In vitro catabolism of quercetin by human fecal bacteria and the antioxidant capacity of its catabolites

References

• Havsteen BH. The biochemistry and medical significance of the flavonoids. Pharmacol Ther. 2002; 96: 167–202.
   Web of Science ®Google Scholar
• Crozier A, Jaganath IB, Clifford MN. Dietary phenolics: chemistry, bioavailability and effects on health. Nat Prod Rep. 2009; 26: 1001–43.
   Google Scholar
• Jaganath B, Mullen W, Lean MEJ, Edwards CA, Crozier A. In vitro catabolism of rutin by human fecal bacteria and the antioxidant capacity of its catabolites. Free Radic Biol Med. 2009; 47: 1180–9.
   Google Scholar
• Spencer JPE. Metabolism of tea flavonoids in the gastrointestinal tract. J Nutr. 2003; 133: 3255–61.
   PubMed Web of Science ®Google Scholar
• Halliwell B, Rafter J, Jenner A. Health promotion by flavonoids, tocopherols, tocotrienols, and other phenols: direct or indirect effects? Antioxidants or not?. Am J Clin Nutr. 2005; 81: 268–76.
   PubMed Web of Science ®Google Scholar
• Gordon MH, Roedig-Penman A. Antioxidant activity of quercetinand myricetin in liposomes. Chem Phys Lipids. 1988; 97: 79–85.
   Web of Science ®Google Scholar
• Ameho CK, Chen CYO, Smith D, Sánchez-Moreno C, Milbury PE, Blumberg JB. Antioxidant activity and metabolite profile of quercetin in vitamin-E-depleted rats. J Nutr Biochem. 2008; 19: 467–74.
   Google Scholar
• Lotito SB, Zhang W, Yang CS, Crozier A, Frei B. Metabolic conversion of dietary flavonoids alters their anti-inflammatory and antioxidant properties. Free Radical Biol Med. 2011; 51: 454–63.
   PubMed Web of Science ®Google Scholar
• Serra A, Macia A, Romero M, Reguant J, Ortega N, Motilva M. Metabolic pathways of the colonic metabolism of flavonoids (flavonols, flavones and flavanones) and phenolic acids. Food Chem. 2012; 130: 383–93.
   Web of Science ®Google Scholar
• Yang J, Qian D, Guo J, Jiang S, Shang E, Duan J, Xu Jun. Identification of the major metabolites of hyperoside produced by the human intestinal bacteria using the ultra performance liquid chromatography/quadrupole-time-of-flight mass spectrometry. J Ethnopharmacol. 2013; 147: 174–9.
   Google Scholar
• Zhang Z, Peng X, Li S, Zhang N, Wang Y, Wei H. Isolation and identification of quercetin degrading bacteria from human fecal microbes. PLOS one. 2014; 9: 1–4.
   Web of Science ®Google Scholar
• Schneider H, Simmering R, Hartmann L, Pforte H, Blaut M. Degradation of quercetin-3-glucoside in gnotobiotic rats associated with human intestinal bacteria. J Appl Microbiol. 2000; 89: 1027–37.
   Google Scholar
• Keppler K, Hein EM, Humpf HU. Metabolism of quercetin and rutin by the pig caecal microflora prepared by freeze-preservation. Mol Nutr Food Res. 2006; 50: 686–95.
   Google Scholar
• Blois MS. Antioxidants determination by the use of a stable free radical. Nature. 1958; 181: 1199–200.
   Web of Science ®Google Scholar
• Halliwell B, Gutteridge JM, Aruoma OI. The deoxyribose method: a simple “test tube” assay for determination of rate constants for reactions of hydroxyl radicals. Anal Biochem. 1987; 165: 215–19.
   Google Scholar
• Walle TU, Walle K, Halushka PV. Carbon dioxide is the major metabolite of quercetin in humans. J Nutr. 2001; 131: 2648–52. [PubMed Abstract] [PubMed Abstract].
   Google Scholar
• Shirai M, Moon J, Tsushida T, Terao J. Inhibitory effect of a quercetin metabolite, quercetin 3-O-β-D-glucuronide, on lipid peroxidation in liposomal membranes. J Agric Food Chem. 2001; 49: 5602–8.
   Google Scholar
• Angeloni C, Spencer JPE, Leoncini E, Biagi PL, Hrelia S. Role of quercetin and its in vivo metabolites in protecting H9c2 cells against oxidative stress. Biochimie. 2007; 89: 73–82.
   Google Scholar
• Chao C, Hou Y, Chao PL, Weng C, Ho F. The antioxidant effects of quercetin metabolites on the prevention of high glucose-induced apoptosis of human umbilical vein endothelial cells. Br J Nutr. 2009; 101: 1165–70.
   Google Scholar
• Dueñas M, González-Manzano S, González-Paramás A, Santos-Buelga C. Antioxidant evaluation of O-methylated metabolites of catechin, epicatechin and quercetin. J Pharm Biomed Anal. 2010; 51: 443–9.
   PubMed Web of Science ®Google Scholar
• Wexler HM. Bacteroides: the good, the bad, and the nitty-gritty. Clin Microbiol Rev. 2007; 20: 593–621.
   Google Scholar
• Tannock GW. The bowel microbiota and inflammatory bowel diseases. Int J Inflamm. 2011; 34: 147–54.
   Google Scholar
• Tannock GW, Lawley B, Munro Lay KC, Taylor C, Daynes C, Baladjay L, etal. Comprehensive analysis of the bacterial content of stool from patients with chronic pouchitis, normal pouches, or familialadenomatous polyposis pouches. Inflamm Bowel Dis. 2012; 18: 925–34.
   Google Scholar