222
Views
17
CrossRef citations to date
0
Altmetric
Original Articles

Lipotoxicity and glucotoxicity in type 2 diabetes

Effects on development and progression

, MD
Pages 55-64 | Published online: 30 Jun 2015

References

  • Bonner-Weir S, Trent DF, Honey RN, et al. Responses of neonatal rat islets to streptozotocin: limited B-cell regeneration and hyperglycemia. Diabetes 1981; 30(1): 64–9
  • Bonner-Weir S, Trent DF, Weir GC. Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release. J Clin Invest 1983; 71 (6): 1544–53
  • Leahy JL, Weir GC. Evolution of abnormal insulin secretory responses during 48-h in vivo hyperglycemia. Diabetes 1988; 37(2): 217–22
  • Leahy JL, Bonner-Weir S, Weir GC. Minimal chronic hyperglycemia is a critical determinant of impaired insulin secretion after an incomplete pancreatectomy. J Clin Invest 1988; 81(5): 1407–14
  • Rossetti L, Shulman GI, Zawalich W, et al. Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats. J Clin Invest 1987; 80(4): 1037–44
  • Rossetti L, Smith D, Shulman Gl, et al. Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats. J Clin Invest 1987; 79(5): 1510–5
  • Kosaka K, Kuzuya T, Akanuma Y, et al. Increase in insulin response after treatment of overt maturity-onset diabetes is independent of the mode of treatment. Diabetologia 1980; 18(1): 23–8
  • Yki-Jarvinen H, Helve E, Koivisto VA. Hyperglycemia decreases glucose uptake in type I diabetes. Diabetes 1987; 36(8): 892–6
  • DeFronzo RA, Bonadonna RC, Ferrannini E. Pathogenesis of NIDDM: a balanced overview. Diabetes Care 1992; 15(3): 318–68
  • Colditz GA, Willett WC, Stampfer MJ, et al. Weight as a risk factor for clinical diabetes in women. Am J Epidemiol 1990; 132(3): 501–13
  • Boden G, Jadali F, White J, et al. Effects of fat on insulin-stimulated carbohydrate metabolism in normal men. J Clin Invest 1991; 88(3): 960–6
  • Boden G, Chen X, Ruiz J, et al. Mechanisms of fatty acid-induced inhibition of glucose uptake. J Clin Invest 1994; 93: 2438–46
  • Boden G. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 1997; 46(1): 3–10
  • Boden G, Chen X, Rosner J, et al. Effects of a 48-h fat infusion on insulin secretion and glucose utilization. Diabetes 1995; 44(10): 1239–42
  • Shimabukuro M, Zhou YT, Lee Y, et al. Troglitazone lowers islet fat and restores beta cell function of Zucker diabetic fatty rats. J Biol Chem 1998; 273(6): 3547–50
  • Wang MY, Shimabukuro M, Lee Y, et al. Adenovirus- mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves beta-cell function. Diabetes 1999; 48(5): 1020–5
  • Patane G, Piro S, Rabuazzo AM, et al. Metformin restores insulin secretion altered by chronic exposure to free fatty acids or high glucose: a direct metformin effect on pancreatic beta-cells. Diabetes 2000; 49(5): 735–40
  • Burant CF, Sivitz WI, Fukumoto H, et al. Mammalian glucose transporters: structure and molecular regulation. Recent Prog Horm Res 1991; 47: 349–87
  • Shepherd PR, Kahn BB. Glucose transporters and insulin action—implications for insulin resistance and diabetes mellitus. N Engl J Med 1999; 341 (4): 248–57
  • Simonson DC, Rossetti L, Giaccari A, et al. Glucose toxicity. In: Alberti KG, Zimmet P, DeFronzo RA, et al, eds. International textbook of diabetes mellitus. 2nd ed. Chichester, NY: John Wiley & Sons, 1997: 713–44
  • Marshall S, Bacote V, Traxinger RR. Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance. J Biol Chem 1991; 266: 4706–12
  • Hresko RC, Heimberg H, Chi MM, et al. Glucosamine- induced insulin resistance in 3T3-L1 adipocytes is caused by depletion of intracellular ATP. J Biol Chem 1998; 273(32): 20658–68
  • Randle PJ, Priestman DA, Mistry SC, et al. Glucose fatty acid interactions and the regulation of glucose disposal. J Cell Biochem 1994; 55Suppl: 1–11
  • Shulman GI. Cellular mechanisms of insulin resistance. J Clin Invest 2000; 106(2): 171–6
  • Kelley DE, Mandarino LJ. Fuel selection in human skeletal muscle in insulin resistance: a reexamination. Diabetes 2000; 49(5): 677–83

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.