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Original Articles

Antibiotics for rheumatoid arthritis?

Minocycline shows promise in some patients

, MD, MPH
Pages 95-98 | Published online: 30 Jun 2015

References

  • O'Dell JR, Haire CE, Palmer W, et al. Treatment of early rheumatoid arthritis with minocycline or placebo: results of a randomized, double-blind, placebo- controlled trial. Arthritis Rheum 1997; 40(5): 842–8
  • Kloppenburg M, Breedveld FC, Terwiel JP, et al. Minocycline in active rheumatoid arthritis: a double-blind, placebo-controlled trial. Arthritis Rheum 1994; 37(5): 629–36
  • Tilley BC, Alarcón GS, Heyse SP, et al, for the MIRA Trial Group. Minocycline in rheumatoid arthritis: a 48-week, double-blind, placebo-controlled trial. Ann Intern Med 1995; 122(2): 81–9
  • Panush RS, Thoburn R. Should minocycline be used to treat rheumatoid arthritis? Bull Rheum Dis 1996; 45(2): 2–5
  • Pruzanski W, Greenwald RA, Street IP, et al. Inhibition of enzymatic activity of phospholipases A2 by minocycline and doxycycline. Biochem Pharmacol 1992; 44(6): 1165–70
  • ElAttar TM, Lin HS, Shultz R. Effect of minocycline on prostaglandin formation in gingival fibroblasts. J Periodontal Res 1988; 23(5): 285–6
  • Golub LM, McNamara TF, D'Angelo G, et al. A non-antibacterial chemically- modified tetracycline inhibits mammalian collagenase activity. J Dent Res 1987; 66(8): 1310–4
  • van Barr HM, van de Kerkhof PC, Mier PD, et al. Tetracyclines are potent scavengers of the superoxide radical. (Letter) Br J Dermatol 1987; 117(1): 131–2
  • Amin AR, Attur MG, Thakker GD, et al. A novel mechanism of action of tetracyclines: effects on nitric oxide synthases. Proc Natl Acad Sci USA 1996; 93(24): 14014–9
  • Golub LM, Ramamurthy N, McNamara TF, et al. Tetracyclines inhibit tissue collagenase activity: a new mechanism in the treatment of periodontal disease. J Periodontal Res 1984; 19(6): 651–5
  • Smith RL, Schurman DJ, Kajiyama G, et al. The effect of antibiotics on the destruction of cartilage in experimental infectious arthritis. J Bone Joint Surg [Am] 1987; 69(7): 1063–8
  • Krane SM. Mechanisms of tissue destruction in rheumatoid arthritis. In: McCarty DJ, Koopman WJ, eds. Arthritis and allied conditions: a textbook of rheumatology. 12th ed. Philadelphia: Lea & Febiger, 1993: 763–9
  • Zvaifler NJ, Firestein GS. Pannus and pannocytes: alternative models of joint destruction in rheumatoid arthritis. Arthritis Rheum 1994; 37(6): 783–9
  • Greenwald RA, Golub LM, Lavietes B, et al. Tetracyclines inhibit human synovial collagenase in vivo and in vitro. J Rheumatol 1987; 14(l): 28–32
  • Breedveld FC, Dijkmans BA, Mattie H. Minocycline treatment for rheumatoid arthritis: an open dose finding study. J Rheumatol 1990; 17(l): 43–6
  • Langevitz P, Bank I, Zemer D, et al. Treatment of resistant rheumatoid arthritis with minocycline: an open study. J Rheumatol 1992; 19(10): 1502–4
  • Paulus HE. Minocycline treatment of rheumatoid arthritis. (Editorial) Ann Intern Med 1995; 122(2): 147–8
  • Bluhm GB, Sharp JT, Tilley BC, et al. Radiographic results from the Minocycline in Rheumatoid Arthritis (MIRA) Trial. J Rheumatol 1997; 24(7): 1295–302
  • Reveille JD, Alarcón GS, Fowler SE, et al, for the MIRA Trial Group. HLA- DRB1 genes and disease severity in rheumatoid arthritis. Arthritis Rheum 1996; 39(11): 1802–7
  • Harris ED Jr. Rheumatoid arthritis: pathophysiology and implications for therapy. N Engl J Med 1990; 322(18): 1277–89 [Erratum, N Engl J Med 1990; 323(14): 996]
  • O'Dell J, Haire C, Palmer W, et al. Minocycline therapy for early rheumatoid arthritis (RA): continued efficacy at three years. (Abstr) Arthritis Rheum 1997; 40: S219
  • Knights SE, Leandro MJ, Khamashta MA, et al. Minocycline induced lupus. (Abstr) Arthritis Rheum 1997; 40: S107
  • Akin E, Miller LC, Tucker LB, et al. Minocycline related lupus-like syndrome: possible association with anti neutrophil cytoplasmic antibodies. (Abstr) Arthritis Rheum 1997; 40: S191
  • Elkayam O, Levartovsky D, Brautbar C, et al. Minocycline (MNC) induced immunologie phenomena: clinical, immunological and genetic characteristics of 6 patients. (Abstr) Arthritis Rheum 1997; 40: S267
  • Alarcón GS. Minocycline for the treatment of rheumatoid arthritis. Rheum Dis Clin North Am 1998; 24(3): 489–99

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