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Clinical Features

Diagnosis and Management of Chronic Rhinosinusitis in Adults

, MD, , MD, , MD, , MD, , MD, , MD, , MD, , MD, , MD, , MD, , MD & , MD show all
Pages 121-139 | Published online: 13 Mar 2015

References

  • . Benninger MS, Ferguson BJ, Hadley JA, . Adult chronic rhinosinusitis: definitions, diagnosis, epidemiology, and pathophysiology. Otolaryngol Head Neck Surg. 2003;129( 3 suppl):S1–S32
  • . Lanza DC, Kennedy DW. Adult rhinosinusitis defined. Otolaryngol Head Neck Surg. 1997;117(3 pt 2):S1–S7
  • . Furukawa CT. The role of allergy in sinusitis in children. J Allergy Clin Immunol. 1992;90(3 pt 2):515–517
  • . Krouse JH. Computed tomography stage, allergy testing, and quality of life in patients with sinusitis. Otolaryngol Head Neck Surg. 2000;123(4):389–391
  • . Ramadan HH, Fornelli R, Ortiz AO, Rodman S. Correlation of allergy and severity of sinus disease. Am J Rhinol. 1999;13(5):345–347
  • . Bachert C, van Cauwenberge P. Nasal polyposis and sinusitis. In: Adkinson N, Yunginger J, Busse W, Bochner B, Holgate S, Simons E, eds. Middleton's Allergy: Principles and Practice. 6th ed. St. Louis, MO: Mosby; 2003
  • . Demoly P, Crampette L, Mondain M, Enander I, Jones I, Bousquet J. Myeloperoxidase and interleukin-8 levels in chronic sinusitis. Clin Exp Allergy. 1997;27(6):672–675
  • . Ghaffar O, Durham S, Al-Ghamdi K, . Expression of IgE heavy chain transcripts in the sinus mucosa of atopic and nonatopic patients with chronic sinusitis. Am J Respir Cell Mol Biol. 1998; 18(5):706–711
  • . Kamil A, Ghaffar O, Lavigne F, Taha R, Renzi PM, Hamid Q. Comparison of inflammatory cell profile and Th2 cytokine expression in the ethmoid sinuses, maxillary sinuses, and turbinates of atopic subjects with chronic sinusitis. Otolaryngol Head Neck Surg. 1998;118(6):804–809
  • . Naclerio RM, deTineo ML, Baroody FM. Ragweed allergic rhinitis and the paranasal sinuses. A computed tomographic study. Arch Otolaryngol Head Neck Surg. 1997;123(2):193–196
  • . Pelikan Z, Pelikan-Filipek M. Role of nasal allergy in chronic maxillary sinusitis—diagnostic value of nasal challenge with allergen. J Allergy Clin Immunol. 1990;86(4 pt 1):484–491
  • . Baroody FM, Mucha SM, Detineo M, Naclerio RM. Nasal challenge with allergen leads to maxillary sinus inflammation. J Allergy Clin Immunol. 2008;121(5):1126–1132.e7
  • . Bachert C, Vignola AM, Gevaert P, Leynaert B, Van Cauwenberge P, Bousquet J. Allergic rhinitis, rhinosinusitis, and asthma: one airway disease. Immunol Allergy Clin North Am. 2004;24(1):19–43
  • . Tripathi A, Kern R, Conley DB, . Staphylococcal exotoxins and nasal polyposis: analysis of systemic and local responses. Am J Rhinol. 2005;19(4):327–333
  • . Bachert C, Gevaert P, Holtappels G, Johansson SG, van Cauwenberge P. Total and specific IgE in nasal polyps is related to local eosinophilic inflammation. J Allergy Clin Immunol. 2001;107(4):607–614
  • . Proft T, Fraser JD. Bacterial superantigens. Clin Exp Immunol. 2003; 133(3):299–306
  • . Herman A, Kappler JW, Marrack P, Pullen AM. Superantigens: mechanism of T-cell stimulation and role in immune responses. Annu Rev Immunol. 1991;9:745–772
  • . Schubert MS. Allergic fungal sinusitis. Clin Allergy Immunol. 2007; 20:263–271
  • . Ferguson BJ. Eosinophilic mucin rhinosinusitis: a distinct clinicopathological entity. Laryngoscope. 2000;110(5 pt 1):799–813
  • . Shin SH, Ponikau JU, Sherris DA, . Chronic rhinosinusitis: an enhanced immune response to ubiquitous airborne fungi. J Allergy Clin Immunol. 2004;114(6):1369–1375
  • . Orlandi RR, Thibeault SL, Ferguson BJ. Microarray analysis of allergic fungal sinusitis and eosinophilic mucin rhinosinusitis. Otolaryngol Head Neck Surg. 2007;136(5):707–713
  • . Pant H, Kette FE, Smith WB, Macardle PJ, Wormald PJ. Eosinophilic mucus chronic rhinosinusitis: clinical subgroups or a homogeneous pathogenic entity? Laryngoscope. 2006;116(7):1241–1247
  • . Wald ER. Microbiology of acute and chronic sinusitis in children and adults. Am J Med Sci. 1998;316(1):13–20
  • . Biel MA, Brown CA, Levinson RM, . Evaluation of the microbiology of chronic maxillary sinusitis. Ann Otol Rhinol Laryngol. 1998;107(11 pt 1):942–945
  • . Fairbanks DN. Inflammatory diseases of the sinuses: bacteriology and antibiotics. Otolaryngol Clin North Am. 1993;26(4):549–559
  • . Brook I. Bacteriology of acute and chronic sphenoid sinusitis. Ann Otol Rhinol Laryngol. 2002;111(11):1002–1004
  • . Brook I. Bacteriology of acute and chronic frontal sinusitis. Arch Otolaryngol Head Neck Surg. 2002;128(5):583–585
  • . Brook I. Bacteriology of chronic sinusitis and acute exacerbation of chronic sinusitis. Arch Otolaryngol Head Neck Surg. 2006;132(10):1099–1101
  • . Yildirim A, Oh C, Erdem H, Kunt T. Bacteriology in patients with chronic sinusitis who have been medically and surgically treated. Ear Nose Throat J. 2004;83(12):836–838
  • . Kennedy DW, Senior BA, Gannon FH, Montone KT, Hwang P, Lanza DC. Histology and histomorphometry of ethmoid bone in chronic rhinosinusitis. Laryngoscope. 1998;108(4 pt 1):502–507
  • . Perloff JR, Gannon FH, Bolger WE, Montone KT, Orlandi R, Kennedy DW. Bone involvement in sinusitis: an apparent pathway for the spread of disease. Laryngoscope. 2000;110(12):2095–2099
  • . Palmer JN. Bacterial biofilms: do they play a role in chronic sinusitis? Otolaryngol Clin North Am. 2005;38(6):1193–1201, viii
  • . Sanclement JA, Webster P, Thomas J, Ramadan HH. Bacterial biofilms in surgical specimens of patients with chronic rhinosinusitis. Laryngoscope. 2005;115(4):578–582
  • . Gwaltney JM Jr. Acute community-acquired sinusitis. Clin Infect Dis. 1996;23(6):1209–1223
  • . Hagerhed-Engman L, Bornehag CG, Sundell J, Aberg N. Day-care attendance and increased risk for respiratory and allergic symptoms in preschool age. Allergy. 2006;61(4):447–453
  • . Moser MR, Bender TR, Margolis HS, Noble GR, Kendal AP, Ritter DG. An outbreak of influenza aboard a commercial airliner. Am J Epidemiol. 1979;110(1):1–6
  • . Lieu JE, Feinstein AR. Confirmations and surprises in the association of tobacco use with sinusitis. Arch Otolaryngol Head Neck Surg. 2000;126(8):940–946
  • . Barr MB, Weiss ST, Segal MR, Tager IB, Speizer FE. The relationship of nasal disorders to lower respiratory tract symptoms and illness in a random sample of children. Pediatr Pulmonol. 1992;14(2):91–94
  • . Chen Y, Dales R, Lin M. The epidemiology of chronic rhinosinusitis in Canadians. Laryngoscope. 2003;113(7):1199–1205
  • . Fokkens W, Lund V, Mullol J; European Position Paper on Rhinosinusitis and Nasal Polyps group. European position paper on rhinosinusitis and nasal polyps 2007. Rhinol Suppl. 2007;(20):1–136
  • . Koltai PJ. Effects of air pollution on the upper respiratory tract of children. Otolaryngol Head Neck Surg. 1994;111(1):9–11
  • . Baser S, Fisekci FE, Ozkurt S, Zencir M. Respiratory effects of chronic animal feed dust exposure. J Occup Health. 2003;45(5):324–330
  • . Rugina M, Serrano E, Klossek JM, . Epidemiological and clinical aspects of nasal polyposis in France; the ORLI group experience. Rhinology. 2002;40(2):75–79
  • . Kim J, Hanley JA. The role of woodstoves in the etiology of nasal polyposis. Arch Otolaryngol Head Neck Surg. 2002;128(6):682–686
  • . Kennedy DW. Pathogenesis of chronic rhinosinusitis. Ann Otol Rhinol Laryngol Suppl. 2004;193:6–9
  • . Wang X, Moylan B, Leopold DA, . Mutation in the gene responsible for cystic fibrosis and predisposition to chronic rhinosinusitis in the general population. JAMA. 2000;284(14):1814–1819
  • . Raman V, Clary R, Siegrist KL, Zehnbauer B, Chatila TA. Increased prevalence of mutations in the cystic fibrosis transmembrane conductance regulator in children with chronic rhinosinusitis. Pediatrics. 2002;109(1):E13
  • . Cowan MJ, Gladwin MT, Shelhamer JH. Disorders of ciliary motility. Am J Med Sci. 2001;321(1):3–10
  • . Armengot M, Juan G, Carda C, Montalt J, Basterra J. Young's syndrome: a further cause of chronic rhinosinusitis. Rhinology. 1996; 34(1):35–37
  • . Cooper MA, Pommering TL, Korányi K. Primary immunodeficiencies. Am Fam Physician. 2003;68(10):2001–2008
  • . Delagrand A, Gilbert-Dussardier B, Burg S, . Nasal polyposis: is there an inheritance pattern? A single family study. Rhinology. 2008;46(2):125–130
  • . Greisner WA 3rd, Settipane GA. Hereditary factor for nasal polyps. Allergy Asthma Proc. 1996;17(5):283–286
  • . Cohen NA, Widelitz JS, Chiu AG, Palmer JN, Kennedy DW. Familial aggregation of sinonasal polyps correlates with severity of disease. Otolaryngol Head Neck Surg. 2006;134(4):601–604
  • . Schapowal AG, Simon HU, Schmitz-Schumann M. Phenomenology, pathogenesis, diagnosis and treatment of aspirin-sensitive rhinosinusitis. Acta Otorhinolaryngol Belg. 1995;49(3):235–250
  • . DiBaise JK, Olusola BF, Huerter JV, Quigley EM. Role of GERD in chronic resistant sinusitis: a prospective, open label, pilot trial. Am J Gastroenterol. 2002;97(4):843–850
  • . Dibaise JK, Sharma VK. Does gastroesophageal reflux contribute to the development of chronic sinusitis? A review of the evidence. Dis Esophagus. 2006;19(6):419–424
  • . Ulualp SO, Toohill RJ, Hoffmann R, Shaker R. Possible relationship of gastroesophagopharyngeal acid reflux with pathogenesis of chronic sinusitis. Am J Rhinol. 1999;13(3):197–202
  • . Loehrl TA, Smith TL. Chronic sinusitis and gastroesophageal reflux: are they related? Curr Opin Otolaryngol Head Neck Surg. 2004;12(1):18–20
  • . Phipps CD, Wood WE, Gibson WS, Cochran WJ. Gastroesophageal reflux contributing to chronic sinus disease in children: a prospective analysis. Arch Otolaryngol Head Neck Surg. 2000;126(7):831–836
  • . Wong IW, Omari TI, Myers JC, . Nasopharyngeal pH monitoring in chronic sinusitis patients using a novel four channel probe. Laryngoscope. 2004;114(9):1582–1585
  • . DelGaudio JM. Direct nasopharyngeal reflux of gastric acid is a contributing factor in refractory chronic rhinosinusitis. Laryngoscope. 2005;115(6):946–957
  • . Hwang PH, Irwin SB, Griest SE, Caro JE, Nesbit GM. Radiologic correlates of symptom-based diagnostic criteria for chronic rhinosinusitis. Otolaryngol Head Neck Surg. 2003;128(4):489–496
  • . Stankiewicz JA, Chow JM. A diagnostic dilemma for chronic rhinosinusitis: definition accuracy and validity. Am J Rhinol. 2002;16(4):199–202
  • . Orlandi RR, Terrell JE. Analysis of the adult chronic rhinosinusitis working definition. Am J Rhinol. 2002;16(1):7–10
  • . Stankiewicz JA, Chow JM. Nasal endoscopy and the definition and diagnosis of chronic rhinosinusitis. Otolaryngol Head Neck Surg. 2002;126(6):623–627
  • . Casiano RR. Correlation of clinical examination with computer tomography in paranasal sinus disease. Am J Rhinol. 1997;11(3):193–196
  • . Dubin MG, Kuhn FA, Melroy CT. Radiographic resolution of chronic rhinosinusitis without polyposis after 6 weeks vs 3 weeks of oral antibiotics. Ann Allergy Asthma Immunol. 2007;98(1):32–35
  • . Cakmak O, Shohet MR, Kern EB. Isolated sphenoid sinus lesions. Am J Rhinol. 2000;14(1):13–19
  • . Lehr AJ, Mabry RL, Mabry CS. The screening RAST: is it a valid concept? Otolaryngol Head Neck Surg. 1997;117(1):54–55
  • . Bousquet J, Van Cauwenberge P, Khaltaev N; Aria Workshop Group; World Health Organization. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol. 2001;108( 5 suppl):S147–S334
  • . Bresciani M, Paradis L, Des Roches A, . Rhinosinusitis in severe asthma. J Allergy Clin Immunol. 2001;107(1):73–80
  • . Staikūniene J, Vaitkus S, Japertiene LM, Ryskiene S. Association of chronic rhinosinusitis with nasal polyps and asthma: clinical and radiological features, allergy and inflammation markers. Medicina (Kaunas). 2008;44(4):257–265
  • . Noone PG, Leigh MW, Sannuti A, . Primary ciliary dyskinesia: diagnostic and phenotypic features. Am J Respir Crit Care Med. 2004; 169(4):459–467
  • . Rott HD. Genetics of Kartagener's syndrome. Eur J Respir Dis Suppl. 1983;127:1–4
  • . Meltzer EO, Orgel HA, Jalowayski AA. Rhinitis: Mechanisms and Management. In: Naclerio RM, Durham SR, Mygind N, eds. Nasal Cytology. New York, NY: Marcel Dekker, Inc; 1999:175–202
  • . Roberts RL, Stiehm ER. Antibody (B-cell) immunodeficiency disorders. In: Parslow TG, Stiles DP, Terr A, Imbodem JB, ed. Medical Immunology. 10th ed. New York, NY: McGraw-Hill, 2001:299–312
  • . Iinuma T, Hirota Y, Kase Y. Radio-opacity of the paranasal sinuses. Conventional views and CT. Rhinology. 1994;32(3):134–136
  • . Konen E, Faibel M, Kleinbaum Y, . The value of the occipitomental (Waters') view in diagnosis of sinusitis: a comparative study with computed tomography. Clin Radiol. 2000;55(11):856–860
  • . Burke TF, Guertler AT, Timmons JH. Comparison of sinus X-rays with computed tomography scans in acute sinusitis. Acad Emerg Med. 1994;1(3):235–239
  • . Puhakka T, Heikkinen T, Mäkelä MJ, . Validity of ultrasonography in diagnosis of acute maxillary sinusitis. Arch Otolaryngol Head Neck Surg. 2000;126(12):1482–1486
  • . Karantanas AH, Sandris V. Maxillary sinus inflammatory disease: ultrasound compared to computed tomography. Comput Med Imaging Graph. 1997;21(4):233–241
  • . Hilbert G, Vargas F, Valentino R, . Comparison of B-mode ultrasound and computed tomography in the diagnosis of maxillary sinusitis in mechanically ventilated patients. Crit Care Med. 2001;29(7):1337–1342
  • . Evans FO Jr, Sydnor JB, Moore WE, . Sinusitis of the maxillary antrum. N Engl J Med. 1975;293(15):735–739
  • . Spector SL, Lotan A, English G, Philpot I. Comparison between transillumination and the roentgenogram in diagnosing paranasal sinus disease. J Allergy Clin Immunol. 1981;67(1):22–26
  • . Otten FW, Grote JJ. The diagnostic value of transillumination for maxillary sinusitis in children. Int J Pediatr Otorhinolaryngol. 1989; 18(1):9–11
  • . Axelsson A, Brorson JE. The correlation between bacteriological findings in the nose and maxillary sinus in acute maxillary sinusitis. Laryngoscope. 1973;83(12):2003–2011
  • . Aral M, Keles E, Kaygusuz I. The microbiology of ethmoid and maxillary sinuses in patients with chronic sinusitis. Am J Otolaryngol. 2003;24(3):163–168
  • . Sener B, Hasçelik G, Onerci M, Tunçkanat F. Evaluation of the microbiology of chronic sinusitis. J Laryngol Otol. 1996;110(6):547–550
  • . Sykes DA, Wilson R, Chan KL, Mackay IS, Cole PJ. Relative importance of antibiotic and improved clearance in topical treatment of chronic mucopurulent rhinosinusitis. A controlled study. Lancet. 1986;2(8503):359–360
  • . Lavigne F, Cameron L, Renzi PM, . Intrasinus administration of topical budesonide to allergic patients with chronic rhinosinusitis following surgery. Laryngoscope. 2002;112(5):858–864
  • . Lund VJ, Black JH, Szabó LZ, Schrewelius C, Akerlund A. Efficacy and tolerability of budesonide aqueous nasal spray in chronic rhinosinusitis patients. Rhinology. 2004;42(2):57–62
  • . Jankowski R, Schrewelius C, Bonfils P, . Efficacy and tolerability of budesonide aqueous nasal spray treatment in patients with nasal polyps. Arch Otolaryngol Head Neck Surg. 2001;127(4):447–452
  • . Ruhno J, Andersson B, Denburg J, . A double-blind comparison of intranasal budesonide with placebo for nasal polyposis. J Allergy Clin Immunol. 1990;86(6 pt 1):946–953
  • . Kaszuba SM, Stewart MG. Medical management and diagnosis of chronic rhinosinusitis: A survey of treatment patterns by United States otolaryngologists. Am J Rhinol. 2006;20(2):186–190
  • . Joe SA, Thambi R, Huang J. A systematic review of the use of intranasal steroids in the treatment of chronic rhinosinusitis. Otolaryngol Head Neck Surg. 2008;139(3):340–347
  • . Damm M, Jungehülsing M, Eckel HE, Schmidt M, Theissen P. Effects of systemic steroid treatment in chronic polypoid rhinosinusitis evaluated with magnetic resonance imaging. Otolaryngol Head Neck Surg. 1999;120(4):517–523
  • . Subramanian HN, Schechtman KB, Hamilos DL. A retrospective analysis of treatment outcomes and time to relapse after intensive medical treatment for chronic sinusitis. Am J Rhinol. 2002;16(6):303–312
  • . Patiar S, Reece P. Oral steroids for nasal polyps. Cochrane Database Syst Rev. 2007;(1):CD005232
  • . Hessler JL, Piccirillo JF, Fang D, . Clinical outcomes of chronic rhinosinusitis in response to medical therapy: results of a prospective study. Am J Rhinol. 2007;21(1):10–18
  • . Dubin MG, Liu C, Lin SY, Senior BA. American Rhinologic Society member survey on “maximal medical therapy” for chronic rhinosinusitis. Am J Rhinol. 2007;21(4):483–488
  • . Sharp HJ, Denman D, Puumala S, Leopold DA. Treatment of acute and chronic rhinosinusitis in the United States, 1999–2002. Arch Otolaryngol Head Neck Surg. 2007;133(3):260–265
  • . Bhattacharyya N, Kepnes LJ. Assessment of trends in antimicrobial resistance in chronic rhinosinusitis. Ann Otol Rhinol Laryngol. 2008;117(6):448–452
  • . Scadding GK, Lund VJ, Darby YC. The effect of long-term antibiotic therapy upon ciliary beat frequency in chronic rhinosinusitis. J Laryngol Otol. 1995;109(1):24–26
  • . Statham MM, Seiden A. Potential new avenues of treatment for chronic rhinosinusitis: an anti-inflammatory approach. Otolaryngol Clin North Am. 2005;38(6):1351–1365, xi
  • . Legent F, Bordure P, Beauvillain C, Berche P. A double-blind comparison of ciprofloxacin and amoxycillin/clavulanic acid in the treatment of chronic sinusitis. Chemotherapy. 1994;40( suppl 1):8–15
  • . Namyslowski G, Misiolek M, Czecior E, . Comparison of the efficacy and tolerability of amoxycillin/clavulanic acid 875 mg b.i.d. with cefuroxime 500 mg b.i.d. in the treatment of chronic and acute exacerbation of chronic sinusitis in adults. J Chemother. 2002;14(5):508–517
  • . Leonard DW, Bolger WE. Topical antibiotic therapy for recalcitrant sinusitis. Laryngoscope. 1999;109(4):668–670
  • . Scheinberg PA, Otsuji A. Nebulized antibiotics for the treatment of acute exacerbations of chronic rhinosinusitis. Ear Nose Throat J. 2002;81(9):648–652
  • . Desrosiers MY, Salas-Prato M. Treatment of chronic rhinosinusitis refractory to other treatments with topical antibiotic therapy delivered by means of a large-particle nebulizer: results of a controlled trial. Otolaryngol Head Neck Surg. 2001;125(3):265–269
  • . Lim M, Citardi MJ, Leong JL. Topical antimicrobials in the management of chronic rhinosinusitis: a systematic review. Am J Rhinol. 2008;22(4):381–389
  • . Anand V, Levine H, Friedman M, . Intravenous antibiotics for refractory rhinosinusitis in nonsurgical patients: preliminary findings of a prospective study. Am J Rhinol. 2003;17(6):363–368
  • . Cervin A, Wallwork B. Macrolide therapy of chronic rhinosinusitis. Rhinology. 2007;45(4):259–267
  • . Wallwork B, Coman W, Mackay-Sim A, Greiff L, Cervin A. A double-blind, randomized, placebo-controlled trial of macrolide in the treatment of chronic rhinosinusitis. Laryngoscope. 2006;116(2):189–193
  • . Desrosiers M, Myntti M, James G. Methods for removing bacterial biofilms: in vitro study using clinical chronic rhinosinusitis specimens. Am J Rhinol. 2007;21(5):527–532
  • . Tamashiro E, Banks CA, Chen B, . In vivo effects of citric acid/zwitterionic surfactant (CAZS) cleansing solution on rabbit sinus mucosa. Am J Rhinol Allergy. 2009 (in press)
  • . Weschta M, Rimek D, Formanek M, Polzehl D, Podbielski A, Riechelmann H. Topical antifungal treatment of chronic rhinosinusitis with nasal polyps: a randomized, double-blind clinical trial. J Allergy Clin Immunol. 2004;113(6):1122–1128
  • . Liang KL, Su MC, Shiao JY, . Amphotericin B irrigation for the treatment of chronic rhinosinusitis without nasal polyps: a randomized, placebo-controlled, double-blind study. Am J Rhinol. 2008;22(1):52–58
  • . Ebbens FA, Scadding GK, Badia L, . Amphotericin B nasal lavages: not a solution for patients with chronic rhinosinusitis. J Allergy Clin Immunol. 2006;118(5):1149–1156
  • . Ebbens FA, Georgalas C, Luiten S, . The effect of topical amphotericin B on inflammatory markers in patients with chronic rhinosinusitis: a multicenter randomized controlled study. Laryngoscope. 2009;119(2):401–408
  • . Ponikau JU, Sherris DA, Kita H, Kern EB. Intranasal antifungal treatment in 51 patients with chronic rhinosinusitis. J Allergy Clin Immunol. 2002;110(6):862–866
  • . Ponikau JU, Sherris DA, Weaver A, Kita H. Treatment of chronic rhinosinusitis with intranasal amphotericin B: a randomized, placebo-controlled, double-blind pilot trial. J Allergy Clin Immunol. 2005;115(1):125–131
  • . Accentia Biopharmaceuticals. 03/24/08: Accentia Biopharmaceuticals Announces Results on Primary Endpoint in Clinical Study of SinuNase Lavage. Press Release. http://www.accentia.net/investors_press.php. Accessed October 20, 2009
  • . Rains BM 3rd, Mineck CW. Treatment of allergic fungal sinusitis with high-dose itraconazole. Am J Rhinol. 2003;17(1):1–8
  • . Kennedy DW, Kuhn FA, Hamilos DL, . Treatment of chronic rhinosinusitis with high-dose oral terbinafine: a double blind, placebo-controlled study. Laryngoscope. 2005;115(10):1793–1799
  • . Stankiewicz JA, Musgrave BK, Scianna JM. Nasal amphotericin irrigation in chronic rhinosinusitis. Curr Opin Otolaryngol Head Neck Surg. 2008;16(1):44–46
  • . Wark PA, Hensley MJ, Saltos N, . Anti-inflammatory effect of itraconazole in stable allergic bronchopulmonary aspergillosis: a randomized controlled trial. J Allergy Clin Immunol. 2003;111(5):952–957
  • . Meltzer EO. Clinical evidence for antileukotriene therapy in the management of allergic rhinitis. Ann Allergy Asthma Immunol. 2002; 88(4 suppl 1):23–29
  • . Nathan RA. Pharmacotherapy for allergic rhinitis: a critical review of leukotriene receptor antagonists compared with other treatments. Ann Allergy Asthma Immunol. 2003;90(2):182–190
  • . Grayson MH, Korenblat PE. The role of antileukotriene drugs in management of rhinitis and rhinosinusitis. Curr Allergy Asthma Rep. 2007;7(3):209–215
  • . Pincus RL, Kim HH, Silvers S, Gold S. A study of the link between gastric reflux and chronic sinusitis in adults. Ear Nose Throat J. 2006;85(3):174–178
  • . Hoffman BB, Lefkowitz RJ, Taylor P. Neurotransmission: the autonomic and somatic motor nervous systems. In: Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, Gilman AG, eds. The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill. 1996:105–139
  • . Meltzer E, Prenner B, Nayak A; Desloratadine Study Group. Efficacy and tolerability of once-daily 5 mg desloratadine, an H1-receptor antagonist, in patients with seasonal allergic rhinitis: assessment during the spring and fall allergy seasons. Clin Drug Invest. 2001;21(1):25–32
  • . Berger WE, Schenkel EJ, Mansfield LE; Desloratadine Study Group. Safety and efficacy of desloratadine 5 mg in asthma patients with seasonal allergic rhinitis and nasal congestion. Ann Allergy Asthma Immunol. 2002;89(5):485–491
  • . Simons FE, Prenner BM, Finn A Jr; Desloratadine Study Group. Efficacy and safety of desloratadine in the treatment of perennial allergic rhinitis. J Allergy Clin Immunol. 2003;111(3):617–622
  • . Marengo R. Mucolytic agents for liquescent of secretions in the treatment of chronic purulent maxillary sinusitis. Prensa Med Argent. 1970;57(14):687–691. [Article in Spanish]
  • . Goldner-Reiss I. The role of an oral mucolytic (Bisolvon) in the treatment of chronic sinusitis. Med J Aust. 1972;1(9):419–420
  • . Rosen EJ, Calhoun KH. Alterations of nasal mucociliary clearance in association with HIV infection and the effect of guaifenesin therapy. Laryngoscope. 2005;115(1):27–30
  • . Harvey R, Hannan SA, Badia L, Scadding G. Nasal saline irrigations for the symptoms of chronic rhinosinusitis. Cochrane Database Syst Rev. 2007;(3):CD006394
  • . Stevenson DD, Hankammer MA, Mathison DA, Christiansen SC, Simon RA. Aspirin desensitization treatment of aspirin-sensitive patients with rhinosinusitis-asthma: long-term outcomes. J Allergy Clin Immunol. 1996;98(4):751–8
  • . Sweet JM, Stevenson DD, Simon RA, Mathison DA. Long-term effects of aspirin desensitization—treatment for aspirin-sensitive rhinosinusitis-asthma. J Allergy Clin Immunol. 1990;85(1 pt 1):59–65
  • . Berges-Gimeno MP, Simon RA, Stevenson DD. Long-term treatment with aspirin desensitization in asthmatic patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2003;111(1):180–186
  • . Williams AN, Woessner KM. The clinical effectiveness of aspirin desensitization in chronic rhinosinusitis. Curr Allergy Asthma Rep. 2008;8(3):245–252
  • . Corrigan CJ, Kettner J, Doemer C, Cromwell O, Narkus A; Study Group. Efficacy and safety of preseasonal-specific immunotherapy with an aluminium-adsorbed six-grass pollen allergoid. Allergy. 2005;60(6):801–807
  • . Ferrer M, Burches E, Peláez A, . Double-blind, placebo-controlled study of immunotherapy with Parietaria judaica: clinical efficacy and tolerance. J Investig Allerg Clin Immunol. 2005;15(4):283–292
  • . Frew AJ, Powell RJ, Corrigan CJ, Durham SR; UK Immunotherapy Study Group. Efficacy and safety of specific immunotherapy with SQ allergen extract in treatment-resistant seasonal allergic rhinoconjunctivitis. J Allergy Clin Immunol. 2006;117(2):319–325
  • . Jutel M, Jaeger L, Suck R, Meyer H, Fiebig H, Cromwell O. Allergen-specific immunotherapy with recombinant grass pollen allergens. J Allergy Clin Immunol. 2005;116(3):608–613
  • . Nishioka GJ, Cook PR, Davis WE, McKinsey JP. Immunotherapy in patients undergoing functional endoscopic sinus surgery. Otolaryngol Head Neck Surg. 1994;110(4):406–412
  • . Mabry RL, Marple BF, Folker RJ, Mabry CS. Immunotherapy for allergic fungal sinusitis: three years' experience. Otolaryngol Head Neck Surg. 1998;119(6):648–651
  • . Bassichis BA, Marple BF, Mabry RL, Newcomer MT, Schwade ND. Use of immunotherapy in previously treated patients with allergic fungal sinusitis. Otolaryngol Head Neck Surg. 2001;125(5):487–490
  • . Kaiser HB, Findlay SR, Georgitis JW, . The anticholinergic agent, ipratropium bromide, is useful in the treatment of rhinorrhea associated with perennial allergic rhinitis. Allergy Asthma Proc. 1998;19(1):23–29
  • . Passàli D, Bernstein JM, Passali FM, Damiani V, Passàli GC, Bellussi L. Treatment of recurrent chronic hyperplastic sinusitis with nasal polyposis. Arch Otolaryngol Head Neck Surg. 2003;129(6):656–659
  • . Zheng CQ, Wang ZM, Lacroix JS. Effect of intranasal treatment with capsaicin on polyp recurrence after polypectomy and ethmoidectomy. Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2000;14(8):344–346. [Article in Chinese]
  • . Nucera E, Schiavino D, Milani A, . Effects of lysine-acetylsalicylate (LAS) treatment in nasal polyposis: two controlled long term prospective follow up studies. Thorax. 2000;55( suppl 2):S75–S78
  • . Helms S, Miller A. Natural treatment of chronic rhinosinusitis. Altern Med Rev. 2006;11(3):196–207
  • . Rössberg E, Larsson PG, Birkeflet O, Söholt LE, Stavem K. Comparison of traditional Chinese acupuncture, minimal acupuncture at non-acupoints and conventional treatment for chronic sinusitis. Complement Ther Med. 2005;13(1):4–10
  • . Pletcher SD, Goldberg AN, Lee J, Acquah J. Use of acupuncture in the treatment of sinus and nasal symptoms: results of a practitioner survey. Am J Rhinol. 2006;20(2):235–237

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