Rare ATGL haplotypes are associated with increased plasma triglyceride concentrations in the Greenland Inuit

References

• Nordestgaard BG, Benn M, Schnohr P, Tybjaerg-Hansen A. Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease and death in men and women. JAMA 2007; 298 (3): 299–308.
   PubMed Web of Science ®Google Scholar
• Bansal S, Buring JE, Rifai N, Mora S, Sacks FM, Ridker PM. Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women. JAMA 2007; 298 (3): 309–316.
   PubMed Web of Science ®Google Scholar
• Freiberg JJ, Tybjaerg-Hansen A, Jensen JS, Nordest-gaard BG. Nonfasting triglycerides and risk of ischemic stroke in the general population. JAMA 2008;300 (18): 21 42–2152.
   Google Scholar
• Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet 2005; 365 (9468): 1415–1428.
   PubMed Web of Science ®Google Scholar
• Nagle CA, Klett EL, Coleman RA. Hepatic triacylglycerol accumulation and insulin resistance. J Lipid Res 2009;50 Suppl:574–79.
   Google Scholar
• Joy T, Hegele RA. Genetics of metabolic syndrome: is there a role for phenomics? Curr Atheroscler Rep 2008; 10 (3): 201–208.
   Web of Science ®Google Scholar
• Hegele RA, Pollex RL. Hypertriglyceridemia: phenomics and genomics. Mol Cell Biochem 2009; 326 (1–2): 35–43.
   PubMed Web of Science ®Google Scholar
• Al-Attar SA, Pollex RL, Ban MR, et al. Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample. Cardiovasc Diabetol 2008; 7: 5.
   PubMed Web of Science ®Google Scholar
• Barrows BR, Parks EJ. Contributions of different fatty acid sources to very low-density lipoprotein-triacylglycerol in the fasted and fed states. J Clin Endocrinol Metab 2006; 91 (4): 1446–1452.
   PubMed Web of Science ®Google Scholar
• Zimmermann R, Strauss JG, Haemmerle G, et al. Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science 2004; 306 (5700): 1383—1386.
   Web of Science ®Google Scholar
• Villena JA, Roy S, Sarkadi-Nagy E, Kim KH, Sul HS. Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis. J Biol Chem 2004; 279 (45): 47066–47075.
   PubMed Web of Science ®Google Scholar
• Jenkins CM, Mancuso DJ, Yan W, Sims HF, Gibson B, Gross RW. Identification, cloning, expression and purification of three novel human calcium-independent phospholipase A2 family members possessing triacyl-glycerol lipase and acylglycerol transacylase activities. J Biol Chem 2004; 279 (47): 48968–48975.
   PubMed Web of Science ®Google Scholar
• Wang S, Soni KG, Semache M, et al. Lipolysis and the integrated physiology of lipid energy metabolism. Mol Genet Metab 2008; 95 (3): 117–126.
   PubMed Web of Science ®Google Scholar
• Zechner R, Kienesberger PC, Haemmerle G, Zimmermann R, Lass A. Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores. J Lipid Res 2009; 50 (1): 3–21.
   PubMed Web of Science ®Google Scholar
• Zimmermann R, Lass A, Haemmerle G, Zechner R. Fate of fat: the role of adipose triglyceride lipase in lipolysis. Biochim Biophys Acta 2009; 1791 (6): 494–500.
   PubMed Web of Science ®Google Scholar
• Reid BN, Ables GP, Otlivanchik OA, et al. Hepatic overexpression of hormone-sensitive lipase and adipose triglyceride lipase promotes fatty acid oxidation, stimulates direct release of free fatty acids, and ameliorates steatosis. J Biol Chem 2008; 283 (19): 13087–13099.
   PubMed Web of Science ®Google Scholar
• Watt MJ, van Denderen BJ, Castelli LA, et al. Adipose triglyceride lipase regulation of skeletal muscle lipid metabolism and insulin responsiveness. Mol Endocrinol 2008; 22 (5): 1200–1212.
   Google Scholar
• Schweiger M, Lass A, Zimmermann R, Eichmann TO, Zechner R. Neutral lipid storage disease: genetic disorders caused by mutations in adipose triglyceride lipase/PNPLA2 or CGI-58/ABHD5. Am J Physiol Endocrinol Metab 2009; 297 (2): E289–296.
   Web of Science ®Google Scholar
• Hegele RA. Genetic prediction of atherosclerosis: lessons from studies in native Canadian populations. Clin Chim Acta 1999; 286 (1–2): 47–61.
   Web of Science ®Google Scholar
• Lahiry P, Ban MR, Pollex RL, et al. Common variants APOC3, AP0A5, APOE and PONI are associated with variation in plasma lipoprotein traits in Greenlanders. Int J Circumpolar Health 2007; 66 (5): 390–400.
   PubMed Web of Science ®Google Scholar
• Rajakumar C, Ban MR, Cao H, Young TK, Bjerregaard P, Hegele RA. Carnitine palmitoyltransferase IA polymorphism P479L is common in Greenland Inuit and is associated with elevated plasma apolipoprotein A-I. J Lipid Res 2009; 50 (6): 1223–1228.
   Web of Science ®Google Scholar
• Bjerregaard P, Curtis T, Borch-Johnsen K, et al. Inuit health in Greenland: a population survey of lifestyle and disease in Greenland and among Inuit living in Denmark. Int J Circumpolar Health 2003 (62) Suppl 1:3–79.
   Google Scholar
• Executive summary of the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA 2001; 285 (19): 2486–2497.
   Google Scholar
• Purcell S, Neale B, Todd-Brown K, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007; 81 (3): 559–575.
   PubMed Web of Science ®Google Scholar
• Barrett JC, Fry B, Mailer J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioin-formatics 2005; 21 (2): 263–265.
   PubMed Web of Science ®Google Scholar
• Hill W, Robertson A. Linkage disequilibrium in finite populations. Theor Appl Genet 1968; 38: 226–231.
   PubMedGoogle Scholar
• Adiels M, Olofsson SO, Taskinen MR, Boren J. Over-production of very low-density lipoproteins is the hallmark of the dyslipidemia in the metabolic syndrome. Arterioscler Thromb Vasc Biol 2008; 28 (7): 1225–1236.
   Web of Science ®Google Scholar
• Jorgensen ME, Moustgaard H, Bjerregaard P, Borch-Johnsen K. Gender differences in the association between Westernization and metabolic risk among Greenland Inuit. Eur J Epidemiol 2006; 21 (10): 741–748.
   Web of Science ®Google Scholar
• Jorgensen ME, Bjeregaard P, Borch-Johnsen K. Diabetes and impaired glucose tolerance among the Inuit population of Greenland. Diabetes Care 2002; 25 (10): 1766–1771.
   Web of Science ®Google Scholar
• Watt MJ. Storing up trouble: does accumulation of intramyocellular triglyceride protect skeletal muscle from insulin resistance? Clin Exp Pharmacol Physiol 2009; 36 (1): 5–11.
   Web of Science ®Google Scholar
• Jorgensen ME, Glumer C, Bjerregaard P, Gyntelberg F, Jorgensen T, Borch-Johnsen K. Obesity and central fat pattern among Greenland Inuit and a general population of Denmark (Inter99): relationship to metabolic risk factors. Int J Obes Relat Metab Disord 2003; 27 (12): 1507–1515.
   Web of Science ®Google Scholar
• Jorgensen ME, Borch-Johnsen K, Bjerregaard P. Life-style modifies obesity-associated risk of cardiovascular disease in a genetically homogeneous population. Am J Clin Nutr 2006;84(1):29–36.
   Web of Science ®Google Scholar
• Schoenborn V, Heid IM, Vollmert C, et al. The ATGL gene is associated with free fatty acids, triglycerides, and type 2 diabetes. Diabetes 2006; 55 (5): 1270–1275.
   PubMed Web of Science ®Google Scholar