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Original Articles

Global Issues Related to the Impact of Untreated Attention-Deficit/Hyperactivity Disorder From Childhood to Young Adulthood

, PhD
Pages 48-59 | Published online: 30 Jun 2015

References

  • American Academy of Pediatrics. Subcommittee on Attention-Deficit/Hyperactivity Disorder and Committee on Quality Improvement. Clinical practice guideline: treatment of the school-aged child with attention-deficit/hyperactivity disorder. Pediatrics. 2001; 108(4): 1033–1044.
  • Wilens TE, Biederman J, Spencer TJ. Attention deficit/hyperactivity disorder across the lifespan. Annu Rev Med. 2002; 53: 113–131.
  • Harpin VA. The effect of ADHD on the life of an individual, their family, and community from preschool to adult life. Arch Dis Child. 2005; 90(suppl 1): i2–i7.
  • Barkley RA, Fischer M, Edelbrock CS, Smallish L. The adolescent outcome of hyperactive children diagnosed by research criteria: I. An 8-year prospective follow-up study. J Am Acad Child Adolesc Psychiatry. 1990; 29(4): 546–557.
  • Murphy KR, Barkley RA. Adults with ADHD: comorbidity and adaptive functioning. ComprPsychiatry. 1996; 37(6): 393–101.
  • Heiligenstein E, Conyers LM, Berns AR, Miller MA. Preliminary normative data on DSM-IV attention deficit hyperactivity disorder in college students. J Am Coll Health. 1998; 46(4): 185–188. Erratum in: J Am Coll Health. 1998; 46(5): 213.
  • Faraone SV, Wilens T. Does stimulant treatment lead to substance use disorders? J Clin Psychiatry. 2003; 11 (suppl 64): 9–13.
  • Kessler RC, Adler L, Ames M, et al. The prevalence and effects of adult attention deficit/hyperactivity disorder on work performance in a nationally representative sample of workers. J Occup Environ Med. 2005; 47(6): 565–572.
  • Barkley RA, Murphy KR, Fischer M. ADHD in Adults: What the Science Says. New York, NY: Guilford; 2008.
  • Hoza B, Mrug S, Gerdes AC, et al. What aspects of peer relationships are impaired in children with attention-deficit/hyperactivity disorder? J Consult Clin Psychol. 2005; 73(3): 411–423.
  • Currie J, Stabile M. Child Mental Health and Human Capital Accumulation: The Case of ADHD. Cambridge, MA: National Bureau of Economic Research; 2004. Working Paper 10435.
  • Swensen A, Birnbaum HG, Ben Hamadi R, Greenberg P, Cremieux PY, Secnik K. Incidence and costs of accidents among attention-deficit/hyperactivity disorder patients. J Adolesc Health. 2004; 35(4): 346. e1–e9.
  • Topolski TD, Edwards TC, Patrick DL, Varley P, Way ME, Buesching DP. Quality of life of adolescent males with attention-deficit hyperactivity disorder. J Atten Disord. 2004; 7(3): 163–173.
  • Antshel KM, Barkley R. Psychosocial interventions in attention deficit hyperactivity disorder. Child Adolesc Psychiatr Clin N Am. 2008; 17(2): 421–437.
  • Barbaresi WJ, Katusic SK, Colligan RC, Weaver AL, Leibson CL, Jacobsen SJ. Long-term stimulant medication treatment of attention-deficit/hyperactivity disorder: results from a population survey. J Dev Behav Pediatr. 2006; 27(1): 1–10.
  • Cox DJ, Merkel L, Kovatchev B, Seward R. Effect of stimulant medication on driving performance of young adults with attention-deficit hyperactivity disorder. J Nerv Ment Dis. 2000; 188: 230–234.
  • Pelham WE, Gnagy EM, Burrows-Maclean E, et al. Once-a-day Concerta methylphenidate versus three-times-daily methylphenidate in laboratory and natural settings. Pediatrics. 2001; 107(6): E105.
  • Biederman J, Wilens T, Mick E, Spencer T, Faraone SV. Pharmacotherapy of attention-deficit/hyperactivity disorder reduces risk for substance use disorder. Pediatrics. 1999; 104(2): e20.
  • Thiruchelvam D, Charach A, Schachar RJ. Moderators and mediators of long-term adherence to stimulant treatment in children with ADHD. J Am Acad Child Adolesc Psychiatry. 2001; 40(8): 922–928.
  • Swanson J. Compliance with stimulants for attention-deficit/hyperactivity disorder: issues and approaches for improvement. CNS Drugs. 2003; 17(2): 117–131.
  • Biederman J, Mick E, Faraone SV. Age-dependent decline of symptoms of attention deficit hyperactivity disorder: impact of remission definition and symptom type. Am J Psychiatry. 2000; 157(5): 816–818.
  • Greene RW, Biederman J, Faraone SV, Sienna M, Garcia-Jetton J. Adolescent outcome of boys with attention-deficit/hyperactivity disorder and social disability: results from a 4-year longitudinal follow-up study. J Consult Clin Psychol. 1997; 65(5): 758–767.
  • Gittelman R, Mannuzza S, Shenker R, Bonagura N. Hyperactive boys almost grown up: I. Psychiatric status. Arch Gen Psychiatry. 1985; 42(10): 937–947.
  • Biederman J, Monuteaux MC, Mick E, et al. Young adult outcome of attention deficit hyperactivity disorder: a controlled 10-year follow-up study. Psychol Med. 2006; 36(2): 167–179.
  • Fergusson DM, Lynskey MT, Horwood LJ. Attention difficulties in middle childhood and psychosocial outcomes in young adulthood. J Child Psychol Psychiatry. 1997; 38(6): 633–644.
  • Hinshaw SP, Owens EB, Sami N, Fargeon S. Prospective follow-up of girls with attention-deficit/hyperactivity disorder into adolescence: evidence for continuing cross-domain impairment. J Consult Clin Psychol. 2006; 74(3): 489–499.
  • Barkley RA, Anastopoulos AD, Guevremont DG, Fletcher KF. Adolescents with attention deficit hyperactivity disorder: patterns of behavioral adjustment, academic functioning, and treatment utilization. J Am Acad Child Adolesc Psychiatry. 1991; 30(5): 752–761.
  • Klassen AF, Miller A, Fine S. Health-related quality of life in children and adolescents who have a diagnosis of attention-deficit/hyperactivity disorder. Pediatrics. 2004; 114(5): e541–e547.
  • Mannuzza S, Klein RG, Bessler A, Malloy P, Hynes ME. Educational and occupational outcome of hyperactive boys grown up. J Am Acad Child Adolesc Psychiatry. 1997; 36(9): 1222–1227.
  • Biederman J, Faraone SV. The effects of attention-deficit/hyperactivity disorder on employment and household income. Med Gen Med. 2006; 8(3): 12.
  • Barkley RA. Attention Deficit Hyperactivity Disorder: A Handbook/or Diagnosis and Treatment. 3rd ed. New York, NY: Guilford; 2006.
  • Johnston C, Mash EJ. Families of children with attention-deficit/ hyperactivity disorder: review and recommendations for future research. Clin Child Fam Psychol Rev. 2001; 4(3): 183–207.
  • Podolski CL, Nigg JT. Parent stress and coping in relation to child ADHD severity and associated child disruptive behavior problems. J Clin Child Psychol. 2001; 30(4): 503–513.
  • Pelham WE Jr, Lang AR. Can your children drive you to drink? Stress and parenting in adults interacting with children with ADHD. Alcohol Res Health. 1999; 23(4): 292–298.
  • Faraone SV, Biederman J, Chen WJ, Milberger S, Warburton R, Tsuang MT. Genetic heterogeneity in attention-deficit hyperactivity disorder (ADHD): gender, psychiatric comorbidity, and maternal ADHD. J Abnorm Psychol. 1995; 104(2): 334–345.
  • Kendall J. Sibling accounts of attention deficit hyperactivity disorder. Fam Process. 1999; 38(1): 117–136.
  • Minde K, Eakin L, Hechtman L, et al. The psychosocial functioning of children and spouses of adults with ADHD. J Child Psychol Psychiatry. 2003; 44(4): 637–646.
  • Eakin L, Minde K, Hechtman L, et al. The marital and family functioning of adults with ADHD and their spouses. J Atten Disord. 2004; 8(1): 1–10.
  • Leibson CL, Katusic SK, Barbaresi WJ, Ransom J, O'Brien PC. Use and costs of medical care for children and adolescents with and without attention-deficit/hyperactivity disorder. JAMA. 2001; 285(1): 60–66.
  • Brook U, Boaz M. Adolescents with attention deficit and hyperactivity disorder/learning disability and their proneness to accidents. Indian J Pediatr. 2006; 73(4): 299–303.
  • Clancy TA, Rucklidge JJ, Owen D. Road-crossing safety in virtual reality: a comparison of adolescents with and without ADHD. J Am Acad Child Adolesc Psychiatry. 2006; 35(2): 203–215.
  • Barkley RA, Guevremont DC, Anastopoulos AD, DuPaul GJ, Shelton TL. Driving-related risks and outcomes of attention deficit hyperactivity disorder in adolescents and young adults: a 3- to 5-year follow-up survey. Pediatrics. 1993; 92(2): 212–218.
  • Barkley RA, Murphy KR, Kwasnik D. Motor vehicle driving competencies and risks in teens and young adults with attention deficit hyperactivity disorder. Pediatrics. 1996; 98(6pt 1): 1089–1095.
  • Barkley RA, Murphy KR, DuPaul GJ, Bush T. Driving in young adults with attention deficit hyperactivity disorder: knowledge, performance, adverse outcomes, and the role of executive functioning. J Int Neuropsychol Soc. 2002; 8: 655–672.
  • Nada-Raja S, Langley JD, McGee R, Williams SM, Begg DJ, Reeder AI. Inattentive and hyperactive behaviors and driving offenses in adolescence. J Am Acad Child Adolesc Psychiatry. 1997; 36(4): 515–522.
  • Richards TL, Deffenbacher JL, Rosén LA. Driving anger and other driving-related behaviors in high and low ADHD symptom college students. J Atten Disord. 2002; 6(1): 25–38.
  • Richards TL, Deffenbacher JL, Rosén LA, Barkley RA, Rodricks T. Driving anger and driving behavior in adults with ADHD. J Atten Disord. 2006; 10(1): 54–64.
  • Fried R, Petty CR, Surman CB, et al. Characterizing impaired driving in adults with attention-deficit/hyperactivity disorder: a controlled study. J Clin Psychiatry. 2006; 67(4): 567–574.
  • Barkley RA, Cox D. A review of driving risks and impairments associated with attention-deficit/hyperactivity disorder and the effects of stimulant medication on driving performance. J Safety Res. 2007; 38(1): 113–128.
  • Biederman J, Wilens TE, Mick E, Faraone SV, Spencer T. Does attention-deficit hyperactivity disorder impact the developmental course of drug and alcohol abuse and dependence? Biol Psychiatry. 1998; 44(4): 269–273.
  • Bukstein OG. Disruptive behavior disorders and substance use disorders in adolescents. J Psychoactive Drugs. 2000; 32(1): 67–79.
  • Mannuzza S, Klein RG, Bessler A, Malloy P, LaPadula M. Adult psychiatric status of hyperactive boys grown up. Am J Psychiatry. 1998; 155(4): 493–498.
  • August GJ, Winters KC, Realmuto GM, Fahnhorst T, Botzet A, Lee S. Prospective study of adolescent drug use among community samples of ADHD and non-ADHD participants. J Am Acad Child Adolesc Psychiatry. 2006; 45(7): 824–832.
  • Ernst M, Luckenbaugh DA, Moolchan ET, et al. Behavioral predictors of substance-use initiation in adolescents with and without attention-deficit/hyperactivity disorder. Pediatrics. 2006; 117(6): 2030–2039.
  • Cox DJ, Humphrey JW, Merkel RL, Penberthy JK, Kovatchev B. Controlled-release methylphenidate improves attention during on-road driving by adolescents with attention-deficit/hyperactivity disorder. J Am Board Fam Pract. 2004; 17(4): 235–239.
  • Cox DJ, Merkel RL, Moore M, Thorndike F, Muller C, Kovatchev B. Relative benefits of stimulant therapy with OROS® methylphenidate versus mixed amphetamine salts extended release in improving the driving performance of adolescent drivers with attention-deficit/hyperactivity disorder. Pediatrics. 2006; 118(3): e704–e710.
  • Barber S, Grubbs L, Cottrell B. Self-perception in children with attention deficit/hyperactivity disorder. J Pediatr Nurs. 2005; 20(4): 235–245.
  • Edbom T, Lichtenstein P, Granlund M, Larsson JO. Long-term relationships between symptoms of attention deficit hyperactivity disorder and self-esteem in a prospective longitudinal study of twins. Acta Paediatr. 2006; 95(6): 650–657.
  • Frankel F, Cantwell DP, Myatt R, Feinberg DT. Do stimulants improve self-esteem in children with ADHD and peer problems? J Child Adolesc Psychopharmacol. 1999; 9(3): 185–194.
  • Hechtman L, Greenfield B. Long-term use of stimulants in children with attention deficit hyperactivity disorder. Pediatr Drugs. 2003; 5(12): 787–794.
  • Zhang HF, Cooper KM. OROS®: MPH significantly improves family relations in adolescents. Poster presented at the 18th Annual US Psychiatric and Mental Health Congress; November 2005; Las Vegas, NV.
  • Connor DF, Edwards G, Fletcher KE, Baird J, Barkley RA, Steingard RJ. Correlates of comorbid psychopathology in children with ADHD. J Am Acad Child Adolesc Psychiatry. 2003; 42(2): 193–200.
  • Goodman DW, Ginsberg L, Weisler RH, Cutler AJ, Hodgkins P. An interim analysis of the Quality of Life, Effectiveness, Safety, and Tolerability (QU.E.S.T.) evaluation of mixed amphetamine salts extended release in adults with ADHD. CNS Spectr. 2005; 10(12): 26–34.
  • Wigal SB, McGough JJ, McCracken JT, et al. A laboratory school comparison of mixed amphetamine salts extended release (Adderall XR) and atomoxetine (Strattera) in school-aged children with attention deficit/hyperactivity disorder. J Atten Disord. 2005; 9(1): 275–289.
  • Faraone SV, Wigal SB, Hodgkins P. Forecasting three-month outcomes in a laboratory school comparison of mixed amphetamine salts extended release (Adderall XR®) and atomoxetine (Strattera®) in school-aged children with ADHD. J, Atten Disord. 2007; 11(1): 74–82.
  • Danforth JS, Anderson LP, Barkley RA, Stokes TF. Observations of parent-child interactions with hyperactive children; Research and clinical implications. Clin Psychol Rev. 1991; 11: 703–727.
  • Zhang HF, Cooper KM. Physician-rated and patient-reported ADHD symptom improvement with OROS® MPH treatment in adolescents. Poster presented at the 18th Annual US Psychiatric and Mental Health Congress; November 2005; Las Vegas, NV.
  • Leibson CL, Barbaresi WJ, Ransom J, et al. Emergency department use and costs for youth with attention-deficit/hyperactivity disorder: associations with stimulant treatment. Ambul Pediatr. 2006; 6(1); 45–53.
  • Barkley RA, Murphy KR, O'Connell T, Connor DF. Effects of two doses of methylphenidate on simulator driving performance in adults with attention deficit hyperactivity disorder. J Safety Res. 2005; 36(2): 121–131.
  • Biederman J. Pharmacotherapy for attention-deficit/hyperactivity disorder (ADHD) decreases the risk for substance abuse: findings from a longitudinal follow-up of youths with and without ADHD. J Clin Psychiatry. 2003; 64(suppl 11): 3–8.
  • DuPont RL, Bensinger PB. Abuse-resistant drug delivery. Psychiatr Ann. 2005; 35(8): 253–256.
  • Katusic SK, Barbaresi WJ, Colligan RC, Weaver AL, Leibson CL, Jacobsen SJ. Psychostimulant treatment and risk for substance abuse among young adults with a history of attention-deficit/hyperactivity disorder: a population-based, birth cohort study. J Am Acad Child Adolesc Psychiatry. 2005; 15(5): 764–776.
  • Biederman J, Monuteaux MC, Spencer T, Wilens TE, Macpherson HA, Faraone SV. Stimulant therapy and risk for subsequent substance use disorders in male adults with ADHD: A naturalistic controlled 10-year follow-up study. Am J Psychiatry. May 2008; 165(5): 553–555.
  • Robison LM, Skaer TL, Sclar DA, Galin RS. Is attention deficit hyperactivity disorder increasing among girls in the US? Trends in diagnosis and the prescribing of stimulants. CNS Drugs. 2002; 16(2): 129–137.
  • Stevens J, Harman JS, Kelleher KJ. Ethnic and regional differences in primary care visits for attention-deficit hyperactivity disorder. J Dev Behav Pediatr. 2004; 25(5): 318–325.
  • Sankaranarayanan J, Puumala SE, Kratochvil CJ. Diagnosis and treatment of adult attention-deficit/hyperactivity disorder at US ambulatory care visits from 1996 to 2003. Curr Med Res Opin. 2006; 22(8): 1475–1491.
  • Perwien A, Hall J, Swensen A, Swindle R. Stimulant treatment patterns and compliance in children and adults with newly treated attention-deficit/hyperactivity disorder. J Manag Care Pharm. 2004; 10(2): 122–129.
  • Claxton AJ, Cramer J, Pierce C. A systematic review of the associations between dose regimens and medication compliance. Clin Ther. 2001; 23(8): 1296–1310.
  • Marcus SC, Wan GJ, Kemner JE, Olfson M. Continuity of methylphenidate treatment for attention-deficit/hyperactivity disorder. Arch Pediatr Adolesc Med. 2005; 159(6): 572–578.
  • Lage M, Hwang P. Effect of methylphenidate formulation for attention deficit hyperactivity disorder on patterns and outcomes of treatment. J Child Adolesc Psychopharmacol. 2004; 14: 575–581.
  • Charach A, Ickowicz A, Schachar R. Stimulant treatment over five years: adherence, effectiveness, and adverse effects. J Am Acad Child Adolesc Psychiatry. 2004; 43(5): 559–567.
  • Birnbaum HG, Kessler RC, Lowe SW, et al. Costs of attention-deficit-hyperactivity disorder (ADHD) in the US: excess costs of persons with ADHD and their family members in 2000. Curr Med Res Opin. 2005; 21(2): 195–206.
  • Swensen AR, Birnbaum HG, Secnik K, Marynchenko M, Greenberg P, Claxton A. Attention-deficit/hyperactivity disorder: increased costs for patients and their families. J Am Acad Child Adolesc Psychiatry. 2003; 42(12): 1415–1423.
  • Matza LS, Paramore C, Prasad M. A review of the economic burden of ADHD. Cost Eff Resour Alloc. 2005; 3: 5.
  • Secnik K, Swensen A, Lage MJ. Comorbidities and costs of adult patients diagnosed with attention-deficit hyperactivity disorder. Pharmacoeconomics. 2005; 23(1): 93–102.
  • Leibson CL, Long KH. Economic implications of attention-deficit hyperactivity disorder for healthcare systems. Pharmacoeconomics. 2003; 21(17): 1239–1262.
  • Chan E, Zhan C, Homer CJ. Health care use and costs for children with attention-deficit/hyperactivity disorder: national estimates from the Medical Expenditure Panel Survey. Arch Pediatr Adolesc Med. 2002; 156(5): 504–511.
  • Burd L, Klug MG, Coumbe MJ, Kerbeshian J. Children and adolescents with attention deficit-hyperactivity disorder: 1. Prevalence and cost of care. J Child Neurol. 2003; 18: 555–561.
  • Guevara J, Lozano P, Wickizer T, Meli L, Gephart H. Utilization and cost of health care services for children with attention-deficit/hyperactivity disorder. Pediatrics. 2001; 108(1): 71–78.
  • Jensen PS, Garcia JA, Glied S, et al. Cost-effectiveness of ADHD treatments: findings from the Multimodal Treatment Study of Children with ADHD. Am J Psychiatry. 2005; 162(9): 1628–1636.
  • MTA Cooperative Group. A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. MTA Cooperative Group. Multimodal Treatment Study of Children with ADHD. Arch Gen Psychiatry. 1999; 56(12): 1073–1086.

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