Faecal short-chain fatty acid pattern in childhood coeliac disease is normalised after more than one year's gluten-free diet

References

• Rubio-Tapia A , Murray JA . Celiac disease. Curr Opin Gastroenterol. 2010; 26: 116–22.
   PubMed Web of Science ®Google Scholar
• Husby S , Koletzko S , Korponay-Szabo IR , Mearin ML , Phillips A , Shamir R , etal. European Society for Paediatric Gastroenterology, Hepatology and Nutrition guidelines for the diagnosis of coeliac disease. J Pediatr Gastroenterol Nutr. 2012; 54: 136–60.
   PubMed Web of Science ®Google Scholar
• Forsberg G , Fahlgren A , Hörstedt P , Hammarström S , Hernell O , Hammarström M-L . Presence of bacteria and innate immunity of intestinal epithelium in childhood celiac disease. Am J Gastroenterol. 2004; 99: 894–904.
   PubMed Web of Science ®Google Scholar
• Ou G , Hedberg M , Hörstedt P , Baranov V , Forsberg G , Drobni M , etal. Proximal small intestinal microbiota and identification of rod-shaped bacteria associated with childhood celiac disease. Am J Gastroenterol. 2009; 104: 3058–67.
   PubMed Web of Science ®Google Scholar
• Sanz YS , De Palma G , Laparra M . Unraveling the ties between celiac disease and intestinal microbiota. Int Rev Immunol. 2011; 30: 207–18.
   PubMed Web of Science ®Google Scholar
• Selitto M , Bai G , Serena G , Fricke F , Sturgeon C , Gajer P , etal. Proof of concept of microbiome-metabolome analysis and delayed gluten exposure on celiac disease autoimmunity in genetically at-risk infants. PLoS One. 2012; 7: e33387.
   Web of Science ®Google Scholar
• Tjellström B , Stenhammar L , Högberg L , Fälth-Magnusson K , Magnusson K-E , Midtvedt T , etal. Gut microflora associated characteristics in children with celiac disease. Am J Gastroenterol. 2005; 100: 2784–8.
   PubMed Web of Science ®Google Scholar
• Tjellström B , Stenhammar L , Högberg L , Fälth-Magnusson K , Magnusson K-E , Midtvedt T , etal. Screening-detected and symptomatic untreated celiac children show similar gut microflora-associated characteristics. Scand J Gastroenterol. 2010; 45: 1059–62.
   PubMed Web of Science ®Google Scholar
• Walker-Smith JA , Guandalini S , Schmitz J , Shmerling DH , Visakorpi JK , etal. Revised criteria for diagnosis of celiac disease. Arch Dis Child. 1990; 65: 909–11.
   PubMed Web of Science ®Google Scholar
• Midtvedt T , Björneklett A , Carlstedt-Duke B , Gustafsson BE , Höverstad T , Lingaas E , etal., Wostmann BS , Pleasants JR , Pollard M , Teah BA , Wagner M . The influence of antibiotics upon microflora-associated characteristics in man and mammals. Germ-free research, microflora control and its application to the biomedical sciences. Progress in clinical and biological research. 1985; New York: Alan R. Liss Corporation. 241–4.
   Google Scholar
• Zijlstra JB , Beukema J , Wolthers BG , Byrne BM , Groen A , Dankert J . Pretreatment methods prior to gas chromatographic analysis of volatile fatty acids from faecal samples. Clin Chim Acta. 1977; 78: 243–50.
   PubMed Web of Science ®Google Scholar
• Höverstad T , Björneklett A . Short-chain fatty acids and bowel functions in man. Scand J Gastroenterol. 1984; 19: 1059–65.
   PubMed Web of Science ®Google Scholar
• Bertini I , Calabrò A , De Carli V , Luchinat C , Nepi S , Porfirio B , etal. The metabonomic signature of celiac disease. J Proteome Res. 2009; 8: 170–7.
   PubMed Web of Science ®Google Scholar
• Caminero A , Nistal E , Arias L , Vivas S , Comino I , Real A , etal. A gluten metabolism study in healthy individuals shows the presence of faecal glutenasic activity. Eur J Nutr. 2012; 51: 293–9.
   Web of Science ®Google Scholar
• Hamer HM , Jonkers D , Venema K , Vanhoutvin S , Troost FJ , Brummer RJ . Review article: the role of butyrate on colonic function. Aliment Pharmacol Ther. 2008; 27: 104–19.
   PubMed Web of Science ®Google Scholar
• Al-Lahham SH , Peppelenbosch MP , Roelofsen H . Biological effects of propionic acid in humans; metabolism, potential applications and underlying mechanisms. Biochim Biophys Acta. 2010; 1801: 1175–83.
   PubMed Web of Science ®Google Scholar
• Maa M-C , Chang MY , Hsieh M-Y , Chen Y-J , Yang C-J , Chen Z-C , etal. Butyrate reduced lipopolysaccharide-mediated macrophage migration by suppression of Src enhancement and focal adhesion kinase activity. J Nutr Biochem. 2010; 21: 1186–92.
   PubMed Web of Science ®Google Scholar
• Kanauchi O , Andoh A , Iwanaga T , Fajiyama Y , Mitsuyama K , Toyonaga A , etal. Germinated barley foodstuffs attenuate colonic mucosa damage and mucosal nuclear factor kappa B activity in a spontaneous colitis model. J Gastroenterol Hepatol. 1999; 14: 1173–9.
   PubMed Web of Science ®Google Scholar
• Tjellström B , Högberg L , Stenhammar L , Magnusson K-E , Midtvedt T , Norin E , etal. Effect of exclusive enteral nutrition on gut microflora function in children with Crohn's disease. Scand J Gastroenterol. 2012; 47: 1454–9.
   PubMed Web of Science ®Google Scholar
• James SP . Prototypic disorders of gastrointestinal mucosal immune function: celiac disease and Crohn's disease. Allergy Clin Immunol. 2005; 115: 25–30.
   Google Scholar
• Tana C , Umesaki Y , Imaoka A , Handa T , Kanazawa M , Fukudo S . Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome. Neurogastroenterol Motil. 2010; 22: 512–9.
   PubMed Web of Science ®Google Scholar
• MacFabe DF . Short-chin fatty acid fermentation products of the gut microbiome: implications in autism spectrum disorders. Microb Ecol Health Dis. 2012; 23: 19260.
   PubMedGoogle Scholar
• Midtvedt A-C . The establishment and development of some metabolic activities associated with the intestinal microflora in healthy children. Medical dissertation. Stockholm, Sweden: Karolinska Institute.
   Google Scholar
• Kalliomäki M , Satokari R , Lähteenoja H , Vähämiko S , Grönlund J , Routi T , etal. Expression of microbiota, toll-like receptors, and their regulators in the small intestinal mucosa in celiac disease. J Pediatr Gastroenterol Nutr. 2012; 54: 727–32.
   PubMed Web of Science ®Google Scholar
• Huibregtse IL , Marietta EV , Rashtak S , Koning F , Rottiers P , David CS , etal. Induction of antigen-specific tolerance by oral administration of Lactococcus lactis delivered immunodominant DQ8-restricted gliadin peptide in sensitized nonobese diabetic AB0 DQ8 transgenic mice. J Immunol. 2009; 183: 2390–6.
   PubMed Web of Science ®Google Scholar
• Rashtak S , Murray JA . Review article: coeliac disease, new approaches to therapy. Aliment Pharmacol Ther. 2012; 35: 768–81.
   PubMed Web of Science ®Google Scholar