4,417
Views
216
CrossRef citations to date
0
Altmetric
Original Research Articles

Exosomal proteins as potential diagnostic markers in advanced non-small cell lung carcinoma

, , , , &
Article: 26659 | Received 17 Nov 2014, Accepted 02 Sep 2015, Published online: 02 Mar 2015

References

  • Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin. 2013; 63: 11–30.
  • American Cancer Society. Cancer facts and figures 2014 [Internet]. 2014. [cited 2014 Sep 22]. Available from: http://www.cancer.org/acs/groups/content/@research/documents/webcontent/acspc-042151.pdf.
  • Engholm G, Ferlay J, Christensen N, Kejs AMT, Johannesen TB, Khan S et al. NORDCAN: Cancer Incidence, Mortality, Prevalence and Survival in the Nordic Countries, Version 6.0. Association of the Nordic Cancer Registries. Danish Cancer Society. 2011. [cited 2014 Sep 22]. Available from: http://www.ancr.nu.
  • Provencio M, Isla D, Sánchez A, Cantos B. Inoperable stage III non-small cell lung cancer: current treatment and role of vinorelbine. J Thorac Dis. 2011; 3: 197–204. [PubMed Abstract] [PubMed CentralFull Text].
  • Pan BT, Teng K, Wu C, Adam M, Johnstone RM. Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes. J Cell Biol. 1985; 101: 942–8.
  • Wilson C, Nicholes K, Bustos D, Lin E, Song Q, Stephan J et al. Overcoming EMT-associated resistance to anti-cancer drugs via Src/FAK pathway inhibition. Oncotarget. 2014; 5: 7328–41. [PubMed Abstract] [PubMed CentralFull Text].
  • Théry C, Boussac M, Véron P, Ricciardi-Castagnoli P, Raposo G, Garin J et al. Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles. J Immunol. 2001; 166: 7309–18.
  • Caby M-P, Lankar D, Vincendeau-Scherrer C, Raposo G, Bonnerot C. Exosomal-like vesicles are present in human blood plasma. Int Immunol. 2005; 17: 879–87.
  • Rabinowits G, Gerçel-Taylor C, Day JM, Taylor DD, Kloecker GH. Exosomal microRNA: a diagnostic marker for lung cancer. Clin Lung Cancer. 2009; 10: 42–6.
  • Logozzi M, De Milito A, Lugini L, Borghi M, Calabrò L, Spada M et al. High levels of exosomes expressing CD63 and caveolin-1 in plasma of melanoma patients. PLoS One. 2009; 4: e5219.
  • Hong C-S, Muller L, Whiteside TL, Boyiadzis M. Plasma exosomes as markers of therapeutic response in patients with acute myeloid leukemia. Front Immunol. 2014; 5: 160.
  • Huang S-H, Li Y, Zhang J, Rong J, Ye S. Epidermal growth factor receptor-containing exosomes induce tumour-specific regulatory T cells. Cancer Invest. 2013; 31: 330–5.
  • Ueda K, Ishikawa N, Tatsuguchi A, Saichi N, Fujii R, Nakagawa H. Antibody-coupled monolithic silica microtips for high throughput molecular profiling of circulating exosomes. Sci Rep. 2014; 4: 6232.
  • Melton L. Protein arrays: proteomics in multiplex. Nature. 2004; 429: 101–7. doi: http://dx.doi.org/10.1038/429101a.
  • Jørgensen M, Bæk R, Pedersen S, Søndergaard EKL, Kristensen SR, Varming K. Extracellular vesicle (EV) Array: microarray capturing of exosomes and other extracellular vesicles for multiplexed phenotyping. J Extracell Vesicles. 2013; 2: 1–9.
  • Rødgaard-Hansen S, Rafique A, Christensen PA, Maniecki MB, Sandahl TD, Nexø E et al. A soluble form of the macrophage-related mannose receptor (MR/CD206) is present in human serum and elevated in critical illness. Clin Chem Lab Med. 2014; 52: 453–61.
  • Kazankov K, Barrera F, Møller HJ, Bibby BM, Vilstrup H, George J et al. Soluble CD163, a macrophage activation marker,is independently associated with fibrosis in patients with chronic viral hepatitis B and C. Hepatology. 2014; 60: 521–30.
  • Théry C, Zitvogel L, Amigorena S. Exosomes: composition, biogenesis and function. Nat Rev Immunol. 2002; 2: 569–79. doi: http://dx.doi.org/10.1038/nri855.
  • Stoorvogel W, Kleijmeer MJ, Geuze HJ, Raposo G. The biogenesis and functions of exosomes. Traffic. 2002; 3: 321–30. doi: http://doi.wiley.com/10.1034/j.1600-0854.2002.30502.x [PubMed Abstract].
  • Shimamura T, Li D, Ji H, Haringsma HJ, Liniker E, Borgman CL et al. Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance. Cancer Res. 2008; 68: 5827–38.
  • Kahlert C, Kalluri R. Exosomes in tumor microenvironment influence cancer progression and metastasis. J Mol Med. 2013; 91: 431–7.
  • Wick MR, Swanson PE, Manivel JC. Placental-like alkaline phosphatase reactivity in human tumors: an immunohistochemical study of 520 cases. Hum Pathol. 1987; 18: 946–54.
  • Ponnusamy MP, Venkatraman G, Singh AP, Chauhan SC, Johansson SL, Jain M et al. Expression of TAG-72 in ovarian cancer and its correlation with tumor stage and patient prognosis. Cancer Lett. 2007; 251: 247–57.
  • Filella X, Molina R, Jo J, Bedini JL, Joseph J, Ballesta AM. Tumor associated glycoprotein-72 (TAG-72) levels in patients with non-malignant and malignant disease. Bull Cancer. 1992; 79: 271–7. [PubMed Abstract].
  • Tiernan JP, Perry SL, Verghese ET, West NP, Yeluri S, Jayne DG et al. Carcinoembryonic antigen is the preferred biomarker for in vivo colorectal cancer targeting. Br J Cancer. 2013; 108: 662–7.
  • Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M et al. Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation. Cancer Res. 2010; 70: 1668–78.
  • Grah JJ, Katalinic D, Juretic A, Santek F, Samarzija M. Clinical significance of immunohistochemical expression of cancer/testis tumor-associated antigens (MAGE-A1, MAGE-A3/4, NY-ESO-1) in patients with non-small cell lung cancer. Tumori. 2014; 100: 60–8. [PubMed Abstract].
  • Sun N, Chen Z, Tan F, Zhang B, Yao R, Zhou C et al. Isocitrate dehydrogenase 1 is a novel plasma biomarker for the diagnosis of non-small cell lung cancer. Clin Cancer Res. 2013; 19: 5136–45.
  • Kimura Y, Fujii T, Hamamoto K, Miyagawa N, Kataoka M, Iio A. Serum CA125 level is a good prognostic indicator in lung cancer. Br J Cancer. 1990; 62: 676–8.
  • Woenckhaus M, Merk J, Stoehr R, Schaeper F, Gaumann A, Wiebe K et al. Prognostic value of FHIT, CTNNB1, and MUC1 expression in non-small cell lung cancer. Hum Pathol. 2008; 39: 126–36.
  • Nagai S, Takenaka K, Sonobe M, Ogawa E, Wada H, Tanaka F. A novel classification of MUC1 expression is correlated with tumor differentiation and postoperative prognosis in non-small cell lung cancer. J Thorac Oncol. 2006; 1: 46–51.
  • Fiala O, Pesek M, Finek J, Benesova L, Minarik M, Bortlicek Z et al. Predictive role of CEA and CYFRA 21-1 in patients with advanced-stage NSCLC treated with erlotinib. Anticancer Res. 2014; 34: 3205–10. [PubMed Abstract].
  • Liu H, Gu X, Lv T, Wu Y, Xiao Y, Yuan D et al. The role of serum carcinoembryonic antigen in predicting responses to chemotherapy and survival in patients with non-small cell lung cancer. J Cancer Res Ther. 2014; 10: 239–43.
  • Zhang P-F, Zeng G-Q, Hu R, Li C, Yi H, Li M-Y et al. Identification of flotillin-1 as a novel biomarker for lymph node metastasis and prognosis of lung adenocarcinoma by quantitative plasma membrane proteome analysis. J Proteomics. 2012; 77: 202–14.
  • Huszar M, Moldenhauer G, Gschwend V, Ben-Arie A, Altevogt P, Fogel M. Expression profile analysis in multiple human tumors identifies L1 (CD171) as a molecular marker for differential diagnosis and targeted therapy. Hum Pathol. 2006; 37: 1000–8.
  • Tokuhara T, Hasegawa H, Hattori N, Ishida H, Taki T, Tachibana S et al. Clinical significance of CD151 gene expression in non-small cell lung cancer. Clin Cancer Res. 2001; 7: 4109–14. [PubMed Abstract].
  • Kwon MJ, Seo J, Kim YJ, Kwon MJ, Choi JY, Kim T-E et al. Prognostic significance of CD151 overexpression in non-small cell lung cancer. Lung Cancer. 2013; 81: 109–16.
  • Goldin-Lang P, Tran Q-V, Fichtner I, Eisenreich A, Antoniak S, Schulze K et al. Tissue factor expression pattern in human non-small cell lung cancer tissues indicate increased blood thrombogenicity and tumour metastasis. Oncol Rep. 2008; 20: 123–8. [PubMed Abstract].
  • Oka S, Uramoto H, Chikaishi Y, Tanaka F. The expression of CD146 predicts a poor overall survival in patients with adenocarcinoma of the lung. Anticancer Res. 2012; 32: 861–4. [PubMed Abstract].
  • Kristiansen G, Yu Y, Schlüns K, Sers C, Dietel M, Petersen I. Expression of the cell adhesion molecule CD146/MCAM in non-small cell lung cancer. Anal Cell Pathol. 2003; 25: 77–81.
  • Weber B, Hager H, Sorensen BS, McCulloch T, Mellemgaard A, Khalil AA et al. EGFR mutation frequency and effectiveness of erlotinib: a prospective observational study in Danish patients with non-small cell lung cancer. Lung Cancer. 2014; 83: 224–30.
  • Ise N, Omi K, Nambara D, Higashiyama S, Goishi K. Overexpressed HER2 in NSCLC is a possible therapeutic target of EGFR inhibitors. Anticancer Res. 2011; 31: 4155–61. [PubMed Abstract].
  • Hirsch FR, Varella-Garcia M, Cappuzzo F. Predictive value of EGFR and HER2 overexpression in advanced non-small-cell lung cancer. Oncogene. 2009; 28: S32–7.
  • Nielsen TO, Poulsen SS, Journe F, Ghanem G, Sorensen BS. HER4 and its cytoplasmic isoforms are associated with progression-free survival of malignant melanoma. Melanoma Res. 2014; 24: 88–91.
  • Higginbotham JN, Demory Beckler M, Gephart JD, Franklin JL, Bogatcheva G, Kremers G-J et al. Amphiregulin exosomes increase cancer cell invasion. Curr Biol. 2011; 21: 779–86.
  • Velcheti V, Schalper KA, Carvajal DE, Anagnostou VK, Syrigos KN, Sznol M et al. Programmed death ligand-1 expression in non-small cell lung cancer. Lab Invest. 2014; 94: 107–16. doi: http://dx.doi.org/10.1038/labinvest.2013.130 [PubMed Abstract].
  • Harvey RD. Immunologic and clinical effects of targeting PD-1 in lung cancer. Clin Pharmacol Ther. 2014; 96: 214–23. doi: http://dx.doi.org/10.1038/clpt.2014.74 [PubMed Abstract].
  • Benedettini E, Sholl LM, Peyton M, Reilly J, Ware C, Davis L et al. Met activation in non-small cell lung cancer is associated with de novo resistance to EGFR inhibitors and the development of brain metastasis. Am J Pathol. 2010; 177: 415–23.
  • Nakamura Y, Niki T, Goto A, Morikawa T, Miyazawa K, Nakajima J et al. c-Met activation in lung adenocarcinoma tissues: an immunohistochemical analysis. Cancer Sci. 2007; 98: 1006–13.
  • Ongusaha PP, Kwak JC, Zwible AJ, Macip S, Higashiyama S, Taniguchi N et al. HB-EGF is a potent inducer of tumor growth and angiogenesis. Cancer Res. 2004; 64: 5283–90.
  • Hui L, Zhang S, Dong X, Tian D, Cui Z, Qiu X. Prognostic significance of twist and N-cadherin expression in NSCLC. PLoS One. 2013; 8: e62171.
  • Lee JS, Yoon A, Kalapurakal SK, Ro JY, Lee JJ, Tu N et al. Expression of p53 oncoprotein in non-small-cell lung cancer: a favorable prognostic factor. J Clin Oncol. 1995; 13: 1893–903. [PubMed Abstract].
  • Murakami H, Yokoyama A, Kondo K, Nakanishi S, Kohno N, Miyake M. Circulating aminopeptidase N/CD13 is an independent prognostic factor in patients with non-small cell lung cancer. Clin Cancer Res. 2005; 11: 8674–9.
  • Del Vecchio CA, Giacomini CP, Vogel H, Jensen KC, Florio T, Merlo A et al. EGFRvIII gene rearrangement is an early event in glioblastoma tumorigenesis and expression defines a hierarchy modulated by epigenetic mechanisms. Oncogene. 2012; 32: 1–12.
  • Maniecki MB, Etzerodt A, Ulhøi BP, Steiniche T, Borre M, Dyrskjøt L et al. Tumor-promoting macrophages induce the expression of the macrophage-specific receptor CD163 in malignant cells. Int J Cancer. 2012; 131: 2320–31.
  • Huang A, Zhang B, Wang B, Zhang F, Fan K-X, Guo Y-J. Increased CD14(+)HLA-DR (−/low) myeloid-derived suppressor cells correlate with extrathoracic metastasis and poor response to chemotherapy in non-small cell lung cancer patients. Cancer Immunol Immunother. 2013; 62: 1439–51.
  • Sano H, Kuroki Y. The lung collectins, SP-A and SP-D, modulate pulmonary innate immunity. Mol Immunol. 2005; 42: 279–87.
  • Zhang J, Hawari FI, Shamburek RD, Adamik B, Kaler M, Islam A et al. Circulating TNFR1 exosome-like vesicles partition with the LDL fraction of human plasma. Biochem Biophys Res Commun. 2008; 366: 579–84.
  • Niewczas MA, Gohda T, Skupien J, Smiles AM, Walker WH, Rosetti F et al. Circulating TNF receptors 1 and 2 predict ESRD in type 2 diabetes. J Am Soc Nephrol. 2012; 23: 507–15.
  • Rauchhaus M, Doehner W, Francis DP, Davos C, Kemp M, Liebenthal C et al. Plasma cytokine parameters and mortality in patients with chronic heart failure. Circulation. 2000; 102: 3060–7.
  • Peinado H, Alečković M, Lavotshkin S, Matei I, Costa-Silva B, Moreno-Bueno G et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med. 2012; 18: 883–91.
  • Bobrie A, Théry C. Exosomes and communication between tumours and the immune system: are all exosomes equal?. Biochem Soc Trans. 2013; 41: 263–7.
  • He M, Crow J, Roth M, Zeng Y, Godwin AK. Integrated immunoisolation and protein analysis of circulating exosomes using microfluidic technology. Lab Chip. 2014; 14: 3773–80.
  • Sasaki H, Kawano O, Endo K, Yukiue H, Yano M, Fujii Y. EGFRvIII mutation in lung cancer correlates with increased EGFR copy number. Oncol Rep. 2007; 17: 319–23. [PubMed Abstract].
  • Okamoto I, Kenyon LC, Emlet DR, Mori T, Sasaki J, Hirosako S et al. Expression of constitutively activated EGFRvIII in non-small cell lung cancer. Cancer Sci. 2003; 94: 50–6.