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Original Articles

Genetic variation in the fat mass and obesity-associated gene (FTO) in association with food preferences in healthy adults

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Article: 20028 | Received 05 Nov 2012, Accepted 14 Mar 2013, Published online: 12 Apr 2013

References

  • Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, etal. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science. 2007; 316: 889–94.
  • Hertel JK, Johansson S, Sonestedt E, Jonsson A, Lie RT, Platou CG, etal. FTO, type 2 diabetes, and weight gain throughout adult life: a meta-analysis of 41,504 subjects from the Scandinavian HUNT, MDC, and MPP studies. Diabetes. 2011; 60: 1637–44.
  • Lee HJ, Kim IK, Kang JH, Ahn Y, Han BG, Lee JY, etal. Effects of common FTO gene variants associated with BMI on dietary intake and physical activity in Koreans. Clin Chim Acta. 2010; 411: 1716–22.
  • Wen W, Cho YS, Zheng W, Dorajoo R, Kato N, Qi L, etal. Meta-analysis identifies common variants associated with body mass index in east Asians. Nat Genet. 2012; 44: 307–11.
  • Adeyemo A, Chen G, Zhou J, Shriner D, Doumatey A, Huang H, etal. FTO genetic variation and association with obesity in West Africans and African Americans. Diabetes. 2010; 59: 1549–54.
  • Sonestedt E, Roos C, Gullberg B, Ericson U, Wirfalt E, Orho-Melander M. Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity. Am J Clin Nutr. 2009; 90: 1418–25.
  • Cecil JE, Tavendale R, Watt P, Hetherington MM, Palmer CN. An obesity-associated FTO gene variant and increased energy intake in children. N Engl J Med. 2008; 359: 2558–66.
  • Timpson NJ, Emmett PM, Frayling TM, Rogers I, Hattersley AT, McCarthy MI, etal. The fat mass- and obesity-associated locus and dietary intake in children. Am J Clin Nutr. 2008; 88: 971–8.
  • Kilpelainen TO, Qi L, Brage S, Sharp SJ, Sonestedt E, Demerath E, etal. Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med. 2011; 8: e1001116.
  • Fischer J, Koch L, Emmerling C, Vierkotten J, Peters T, Bruning JC, etal. Inactivation of the Fto gene protects from obesity. Nature. 2009; 458: 894–8.
  • Church C, Moir L, McMurray F, Girard C, Banks GT, Teboul L, etal. Overexpression of Fto leads to increased food intake and results in obesity. Nat Genet. 2010; 42: 1086–92.
  • Phillips CM, Kesse-Guyot E, McManus R, Hercberg S, Lairon D, Planells R, etal. High dietary saturated fat intake accentuates obesity risk associated with the fat mass and obesity associated gene in adults. J Nutr. 2012; 142: 824–31.
  • Lappalainen T, Lindstrom J, Paananen J, Eriksson JG, Karhunen L, Tuomilehto J, etal. Association of the fat mass and obesity-associated (FTO) gene variant (rs9939609) with dietary intake in the Finnish Diabetes Prevention Study. Br J Nutr. 2012; 1–7.
  • Wardle J, Llewellyn C, Sanderson S, Plomin R. The FTO gene and measured food intake in children. Int J Obes (Lond). 2009; 33: 42–5.
  • Olszewski PK, Fredriksson R, Olszewska AM, Stephansson O, Alsio J, Radomska KJ, etal. Hypothalamic FTO is associated with the regulation of energy intake not feeding reward. BMC Neurosci. 2009; 10: 129.
  • Llewellyn CH, van Jaarsveld CH, Plomin R, Fisher A, Wardle J. Inherited behavioral susceptibility to adiposity in infancy: a multivariate genetic analysis of appetite and weight in the Gemini birth cohort. Am J Clin Nutr. 2012; 95: 633–9.
  • Hasselbalch AL, Angquist L, Christiansen L, Heitmann BL, Kyvik KO, Sorensen TI. A variant in the fat mass and obesity-associated gene (FTO) and variants near the melanocortin-4 receptor gene (MC4R) do not influence dietary intake. J Nutr. 2010; 140: 831–4.
  • Corella D, Arnett DK, Tucker KL, Kabagambe EK, Tsai M, Parnell LD, etal. A high intake of saturated fatty acids strengthens the association between the fat mass and obesity-associated gene and BMI. J Nutr. 2011; 141: 2219–25.
  • Grau K, Hansen T, Holst C, Astrup A, Saris WH, Arner P, etal. Macronutrient-specific effect of FTO rs9939609 in response to a 10-week randomized hypo-energetic diet among obese Europeans. Int J Obes (Lond). 2009; 33: 1227–34.
  • Moleres A, Ochoa MC, Rendo-Urteaga T, Martinez-Gonzalez MA, Azcona San Julian MC, Martinez JA, etal. Dietary fatty acid distribution modifies obesity risk linked to the rs9939609 polymorphism of the fat mass and obesity-associated gene in a Spanish case-control study of children. Br J Nutr. 2012; 107: 533–8.
  • Bauer F, Elbers CC, Adan RA, Loos RJ, Onland-Moret NC, Grobbee DE, etal. Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference. Am J Clin Nutr. 2009; 90: 951–9.
  • Sonestedt E, Gullberg B, Ericson U, Wirfalt E, Hedblad B, Orho-Melander M. Association between fat intake, physical activity and mortality depending on genetic variation in FTO . Int J Obes (Lond). 2010; 35: 1041–9.
  • Manjer J, Carlsson S, Elmstahl S, Gullberg B, Janzon L, Lindstrom M, etal. The Malmo diet and cancer study: representativity, cancer incidence and mortality in participants and non-participants. Eur J Cancer Prev. 2001; 10: 489–99.
  • Callmer E, Riboli E, Saracci R, Akesson B, Lindgarde F. Dietary assessment methods evaluated in the Malmo food study. J Intern Med. 1993; 233: 53–7.
  • Mattisson I, Wirfalt E, Aronsson CA, Wallstrom P, Sonestedt E, Gullberg B, etal. Misreporting of energy: prevalence, characteristics of misreporters and influence on observed risk estimates in the Malmo Diet and Cancer cohort. Br J Nutr. 2005; 94: 832–42.
  • Wallstrom P, Sonestedt E, Hlebowicz J, Ericson U, Drake I, Persson M, etal. Dietary fiber and saturated fat intake associations with cardiovascular disease differ by sex in the malmo diet and cancer cohort: a prospective study. PloS one. 2012; 7: e31637.
  • Siegel S, John Castellan N Jr. Nonparametric statistics for the behavioral sciences. 1988; 2nd ed, New York: McGraw-Hill.
  • McCaffery JM, Papandonatos GD, Peter I, Huggins GS, Raynor HA, Delahanty LM, etal. Obesity susceptibility loci and dietary intake in the Look AHEAD Trial. Am J Clin Nutr. 2012; 95: 1477–86.
  • Tanofsky-Kraff M, Han JC, Anandalingam K, Shomaker LB, Columbo KM, Wolkoff LE, etal. The FTO gene rs9939609 obesity-risk allele and loss of control over eating. Am J Clin Nutr. 2009; 90: 1483–8.
  • Lissner L. Measuring food intake in studies of obesity. Public Health Nutr. 2002; 5: 889–92.
  • Hubacek JA, Pikhart H, Peasey A, Kubinova R, Bobak M. FTO variant, energy intake, physical activity and basal metabolic rate in Caucasians. The HAPIEE study. Physiol Res. 2011; 60: 175–83.
  • Speakman JR, Rance KA, Johnstone AM. Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure. Obesity (Silver Spring). 2008; 16: 1961–5.
  • Li C, Aronsson CA, Hedblad B, Gullberg B, Wirfalt E, Berglund G. Ability of physical activity measurements to assess health-related risks. Eur J Clin Nutr. 2009; 63: 1448–51.
  • Holmback I, Ericson U, Gullberg B, Wirfalt E. Five meal patterns are differently associated with nutrient intakes, lifestyle factors and energy misreporting in a sub-sample of the Malmo Diet and Cancer cohort. Food Nutr Res. 2009; 53
  • Rokholm B, Silventoinen K, Tynelius P, Gamborg M, Sorensen TI, Rasmussen F. Increasing genetic variance of body mass index during the Swedish obesity epidemic. PloS one. 2011; 6: e27135.