Age-dependent changes in innate immune phenotype and function in rhesus macaques (Macaca mulatta)

References

• Iwasaki A, Medzhitov R. Regulation of adaptive immunity by the innate immune system. 2010; 327: 291-5.
   Google Scholar
• Siegrist CA, Aspinall R. B-cell responses to vaccination at the extremes of age. 2009; 9: 185-94.
   Google Scholar
• Siegrist CA. Neonatal and early life vaccinology. 2001; 19: 3331-46.
   Google Scholar
• Adkins B, Leclerc C, Marshall-Clarke S. Neonatal adaptive immunity comes of age. 2004; 4: 553-64.
   Google Scholar
• Yoshikawa TT. Epidemiology and unique aspects of aging and infectious diseases. 2000; 30: 931-33.
   Google Scholar
• Yoshikawa TT. Perspective: aging and infectious diseases: past, present, and future. 1997; 176: 1053-57.
   Google Scholar
• Kawai T, Akira S. Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. 2011; 34: 637-50.
   Google Scholar
• Plackett TP., Boehmer ED, Faunce DE, Kovacs EJ. Aging and innate immune cells. 2004; 76: 291-9.
   Google Scholar
• Franceschi C, Capri M, Monti D, Giunta S, Olivieri F, Sevini F et al. Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. 2007; 128: 92-105.
   Google Scholar
• Levy O, Zarember KA, Roy RM, Cywes C, Godowski PJ, Wessels MR. Selective impairment of TLR-mediated innate immunity in human newborns: neonatal blood plasma reduces monocyte TNF-alpha induction by bacterial lipopeptides, lipopolysaccharide, and imiquimod, but preserves the response to R-848. 2004; 173: 4627-34.
   Google Scholar
• Wynn JL., Levy O. Role of innate host defenses in susceptibility to early-onset neonatal sepsis. 2011; 37: 307-37.
   Google Scholar
• Angelone DF, Wessels MR, Coughlin M, Suter EE, Valentini P, Kalish LA et al. Innate immunity of the human newborn is polarized toward a high ratio of IL-6/TNF-alpha production in vitro and in vivo. 2006; 60: 205-9.
   Google Scholar
• Pitcher CJ, Hagen SI, Walker JM, Lum R, Mitchell BL, Maino VC et al. Development and homeostasis of T cell memory in rhesus macaque. 2002; 168: 29-43.
   Google Scholar
• Ketloy C, Engering A, Srichairatanakul U, Limsalakpetch A, Yongvanitchit K, Pichyangkul S et al. Expression and function of Toll-like receptors on dendritic cells and other antigen presenting cells from non-human primates. 2008; 125: 18-30.
   Google Scholar
• Coates PT, Barratt-Boyes SM, Zhang L, Donnenberg VS, O'Connell PJ, Logar AJ et al. Dendritic cell subsets in blood and lymphoid tissue of rhesus monkeys and their mobilization with Flt3 ligand. 2003; 102: 2513-21.
   Google Scholar
• Pawelec G, Akbar A, Caruso C, Solana R, Grubeck-Loebenstein B, Wikby A. Human immunosenescence: is it infectious?. 2005; 205: 257-68.
   Google Scholar
• Schenten D, Medzhitov R. The control of adaptive immune responses by the innate immune system. 2011; 109: 87-124.
   Google Scholar
• Barbalat R, Ewald SE, Mouchess ML, Barton GM. Nucleic acid recognition by the innate immune system. 2011; 29: 185-214.
   Google Scholar
• Agostini L, Martinon F, Burns K, McDermott MF, Hawkins PN, Tschopp J. NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. 2004; 20: 319-25.
   Google Scholar
• Zhang G, Ghosh S. Negative regulation of toll-like receptor-mediated signaling by Tollip. 2002; 277: 7059-65.
   Google Scholar
• Kobayashi K, Hernandez LD, Galan JE, Janeway CA Jr., Medzhitov R, Flavell RA. IRAK-M is a negative regulator of Toll-like receptor signaling. 2002; 110: 191-202.
   Google Scholar
• Allen IC, Moore CB, Schneider M, Lei Y, Davis BK, Scull MA et al. NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-kappaB signaling pathways. 2011; 34: 854-65.
   Google Scholar
• Xia X, Cui J, Wang HY, Zhu L, Matsueda S, Wang Q et al. NLRX1 negatively regulates TLR-induced NF-kappaB signaling by targeting TRAF6 and IKK. 2011; 34: 843-53.
   Google Scholar
• Gilchrist M, Thorsson V, Li B, Rust AG, Korb M, Roach JC et al. Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4. 2006; 441: 173-8.
   Google Scholar
• Peng J, Yuan Q, Lin B, Panneerselvam P, Wang X, Luan XL et al. SARM inhibits both TRIF- and MyD88-mediated AP-1 activation. 2010; 40: 1738-47.
   Google Scholar
• Carty M, Goodbody R, Schroder M, Stack J, Moynagh PN, Bowie AG. The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling. 2006; 7: 1074-81.
   Google Scholar
• Ikeda F, Deribe YL, Skanland SS, Stieglitz B, Grabbe C, Franz-Wachtel M et al. SHARPIN forms a linear ubiquitin ligase complex regulating NF-kappaB activity and apoptosis. 2011; 471: 637-41.
   Google Scholar
• Tokunaga F, Nakagawa T, Nakahara M, Saeki Y, Taniguchi M, Sakata S et al. SHARPIN is a component of the NF-kappaB-activating linear ubiquitin chain assembly complex. 2011; 471: 633-36.
   Google Scholar
• Gerlach B, Cordier SM, Schmukle AC, Emmerich CH, Rieser E, Haas TL et al. Linear ubiquitination prevents inflammation and regulates immune signalling. 2011; 471: 591-6.
   Google Scholar
• Zhang M, Tian Y, Wang RP, Gao D, Zhang Y, Diao FC et al. Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3. 2008; 18: 1096-1104.
   Google Scholar
• Arnold CR, Wolf J, Brunner S, Herndler-Brandstetter D, Grubeck-Loebenstein B. Gain and loss of T cell subsets in old age – age-related reshaping of the T cell repertoire. 2011; 31: 137-46.
   Google Scholar
• Messaoudi I, Ingram DK. Overview of aging research using nonhuman primate models. Age (Dordr). 2011..
   Google Scholar
• Xia HJ, Zhang GH, Wang RR, Zheng YT. The influence of age and sex on the cell counts of peripheral blood leukocyte subpopulations in Chinese rhesus macaques. 2009; 6: 433-40.
   Google Scholar
• Takahashi I, Ohmoto E, Aoyama S, Takizawa M, Oda Y, Nonaka K et al. Monocyte chemiluminescence and macrophage precursors in the aged. 1985; 39: 447-51.
   Google Scholar
• Nyugen J, Agrawal S, Gollapudi S, Gupta S. Impaired functions of peripheral blood monocyte subpopulations in aged humans. 2010; 30: 806-13.
   Google Scholar
• McFarlane D, Wolf RF, McDaniel KA, White GL. Age-associated alteration in innate immune response in captive baboons. 2011; 66: 1309-17.
   Google Scholar
• Mascarucci P, Taub D, Saccani S, Paloma MA, Dawson H, Roth GS et al. Cytokine responses in young and old rhesus monkeys: effect of caloric restriction. 2002; 22: 565-71.
   Google Scholar
• van Duin D, Mohanty S, Thomas V, Ginter S, Montgomery RR, Fikrig E et al. Age-associated defect in human TLR-1/2 function. 2007; 178: 970-5.
   Google Scholar
• Panda A, Qian F, Mohanty S, van Duin D, Newman FK, Zhang L et al. Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response. 2010; 184: 2518-27.
   Google Scholar
• Philbin VJ, Levy O. Developmental biology of the innate immune response: implications for neonatal and infant vaccine development. 2009; 65: 98R-105R.
   Google Scholar
• Corbett NP, Blimkie D, Ho KC, Cai B, Sutherland DP, Kallos A et al. Ontogeny of Toll-like receptor mediated cytokine responses of human blood mononuclear cells. 2010; 5: e15041.
   Google Scholar
• Nguyen M, Leuridan E, Zhang T, De Wit D, Willems F, Van Damme P et al. Acquisition of adult-like TLR4 and TLR9 responses during the first year of life. 2010; 5: e10407.
   Google Scholar
• Belderbos ME, van Bleek GM, Levy O, Blanken MO, Houben ML, Schuijff L et al. Skewed pattern of Toll-like receptor 4-mediated cytokine production in human neonatal blood: low LPS-induced IL-12p70 and high IL-10 persist throughout the first month of life. 2009; 133: 228-37.
   Google Scholar
• Mink M, Fogelgren B, Olszewski K, Maroy P, Csiszar K. A novel human gene (SARM) at chromosome 17q11 encodes a protein with a SAM motif and structural similarity to Armadillo/beta-catenin that is conserved in mouse Drosophila, and Caenorhabditis elegans. 2001; 74: 234-44.
   Google Scholar
• Hornung V, Ellegast J, Kim S, Brzozka K, Jung A, Kato H et al. 5′-Triphosphate RNA is the ligand for RIG-I. 2006; 314: 994-7.
   Google Scholar
• Kato H, Takeuchi O, Sato S, Yoneyama M, Yamamoto M, Matsui K et al. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. 2006; 441: 101-5.
   Google Scholar
• Fredericksen BL, Gale M Jr. West Nile virus evades activation of interferon regulatory factor 3 through RIG-I-dependent and -independent pathways without antagonizing host defense signaling. 2006; 80: 2913-23.
   Google Scholar
• Gubler DJ. The continuing spread of West Nile virus in the western hemisphere. 2007; 45: 1039-46.
   Google Scholar
• La Gruta NL, Kedzierska K, Stambas J, Doherty PC. A question of self-preservation: immunopathology in influenza virus infection. 2007; 85: 85-92.
   Google Scholar
• Rathinam VA, Jiang Z, Waggoner SN, Sharma S, Cole LE, Waggoner L et al. The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. 2010; 11: 395-402.
   Google Scholar
• Fernandes-Alnemri T, Yu JW, Juliana C, Solorzano L, Kang S, Wu J et al. The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. 2010; 11: 385-93.
   Google Scholar
• Lund BM, O'Brien SJ. The occurrence and prevention of foodborne disease in vulnerable people. 2011; 8: 961-73.
   Google Scholar
• Alvarez-Rodriguez L, Lopez-Hoyos M, Munoz-Cacho P, Martinez-Taboada VM. Aging is associated with circulating cytokine dysregulation. Cell Immunol. 2012.
   Google Scholar
• Kim HO, Kim HS, Youn JC, Shin EC, Park S. Serum cytokine profiles in healthy young and elderly population assessed using multiplexed bead-based immunoassays. 2011; 9: 113.
   Google Scholar
• Bonizzi G, Karin M. The two NF-kappaB activation pathways and their role in innate and adaptive immunity. 2004; 25: 280-8.
   Google Scholar
• Scheller J, Chalaris A, Schmidt-Arras D, Rose-John S. The pro- and anti-inflammatory properties of the cytokine interleukin-6. 2011; 1813: 878-88.
   Google Scholar
• McGeachy MJ, Cua DJ. Th17 cell differentiation: the long and winding road. 2008; 28: 445-53.
   Google Scholar
• Jakobisiak M, Golab J, Lasek W. Interleukin 15 as a promising candidate for tumor immunotherapy. 2011; 22: 99-108.
   Google Scholar
• Berger C, Berger M, Hackman RC, Gough M, Elliott C, Jensen MC et al. Safety and immunologic effects of IL-15 administration in nonhuman primates. 2009; 114: 2417-26.
   Google Scholar