Ginger-derived nanoparticles protect against alcohol-induced liver damage

References

• Ju S, Mu J, Dokland T, Zhuang X, Wang Q, Jiang Het al. Grape exosome-like nanoparticles induce intestinal stem cells and protect mice from DSS-induced colitis. Mol Ther. 2013; 21: 1345–57. [PubMed Abstract] [PubMed CentralFull Text].
   Google Scholar
• Mu J, Zhuang X, Wang Q, Jiang H, Deng ZB, Wang Bet al. Interspecies communication between plant and mouse gut host cells through edible plant derived exosome-like nanoparticles. Mol Nutr Food Res. 2014; 58: 1561–73. [PubMed Abstract].
   Google Scholar
• Raimondo S, Naselli F, Fontana S, Monteleone F, Lo Dico A, Saieva Let al. Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death. Oncotarget. 2015; 6: 19514–27. [PubMed Abstract].
   Google Scholar
• Bak MJ, Ok S, Jun M, Jeong WS. 6-Shogaol-rich extract from ginger up-regulates the antioxidant defense systems in cells and mice. Molecules. 2012; 17: 8037–55. [PubMed Abstract].
   Google Scholar
• Lu Y, Zhang XH, Cederbaum AI. Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway. Toxicol Sci. 2012; 128: 427–38. [PubMed Abstract] [PubMed CentralFull Text].
   Google Scholar
• Lee HG, Li MH, Joung EJ, Na HK, Cha YN, Surh YJ. Nrf2-mediated heme oxygenase-1 upregulation as adaptive survival response to glucose deprivation-induced apoptosis in HepG2 cells. Antioxid Redox Signal. 2010; 13: 1639–48. [PubMed Abstract].
   Google Scholar
• Beyer TA, Xu W, Teupser D, auf dem Keller U, Bugnon P, Hildt Eet al. Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance. EMBO J. 2008; 27: 212–23. [PubMed Abstract] [PubMed CentralFull Text].
   Google Scholar
• Wang B, Zhuang X, Deng ZB, Jiang H, Mu J, Wang Qet al. Targeted drug delivery to intestinal macrophages by bioactive nanovesicles released from grapefruit. Mol Ther. 2014; 22: 522–34. [PubMed Abstract] [PubMed CentralFull Text].
   Google Scholar
• Johnson DA, Amirahmadi S, Ward C, Fabry Z, Johnson JA. The absence of the pro-antioxidant transcription factor Nrf2 exacerbates experimental autoimmune encephalomyelitis. Toxicol Sci. 2010; 114: 237–46. [PubMed Abstract] [PubMed CentralFull Text].
   Google Scholar
• Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol. 1959; 37: 911–17. [PubMed Abstract].
   Google Scholar
• Wanjie SW, Welti R, Moreau RA, Chapman KD. Identification and quantification of glycerolipids in cotton fibers: reconciliation with metabolic pathway predictions from DNA databases. Lipids. 2005; 40: 773–85. [PubMed Abstract].
   Google Scholar
• Torrelles JB, Sieling PA, Zhang N, Keen MA, McNeil MR, Belisle JTet al. Isolation of a distinct Mycobacterium tuberculosis mannose-capped lipoarabinomannan isoform responsible for recognition by CD1b-restricted T cells. Glycobiology. 2012; 22: 1118–27. [PubMed Abstract] [PubMed CentralFull Text].
   Google Scholar
• Guo P. RNA Nanotechnology: methods for synthesis, conjugation, assembly and application of RNA nanoparticles. Methods. 2011; 54: 201–3. [PubMed Abstract].
   Google Scholar
• Hermida LG, Sabés-Xamaní M, Barnadas-Rodríguez R. Combined strategies for liposome characterization during in vitro digestion. J Liposome Res. 2009; 19: 207–19. [PubMed Abstract].
   Google Scholar
• Liu Y, Shah SV, Xiang X, Wang J, Deng ZB, Liu Cet al. COP9-associated CSN5 regulates exosomal protein deubiquitination and sorting. Am J Pathol. 2009; 174: 1415–25. [PubMed Abstract] [PubMed CentralFull Text].
   Google Scholar
• Sun D, Zhuang X, Xiang X, Liu Y, Zhang S, Liu Cet al. A novel nanoparticle drug delivery system: the anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes. Mol Ther. 2010; 18: 1606–14. [PubMed Abstract] [PubMed CentralFull Text].
   Google Scholar
• Yoh K, Itoh K, Enomoto A, Hirayama A, Yamaguchi N, Kobayashi Met al. Nrf2-deficient female mice develop lupus-like autoimmune nephritis. Kidney Int. 2001; 60: 1343–53. [PubMed Abstract].
   Google Scholar
• Park SH, Kyeong MS, Hwang Y, Ryu SY, Han SB, Kim Y. Inhibition of LPS binding to MD-2 co-receptor for suppressing TLR4-mediated expression of inflammatory cytokine by 1-dehydro-10-gingerdione from dietary ginger. Biochem Biophys Res Commun. 2012; 419: 735–40. [PubMed Abstract].
   Google Scholar
• Ahn SI, Lee JK, Youn HS. Inhibition of homodimerization of toll-like receptor 4 by 6-shogaol. Mol Cells. 2009; 27: 211–15. [PubMed Abstract].
   Google Scholar
• Gould SJ, Raposo G. As we wait: coping with an imperfect nomenclature for extracellular vesicles. J Extracell Vesicles. 2013; 2 20389, doi: http://dx.doi.org/10.3402/jev.v2i0.20389.
   Google Scholar
• Treuel L, Jiang X, Nienhaus GU. New views on cellular uptake and trafficking of manufactured nanoparticles. J R Soc Interface. 2013; 10: 20120939. [PubMed Abstract] [PubMed CentralFull Text].
   Google Scholar
• Rehman Z, Zuhorn IS, Hoekstra D. How cationic lipids transfer nucleic acids into cells and across cellular membranes: recent advances. J Control Release. 2013; 166: 46–56. [PubMed Abstract].
   Google Scholar
• Xu S, Olenyuk BZ, Okamoto CT, Hamm-Alvarez SF. Targeting receptor-mediated endocytotic pathways with nanoparticles: rationale and advances. Adv Drug Deliv Rev. 2013; 65: 121–38. [PubMed Abstract] [PubMed CentralFull Text].
   Google Scholar
• Deng ZB, Zhuang X, Ju S, Xiang X, Mu J, Liu Yet al. Exosome-like nanoparticles from intestinal mucosal cells carry prostaglandin E2 and suppress activation of liver NKT cells. J Immunol. 2013; 190: 3579–89. [PubMed Abstract] [PubMed CentralFull Text].
   Google Scholar
• Wang R, Paul VJ, Luesch H. Seaweed extracts and unsaturated fatty acid constituents from the green alga Ulva lactuca as activators of the cytoprotective Nrf2-ARE pathway. Free Radic Biol Med. 2013; 57: 141–53. [PubMed Abstract] [PubMed CentralFull Text].
   Google Scholar
• Wu KC, Cui JY, Klaassen CD. Effect of graded Nrf2 activation on phase-I and -II drug metabolizing enzymes and transporters in mouse liver. PLoS One. 2012; 7: e39006. [PubMed Abstract] [PubMed CentralFull Text].
   Google Scholar
• Kaspar JW, Niture SK, Jaiswal AK. Antioxidant-induced INrf2 (Keap1) tyrosine 85 phosphorylation controls the nuclear export and degradation of the INrf2-Cul3-Rbx1 complex to allow normal Nrf2 activation and repression. J Cell Sci. 2012; 125(Pt 4): 1027–38. [PubMed Abstract] [PubMed CentralFull Text].
   Google Scholar
• Jyrkkanen HK, Kansanen E, Inkala M, Kivela AM, Hurttila H, Heinonen SEet al. Nrf2 regulates antioxidant gene expression evoked by oxidized phospholipids in endothelial cells and murine arteries in vivo. Circ Res. 2008; 103: e1–9. [PubMed Abstract].
   Google Scholar
• Kang JW, Lee SM. Melatonin inhibits type 1 interferon signaling of Toll-like receptor 4 via heme oxygenase-1 induction in hepatic ischemia/reperfusion. J Pineal Res. 2012; 53: 67–76. [PubMed Abstract].
   Google Scholar
• Vandenbon A, Teraguchi S, Akira S, Takeda K, Standley DM. Systems biology approaches to Toll-like receptor signaling. Wiley Interdiscip Rev Syst Biol Med. 2012; 4: 497–507. [PubMed Abstract] [PubMed CentralFull Text].
   Google Scholar
• Kawai T, Akira S. Pathogen recognition with Toll-like receptors. Curr Opin Immunol. 2005; 17: 338–44. [PubMed Abstract].
   Google Scholar
• Medzhitov R, Janeway CJr. Innate immune recognition: mechanisms and pathways. Immunol Rev. 2000; 173: 89–97. [PubMed Abstract].
   Google Scholar
• Magrone T, Jirillo E. The interplay between the gut immune system and microbiota in health and disease: nutraceutical intervention for restoring intestinal homeostasis. Curr Pharm Design. 2013; 19: 1329–42.
   PubMed Web of Science ®Google Scholar
• Crispe IN. The liver as a lymphoid organ. Ann Rev Immunol. 2009; 27: 147–63.
   PubMed Web of Science ®Google Scholar
• Alonso C, Vicario M, Pigrau M, Lobo B, Santos J. Intestinal barrier function and the brain–gut axis. Adv Exp Med Biol. 2014; 817: 73–113. [PubMed Abstract].
   Google Scholar
• Faria AM, Gomes-Santos AC, Goncalves JL, Moreira TG, Medeiros SR, Dourado LPet al. Food components and the immune system: from tonic agents to allergens. Front Immunol. 2013; 4: 102. [PubMed Abstract] [PubMed CentralFull Text].
   Google Scholar
• Mann ER, Landy JD, Bernardo D, Peake ST, Hart AL, Al-Hassi HOet al. Intestinal dendritic cells: their role in intestinal inflammation, manipulation by the gut microbiota and differences between mice and men. Immunol Lett. 2013; 150: 30–40. [PubMed Abstract].
   Google Scholar
• Jacobi SK, Odle J. Nutritional factors influencing intestinal health of the neonate. Adv Nutr. 2012; 3: 687–96. [PubMed Abstract] [PubMed CentralFull Text].
   Google Scholar
• Kayama H, Takeda K. Regulation of intestinal homeostasis by innate and adaptive immunity. Int Immunol. 2012; 24: 673–80. [PubMed Abstract].
   Google Scholar
• Vitetta L, Briskey D, Hayes E, Shing C, Peake J. A review of the pharmacobiotic regulation of gastrointestinal inflammation by probiotics, commensal bacteria and prebiotics. Inflammopharmacology. 2012; 20: 251–66. [PubMed Abstract].
   Google Scholar
• Magnusson MK, Wick MJ. Intestinal dendritic cell and macrophage subsets: tipping the balance to Crohn's disease?. Eur J Microbiol Immunol. 2011; 1: 19–24.
   Google Scholar
• Peron JP, de Oliveira AP, Rizzo LV. It takes guts for tolerance: the phenomenon of oral tolerance and the regulation of autoimmune response. Autoimmun Rev. 2009; 9: 1–4. [PubMed Abstract].
   Google Scholar
• Zhang L, Hou D, Chen X, Li D, Zhu L, Zhang Yet al. Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by micro-RNA. Cell Res. 2012; 22: 107–26. [PubMed Abstract] [PubMed CentralFull Text].
   Google Scholar
• Sala-Cirtog M, Marian C, Anghel A. New insights of medicinal plant therapeutic activity – the miRNA transfer. Biomed Pharmacother. 2015; 74: 228–32. [PubMed Abstract].
   Google Scholar
• Regente M, Pinedo M, Elizalde M, de la Canal L. Apoplastic exosome-like vesicles: a new way of protein secretion in plants?. Plant Signal Behav. 2012; 7: 544–6. [PubMed Abstract] [PubMed CentralFull Text].
   Google Scholar
• Ding Y, Wang J, Wang J, Stierhof YD, Robinson DG, Jiang L. Unconventional protein secretion. Trends Plant Sci. 2012; 17: 606–15. [PubMed Abstract].
   Google Scholar