Microvesicle phenotypes are associated with transfusion requirements and mortality in subjects with severe injuries

References

• van der Pol E, Boing AN, Harrison P, Sturk A, Nieuwland R. Classification, functions, and clinical relevance of extracellular vesicles. Pharmacol Rev. 2012; 64: 676–705. [PubMed Abstract].
   Google Scholar
• Yanez-Mo M, Siljander PR, Andreu Z, Zavec AB, Borras FE, Buzas EI, etal. Biological properties of extracellular vesicles and their physiological functions. J Extracell Vesicles. 2015; 4 27066, doi: http://dx.doi.org/10.3402/jev.v4.27066.
   Google Scholar
• Raposo G, Stoorvogel W. Extracellular vesicles: exosomes, microvesicles, and friends. J Cell Biol. 2013; 200: 373–83. [PubMed Abstract] [PubMed CentralFull Text].
   Google Scholar
• Gyorgy B, Szabo TG, Pasztoi M, Pal Z, Misjak P, Aradi B, etal. Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles. Cell Mol Life Sci. 2011; 68: 2667–88. [PubMed Abstract] [PubMed CentralFull Text].
   Google Scholar
• Yuana Y, Sturk A, Nieuwland R. Extracellular vesicles in physiological and pathological conditions. Blood Rev. 2013; 27: 31–9. [PubMed Abstract].
   Google Scholar
• Lacroix R, Dubois C, Leroyer AS, Sabatier F, Dignat-George F. Revisited role of microparticles in arterial and venous thrombosis. J Thromb Haemost. 2013; 11(Suppl 1): 24–35. [PubMed Abstract].
   Google Scholar
• van der Meel R, Krawczyk-Durka M, van Solinge WW, Schiffelers RM. Toward routine detection of extracellular vesicles in clinical samples. Int J Lab Hematol. 2014; 36: 244–53. [PubMed Abstract].
   Google Scholar
• Revenfeld AL, Baek R, Nielsen MH, Stensballe A, Varming K, Jorgensen M. Diagnostic and prognostic potential of extracellular vesicles in peripheral blood. Clin Ther. 2014; 36: 830–46. [PubMed Abstract].
   Google Scholar
• Piccin A, Murphy WG, Smith OP. Circulating microparticles: pathophysiology and clinical implications. Blood Rev. 2007; 21: 157–71. [PubMed Abstract].
   Google Scholar
• US Centers for Disease Control and Prevention. Injury prevention and control: data and statistics. 2012. [updated 2012; cited 2014 Dec 21]. Available from: http://webappa.cbc.gov/cgi-bin/broker.exe.
   Google Scholar
• Holcomb JB, Jenkins D, Rhee P, Johannigman J, Mahoney P, Mehta S, etal. Damage control resuscitation: directly addressing the early coagulopathy of trauma. J Trauma. 2007; 62: 307–10. [PubMed Abstract].
   Google Scholar
• Kauvar DS, Lefering R, Wade CE. Impact of hemorrhage on trauma outcome: an overview of epidemiology, clinical presentations, and therapeutic considerations. J Trauma. 2006; 60: S3–11. [PubMed Abstract].
   Google Scholar
• Kauvar DS, Wade CE. The epidemiology and modern management of traumatic hemorrhage: US and international perspectives. Crit Care. 2005; 9(Suppl 5): S1–9. [PubMed Abstract] [PubMed CentralFull Text].
   Google Scholar
• Matijevic N, Wang YW, Wade CE, Holcomb JB, Cotton BA, Schreiber MA, etal. Cellular microparticle and thrombogram phenotypes in the Prospective Observational Multicenter Major Trauma Transfusion (PROMMTT) study: correlation with coagulopathy. Thromb Res. 2014; 134: 652–8. [PubMed Abstract] [PubMed CentralFull Text].
   Google Scholar
• Curry N, Raja A, Beavis J, Stanworth S, Harrison P. Levels of procoagulant microvesicles are elevated after traumatic injury and platelet microvesicles are negatively correlated with mortality. J Extracell Vesicles. 2014; 3 25625, doi: http://dx.doi.org/10.3402/jev.v3.25625.
   Google Scholar
• Windelov NA, Johansson PI, Sorensen AM, Perner A, Wanscher M, Larsen CF, etal. Low level of procoagulant platelet microparticles is associated with impaired coagulation and transfusion requirements in trauma patients. J Trauma Acute Care Surg. 2014; 77: 692–700. [PubMed Abstract].
   Google Scholar
• Balvers K, Curry N, Kleinveld DJ, Boing AN, Nieuwland R, Goslings JC, etal. Endogenous microparticles drive the proinflammatory host immune response in severely injured trauma patients. Shock. 2015; 43: 317–21. [PubMed Abstract].
   Google Scholar
• Park MS, Owen BA, Ballinger BA, Sarr MG, Schiller HJ, Zietlow SP, etal. Quantification of hypercoagulable state after blunt trauma: microparticle and thrombin generation are increased relative to injury severity, while standard markers are not. Surgery. 2012; 151: 831–6. [PubMed Abstract] [PubMed CentralFull Text].
   Google Scholar
• Fujimi S, Ogura H, Tanaka H, Koh T, Hosotsubo H, Nakamori Y, etal. Increased production of leukocyte microparticles with enhanced expression of adhesion molecules from activated polymorphonuclear leukocytes in severely injured patients. J Trauma. 2003; 54: 114–19. [PubMed Abstract] discussion 9–20.
   Google Scholar
• Ogura H, Kawasaki T, Tanaka H, Koh T, Tanaka R, Ozeki Y, etal. Activated platelets enhance microparticle formation and platelet-leukocyte interaction in severe trauma and sepsis. J Trauma. 2001; 50: 801–9. [PubMed Abstract].
   Google Scholar
• Nekludov M, Mobarrez F, Gryth D, Bellander BM, Wallen H. Formation of microparticles in the injured brain of patients with severe isolated traumatic brain injury. J Neurotrauma. 2014; 31: 1927–33. [PubMed Abstract].
   Google Scholar
• Midura EF, Jernigan PL, Kuethe JW, Friend LA, Veile R, Makley AT, etal. Microparticles impact coagulation after traumatic brain injury. J Surg Res. 2015; 197: 25–31. [PubMed Abstract].
   Google Scholar
• Morel N, Morel O, Petit L, Hugel B, Cochard JF, Freyssinet JM, etal. Generation of procoagulant microparticles in cerebrospinal fluid and peripheral blood after traumatic brain injury. J Trauma. 2008; 64: 698–704. [PubMed Abstract].
   Google Scholar
• Matijevic N, Wang YW, Kostousov V, Wade CE, Vijayan KV, Holcomb JB. Decline in platelet microparticles contributes to reduced hemostatic potential of stored plasma. Thromb Res. 2011; 128: 35–41. [PubMed Abstract] [PubMed CentralFull Text].
   Google Scholar
• Matijevic N, Kostousov V, Wang YW, Wade CE, Wang W, Letourneau P, etal. Multiple levels of degradation diminish hemostatic potential of thawed plasma. J Trauma. 2011; 70: 71–9. [PubMed Abstract] [PubMed CentralFull Text] discussion 9–80.
   Google Scholar
• Lawrie AS, Harrison P, Cardigan RA, Mackie IJ. The characterization and impact of microparticles on haemostasis within fresh-frozen plasma. Vox Sang. 2008; 95: 197–204. [PubMed Abstract].
   Google Scholar
• Lacroix R, Robert S, Poncelet P, Kasthuri RS, Key NS, Dignat-George F, etal. Standardization of platelet-derived microparticle enumeration by flow cytometry with calibrated beads: results of the International Society on Thrombosis and Haemostasis SSC Collaborative workshop. J Thromb Haemost. 2010; 8: 2571–4. [PubMed Abstract].
   Google Scholar
• Nielsen MH, Beck-Nielsen H, Andersen MN, Handberg A. A flow cytometric method for characterization of circulating cell-derived microparticles in plasma. J Extracell Vesicles. 2014; 3 20795, doi: http://dx.doi.org/10.3402/jev.v3.20795.
   Google Scholar
• Ayers L, Harrison P, Kohler M, Ferry B. Procoagulant and platelet-derived microvesicle absolute counts determined by flow cytometry correlates with a measurement of their functional capacity. J Extracell Vesicles. 2014; 3 25348, doi: http://dx.doi.org/10.3402/jev.v3.25348.
   Google Scholar
• Lechner D, Weltermann A. Circulating tissue factor-exposing microparticles. Thromb Res. 2008; 122(Suppl 1): S47–54. [PubMed Abstract].
   Google Scholar
• Owens AP3rd, Mackman N. Microparticles in hemostasis and thrombosis. Circ Res. 2011; 108: 1284–97. [PubMed Abstract] [PubMed CentralFull Text].
   Google Scholar
• Key NS, Mackman N. Tissue factor and its measurement in whole blood, plasma, and microparticles. Sem Thromb Hemost. 2010; 36: 865–75.
   PubMed Web of Science ®Google Scholar
• Basavaraj MG, Olsen JO, Osterud B, Hansen JB. Differential ability of tissue factor antibody clones on detection of tissue factor in blood cells and microparticles. Thromb Res. 2012; 130: 538–46. [PubMed Abstract].
   Google Scholar
• Aass HC, Ovstebo R, Troseid AM, Kierulf P, Berg JP, Henriksson CE. Fluorescent particles in the antibody solution result in false TF- and CD14-positive microparticles in flow cytometric analysis. Cytometry A. 2011; 79: 990–9. [PubMed Abstract].
   Google Scholar
• Jacoby RC, Owings JT, Holmes J, Battistella FD, Gosselin RC, Paglieroni TG. Platelet activation and function after trauma. J Trauma. 2001; 51: 639–47. [PubMed Abstract].
   Google Scholar
• Soriano AO, Jy W, Chirinos JA, Valdivia MA, Velasquez HS, Jimenez JJ, etal. Levels of endothelial and platelet microparticles and their interactions with leukocytes negatively correlate with organ dysfunction and predict mortality in severe sepsis. Crit Care Med. 2005; 33: 2540–6. [PubMed Abstract].
   Google Scholar
• Joop K, Berckmans RJ, Nieuwland R, Berkhout J, Romijn FP, Hack CE, etal. Microparticles from patients with multiple organ dysfunction syndrome and sepsis support coagulation through multiple mechanisms. Thromb Haemost. 2001; 85: 810–20. [PubMed Abstract].
   Google Scholar
• Mooberry MJ, Key NS. Microparticle analysis in disorders of hemostasis and thrombosis. Cytometry A. 2015. doi: http://dx.doi.org/10.1002/cyto.a.22647 [Epub ahead of print]..
   Google Scholar
• Dhillon SK, Houck ML, Jenkins DH, Rosedahl JK, Harmsen WS, Halling TM, etal. Transfusion of stored red blood cells in trauma patients is not associated with increased procoagulant microparticles. J Trauma Acute Care Surg. 2014; 77: 674–8. [PubMed Abstract].
   Google Scholar
• Rubin O, Delobel J, Prudent M, Lion N, Kohl K, Tucker EI, etal. Red blood cell-derived microparticles isolated from blood units initiate and propagate thrombin generation. Transfusion. 2013; 53: 1744–54. [PubMed Abstract].
   Google Scholar
• van Beers EJ, Schaap MC, Berckmans RJ, Nieuwland R, Sturk A, van Doormaal FF, etal. Circulating erythrocyte-derived microparticles are associated with coagulation activation in sickle cell disease. Haematologica. 2009; 94: 1513–9. [PubMed Abstract] [PubMed CentralFull Text].
   Google Scholar
• Koshiar RL, Somajo S, Norstrom E, Dahlback B. Erythrocyte-derived microparticles supporting activated protein C-mediated regulation of blood coagulation. PLoS One. 2014; 9: e104200. [PubMed Abstract].
   Google Scholar
• Mause SF, Ritzel E, Liehn EA, Hristov M, Bidzhekov K, Muller-Newen G, etal. Platelet microparticles enhance the vasoregenerative potential of angiogenic early outgrowth cells after vascular injury. Circulation. 2010; 122: 495–506. [PubMed Abstract].
   Google Scholar
• Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, etal. Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial. JAMA. 2015; 313: 471–82. [PubMed Abstract] [PubMed CentralFull Text].
   Google Scholar
• Del Junco DJ, Bulger EM, Fox EE, Holcomb JB, Brasel KJ, Hoyt DB, etal. Collider bias in trauma comparative effectiveness research: the stratification blues for systematic reviews. Injury. 2015; 46: 775–80. [PubMed Abstract].
   Google Scholar