Allergic Rhinitis in Family Practice: The Role of Levocetirizine in Clinical Care

References

• American Academy of Allergy, Asthma and Immunology. Rhinitis and sinusitis statistics. 2008. http://www.aaaai.org/patients/gallery/rhinitis-sinusitis.asp?item=la. Accessed June 5, 2008.
   Google Scholar
• Arbes SJ Jr, Gergen PJ, Elliott L, Zeldin DC. Prevalences of positive skin test responses to 10 common allergens in the US population: results from the third National Health and Nutrition Examination Survey. J Allergy- Clin Immunol. 2005; 116(2): 377–383.
   PubMed Web of Science ®Google Scholar
• Faber JA. Allergists explore rising prevalence and unmet needs attributed to allergic rhinitis. American College of Allergy, Asthma and Immunology. http://www.acaai.org/public/linkpages/NR+Rising+Pr-evalence+and+Unmet+Needs+of+AIlergic+Rhinitis.htm. November 12, 2006. Accessed June 5, 2008.
   Google Scholar
• Nathan RA. The burden of allergic rhinitis. Allergy Asthma Proc. 2007: 28(1): 3–9.
   PubMed Web of Science ®Google Scholar
• Agency for Healthcare Research and Quality. McCrory DC, Williams JW, Dolor RJ, et al. Management of allergic rhinitis in the working-age population, http://www.ahrq.gov/clinic/tp/rhinworktp.htm. Published February 2003. Accessed May 15, 2008.
   Google Scholar
• Scadding GK, Richards DH, Price MJ. Patient and physician perspectives on the impact and management of perennial and seasonal allergic rhinitis. Clin Otolaryngol Allied Sci. 2000; 25(6): 551–557.
   PubMed Web of Science ®Google Scholar
• Allergies in America: a landmark survey of nasal allergy sufferers. Executive summary: adult. http://www.mmcpub.com/scsaia/Adult-Summary.pdf. Sepracor. Published March 2006. Accessed June 3, 2008.
   Google Scholar
• Bousquet J, Bullinger M, Fayol C, Marquis P, Valentin B, Burtin B. Assessment of quality of life in patients with perennial allergic rhinitis with the French version of the SF-36 Health Status Questionnaire. J Allergy Clin Immunol. 1994; 94(2pt 1): 182–188.
   PubMedGoogle Scholar
• Ciprandi G, Klersy C, Cirillo I, Marseglia GL. Quality of life in allergic rhinitis: relationship with clinical, immunological, and functional aspects. Clin Exp Allergy. 2007; 37(10): 1528–1535.
   PubMed Web of Science ®Google Scholar
• Santos CB, Pratt EL, Hanks C, McCann J, Craig TJ. Allergic rhinitis and its effect on sleep, fatigue, and daytime somnolence. Ann Allergy Asthma Immunol 2006; 97(5): 579–586.
   PubMed Web of Science ®Google Scholar
• Reinberg A, Gervais P, Levi F, Smolensky M, Del Cerro L, Ugolini C. Circadian and circannual rhythms of allergic rhinitis: an epidemiologic study involving chronobiologic methods. J Allergy Clin Immunol 1998; 81(1): 51–62.
   Google Scholar
• Punjabi NM. The epidemiology of adult obstructive sleep apnea. Proc Am Thorac Soc. 2008; 5(2): 136–143.
   PubMedGoogle Scholar
• Breslau N, Roth T, Rosenthal L, Andreski P. Sleep disturbance and psychiatric disorders: a longitudinal epidemiological study of young adults. Biol Psychiatry. 1996; 39(6): 411–418.
   PubMed Web of Science ®Google Scholar
• Szeinbach SL, Seoane-Vazquez EC, Beyer A, Williams PB. The impact of allergic rhinitis on work productivity. Prim Care Respir J. 2007; 16(2): 98–105.
   PubMedGoogle Scholar
• Wilken JA, Berkowitz R, Kane R. Decrements in vigilance and cognitive functioning associated with ragweed-induced allergic rhinitis. Ann Allergy Asthma Immunol. 2002; 89(4): 372–380.
   PubMed Web of Science ®Google Scholar
• Shedden A. Impact of nasal congestion on quality of life and work productivity in allergic rhinitis: findings from a large online survey. Treat Respir Med. 2005; 4(6): 439–446.
   PubMedGoogle Scholar
• Reed SD, Lee TA, McCrory DC. The economic burden of allergic rhinitis: a critical evaluation of the literature. Pharmacoeconomics. 2004; 22(6): 345–361.
   PubMed Web of Science ®Google Scholar
• Fireman P. Treatment of allergic rhinitis: effect on occupation productivity and work force costs. Allergy Asthma Proc. 1997; 18(2): 63–67.
   PubMed Web of Science ®Google Scholar
• American Academy of Allergy, Asthma and Immunology. Task Force on Allergic Disorders: Promoting Best Practice. Raising the Standard of Care of Patients with Allergic Disorders. Executive Summary Report. Milwaukee. WI: American Academy of Allergy, Asthma and Immunology; 1998.
   Google Scholar
• Guerra S, Sherrill DL, Martinez FD, Barbee RA. Rhinitis as an independent risk factor for adult-onset asthma. J Allergy Clin Immunol 2002; 109(3): 419–425.
   PubMed Web of Science ®Google Scholar
• American Academy of Allergy, Asthma, and Immunology. The Allergy- Report. Overview of Allergic Diseases: Diagnosis, Management and Barriers to Care. Vol. 1. Milwaukee, WI: American Academy of Allergy, Asthma and Immunology; 2000.
   Google Scholar
• Crystal-Peters J, Neslusan C, Crown WH, Torres A. Treating allergic rhinitis in patients with comorbid asthma: the risk of asthma-related hospitalizations and emergency department visits. J Allergy Clin Immunol. 2002; 109(1): 57–62.
   PubMed Web of Science ®Google Scholar
• Spector SL. Overview of comorbid associations of allergic rhinitis. J Allergy Clin Immunol. 1997; 99(2): S773–S780.
   PubMed Web of Science ®Google Scholar
• Tomonaga K,” Kurono Y, Mogi G. The role of nasal allergy in otitis media with effusion. A clinical study. Acta Otolaryngol Suppl. 1988; 458: 41–47.
   PubMedGoogle Scholar
• Bernstein JM. The role of IgE-mediated hypersensitivity in the development of otitis media with effusion. Otolaryngol Clin North Am. 1992; 25(1): 197–211.
   PubMed Web of Science ®Google Scholar
• Reiner PB, Kamondi A. Mechanisms of antihistamine-induced sedation in the human brain: HI-receptor activation reduces a background leakage potassium current. Neuroscience. 1994; 59(3): 579–588.
   PubMed Web of Science ®Google Scholar
• Bousquet J, Van Cauwenberge P, Khaltaev N; ARIA Workshop Group; World Health Organization. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol 2001; 108(5 supp1): S147–S334.
   Web of Science ®Google Scholar
• Weiler JM, Bloomfield JR, Woodworth GG, et al. Effects of fexofenadine, diphenhydramine, and alcohol on driving performance. A randomized, placebo-controlled trial in the Iowa driving simulator. Ann Intern Med. 2000; 132(5): 354–363.
   PubMed Web of Science ®Google Scholar
• Hanrahan LP, Paramore LC. Aeroallergens, allergic rhinitis, and sedating antihistamines: risk factors for traumatic occupational injury and economic impact. Am J Ind Med. 2003; 44(4): 438–146.
   PubMed Web of Science ®Google Scholar
• Simons FE, Fraser TG, Reggin JD, Simons K.J. Comparison of the central nervous system effects produced by six H1 -receptor antagonists. Clin Exp Allergy. 1996; 26(9): 1092–1097.
   PubMed Web of Science ®Google Scholar
• Berger WE. The safety and efficacy of desloratadine for the management of allergic disease. Drug Saf. 2005; 28(12): 1101–1118.
   PubMed Web of Science ®Google Scholar
• Conboy-Ellis K. Management of seasonal allergic rhinitis: comparative efficacy of the newer-generation prescription antihistamines. J Am Acad Nurse Pract. 2005; 17(8): 295–301.
   PubMedGoogle Scholar
• Handley DA, Magnetti A, Higgins AJ. Therapeutic advantages of third generation antihistamines. Expert Opin Investig Drugs. 1998; 7(7): 1045–1054.
   PubMedGoogle Scholar
• Spangler DL, Brunton S. Efficacy and central nervous system impairment of newer-generation prescription antihistamines in seasonal allergic rhinitis. South Med J. 2006; 99(6): 593–599.
   PubMed Web of Science ®Google Scholar
• Xyzal [package insert]. Bridgewater, NJ, and Smyrna, GA: sanofi-aventis US, LLC and UCB, Inc, 2008.
   Google Scholar
• Gillard M, Van der Perren C, Moguilevsky N, Massingham R, Chatelain P. Major role for the carboxylic function of cetirizine and levocetirizine in their binding characteristics to human Hl-histamine- receptors. Inflamm Res. 2002; 51(supp1 1): S79–S80.
   Google Scholar
• Gillard M, Van Der Perren C, Moguilevsky N, Massingham R, Chatelain P. Binding characteristics of cetirizine and levocetirizine to human H(1) histamine receptors: contribution of Lys(191) and Thr(194). Mol Pharmacol. 2002; 61(2): 391–399.
   PubMed Web of Science ®Google Scholar
• Devalia JL, De Vos C, Hanotte F, Baltes E. A randomized, double-blind, crossover comparison among cetirizine, levocetirizine, and ucb 28557 on histamine-induced cutaneous responses in healthy adult volunteers. Allergy. 2001; 56: 50–57.
   PubMed Web of Science ®Google Scholar
• Wang DY, Hanotte F, De Vos C, Clement P. Effect of cetirizine, levocetirizine, and dextrocetirizine on histamine-induced nasal response in healthy adult volunteers. Allergy. 2001; 56(1): 339–343.
   PubMedGoogle Scholar
• Gupta A, Chatelain P, Massingham R, Jonsson EN, Hammarlund- Udenaes M. Brain distribution of cetirizine enantiomers: comparison of three different tissue-to-plasma partition coefficients: K(p), K(p,u), and K(p,uu). Drug Metab Dispos. 2006; 34(2): 318–323.
   PubMed Web of Science ®Google Scholar
• Gupta A, Gillard M, Christophe B, Chatelain P, Massingham R, Hammarlund-Udenaes M. Peripheral and central H1 histamine receptor occupancy by levocetirizine, a non-sedating antihistamine; a time course study in the guinea pig. Br J Pharmacol. 2007; 151 (7): 1129–1136.
   PubMed Web of Science ®Google Scholar
• Gillard M, Christophe B, Wels B, Peck M, Massingham R, Chatelain P. HI antagonists: receptor affinity versus selectivity. Inflamm Res. 2003; 52(supp1 1): S49–S50.
   Google Scholar
• Gillard M, Benedetti MS, Chatelain P, Baltes E. Histamine Hl receptor occupancy and pharmacodynamics of second generation H1-antihistamines. Inflamm Res. 2005; 54(9): 367–369.
   PubMed Web of Science ®Google Scholar
• Frossard N, Strolin-Benedetti M, Purohit A, Pauli G. Inhibition of allergen-induced wheal and flare reactions by levocetirizine and desloratadine. Br J Clin Pharmacol. 2008; 65(2): 172–179.
   PubMed Web of Science ®Google Scholar
• Leynadier F, Mees K, Arendt C, Pinelli ME. Efficacy and safety of levocetirizine in seasonal allergic rhinitis. Acta Otorhinolaryngol Belg. 2001; 55(4): 305–312.
   PubMedGoogle Scholar
• Bachert C, Bousquet J, Canonica GW, Durham SR, Klimek L, Mullol J, Van Cauwenberge PB, Van Hammée G; XPERT Study Group. Levocetirizine improves quality of life and reduces costs in long-term management of persistent allergic rhinitis. J Allergy Clin Immunol. 2004; 114(4): 838–844.
   PubMed Web of Science ®Google Scholar
• Day JH, Briscoe MP, Rafeiro E, Ratz JD. Comparative clinical efficacy, onset and duration of action of levocetirizine and desloratadine for symptoms of seasonal allergic rhinitis in subjects evaluated in the Environmental Exposure Unit (EEU). Int J Clin Pract. 2004; 58(2): 109–118.
   PubMed Web of Science ®Google Scholar
• Potter PC; Study Group. Levocetirizine is effective for symptom relief including nasal congestion in adolescent and adult (PAR) sensitized to house dust mites. Allergy. 2003; 58(9): 893–899.
   PubMed Web of Science ®Google Scholar
• Walter Canonica G, Bousquet J, Van Hammee G, et al; XPERT Study Group. Levocetirizine improves health-related quality of life and health status in persistent allergic rhinitis. Respir Med. 2006; 100(10): 1706–1715.
   PubMed Web of Science ®Google Scholar
• Ciprandi G, Cirillo I, Vizzaccaro A, Tosca MA. Levocetirizine improves nasal obstruction and modulates cytokine pattern in patients with seasonal allergic rhinitis: a pilot study. Clin Exp Allergy. 2004; 34: 958–964.
   PubMed Web of Science ®Google Scholar
• Ciprandi G, Cirillo I, Vizzaccaro A, et al. Desloratadine and levocetirizine improve nasal symptoms, airflow, and allergic inflammation in patients with perennial allergic rhinitis: a pilot study. Int Immunopharmacol. 2005; 5(13–14): 1800–1808.
   PubMed Web of Science ®Google Scholar
• Horak F, Zieglmayer PU, Zieglmayer R, Kavina A, Lemell P. Levocetirizine has a longer duration of action on improving total nasal symptoms score than fexofenadine after single administration. Br J Clin Pharmacol. 2005; 60(1): 24–31.
   PubMed Web of Science ®Google Scholar
• Ciebiada M, Górska-Ciebiada M, Dubuske LM, Górski P. Montelukast with desloratadine or levocetirizine for the treatment of persistent allergie rhinitis. Ann Allergy Asthma Immunol. 2006; 97(5): 664–671.
   PubMed Web of Science ®Google Scholar
• Day J, Briscoe M, Ratz J. Efficacy of levocetirizine compared with montelukast in subjects with ragweed-induced seasonal allergic rhinitis in the Environmental Exposure Unit. Allergy Asthma Proc. 2008; 29(3): 304–312.
   PubMed Web of Science ®Google Scholar
• Patel D, Patel P. Levocetirizine is more effective than montelukast in improving symptoms of seasonal allergic rhinitis in subjects exposed to ragweed in the Environmental Exposure Chamber. Presented at: the Annual Meeting of the American College of Allergy, Asthma and Immunology; November 8–14, 2007; Dallas, TX. Abstract P237.
   Google Scholar
• De Vos C, Mitchev K, Pinelli ME, Derde MP, Boev R. Non-interventional study comparing treatment satisfaction in patients treated with antihistamines. Clin Drug Investig. 2008; 28(4): 221–230.
   PubMed Web of Science ®Google Scholar
• Jorissen M, Bertrand B, Stiels B, Vandenbulcke K. Levocetirizine as treatment for symptoms of seasonal allergic rhinitis. B-ENT. 2006; 2: 55–62.
   PubMed Web of Science ®Google Scholar
• Patou J, De Smedt H, van Cauwenberge P, Bachert C. Pathophysiology of nasal obstruction and meta-analysis of early and late effects of levocetirizine. Clin Exp Allergy. 2006; 36(8): 972–981.
   PubMed Web of Science ®Google Scholar
• Hasala H, Janka-Junttila M, Moilanen E, Kankaanranta H. Levocetirizine and cytokine production and apoptosis of human eosinophils. Allergy Asthma Proc. 2007; 28(5): 582–591.
   PubMed Web of Science ®Google Scholar
• Petecchia L, Serpero L, Silvestri M, Sabatini F, Scarso L, Rossi GA. The histamine-induced enhanced expression of vascular cell adhesion molecule-1 by nasal polyp-derived fibroblasts is-inhibited by levocetirizine. Am J Rhinol. 2006; 20(5): 445–49.
   PubMedGoogle Scholar
• de Blic J, Wahn U, Billard E, Alt R, Pujazon MC. Levocetirizine in children: evidenced efficacy and safety in a 6-week randomized seasonal allergic rhinitis trial. Pediatr Allergy Immunol. 2005; 16(3): 267–275.
   PubMed Web of Science ®Google Scholar
• Kapp A, Pichler WJ. Levocetirizine is an effective treatment in patients suffering from chronic idiopathic urticaria: a randomized, double blind, placebo-controlled, parallel, multicenter study. Int J Dermatol. 2006; 45(5): 469–474.
   PubMedGoogle Scholar
• Nettis E, Colanardi MC, Barra L, Ferrannini A, Vacca A, Tursi A. Levocetirizine in the treatment of chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled study. Br J Dermatol. 2006; 154(3): 533–538.
   PubMed Web of Science ®Google Scholar
• Potter PC. Efficacy and safety of levocetirizine on symptoms and health-related quality of life of children with perennial allergic rhinitis: a double-blind, placebo-controlled randomized clinical trial. Ann Allergy Asthma Immunol. 2005; 95(2); 175–180.
   PubMed Web of Science ®Google Scholar
• Gandon JM, Allain H. Lack of effect of single and repeated doses of levocetirizine, a new antihistamine drug, on cognitive and psychomotor functions in healthy volunteers. Br J Clin Pharmacol. 2002; 54(1): 51–58.
   PubMed Web of Science ®Google Scholar
• Hindmarch I, Johnson S, Meadows R, Kirkpatrick T, Shamsi Z. The acute and sub-chronic effects of levocetirizine, cetirizine, loratadine, promethazine and placebo on cognitive function, psychomotor performance, and weal and flare. Curr Med Res Opin. 2001; 17(4); 241–255.
   PubMed Web of Science ®Google Scholar
• Verster JC, de Weert AM, Bijtjes SI, et al. Driving ability after acute and sub-chronic administration of levocetirizine and diphenhydramine: a randomized, double-blind, placebo-controlled trial. Psychopharmacology (Berl). 2003(1); 169: 84–90.
   PubMed Web of Science ®Google Scholar
• Bousquet J, Demarteau N, Mullol J, van den Akker-van Marie ME, Van Ganse E, Bachert C. Costs associated with persistent allergic rhinitis are reduced by levocetirizine. Allergy. 2005; 60(6): 788–794.
   PubMed Web of Science ®Google Scholar