Challenges Associated with Scaling up Artemisinin Combination Therapy in Sub-Saharan Africa A Review Article

References

• Snow R, Craig MH, Newton CRJC, Steketee RW. The public health burden of Plasmodium falciparum malaria in Africa:Deriving the number. Working Paper No. 11, Disease Control Priorities Project. Bethesda, Maryland: Fogarty International Center, National Institutes of Health; 2003.
   Google Scholar
• WHO, UNICEF. The Africa malaria report 2003. Geneva: WHO, UNICEF, 2003.
   Google Scholar
• Rugemalila JB, Lwanga CL, Kilama WL. Sixth Malaria Day in 2006: How far have we come after Abuja Declaration? Malar J. 2006; 5:102.
   Web of Science ®Google Scholar
• WHO. WHO Expert Committee on Malaria, Twentieth Report. Geneva: WHO, 2000.
   Google Scholar
• Roll Back Malaria. Malaria in Africa. Accessed from RBM website May 2007: http://www.rbm.who.int/cmc_upload/0/000/015/370/RBMInfosheet_3.htm
   Google Scholar
• Roll Back Malaria. What is the Roll Back Malaria Partnership? Accessed from RBM website May 2007: http://www.rollbackmalaria.org/aboutus.html
   Google Scholar
• Dillen J, Custers M, Wensin KA, Wouters B, Voorthorzeen T, Voorn W et al. A comparison of Amodiaquine and sulphadoxine-pyrimethamine as first line treatment of falciparum malaria in Kenya. Trans R Soc Trop Med Hyg. 1999; 93:185–188.
   Web of Science ®Google Scholar
• WHO, Guidelines for the treatment of malaria. Geneva: WHO; 2006, Accessed April 2007 http://www.who.int/malaria/docs/TreatmentGuidelines2006.pdf
   Google Scholar
• Falade C, Makanga M, Premji Z, Ortman CE, Stockmeyer, Palacios PI. Efficacy and safety of Artemether-Lumefantrine (CoartemC)) tablets (six dose regimen) in African infants and children with acute, uncomplicated falciparum malaria. Trans R Soc Trop Med Hyg. 2005; 99:459–467.
   PubMed Web of Science ®Google Scholar
• UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases. Social science research on tropical diseases (CD ROM). Version 1.0 Geneva: WHO/TDR; 2004.
   Google Scholar
• Kindermans JM, Pecoul B, Perez CC, Den Boer M, Bergman D, Cox C. Changing national malaria treatment protocols in Africa: What is the cost and who will pay? Case studies:Burundi, Kenya, Rwanda, Tanzania and Uganda. Medecins Sans Frontiers. 2002. Available at: http://www.accessmedmsf.org/prod/publications.asp?scntid=25220021844238&contenttype=PARA&. Accessed:April 2007.
   Google Scholar
• Leonardi E, Gilvary G, White NJ, Nosten F. Severe allergic reactions to oral artesunate:a report of 2 cases. Trans R Soc Trop Med Hyg. 2001; 95:182–183.
   PubMed Web of Science ®Google Scholar
• Lang T, Hughes D, Kanyok T, Kengeya-Kayondo J, Marsh V, Haaland A, et. al. Beyond registration-measuring the public health potential of new treatments for malaria in Africa. Lancet Ifect Dis. 2006; 6:46–52.
   PubMed Web of Science ®Google Scholar
• van Vugt M, Brockman A, Gemperli B, Luxemburger C, Gathmann I, Royce C, et. al. A randomised comparison of Artemether-benflumetol and artesunate-mefloquine in the treatment of multi-drug resistant falciparum malaria. Antimicrob Agent Chemother. 1998; 42:135–139.
   PubMed Web of Science ®Google Scholar
• White NJ. Preventing antimalarial drug resistance through combinations. Drug Resistance Updates. 1997; 1:3–6.
   Web of Science ®Google Scholar
• White NJ. Assessment of the pharmacodynamic properties of antimalarial drugs in vivo. Antimicrob Agent Chemother. 1997; 41:1413–1422.
   PubMed Web of Science ®Google Scholar
• Ashley EA, Stepniewska K, Lindegardh S, Annerberg A, Kham A, Brockman A. et al. How much fat is necessary to optimize Lumefantrine oral bioavailability? Trop Med Int Health. 2007; 12:195–200.
   Google Scholar
• World Health Organisation. Malaria diagnosis:Memorandum from a WHO meeting. Bull World Health Organ. 1988; 66:575
   Web of Science ®Google Scholar
• Meya DN, Clark MN, Nzarubara B, Staedke S, Kamya MS, Dorsey G. Treatment of malaria restricted to laboratory-confirmed cases:a prospective cohort in Ugandan children. Malar J. 2007; 6:7.
   Web of Science ®Google Scholar
• Zurovac D, Midia B, Ochola SA, English M, Snow R. Microscopy and outpatient malaria case management among older children and adults in Kenya. Trop Med Int Health. 2006; 2:432–440.
   Web of Science ®Google Scholar
• Zurovac D, Ndhlovu M, Rowe AK, Hamer DH, Thea DM, Snow RM. Treatment of paediatric malaria during a period of drug transition to Artemether-Lumefantrine in Zambia:a cross sectional study. BMJ. 2005; 331:734–737.
   PubMed Web of Science ®Google Scholar
• Chiodini P, Bowers K, Jorgensen P, Barnwell JW, Grady KK, Luchavez J et al. The heat stability of Plasmodium lactate dehydrogenase-based and histidine rich protein 2-based malaria rapid diagnostic tests. Trans R Soc Trop Med Hyg. 2007; 101:331–337.
   PubMed Web of Science ®Google Scholar
• Amexo M, Tolhurst R, Burnish G, Bates I. Malaria misdiagnosis:effects on the poor and vulnerable. Lancet. 2004; 364:1896–1898.
   PubMed Web of Science ®Google Scholar
• Berkley JA, Lowe BS, Mwangi et al. Bacteremia among children admitted to a rural hospital in Kenya. New England Journal of Medicine. 2005; 352:39–47.
   PubMed Web of Science ®Google Scholar
• Subo J, Chimpeni P, Hatcher J, Kublin J, Plowe C, Molyneux M et al. Chlorproguanil-dapsone versus sulfadoxine - pyrimethamine for sequential episodes of uncomplicated falciparum malaria in Kenya and Malawi:a randomised clinical trial. Lancet. 2002; 360:1136–1143.
   Web of Science ®Google Scholar
• Rayburn H, Mbatia R, Drakeley C, Carneiro I, Mwakasungula E, Mwerinde O et al. overdiagnosis of malaria in patients with severe febrile illness in Tanzania:a prospective study. BMJ. 2004; 329:1212–1217.
   Web of Science ®Google Scholar
• Nwanyanwu OC, Kumwenda N, Kazembe PN, Jemu S, Ziba C, Nkhoma WC, Redd SC. Malaria and Human Immunodeficiency virus infection among male employees of a sugar estate in Malawi. Trans R Soc Trop Med Hyg. 1997; 91:567–569.
   Web of Science ®Google Scholar
• Chandramohan D, Jaffar S, Greenwood B. Use of clinical algorithms for diagnosing malaria. Trop Med Int Health. 2002; 7:45–52.
   PubMed Web of Science ®Google Scholar
• Muheki C, MacIntyre D, Barnes KI. Artemisinin Combination Therapy reduces expenditure on Malaria treatment in Kwa Zulu Natal, South Africa. Trop Med Int Health. 2004; 9:959–66.
   PubMed Web of Science ®Google Scholar
• Zurovac D, Ndhlovu M, Sipilanyambe N, Chanda P, Hamer DH, Simon JL et al. Paediatric malaria case-management with Artemether Lumefantrine in Zambia:a repeat cross sectional study. Malar J. 2007; 6: 31.
   PubMed Web of Science ®Google Scholar
• Masika P, Semarundu WJ, Urassa R, Mosha J, Chandramohan D, Gosling RD. Over-diagnosis of malaria is not a lost cause. Malar Journal. 2006; 5:120–122.
   Web of Science ®Google Scholar
• Fogg C, Bajunirwe F, Piola P, Biraro S, Checchi F, Kiguli J et al. Adherence to a six-dose regimen of Artemether-Lumefantrine for treatment of uncomplicated Plasmodium falciparum malaria in Uganda. Am J Trop Med Hyg. 2004; 71:525–30.
   PubMed Web of Science ®Google Scholar
• Depoortere E, Guthmann JP, Sipilnyambe N, Nkandu E, Fermon F, Balkan S, et. al. Adherence to the combination of sulfadoxine-pyrimethamine and artesunate in the Maheba Refugee Settlement, Zambia. Trop Med Int Health. 2004; 9:62–67.
   PubMed Web of Science ®Google Scholar
• Depoortere E, Salvador ET, Stivanello E, Bisoffi Z, Guthmann JP. Adherence to a combination of Artemether and Lumefantrine (CoartemC)) in Keji, Southern Sudan. Ann Trop Med Parasitol. 2004; 98:635–637.
   PubMed Web of Science ®Google Scholar
• Piola P, Fogg C, Bajunirwe F, Biraro S, Grandesso F, Ruzagira et. al. Supervised versus unsupervised intake of six-dose Artemether-Lumefantrine for treatment of acute, uncomplicated Plasmodium falciparum malaria in Mbarara, Uganda:a randomised trial. Lancet. 2005; 365:1467–73.
   PubMed Web of Science ®Google Scholar
• Kachur SP, Rashid AK, Kaizer E, Fox SA, Abdulla SM, Bloland PB. Adherence to antimalarial combination therapy with sulfadoxine-pyrimethamine and artesunate in rural Tanzania. Am J Trop Med Hyg. 2004; 71:715–22.
   PubMed Web of Science ®Google Scholar
• Ouma WA, Thiongo FW, Odero MA, Ouma JH. The Health workers for change impact study in Kenya. Health Policy and Planning. 2001; 16:33–39.
   Web of Science ®Google Scholar
• Levy-Bruhl D, Soucat A, Osseni R, Ndiaye JM, Dieng B, De Bethune X et al. The Bamako Initiative in Benin and Guinea:improving the effectiveness of primary health care. Int J Health Plann Manage. 1997 Jun; 12 Suppl 1:S49–79.
   Web of Science ®Google Scholar
• Marsh VM, Mutemi WM, Willets A, Baych K, Were S, Ross A, et. al. Improving malaria treatment by training drug retailers in rural Kenya. Trop Med Int Health. 2004; 9:451–460.
   PubMed Web of Science ®Google Scholar
• Rollback Malaria available at:http://www.rollbackmalaria.org/amd2006 Accessed April 2007.
   Google Scholar
• Amin AA, Marsh V, Noor AM, Ochola SA, Snow RW. The use of formal and informal curative services in the management of paediatric fever in 4 districts in Kenya. Trop Med Int Health. 2003; 8:1143-1152
   PubMed Web of Science ®Google Scholar
• Kidane G, Morrow RH. Teaching mothers to provide home treatment of malaria in Tigray, Ethiopia:a randomised trial. Lancet. 2000; 356:550–555.
   PubMed Web of Science ®Google Scholar
• D’Allessandro U, Talisuna A, Boelart M. Should artemisinin-based combination treatment be used in the home-based management of malaria? Trop Med Int Health. 2005; 10:1.
   Google Scholar
• Amanua C, Gyapong JO, Pagnoni F, Wellington EK, Gyapong M. Feasibility and acceptability of the use of Artemether Lumefantrine in the home management of uncomplicated malaria in children 6-59 months old in Ghana. Trop Med Int Health. 2006; 11:1003-1016.
   Google Scholar
• Amin AA, Zurovac D, Kangwana BB, Greenfield J, Otieno DO, Akhwale WS, et. al. The challenges of changing national malaria drug policy to artemisinin-based combinations in Kenya. Malaria journal. 2007; 6:72–82.
   PubMed Web of Science ®Google Scholar
• Pagnoni F, Kengeya-Kayondo J, Ridley R. Artemisinin-based combination treatment in home-based management of malaria. Trop Med Int Health. 2005; 6:621–622.
   Google Scholar
• Mutabingwa TK. Artemisinin based Combination Therapies (ACTs):best hope for malaria treatment but inaccessible to the needyl Acta Tropica. 2005; 95:305–15.
   Google Scholar
• Chanda P, Masiye F, Chitah BM, Sipilanyambe N, Hawela M, Banda P, Okorosobo T. A cost-effectiveness analysis of Artemether Lumefantrine for treatment of uncomplicated malaria in Zambia. Malar J. 2007; 21:21.
   Web of Science ®Google Scholar
• Arrow KJ, Panosian CB, Gelband H, editors. Saving lives, buying time:economics of malaria drugs an age of resistance. Washington DC:National Academies Press; 2000.
   Google Scholar
• World Health Organization. Procurement of Artemether-Lumefantrine through the WHO Available at http://www.who.int/malaria/cmc_upload/0/000/015/789/CoA_website5.pdf Accessed:April 2007.
   Google Scholar
• Parry J. WHO combats counterfeit drugs in Asia. BMJ. 2005; 330:1044
   Google Scholar
• Drugs for Neglected diseases Initiative. ASAQ in a few words. Accessed April 2007 from: http://www.actwithasaq.org/en/asaq1.htm
   Google Scholar
• Morel CM, Laver AJ, Evans DB. Cost effectiveness analysis of strategies to combat malaria in developing countries. BMJ. 2005; 331:1299.
   PubMed Web of Science ®Google Scholar
• Wiseman V, Kim M, Mutabingwa TK, Whitty CJ. Cost-effectiveness study of three antimalarial drug combinations in Tanzania. PLoS Med. 2006; 3 (10) .
   Web of Science ®Google Scholar
• Unger JP, D’Allessandro U, Paepe PD, Green A. Can malaria be controlled where basic health services are not used? Trop Med Int Health. 2006; 3:314–322.
   Web of Science ®Google Scholar