Delta- and gamma-tocotrienol isomers are potent in inhibiting inflammation and endothelial activation in stimulated human endothelial cells

References

• De Winther MPJ, Kanters E, Kraal G, Hofker MH. Nuclear factor kB signaling in atherogenesis. Arterioscler Thromb Vasc Biol. 2005; 25: 904–14. [PubMed Abstract].
   Google Scholar
• Hansson GK, Hermansson A. The immune system in atherosclerosis. Nat Immunol. 2011; 12(3): 2014–212.
   Web of Science ®Google Scholar
• Lonn E, Bosch J, Yusuf S, Sheridan P, Pogue J, Arnold JM, etal. Effects of long-term vitamin E supplementation on cardiovascular events: randomized controlled: a randomized controlled trial. JAMA. 2005; 293(11): 1338–47. [PubMed Abstract].
   Google Scholar
• De Leeuw K, Sanders JS, Stegeman C, Smit A, Kallenberg CG, Bijl M. Accelerated atherosclerosis in patients with Wegener's granulomatosis. Ann Rheum Dis. 2005; 64: 753–9. [PubMed Abstract].
   Google Scholar
• Nawawi H, Osman NS, Annuar R, Khalid BAK, Yusoff K. Soluble intercellular adhesion molecule-1 and interleukin-6 levels reflect endothelial dysfunction in patients with primary hypercholesterolaemia treated with atorvastatin. Atherosclerosis. 2003; 169: 283–91. [PubMed Abstract].
   Google Scholar
• Van Guilder GP, Hoetzer GL, Greiner JJ, Stauffer BL, DeSouza CA. Influence of metabolic syndrome on biomarkers of oxidative stress and inflammation in obese adults. Obesity. 2006; 14: 2127–31. [PubMed Abstract].
   Google Scholar
• Fish JE, Matouk CC, Rachlis A, Lin S, Tai SC, D'Abreo C, etal. The expression of endothelial nitric-oxide synthase is controlled by a cell-specific histone code. J Biol Chem. 2005; 280(26): 24824–38. [PubMed Abstract].
   Google Scholar
• Huang PL, Lo EH. Genetic analysis of NOS isoforms using nNOS and eNOS knockout animals. Prog Brain Res. 1998; 118: 13–25. [PubMed Abstract].
   Google Scholar
• Zhang R, Ran H, Gao Y, Huang Y, Bai Y, Lin L. Differential vascular cell adhesion molecule-1 expression and superoxide production in simulated microgravity rat vasculature. EXCLI J. 2010; 9: 195–204.
   Web of Science ®Google Scholar
• Spiecker M, Peng HB, Liao JK. Inhibition of endothelial vascular cell adhesion molecule-1 expression by nitric oxide involves the induction and nuclear translocation of IkappaBalpha. J Biol Chem. 1997; 272(49): 30969–74. [PubMed Abstract].
   Google Scholar
• Peng HB, Libby P, Liao JK. Induction and stabilization of I kappa B alpha by nitric oxide mediates inhibition of NF-kappa B. J Biol Chem. 1995; 270: 14214–19. [PubMed Abstract].
   Google Scholar
• Kuhlencordt PJ, Rosel E, Gerszten RE, Morales-Ruiz M, Dombkowski D, Atkinson WJ, etal. Role of endothelial nitric oxide synthase in endothelial activation: insights from eNOS knockout endothelial cells. Am J Physiol Cell Physiol. 2004; 286: C1195–202. [PubMed Abstract].
   Google Scholar
• Rimm B, Stampfer M, Ascherio A, Giovannuci E, Colditz G, Willet W. Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med. 1993; 328(20): 1450–6. [PubMed Abstract].
   Google Scholar
• Qureshi AA, Burger WC, Peterson DM, Elson CE. The structure of an inhibitor of cholesterol biosysnthesis isolated from barley. J Biol Chem. 1986; 261(23): 10544–50. [PubMed Abstract].
   Google Scholar
• Qureshi AA, Sami SA, Salser WA, Khan FA. Dose-dependent suppression of serum cholesterol by tocotrienol-rich fraction (TRF25) of rice bran in hypercholesterolemic humans. Atherosclerosis. 2002; 161: 199–207. [PubMed Abstract].
   Google Scholar
• Muid S, Ali AM, Yusoff K, Nawawi H. Optimal antioxidant activity with moderate concentrations of tocotrienol rich fraction (TRF) in vitro assays. Int Food Res J. 2013; 20(2): 687–94.
   Google Scholar
• Mukherjee S, Mitra A. Health effects of palm oil. J Hum Ecol. 2009; 26(3): 197–203.
   Google Scholar
• Khanna S, Patel V, Rink C, Roy S, Sen CK. Delivery of orally supplemented α-tocotrienol to vital organs of rats and tocopherol-transport protein deficient mice. Changes. 2005; 39(10): 1310–19.
   Google Scholar
• Khosla P, Patel V, Whinter JM, Khanna S, Rakhkovskaya M, Roy S, etal. Postprandial levels of the natural vitamin E tocotrienol in human circulation. Antioxid Redox Signal. 2006; 8(5–6): 1059–68. [PubMed Abstract].
   Google Scholar
• Nakagawa K, Shibata A, Yamashita S, Tsuzuki T, Kariya J, Oikawa S, etal. In vivo angiogenesis is suppressed by unsaturated vitamin E, tocotrienol. J Nutr. 2007; 137: 1938–43. [PubMed Abstract].
   Google Scholar
• Baliarsingh S, Beg ZH, Ahmad J. The therapeutic impacts of tocotrienols in type 2 diabetic patients with hyperlipidemia. Atherosclerosis. 2005; 182: 367–74. [PubMed Abstract].
   Google Scholar
• Maclellan M. Palm oil. J Am Oil Chem Soc. 1983; 60(2): 368–73.
   Web of Science ®Google Scholar
• Tan B. Tocotrienols: the new vitamin E. spacedoc. 2011. Available from: http://www.spacedoc.com/tocotrienols [cited 15 Oct 2015]..
   Google Scholar
• Selvaduray KR, Radhakrishnan AK, Kutty MK, Nesaretnam K. Palm tocotrienols decrease levels of pro-angiogenic markers in human umbilical vein endothelial cells (HUVEC) and murine mammary cancer cells. Genes Nutr. 2012; 7: 53–61. [PubMed Abstract].
   Google Scholar
• Theriault A, Chao JT, Gapor A. Tocotrienol is the most effective vitamin E for reducing endothelial expression of adhesion molecules and adhesion to monocytes. Atherosclerosis. 2002; 160: 21–30. [PubMed Abstract].
   Google Scholar
• Naito Y, Shimozawa M, Kuroda M, Nakabe N, Manabe H, Katada K, etal. Tocotrienols reduce 25-hydroxycholesterol-induced monocyte-endothelial cell interaction by inhibiting the surface expression of adhesion molecules. Atherosclerosis. 2005; 180: 19–25. [PubMed Abstract].
   Google Scholar
• Vasanthi HR, Parameswari RP, Das DK. Multifaceted role of tocotrienols in cardioprotection supports their structure: function relation. Genes Nutr. 2012; 7: 19–28. [PubMed Abstract].
   Google Scholar
• Nawawi H, Muid S, Manaf A, Yusoff K. Low to moderate tocotrienol concentration exhibits optimal antioxidant activity and reduces production of inflammatory markers by endothelial cells. Atherosclerosis Suppl. 2006; 7: 224
   Web of Science ®Google Scholar
• Qureshi AA, Reis JC, Papasian CJ, Morrison DC, Qureshi N. Tocotrienols inhibit lipopolysaccharide-induced pro-inflammatory cytokines in macrophages of female mice. Lipids in Health and Disease. 2010; 9(1): 143. [PubMed CentralFull Text].
   Google Scholar
• Muid S, Froemming G, Ali M, Nawawi H. Tocotrienol rich fraction upregulates endothelial nitric oxide synthase protein expression in stimulated endothelial cells. Atherosclerosis Suppl. 2009; 10 e580. doi: http://dx.doi.org/10.1016/S1567-5688(09)70568-9 [PubMed CentralFull Text].
   Google Scholar
• Yam ML, Abdul Hafid SR, Cheng HM, Nesaretnam K. Tocotrienols suppress proinflammatory markers and cyclooxygenase-2 expression in RAW264.7 macrophages. Lipids. 2009; 44: 787–97. [PubMed Abstract].
   Google Scholar
• Chao JT, Gapor A, Theriault A. Inhibitory effect of delta-tocotrienol, a HMG CoA reductase inhibitor, on monocyte-endothelial cell adhesion. Journal of Nutritional Science and Vitaminology. 2002; 48(5): 332–337.
   Web of Science ®Google Scholar
• Abdul Rahman Sazli F, Jubri Z, Abdul Rahman M, Karsani SA, Md Top AG, Wan Ngah WZ. Gamma-tocotrienol treatment increased peroxiredoxin-4 expression in HepG2 liver cancer cell line. BMC Complementary and Alternative Medicine. 2015; 15(1): 1–7.
   Web of Science ®Google Scholar
• Hickey MJ. Role of inducible nitric oxide synthase in the regulation of leucocyte recruitment. Clin Sci (Lond). 2001; 100: 1–12. [PubMed Abstract].
   Google Scholar
• Förstermann U. Nitric oxide and oxidative stress in vascular disease. Pflugers Arch Eur J Physiol. 2010; 459: 923–39.
   PubMed Web of Science ®Google Scholar
• Das S, Powell SR, Wang P, Divald A, Nasaretnam K, Tosaki A, etal. Cardioprotection with palm tocotrienol: antioxidant activity of tocotrienol is linked with its ability to stabilize proteasomes. Am J Physiol Heart Circ Physiol. 2008; 289: H361–H367.
   Google Scholar
• Ikeda S, Tohyama T, Yoshimura H, Hamamura K, Abe K, Yamashita K. Dietary alpha-tocopherol decreases alpha-tocotrienol but not gamma-tocotrienol concentration in rats. The Journal of Nutrition. 2003; 133(2): 428–434.
   Google Scholar
• Saura M, Zaragoza C, Bao C, Herranz B, Rodriguez-Puyol M, Lowenstein CJ. Stat3 mediates interleukin-6 inhibition of human endothelial nitric-oxide synthase expression. J Biol Chem. 2006; 281(40): 30057–62. [PubMed Abstract].
   Google Scholar
• Nesaretnam K, Meganathan P. Tocotrienols: inflammation and cancer. Ann N Y Acad Sci. 2011; 1229: 18–22. [PubMed Abstract].
   Google Scholar
• Ng LT, Ko HJ. Comparative effects of tocotrienol-rich fraction, α-tocopherol and α-tocopheryl acetate on inflammatory mediators and nuclear factor kappa B expression in mouse peritoneal macrophages. 2012; 134: 920–5. doi: http://dx.doi.org/10.1016/j.foodchem.2012.02.206 [PubMed Abstract] Food Chem.
   Google Scholar
• Qureshi AA, Reis JC, Qureshi N, Papasian CJ, Morrison DC, Schaefer DM. δ-Tocotrienol and quercetin reduce serum levels of nitric oxide and lipid parameters in female chickens. Lipids Health Dis. 2011; 10: 39. [PubMed Abstract] [PubMed CentralFull Text].
   Google Scholar
• Noguchi N, Hanyu R, Nonaka A, Okimoto Y, Kodama T. Inhibition of THP-1 cell adhesion to endothelial cells by alpha-tocopherol and alpha-tocotrienol is dependent on intracellular concentration of the antioxidants. Free Radic Biol Med. 2003; 34(12): 1614–20. [PubMed Abstract].
   Google Scholar