Circulating microparticles, protein C, free protein S and endothelial vascular markers in children with sickle cell anaemia

References

• Jimenez JJ, Jy W, Mauro LM, Soderland C, Horstman LL, Ahn YS. Endothelial cells release phenotypically and quantitatively distinct microparticles in activation and apoptosis. Thromb Res. 2003; 109: 175–80.
   Google Scholar
• Shcherbina A, Remold-O'Donnell E. Role of caspase in a subset of human platelet activation responses. Blood. 1999; 93: 4222–31.
   Google Scholar
• Hugel B, Weltin D, Holl V, Marchal J, Dufour P, Freyssinet JM et al. Assessment of apoptosis occurring in spleen cells from nitrogen mustard-treated or gamma-irradiated mice. Anticancer Res. 1998; 18: 3289–94.
   Google Scholar
• Piccin A, Murphy WG, Smith OP. Circulating microparticles: pathophysiology and clinical implications. Blood Rev. 2007; 21: 157–71.
   Google Scholar
• Berckmans RJ, Neiuwland R, Böing AN, Romijn FP, Hack CE, Sturk A. Cell-derived microparticles circulate in healthy humans and support low grade thrombin generation. Thromb Haemost. 2001; 85: 639–46.
   Google Scholar
• Sims PJ, Wiedmer T, Esmon CT, Weiss HJ, Shattil SJ. Assembly of the platelet prothrombinase complex is linked to vesiculation of the platelet plasma membrane. Studies in Scott syndrome: an isolated defect in platelet procoagulant activity. J Biol Chem. 1989; 264: 17049–57.
   Google Scholar
• Satta N, Toti F, Feugeas O, Bohbot A, Dachary-Prigent J, Eschwège V et al. Monocyte vesiculation is a possible mechanism for dissemination of membrane-associated procoagulant activities and adhesion molecules after stimulation by lipopolysaccharide. J Immunol. 1994; 153: 3245–55.
   Google Scholar
• Nieuwland R, Berckmans RJ, McGregor S, Böing AN, Romijn FP, Westendorp RG et al. Cellular origin and procoagulant properties of microparticles in meningococcal sepsis. Blood. 2000; 95: 930–5.
   Google Scholar
• Dahlbäck B, Wiedmer T, Sims PJ. Binding of anticoagulant vitamin K-dependent protein S to platelet-derived microparticles. Biochemistry. 1992; 31: 12769–77.
   Web of Science ®Google Scholar
• Tans G, Rosing J, Thomassen MC, Heeb MJ, Zwaal RF, Griffin JH. Comparison of anticoagulant and procoagulant activities of stimulated platelets and platelet-derived microparticles. Blood. 1991; 77: 2641–8.
   Google Scholar
• Horstman LL, Jy W, Jimenez JJ, Bidot C, Ahn YS. New horizons in the analysis of circulating cell-derived microparticles. Keio J Med. 2004; 53: 210–30.
   Google Scholar
• Morel O, Morel N, Freyssinet JM, Toti F. Platelet microparticles and vascular cells interactions: a checkpoint between the haemostatic and thrombotic responses. Platelets. 2008; 19: 9–23.
   Google Scholar
• Wun T, Paglieroni T, Tablin F, Welborn J, Nelson K, Cheung A. Platelet activation and platelet-erythrocyte aggregates in patients with sickle cell anemia. J Lab Clin Med. 1997; 129: 507–16.
   Google Scholar
• Wun T, Paglieroni T, Rangaswami A, Franklin PH, Welborn J, Cheung A et al. Platelet activation in patients with sickle cell disease. Br J Haematol. 1998; 100: 741–9.
   Google Scholar
• Wun T, Cordoba M, Rangaswami A, Cheung AW, Paglieroni T. Activated monocytes and platelet-monocyte aggregates in patients with sickle cell disease. Clin Lab Haematol. 2002; 24: 81–8.
   Google Scholar
• Shet AS, Aras O, Gupta K, Hass MJ, Rausch DJ, Saba N et al. Sickle blood contains tissue factor-positive microparticles derived from endothelial cells and monocytes. Blood. 2003; 102: 2678–83.
   Google Scholar
• Tomer A, Harker LA, Kasey S, Eckman JR. Thrombogenesis in sickle cell disease. J Lab Clin Med. 2001; 137: 398–407.
   Google Scholar
• Piccin A, Murphy C, Eakins E, Kinsella A, McMahon C, Smith OP et al. Protein C and free protein S in children with sickle cell anemia. Ann Hematol. 2012; 91: 1669–71.
   Google Scholar
• Telen MJ. Role of adhesion molecules and vascular endothelium in the pathogenesis of sickle cell disease. Hematology Am Soc Hematol Educ Program. 2007; 84–90.
   PubMedGoogle Scholar
• Gladwin MT, Crawford JH, Patel RP. The biochemistry of nitric oxide, nitrite, and hemoglobin: role in blood flow regulation. Free Radic Biol Med. 2004; 36: 707–17.
   Google Scholar
• Chaar V, Tarer V, Etienne-Julan M, Diara JP, Elion J, Romana M. ET-1 and eNOS gene polymorphisms and susceptibility to acute chest syndrome and painful vaso-occlusive crises in children with sickle cell anemia. Haematologica. 2006; 91: 1277–8.
   Google Scholar
• Rossi GP, Sacchetto A, Cesari M, Pessina AC. Interactions between endothelin-1 and the renin-angiotensin-aldosterone system. Cardiovasc Res. 1999; 43: 300–7.
   Google Scholar
• Biró E, Sturk-Maquelin KN, Vogel GM, Meuleman DG, Smit MJ, Hack CE et al. Human cell-derived microparticles promote thrombus formation in vivo in a tissue factor-dependent manner. J Thromb Haemost. 2003; 1: 2561–8.
   PubMed Web of Science ®Google Scholar
• Morgenthaler NG, Struck J, Alonso C, Bergmann A. Measurement of midregional proadrenomedullin in plasma with an immunoluminometric assay. Clin Chem. 2005; 51: 1823–9.
   Google Scholar
• Papassotiriou J, Morgenthaler NG, Struck J, Alonso C, Bergmann A. Immunoluminometric assay for measurement of the C-terminal endthelin-1 precursor fragment in human plasma. Clin Chem. 2006; 52: 1144–51.
   Google Scholar
• McMahon RP, Waclawiw MA, Geller NL, Barton FB, Terrin ML, Bonds DR. An extension of stochastic curtailment for incompletely reported and classified recurrent events: the multicenter study of hydroxyurea in sickle cell anemia (MSH). Control Clin Trials. 1997; 18: 420–30.
   Google Scholar
• Brunetta DM, De Santis GC, Silva-Pinto AC, Oliveira de Oliveira LC, Covas DT. Hydroxyurea increases plasma concentrations of microparticles and reduces coagulation activation and fibrinolysis in patients with sickle cell anemia. Acta Haematol. 2015; 133: 287–94.
   Google Scholar
• Noubouossie DC, Lê PQ, Rozen L, Debaugnies F, Ferster A, Demulder A. Evaluation of the procoagulant activity of endogenous phospholipids in the platelet-free plasma of children with sickle cell disease using functional assays. Thromb Res. 2012; 130: 259–64.
   Google Scholar
• Kasar M, Boğa C, Yeral M, Asma S, Kozanoglu I, Ozdogu H. Clinical significance of circulating blood and endothelial cell microparticles in sickle-cell disease. J Thromb Thrombolysis. 2014; 38: 167–75.
   Google Scholar
• Simak J, Holada K, Risitano AM, Zivny JH, Young NS, Vostal JG. Elevated circulating endothelial membrane microparticles in paroxysmal nocturnal haemoglobinuria. Br J Haematol. 2004; 125: 804–13.
   Google Scholar
• Joop K, Berckmans RJ, Nieuwland R, Berkhout J, Romijn FP, Hack CE et al. Microparticles from patients with multiple organ dysfunction syndrome and sepsis support coagulation through multiple mechanisms. Thromb Haemost. 2001; 85: 810–20.
   Google Scholar
• Chirinos JA, Heresi GA, Velasquez H, Jy W, Jimenez JJ, Ahn E et al. Elevation of endothelial microparticles, platelets, and leukocyte activation in patients with venous thromboembolism. J Am Coll Cardiol. 2005; 45: 1467–71.
   Google Scholar
• Keuren JF, Magdeleyns EJ, Bennaghmouch A, Bevers EM, Curvers J, Lindhout T. Microparticles adhere to collagen type I, fibrinogen, von Willebrand factor and surface immobilised platelets at physiological shear rates. Br J Haematol. 2007; 138: 527–33.
   Google Scholar
• Jy W, Jimenez JJ, Mauro LM, Horstman LL, Cheng P, Ahn ER et al. Endothelial microparticles induce formation of platelet aggregates via a von Willebrand factor/ristocetin dependent pathway, rendering them resistant to dissociation. J Thromb Haemost. 2005; 3: 1301–8.
   Google Scholar
• Kelton JG, Warkentin TE, Hayward CP, Murphy WG, Moore JC. Calpain activity in patients with thrombotic thrombocytopenic purpura is associated with platelet microparticles. Blood. 1992; 80: 2246–51.
   Google Scholar
• Ljungsted I, Ekman B, Sjöholm I. Detection and separation of lymphocytes with specific surface receptors, by using microparticles. Biochem J. 1978; 170: 161–5.
   Google Scholar
• Nieuwland R, Berckmans RJ, Rotteveel-Eijkman RC, Maquelin KN, Roozendaal KJ, Jansen PG et al. Cell-derived microparticles generated in patients during cardiopulmonary bypass are highly procoagulant. Circulation. 1997; 96: 3534–41.
   Google Scholar
• VanWijk MJ, Boer K, Berckmans RJ, Meijers JC, van der Post JA, Sturk A et al. Enhanced coagulation activation in preeclampsia: the role of APC resistance, microparticles and other plasma constituents. Thromb Haemost. 2002; 88: 415–20.
   Google Scholar
• Rand ML, Wang H, Bang KW, Packham MA, Freedman J. Rapid clearance of procoagulant platelet-derived microparticles from the circulation of rabbits. J Thromb Haemost. 2006; 4: 1621–39.
   Google Scholar
• Pérez-Casal M, Downey C, Fukudome K, Marx G, Toh CH. Activated protein C induces the release of microparticle-associated endothelial protein C receptor. Blood. 2005; 105: 1515–22.
   PubMed Web of Science ®Google Scholar
• Francis RB Jr. Protein S deficiency in sickle cell anemia. J Lab Clin Med. 1988; 111: 571–6.
   Google Scholar
• Schnog JB, Mac Gillavry MR, van Zanten AP, Meijers JC, Rojer RA, Duits AJ et al. Protein C and S and inflammation in sickle cell disease. Am J Hematol. 2004; 76: 26–32.
   Google Scholar
• Wright JG, Malia R, Cooper P, Thomas P, Preston FE, Serjeant GR. Protein C and protein S in homozygous sickle cell disease: does hepatic dysfunction contribute to low levels?. Br J Haematol. 1997; 98: 627–31.
   Google Scholar
• Piccin A, O'Marcaigh A, Mc Mahon C, Murphy C, Okafor I, Marcheselli L et al. Non-activated plasma-derived PC improves amputation rate of children undergoing sepsis. Thromb Res. 2014; 134: 63–7.
   Google Scholar
• Qari MH, Aljaouni SK, Alardawi MS, Fatani H, Alsayes FM, Zografos P et al. Reduction of painful vaso-occlusive crisis of sickle cell anaemia by tinzaparin in a double-blind randomized trial. Thromb Haemost. 2007; 98: 392–6.
   Google Scholar
• Wood KC, Hsu LL, Gladwin MT. Sickle cell disease vasculopathy: a state of nitric oxide resistance. Free Radic Biol Med. 2008; 44: 1506–28.
   Google Scholar
• King SB. Nitric oxide production from hydroxyurea. Free Radic Biol Med. 2004; 37: 737–44.
   Google Scholar
• Rao SV, Jollis JG, Harrington RA, Granger CB, Newby LK, Armstrong PW et al. Relationship of blood transfusion and clinical outcomes in patients with acute coronary syndromes. JAMA. 2004; 292: 1555–62.
   Google Scholar
• Alayash AI. Hemoglobin-based blood substitutes and the hazards of blood radicals. Free Radic Res. 2000; 33: 341–8.
   Google Scholar
• Simoni J, Simoni G, Moeller JF, Tsikouris JP, Wesson DE. Evaluation of angiotensin converting enzyme (ACE)-like activity of acellular hemoglobin. Artif Cells Blood Substit Immobil Biotechnol. 2007; 35: 191–210.
   Google Scholar
• Schuetz P, Christ-Crain M, Morgenthaler NG, Struck J, Bergmann A, Müller B. Circulating precursor levels of endothelin-1 and adrenomedullin, two endothelium-derived, counteracting substances, in sepsis. Endothelium. 2007; 14: 345–51.
   Google Scholar
• Bookchin RM, Balazs T, Landau LC. Determinants of red cell sickling. Effects of varying pH and of increasing intracellular hemoglobin concentration by osmotic shrinkage. J Lab Clin Med. 1976; 87: 597–616.
   Google Scholar
• Dschietzig T, Richter C, Asswad L, Baumann G, Stangl K. Hypoxic induction of receptor activity-modifying protein 2 alters regulation of pulmonary endothelin-1 by adrenomedullin: induction under normoxia versus inhibition under hypoxia. J Pharmacol Exp Ther. 2007; 321: 409–19.
   Google Scholar
• von der Hardt K, Kandler MA, Chada M, Cubra A, Schoof E, Amann K et al. Brief adrenomedullin inhalation leads to sustained reduction of pulmonary artery pressure. Eur Respir J. 2004; 24: 615–23.
   Google Scholar
• Nagaya N, Kyotani S, Uematsu M, Ueno K, Oya H, Nakanishi N et al. Effects of adrenomedullin inhalation on hemodynamics and exercise capacity in patients with idiopathic pulmonary arterial hypertension. Circulation. 2004; 109: 351–6.
   Google Scholar