fever and atopy. Pediatr Allergy Immunol. 2013; 24: 293–8.
   Web of Science ®Google Scholar
• Svanes C, Heinrich J, Jarvis D, Chinn S, Omenaas E, Gulsvik A, etal. Pet-keeping in childhood and adult asthma and hay fever: European community respiratory health survey. J Allergy Clin Immunol. 2003; 112: 289–300.
   PubMed Web of Science ®Google Scholar