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Original Articles

Expression levels of novel cytokine IL-32 in periodontitis and its role in the suppression of IL-8 production by human gingival fibroblasts stimulated with Porphyromonas gingivalis

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Article: 14832 | Received 25 Nov 2011, Accepted 22 Feb 2012, Published online: 16 Mar 2012

References

  • Socransky SS, Haffajee AD. Implications of periodontal microbiology for the treatment of periodontal infections. Compend Suppl. 1994: S684–5., 8–93; quiz S714–7.
  • Kadowaki T, Nakayama K, Okamoto K, Abe N, Baba A, Shi Y, et al.. Porphyromonas gingivalis proteinases as virulence determinants in progression of periodontal diseases. J Biochem. 2000; 128: 153–9.
  • Barksby HE, Nile CJ, Jaedicke KM, Taylor JJ, Preshaw PM. Differential expression of immunoregulatory genes in monocytes in response to Porphyromonas gingivalis and Escherichia coli lipopolysaccharide. Clin Exp Immunol. 2009; 156: 479–87.
  • Oshiro T, Shiotani A, Shibasaki Y, Sasaki T. Osteoclast induction in periodontal tissue during experimental movement of incisors in osteoprotegerin-deficient mice. Anat Rec. 2002; 266: 218–25.
  • Teng YT, Nguyen H, Gao X, Kong YY, Gorczynski RM, Singh B, et al.. Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection. J Clin Invest. 2000; 106: R59–67.
  • Steffen MJ, Holt SC, Ebersole JL. Porphyromonas gingivalis induction of mediator and cytokine secretion by human gingival fibroblasts. Oral Microbiol Immunol. 2000; 15: 172–80.
  • Imatani T, Kato T, Okuda K. Production of inflammatory cytokines by human gingival fibroblasts stimulated by cell-surface preparations of Porphyromonas gingivalis. Oral Microbiol Immunol. 2001; 16: 65–72.
  • van Winkelhoff AJ. Antibiotics in periodontics: are we getting somewhere?. J Clin Periodontol. 2005; 32: 1094–5.
  • Kim SH, Han SY, Azam T, Yoon DY, Dinarello CA. Interleukin-32: a cytokine and inducer of TNFalpha. Immunity. 2005; 22: 131–42.
  • Dinarello CA, Kim SH. IL-32, a novel cytokine with a possible role in disease. Ann Rheum Dis. 2006; 65 (Suppl 3): iii61–4.
  • Dahl CA, Schall RP, He HL, Cairns JS. Identification of a novel gene expressed in activated natural killer cells and T cells. J Immunol. 1992; 148: 597–603.
  • Shioya M, Nishida A, Yagi Y, Ogawa A, Tsujikawa T, Kim-Mitsuyama S, et al.. Epithelial overexpression of interleukin-32alpha in inflammatory bowel disease. Clin Exp Immunol. 2007; 149: 480–6.
  • Joosten LA, Netea MG, Kim SH, Yoon DY, Oppers-Walgreen B, Radstake TR, et al.. IL-32, a proinflammatory cytokine in rheumatoid arthritis. Proc Natl Acad Sci USA. 2006; 103: 3298–303.
  • Fujita T, Iwata T, Shiba H, Igarashi A, Hirata R, Takeda K, et al.. Identification of marker genes distinguishing human periodontal ligament cells from human mesenchymal stem cells and human gingival fibroblasts. J Periodontal Res. 2007; 42: 283–6.
  • Ueki Y, Lin CY, Senoo M, Ebihara T, Agata N, Onji M, et al.. Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 ‘cherubism’ mice. Cell. 2007; 128: 71–83.
  • Hosokawa I, Hosokawa Y, Komatsuzawa H, Goncalves RB, Karimbux N, Napimoga MH, et al.. Innate immune peptide LL-37 displays distinct expression pattern from beta-defensins in inflamed gingival tissue. Clin Exp Immunol. 2006; 146: 218–25.
  • Shiba H, Tsuda H, Kajiya M, Fujita T, Takeda K, Hino T, et al.. Neodymium-doped yttrium-aluminium-garnet laser irradiation abolishes the increase in interleukin-6 levels caused by peptidoglycan through the p38 mitogen-activated protein kinase pathway in human pulp cells. J Endod. 2009; 35: 373–6.
  • Netea MG, Azam T, Ferwerda G, Girardin SE, Walsh M, Park JS, et al.. IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism. Proc Natl Acad Sci U S A. 2005; 102: 16309–14.
  • Mun SH, Kim JW, Nah SS, Ko NY, Lee JH, Kim JD, et al.. Tumor necrosis factor alpha-induced interleukin-32 is positively regulated via the Syk/protein kinase Cdelta/JNK pathway in rheumatoid synovial fibroblasts. Arthritis Rheum. 2009; 60: 678–85.
  • Nold-Petry CA, Nold MF, Zepp JA, Kim SH, Voelkel NF, Dinarello CA. IL-32-dependent effects of IL-1beta on endothelial cell functions. Proc Natl Acad Sci USA. 2009; 106: 3883–8.
  • Takashiba S, Naruishi K. Gene polymorphisms in periodontal health and disease. Periodontol 2000. 2006; 40: 94–106.
  • de Heens GL, van der Velden U, Loos BG. Cigarette smoking enhances T cell activation and a Th2 immune response; an aspect of the pathophysiology in periodontal disease. Cytokine. 2009; 47: 157–61.
  • Smolik I, Robinson D, El-Gabalawy HS. Periodontitis and rheumatoid arthritis: epidemiologic, clinical, and immunologic associations. Compend Contin Educ Dent. 2009; 30: 188–90., 92, 94 passim; quiz 98, 210.
  • Stathopoulou PG, Benakanakere MR, Galicia JC, Kinane DF. The host cytokine response to Porphyromonas gingivalis is modified by gingipains. Oral Microbiol Immunol. 2009; 24: 11–7.
  • Baba A, Kadowaki T, Asao T, Yamamoto K. Roles for Arg- and Lys-gingipains in the disruption of cytokine responses and loss of viability of human endothelial cells by Porphyromonas gingivalis infection. Biol Chem. 2002; 383: 1223–30.
  • Pingel LC, Kohlgraf KG, Hansen CJ, Eastman CG, Dietrich DE, Burnell KK, et al.. Human beta-defensin 3 binds to hemagglutinin B (rHagB), a non-fimbrial adhesin from Porphyromonas gingivalis, and attenuates a pro-inflammatory cytokine response. Immunol Cell Biol. 2008; 86: 643–9.
  • Hong J, Bae S, Kang Y, Yoon D, Bai X, Chan ED, et al.. 2009Suppressing IL-32 in monocytes impairs the induction of the proinflammatory cytokines TNFalpha and IL-1beta. Cytokine. 49: 171–6.
  • Colic M, Gazivoda D, Vasilijic S, Vucevic D, Lukic A. Production of IL-10 and IL-12 by antigen-presenting cells in periapical lesions. J Oral Pathol Med. 39: 690–6.
  • Conti P, Kempuraj D, Kandere K, Di Gioacchino M, Barbacane RC, Castellani ML, et al.. IL-10, an inflammatory/inhibitory cytokine, but not always. Immunol Lett. 2003; 86: 123–9.
  • Morandini AC, Sipert CR, Ramos-Junior ES, Brozoski DT, Santos CF. Periodontal ligament and gingival fibroblasts participate in the production of TGF-beta, interleukin (IL)-8 and IL-10. Braz Oral Res. 2009; 25: 157–62.
  • Uchida Y, Shiba H, Komatsuzawa H, Takemoto T, Sakata M, Fujita T, et al.. Expression of IL-1 beta and IL-8 by human gingival epithelial cells in response to Actinobacillus actinomycetemcomitans. Cytokine. 2001; 14: 152–61.
  • Baggiolini M, Clark-Lewis I. Interleukin-8, a chemotactic and inflammatory cytokine. FEBS Lett. 1992; 307: 97–101.
  • Novick D, Rubinstein M, Azam T, Rabinkov A, Dinarello CA, Kim SH. Proteinase 3 is an IL-32 binding protein. Proc Natl Acad Sci USA. 2006; 103: 3316–21.