The Nature, Assessment, and Treatment of Obsessive–Compulsive Disorder

References

• . Ruscio AM, Stein DJ, Chiu WT, Kessler RC. The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication. Mol Psychiatry. 2010;15(1):53–63
   PubMed Web of Science ®Google Scholar
• . Storch EA, Larson MJ, Muroff J,. Predictors of functional impairment in pediatric obsessive-compulsive disorder. J Anxiety Disord. 2010;24(2):275–283
   PubMed Web of Science ®Google Scholar
• . Huppert JD, Simpson HB, Nissenson KJ, Liebowitz MR, Foa EB. Quality of life and functional impairment in obsessive-compulsive disorder: a comparison of patients with and without comorbidity, patients in remission, and healthy controls. Depress Anxiety. 2009;26(1):39–45
   PubMed Web of Science ®Google Scholar
• . Markarian Y, Larson MJ, Aldea MA,. Multiple pathways to functional impairment in obsessive-compulsive disorder. Clin Psychol Rev. 2010;30(1):78–88
   PubMed Web of Science ®Google Scholar
• . Lack CW, Storch EA, Keeley ML,. Quality of life in children and adolescents with obsessive-compulsive disorder: base rates, parent-child agreement, and clinical correlates. Soc Psychiatry Psychiatr Epidemiol. 2009;44(11):935–942
   PubMed Web of Science ®Google Scholar
• . Eisen JL, Mancebo MA, Pinto A,. Impact of obsessive-compulsive disorder on quality of life. Compr Psychiatry. 2006;47(4):270–275
   PubMed Web of Science ®Google Scholar
• . Murray CJ, Lopez AD. The Global Burden of Disease. A Comprehensive Assessment of Mortality and Disability From Diseases, Injuries and Risk Factors in 1990 and Projected to 2020. Cambridge, MA: Harvard School of Public Health on behalf of the World Health Organization and the World Bank; 1996
   Google Scholar
• . Crye J, Laskey B, Cartwright–Hatton S. Non-clinical obsessions in a young adolescent population: frequency and association with metacognitive variables. Psychol Psychother. 2010;83(pt 1):15–26
   PubMed Web of Science ®Google Scholar
• . Allsopp M, Williams T. Intrusive thoughts in a non-clinical adolescent population. Eur Child Adolesc Psychiatry. 1996;5(1):25–32
   PubMed Web of Science ®Google Scholar
• . Rachman S, de Silva P. Abnormal and normal obsessions. Behav Res Ther. 1978;16(4):233–248
   PubMed Web of Science ®Google Scholar
• . Salkovskis PM, Harrison J. Abnormal and normal obsessions—a replication. Behav Res Ther. 1984;22(5):549–552
   PubMed Web of Science ®Google Scholar
• . Masi G, Millepiedi S, Mucci M, Bertini N, Milantoni L, Arcangeli F. A naturalistic study of referred children and adolescents with obsessive-compulsive disorder. J Am Acad Child Adolesc Psychiatry. 2005;44(7): 673–681
   PubMed Web of Science ®Google Scholar
• . Storch EA, Kaufman DA, Bagner D,. Florida obsessive-compulsive inventory: development, reliability, and validity. J Clin Psychol. 2007;63(9):851–859
   PubMed Web of Science ®Google Scholar
• . Storch EA, Larson MJ, Price LH, Rasmussen SA, Murphy TK, Goodman WK. Psychometric analysis of the Yale-Brown Obsessive-Compulsive Scale Second Edition Symptom Checklist. J Anxiety Disord. 2010;24(6):650–656
   PubMed Web of Science ®Google Scholar
• . Abramowitz JS, Lackey GR, Wheaton MG. Obsessive-compulsive symptoms: the contribution of obsessional beliefs and experiential avoidance. J Anxiety Disord. 2009;23(2):160–166
   PubMed Web of Science ®Google Scholar
• . Pinto A, Mancebo MC, Eisen JL, Pagano ME, Rasmussen SA. The Brown Longitudinal Obsessive Compulsive Study: clinical features and symptoms of the sample at intake. J Clin Psychiatry. 2006;67(5):703–711
   PubMed Web of Science ®Google Scholar
• . McGuire JF, Storch EA, Lewin AB, Price LH, Rasmussen SA, Goodman WK. The role of avoidance in the phenomenology of obsessive-compulsive disorder [published online ahead of print May 5, 2011]. Compr Psychiatry
   Google Scholar
• . Bloch MH, Landeros–Weisenberger A, Rosario MC, Pittenger C, Leckman JF. Meta-analysis of the symptom structure of obsessive-compulsive disorder. Am J Psychiatry. 2008;165(12):1532–1542
   PubMed Web of Science ®Google Scholar
• . Stewart SE, Rosario MC, Baer L,. Four-factor structure of obsessive-compulsive disorder symptoms in children, adolescents, and adults. J Am Acad Child Adolesc Psychiatry. 2008;47(7): 763–772
   PubMed Web of Science ®Google Scholar
• . Hasler G, LaSalle–Ricci VH, Ronquillo JG,. Obsessive-compulsive disorder symptom dimensions show specific relationships to psychiatric comorbidity. Psychiatry Res. 2005;135(2):121–132
   PubMed Web of Science ®Google Scholar
• . Leckman JF, Pauls DL, Zhang H,; Tourette Syndrome Assocation International Consortium for Genetics. Obsessive-compulsive symptom dimensions in affected sibling pairs diagnosed with Gilles de la Tourette syndrome. Am J Med Genet B Neuropsychiatr Genet. 2003;116B(1):60–68
   PubMed Web of Science ®Google Scholar
• . Hasler G, Pinto A, Greenberg BD,; OCD Collaborative Genetics Study. Familiality of factor analysis-derived YBOCS dimensions in OCD-affected sibling pairs from the OCD Collaborative Genetics Study. Biol Psychiatry. 2007;61(5):617–625
   PubMed Web of Science ®Google Scholar
• . Mataix–Cols D, Wooderson S, Lawrence N, Brammer MJ, Speckens A, Phillips ML. Distinct neural correlates of washing, checking, and hoarding symptom dimensions in obsessive-compulsive disorder. Arch Gen Psychiatry. 2004;61(6):564–576
   PubMed Web of Science ®Google Scholar
• . Mataix–Cols D, Rauch SL, Manzo PA, Jenike MA, Baer L. Use of factor-analyzed symptom dimensions to predict outcome with serotonin reuptake inhibitors and placebo in the treatment of obsessive-compulsive disorder. Am J Psychiatry. 1999;156(9):1409–1416
   PubMed Web of Science ®Google Scholar
• . Landeros–Weisenberger A, Bloch MH, Kelmendi B,. Dimensional predictors of response to SRI pharmacotherapy in obsessive-compulsive disorder. J Affect Disord. 2010;121(1–2):175–179
   PubMed Web of Science ®Google Scholar
• . Mataix–Cols D, Marks IM, Greist JH, Kobak KA, Baer L. Obsessive-compulsive symptom dimensions as predictors of compliance with and response to behaviour therapy: results from a controlled trial. Psychother Psychosom. 2002;71(5):255–262
   PubMed Web of Science ®Google Scholar
• . Storch EA, Merlo LJ, Larson MJ,. Symptom dimensions and cognitive-behavioural therapy outcome for pediatric obsessive-compulsive disorder. Acta Psychiatr Scand. 2008;117(1):67–75
   PubMed Web of Science ®Google Scholar
• . Bloch MH, Craiglow BG, Landeros–Weisenberger A,. Predictors of early adult outcomes in pediatric-onset obsessive-compulsive disorder. Pediatrics. 2009;124(4):1085–1093
   PubMed Web of Science ®Google Scholar
• . Saxena S, Rauch SL. Functional neuroimaging and the neuroanatomy of obsessive-compulsive disorder. Psychiatr Clin North Am. 2000;23(3):563–586
   PubMed Web of Science ®Google Scholar
• . Saxena S, Bota RG, Brody AL. Brain-behavior relationships in obsessive-compulsive disorder. Semin Clin Neuropsychiatry. 2001;6(2):82–101
   PubMedGoogle Scholar
• . Whiteside SP, Port JD, Abramowitz JS. A meta-analysis of functional neuroimaging in obsessive-compulsive disorder. Psychiatry Res. 2004; 132(1):69–79
   PubMed Web of Science ®Google Scholar
• . Maia TV, Cooney RE, Peterson BS. The neural bases of obsessive-compulsive disorder in children and adults. Dev Psychopathol. 2008; 20(4):1251–1283
   PubMed Web of Science ®Google Scholar
• . Saxena S, Brody AL, Schwartz JM, Baxter LR. Neuroimaging and frontal-subcortical circuitry in obsessive-compulsive disorder. Br J Psychiatry Suppl. 1998;35:26–37
   PubMedGoogle Scholar
• . Menzies L, Chamberlain SR, Laird AR, Thelen SM, Sahakian BJ, Bullmore ET. Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orbitofronto-striatal model revisited. Neurosci Biobehav Rev. 2008;32(3): 525–549
   PubMed Web of Science ®Google Scholar
• . Del Casale A, Kotzalidis GD, Rapinesi C,. Functional neuroimaging in obsessive-compulsive disorder. Neuropsychobiology. 2011;64(2):61–85
   PubMed Web of Science ®Google Scholar
• . Greisberg S, McKay D. Neuropsychology of obsessive-compulsive disorder: a review and treatment implications. Clin Psychol Rev. 2003; 23(1):95–117
   PubMed Web of Science ®Google Scholar
• . Chamberlain SR, Fineberg NA, Blackwell AD, Robbins TW, Sahakian BJ. Motor inhibition and cognitive flexibility in obsessive-compulsive disorder and trichotillomania. Am J Psychiatry. 2006;163(7): 1282–1284
   PubMed Web of Science ®Google Scholar
• . Swedo SE, Pietrini P, Leonard HL,. Cerebral glucose metabolism in childhood-onset obsessive-compulsive disorder. Revisualization during pharmacotherapy. Arch Gen Psychiatry. 1992;49(9):690–694
   PubMed Web of Science ®Google Scholar
• . Perani D, Colombo C, Bressi S,. [18F]FDG PET study in obsessive-compulsive disorder. A clinical/metabolic correlation study after treatment. Br J Psychiatry. 1995;166(2):244–250
   PubMedGoogle Scholar
• . Brody AL, Saxena S, Schwartz JM,. FDG-PET predictors of response to behavioral therapy and pharmacotherapy in obsessive compulsive disorder. Psychiatry Res. 1998;84(1):1–6
   PubMed Web of Science ®Google Scholar
• . Schwartz JM, Stoessel PW, Baxter LR Jr, Martin KM, Phelps ME. Systematic changes in cerebral glucose metabolic rate after successful behavior modification treatment of obsessive-compulsive disorder. Arch Gen Psychiatry. 1996;53(2):109–113
   PubMed Web of Science ®Google Scholar
• . van Grootheest DS, Cath DC, Beekman AT, Boomsma DI. Twin studies on obsessive-compulsive disorder: a review. Twin Res Hum Genet. 2005;8(5):450–458
   PubMed Web of Science ®Google Scholar
• . Hanna GL, Himle JA, Curtis GC, Gillespie B W. A family study of obsessive-compulsive disorder with pediatric probands. Am J Med Genet B Neuropsychiatr Genet. 2005;134B(1):13–19
   PubMed Web of Science ®Google Scholar
• . Riddle MA, Scahill L, King R,. Obsessive compulsive disorder in children and adolescents: phenomenology and family history. J Am Acad Child Adolesc Psychiatry. 1990;29(5):766–772
   PubMed Web of Science ®Google Scholar
• . Pauls DL, Alsobrook JP 2nd, Goodman W, Rasmussen S, Leckman J. A family study of obsessive-compulsive disorder. Am J Psychiatry. 1995;152(1):76–84
   PubMed Web of Science ®Google Scholar
• . de Rosario–Campos MC, Leckman JF, Curi M,. A family study of early-onset obsessive-compulsive disorder. Am J Med Genet B Neuropsychiatr Genet. 2005;136B(1):92–97
   PubMed Web of Science ®Google Scholar
• . Pauls DL. The genetics of obsessive-compulsive disorder: a review. Dialogues Clin NeuroSci. 2010;12(2):149–163
   PubMedGoogle Scholar
• . Stewart SE, Fagerness JA, Platko J,. Association of the SLC1 A1 glutamate transporter gene and obsessive-compulsive disorder. Am J Med Genet B Neuropsychiatr Genet. 2007;144B(8):1027–1033
   PubMed Web of Science ®Google Scholar
• . Wendland JR, Moya PR, Timpano KR,. A haplotype containing quantitative trait loci for SLC1 A1 gene expression and its association with obsessive-compulsive disorder. Arch Gen Psychiatry. 2009;66(4): 408–416
   PubMed Web of Science ®Google Scholar
• . Mowrer OH. Learning Theory and Behavior. New York, NY: Wiley; 1960
   Google Scholar
• . Rachman S. A cognitive theory of obsessions. Behav Res Ther. 1997;35(9):793–802
   PubMed Web of Science ®Google Scholar
• . Salkovskis PM. Cognitive-behavioural factors and the persistence of intrusive thoughts in obsessional problems. Behav Res Ther. 1989;27(6):677–682
   PubMed Web of Science ®Google Scholar
• . Obsessive Compulsive Cognitions Working Group. Cognitive assessment of obsessive-compulsive disorder. Behav Res Ther. 1997;35(7): 667–681
   PubMed Web of Science ®Google Scholar
• . Salkovskis PM. Understanding and treating obsessive-compulsive disorder. Behav Res Ther. 1999;37( suppl 1):S29–S52
   PubMed Web of Science ®Google Scholar
• . Brady RE, Adams TG, Lohr JM. Disgust in contamination-based obsessive-compulsive disorder: a review and model. Expert Rev Neurother. 2010;10(8):1295–1305
   PubMed Web of Science ®Google Scholar
• . Leckman JF, Grice DE, Boardman J, Zhang H. Symptoms of obsessive-compulsive disorder. Am J Psychiatry. 1997;154(7):911–917
   PubMed Web of Science ®Google Scholar
• . Coles ME, Heimberg RG, Frost RO, Steketee G. Not just right experiences and obsessive-compulsive features: experimental and self-monitoring perspectives. Behav Res Ther. 2005;43(2):153–167
   PubMed Web of Science ®Google Scholar
• . Abramowitz JS, Taylor S, McKay D. Potentials and limitations of cognitive treatments for obsessive-compulsive disorder. Cogn Behav Ther. 2005;34(3):140–147
   PubMedGoogle Scholar
• . Murphy TK, Frasier S, Kim S. Obsessive compulsive disorder. In: Fatemi SH, Clayton PJ, eds. The Medical Basis of Psychiatry. 3rd ed. Totowa, NJ: Humana Press; 2008:161–180
   Google Scholar
• . Murphy TK, Kurlan R, Leckman J. The immunobiology of Tourette's disorder, pediatric autoimmune neuropsychiatric disorders associated with Streptococcus, and related disorders: a way forward. J Child Adolesc Psychopharmacol. 2010;20(4):317–331
   PubMed Web of Science ®Google Scholar
• . Swedo SE, Leonard HL, Garvey M,. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases. Am J Psychiatry. 1998;155(2): 264–271
   PubMed Web of Science ®Google Scholar
• . Murphy TK, Sajid MW, Goodman WK. Immunology of obsessive-compulsive disorder. Psychiatr Clin North Am. 2006;29(2):445–469
   PubMed Web of Science ®Google Scholar
• . Geller DA, Biederman J, Jones J, Shapiro S, Schwartz S, Park KS. Obsessive-compulsive disorder in children and adolescents: a review. Harv Rev Psychiatry. 1998;5(5):260–273
   PubMed Web of Science ®Google Scholar
• . Geller DA. Obsessive-compulsive and spectrum disorders in children and adolescents. Psychiatr Clin North Am. 2006;29(2):353–370
   PubMed Web of Science ®Google Scholar
• . Geller DA, Biederman J, Faraone S,. Developmental aspects of obsessive compulsive disorder: findings in children, adolescents, and adults. J Nerv Ment Dis. 2001;189(7):471–477
   PubMed Web of Science ®Google Scholar
• . Hanna GL. Demographic and clinical features of obsessive-compulsive disorder in children and adolescents. J Am Acad Child Adolesc Psychiatry. 1995;34(1):19–27
   PubMed Web of Science ®Google Scholar
• . Swedo SE, Rapoport JL, Leonard HL, Lenane M, Cheslow D. Obsessive-compulsive disorder in children and adolescents. Clinical phenomenology of 70 consecutive cases. Arch Gen Psychiatry. 1989; 46(4):335–341
   PubMed Web of Science ®Google Scholar
• . Farrell L, Barrett P, Piacentini J. Obsessive-compulsive disorder across developmental trajectory: Clinical correlates in children, adolescents and adults. Behav Change. 2006;23(2):103–120
   Web of Science ®Google Scholar
• . Piacentini J, Bergman RL, Keller M, McCracken J. Functional impairment in children and adolescents with obsessive-compulsive disorder. J Child Adolesc Psychopharmacol. 2003;13( suppl 1):S61–S69
   PubMed Web of Science ®Google Scholar
• . Storch EA, Murphy TK, Lack CW, Geffken GR, Jacob ML, Goodman WK. Sleep-related problems in pediatric obsessive-compulsive disorder. J Anxiety Disord. 2008;22(5):877–885
   PubMed Web of Science ®Google Scholar
• . Sukhodolsky DG, do Rosario–Campos MC, Scahill L,. Adaptive, emotional, and family functioning of children with obsessive-compulsive disorder and comorbid attention deficit hyperactivity disorder. Am J Psychiatry. 2005;162(6):1125–1132
   PubMed Web of Science ®Google Scholar
• . Valderhaug R, Ivarsson T. Functional impairment in clinical samples of Norwegian and Swedish children and adolescents with obsessive-compulsive disorder. Eur Child Adolesc Psychiatry. 2005; 14(3):164–173
   PubMed Web of Science ®Google Scholar
• . Piacentini J, Peris TS, Bergman RL, Chang S, Jaffer M. Functional impairment in childhood OCD: development and psychometrics properties of the Child Obsessive-Compulsive Impact Scale–Revised (COIS-R). J Clin Child Adolesc Psychol. 2007;36(4):645–653
   PubMed Web of Science ®Google Scholar
• . Hollander E. Anxiety and OC spectrum disorders over life cycle. Int J Psychiatry Clin Pract. 2007;11(s2):5–10
   PubMedGoogle Scholar
• . Peris TS, Bergman RL, Langley A, Chang S, McCracken JT, Piacentini J. Correlates of accommodation of pediatric obsessive-compulsive disorder: parent, child, and family characteristics. J Am Acad Child Adolesc Psychiatry. 2008;47(10):1173–1181
   PubMed Web of Science ®Google Scholar
• . Stewart SE, Geller DA, Jenike M,. Long-term outcome of pediatric obsessive-compulsive disorder: a meta-analysis and qualitative review of the literature. Acta Psychiatr Scand. 2004;110(1):4–13
   PubMed Web of Science ®Google Scholar
• . Eichstedt JA, Arnold SL. Childhood-onset obsessive-compulsive disorder: a tic-related subtype of OCD? Clin Psychol Rev. 2001;21(1): 137–157
   PubMed Web of Science ®Google Scholar
• . Mancebo MC, Greenberg B, Grant JE,. Correlates of occupational disability in a clinical sample of obsessive-compulsive disorder. Compr Psychiatry. 2008;49(1):43–50
   PubMed Web of Science ®Google Scholar
• . Lochner C, Mogotsi M, du Toit PL, Kaminer D, Niehaus DJ, Stein DJ. Quality of life in anxiety disorders: a comparison of obsessive-compulsive disorder, social anxiety disorder, and panic disorder. Psychopathology. 2003;36(5):255–262
   PubMed Web of Science ®Google Scholar
• . Moritz S, Rufer M, Fricke S,. Quality of life in obsessive-compulsive disorder before and after treatment. Compr Psychiatry. 2005;46(6):453–459
   PubMed Web of Science ®Google Scholar
• . Kessler RC, Chiu WT, Demler O, Merikangas KR, Walters EE. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the national comorbidity survey replication. Arch Gen Psychiatry. 2005;62(6):617–627
   PubMed Web of Science ®Google Scholar
• . Masi G, Millepiedi S, Perugi G,. A naturalistic exploratory study of the impact of demographic, phenotypic and comorbid features in pediatric obsessive-compulsive disorder. Psychopathology. 2010;43(2):69–78
   PubMed Web of Science ®Google Scholar
• . Joshi G, Wozniak J, Petty C,. Clinical characteristics of comorbid obsessive-compulsive disorder and bipolar disorder in children and adolescents. Bipolar Disord. 2010;12(2):185–195
   PubMed Web of Science ®Google Scholar
• . Rumsey JM, Rapoport JL, Sceery WR. Autistic children as adults: psychiatric, social, and behavioral outcomes. J Am Acad Child Psychiatry. 1985;24(4):465–473
   PubMedGoogle Scholar
• . Bejerot S, Nylander L, Lindström E. Autistic traits in obsessive-compulsive disorder. Nord J Psychiatry. 2001;55(3):169–176
   PubMed Web of Science ®Google Scholar
• . Storch EA, Abramowitz JS, Keeley M. Correlates and mediators of functional disability in obsessive-compulsive disorder. Depress Anxiety. 2009;26(9):806–813
   PubMed Web of Science ®Google Scholar
• . Storch EA, Merlo LJ, Larson MJ,. Impact of comorbidity on cognitive-behavioral therapy response in pediatric obsessive-compulsive disorder. J Am Acad Child Adolesc Psychiatry. 2008;47(5):583–592
   PubMed Web of Science ®Google Scholar
• . Keeley ML, Storch EA, Merlo LJ, Geffken GR. Clinical predictors of response to cognitive-behavioral therapy for obsessive-compulsive disorder. Clin Psychol Rev. 2008;28(1):118–130
   PubMed Web of Science ®Google Scholar
• . Geller DA, Biederman J, Stewart SE,. Which SSRI? A meta-analysis of pharmacotherapy trials in pediatric obsessive-compulsive disorder. Am J Psychiatry. 2003;160(11):1919–1928
   PubMed Web of Science ®Google Scholar
• . Lewin AB, Piacentini J. Evidence-based assessment of child obsessive compulsive disorder: recommendations for clinical practice and treatment research. Child Youth Care Forum. 2010;39(2):73–89
   PubMed Web of Science ®Google Scholar
• . Alonso P, Menchón JM, Segalàs C,. Clinical implications of insight assessment in obsessive-compulsive disorder. Compr Psychiatry. 2008;49(3):305–312
   PubMed Web of Science ®Google Scholar
• . Lewin AB, Bergman RL, Peris TS, Chang S, McCracken JT, Piacentini J. Correlates of insight among youth with obsessive-compulsive disorder. J Child Psychol Psychiatry. 2010;51(5):603–611
   PubMed Web of Science ®Google Scholar
• . First MB, Spitzer RL, Gibbon M, Williams J. Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition. (SCID-I/P). New York, NY: New York State Psychiatric Institute; 2002
   Google Scholar
• . Kaufman J, Birmaher B, Brent D, Rao U. Schedule for Affective Disorders and Schizophrenia for School-Age Children–Present and Lifetime version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry. 1997;36(7):980–988
   PubMed Web of Science ®Google Scholar
• . Brown TA, DiNardo PA, Barlow DH. Anxiety Disorders Interview Schedule for DSM-IV. Albany, NY: Graywind Publications, Inc.; 1994
   Google Scholar
• . Silverman WK, Albano AM. The Anxiety Disorders Interview Schedule for DSM-IV: Child and Parent Versions. San Antonio, TX: Psychological Corporation; 1996
   Google Scholar
• . Goodman WK, Price LH, Rasmussen SA,. The Yale-Brown Obsessive Compulsive Scale: I. Development, use, and reliability. Arch Gen Psychiatry. 1989;46(11):1006–1011
   PubMed Web of Science ®Google Scholar
• . Goodman WK, Price LH, Rasmussen SA,. The Yale-Brown Obsessive Compulsive Scale: II. Validity. Arch Gen Psychiatry. 1989;46(11): 1012–1016
   PubMed Web of Science ®Google Scholar
• . Sulkowski ML, Storch EA, Geffken GR, Ricketts E, Murphy TK, Goodman WK. Concurrent validity of the Yale-Brown Obsessive-Compulsive Scale—Symptom Checklist. J Clin Psychol. 2008;64(12): 1338–1351
   PubMed Web of Science ®Google Scholar
• . Storch EA, Rasmussen SA, Price LH, Larson MJ, Murphy TK, Goodman WK. Development and psychometric evaluation of the Yale-Brown Obsessive-Compulsive Scale—Second Edition. Psychol Assess. 2010;22(2):223–232
   PubMed Web of Science ®Google Scholar
• . Lewin AB, De Nadai AS, Park J, Goodman WK, Murphy TK, Storch EA. Refining clinical judgment of treatment outcome in obsessive-compulsive disorder. Psychiatry Res. 2011;185(3):394–401
   PubMed Web of Science ®Google Scholar
• . Tolin DF, Abramowitz JS, Diefenbach GJ. Defining response in clinical trials for obsessive-compulsive disorder: a signal detection analysis of the Yale-Brown Obsessive Compulsive Scale. J Clin Psychiatry. 2005;66(12):1549–1557
   PubMed Web of Science ®Google Scholar
• . Foa EB, Huppert JD, Leiberg S,. The Obsessive-Complusive Inventory: development and validation of a short version. Psychol Assess. 2002;14(4):485–496
   PubMed Web of Science ®Google Scholar
• . Steketee G, Frost R, Bogart K. The Yale-Brown Obsessive Compulsive Scale: interview versus self-report. Behav Res Ther. 1996;34(8): 675–684
   PubMed Web of Science ®Google Scholar
• . Benito K, Storch EA. Assessment of obsessive-compulsive disorder: review and future directions. Exp Rev Neurother. 2011;11(2):287–298
   PubMed Web of Science ®Google Scholar
• . Practice parameters for the assessment and treatment of children and adolescents with obsessive-compulsive disorder. J Am Acad Child Adolesc Psychiatry. 1998;37( 10 suppl):27S–45S
   PubMed Web of Science ®Google Scholar
• . Kircanski K, Peris TS, Piacentini JC. Cognitive-behavioral therapy for obsessive-compulsive disorder in children and adolescents. Child Adolesc Psychiatr Clin N Am. 2011;20(2):239–254
   PubMed Web of Science ®Google Scholar
• . Scahill L, Riddle MA, McSwiggin–Hardin M,. Children's Yale-Brown Obsessive Compulsive Scale: reliability and validity. J Am Acad Child Adolesc Psychiatry. 1997;36(6):844–852
   PubMed Web of Science ®Google Scholar
• . Storch EA, Murphy TK, Geffken GR,. Psychometric evaluation of the Children's Yale-Brown Obsessive-Compulsive Scale. Psychiatry Res. 2004;129(1):91–98
   PubMed Web of Science ®Google Scholar
• . Storch EA, Lewin AB, De Nadai AS, Murphy TK. Defining treatment response and remission in obsessive-compulsive disorder: a signal detection analysis of the Children's Yale-Brown Obsessive-Compulsive Scale. J Am Acad Child Adolesc Psychiatry. 2010;49(7):708–717
   PubMed Web of Science ®Google Scholar
• . Shafran R, Frampton I, Heyman I, Reynolds M, Teachman B, Rachman S. The preliminary development of a new self-report measure for OCD in young people. J Adolesc. 2003;26(1):137–142
   PubMed Web of Science ®Google Scholar
• . Storch EA, Khanna M, Merlo LJ,. Children's Florida Obsessive Compulsive Inventory: psychometric properties and feasibility of a self-report measure of obsessive-compulsive symptoms in youth. Child Psychiatry Hum Dev. 2009;40(3):467–483
   PubMed Web of Science ®Google Scholar
• . Foa EB, Coles M, Huppert JD, Pasupuleti RV, Franklin ME, March J. Development and validation of a child version of the obsessive compulsive inventory. Behav Ther. 2010;41(1):121–132
   PubMed Web of Science ®Google Scholar
• . Merlo LJ, Storch EA, Murphy TK, Goodman WK, Geffken GR. Assessment of pediatric obsessive-compulsive disorder: a critical review of current methodology. Child Psychiatry Hum Dev. 2005; 36(2):195–214
   PubMed Web of Science ®Google Scholar
• . Pediatric OCD Treatment (POTS) Study Team. Cognitive-behavior therapy, sertraline, and their combination for children and adolescents with obsessive-compulsive disorder: the Pediatric OCD Treatment Study (POTS) randomized controlled trial. JAMA. 2004;292(16):1969–1976
   PubMed Web of Science ®Google Scholar
• . Watson HJ, Rees CS. Meta-analysis of randomized, controlled treatment trials for pediatric obsessive-compulsive disorder. J Child Psychol Psychiatry. 2008;49(5):489–498
   PubMed Web of Science ®Google Scholar
• . Foa EB, Liebowitz MR, Kozak MJ,. Randomized, placebo-controlled trial of exposure and ritual prevention, clomipramine, and their combination in the treatment of obsessive-compulsive disorder. Am J Psychiatry. 2005;162(1):151–161
   PubMed Web of Science ®Google Scholar
• . Rosa–Alcázar AI, Sánchez–Meca J, Gómez–Conesa A, Marín–Martínez F. Psychological treatment of obsessive-compulsive disorder: a meta-analysis. Clin Psychol Rev. 2008;28(8):1310–1325
   PubMed Web of Science ®Google Scholar
• . March J, Frances A, Carpenter D, Kahn D. The expert consensus guidelines series: Treatment of Obsessive-compulsive disorder. J Clin Psychiatry. 1997;58( suppl 4):2–65
   PubMedGoogle Scholar
• . Koran LM, Hanna GL, Hollander E, Nestadt G, Simpson HB. American Psychiatric Association. Practice guideline for the treatment of patients with obsessive-compulsive disorder. Am J Psychiatry. 2007;164( 7 suppl):S5–S53
   PubMed Web of Science ®Google Scholar
• . O'Kearney RT, Anstey KJ, von Sanden C. Behavioural and cognitive behavioural therapy for obsessive compulsive disorder in children and adolescents. Cochrane Database Syst Rev. 2006;(4):CD004856
   Google Scholar
• . Fama J, Wilhelm S. Formal cognitive therapy: a new treatment for OCD. In: Abramowitz JS, Houts AC, eds. Concepts and Controversies in Obsessive-Compulsive Disorder. New York, NY: Springer; 2005:263–281
   Google Scholar
• . Abramowitz JS, Whiteside SP, Deacon BJ. The effectiveness of treatment for pediatric obsessive-compulsive disorder: a meta-analysis. Behav Ther. 2005;36(1):55–63
   Web of Science ®Google Scholar
• . Storch EA, Geffken GR, Merlo LJ,. Family-based cognitive-behavioral therapy for pediatric obsessive-compulsive disorder: Comparison of intensive and weekly approaches. J Am Acad Child Adolesc Psychiatry. 2007;46(4):469–478
   PubMed Web of Science ®Google Scholar
• . Abramowitz JS, Foa EB, Franklin ME. Exposure and ritual prevention for obsessive-compulsive disorder: effects of intensive versus twice-weekly sessions. J Consult Clin Psychol. 2003;71(2):394–398
   PubMed Web of Science ®Google Scholar
• . Storch EA, Lehmkuhl HD, Ricketts E, Geffken GR, Marien W, Murphy TK. An open trial of intensive family based cognitive-behavioral therapy in youth with obsessive-compulsive disorder who are medication partial responders or nonresponders. J Clin Child Adolesc Psychol. 2010;39(2):260–268
   PubMed Web of Science ®Google Scholar
• . McKay D. A maintenance program for obsessive-compulsive disorder using exposure with response prevention: 2-year follow-up. Behav Res Ther. 1997;35(4):367–369
   PubMed Web of Science ®Google Scholar
• . O'Leary EM, Barrett P, Fjermestad K W. Cognitive-behavioral family treatment for childhood obsessive-compulsive disorder: a 7-year follow-up study. J Anxiety Disord. 2009;23(7):973–978
   PubMed Web of Science ®Google Scholar
• . Lewin AB, Peris TS, Lindsey Bergman R, McCracken JT, Piacentini J. The role of treatment expectancy in youth receiving exposure-based CBT for obsessive compulsive disorder. Behav Res Ther. 2011; 49(9):536–543
   PubMed Web of Science ®Google Scholar
• . Merlo LJ, Storch EA, Lehmkuhl HD,. Cognitive behavioral therapy plus motivational interviewing improves outcome for pediatric obsessive-compulsive disorder: a preliminary study. Cogn Behav Ther. 2010;39(1):24–27
   PubMedGoogle Scholar
• . Simpson HB, Zuckoff AM, Maher MJ,. Challenges using motivational interviewing as an adjunct to exposure therapy for obsessive-compulsive disorder. Behav Res Ther. 2010;48(10):941–948
   PubMed Web of Science ®Google Scholar
• . March S, Spence SH, Donovan CL. The efficacy of an internet-based cognitive-behavioral therapy intervention for child anxiety disorders. J Pediatr Psychol. 2009;34(5):474–487
   PubMed Web of Science ®Google Scholar
• . Storch EA, Caporino NE, Morgan JR,. Preliminary investigation of web-camera delivered cognitive-behavioral therapy for youth with obsessive-compulsive disorder. Psychiatry Res. 2011;189(3):407–412
   PubMed Web of Science ®Google Scholar
• . De Nadai AS, Storch EA, McGuire JF, Lewin AB, Murphy TK. Evidence-based pharmacotherapy for pediatric obsessive-compulsive disorder and chronic tic disorders. J Cent Nerve Syst Dis. 2011;3:125–142
   PubMedGoogle Scholar
• . Abramowitz JS. Effectiveness of psychological and pharmacological treatments for obsessive-compulsive disorder: a quantitative review. J Consult Clin Psychol. 1997;65(1):44–52
   PubMed Web of Science ®Google Scholar
• . Simpson HB, Foa EB, Liebowitz MR,. A randomized, controlled trial of cognitive-behavioral therapy for augmenting pharmacotherapy in obsessive-compulsive disorder. Am J Psychiatry. 2008;165(5):621–630
   PubMed Web of Science ®Google Scholar
• . The Clomipramine Collaborative Study Group. Clomipramine in the treatment of patients with obsessive-compulsive disorder. Arch Gen Psychiatry. 1991;48(8):730–738
   PubMed Web of Science ®Google Scholar
• . DeVeaugh–Geiss J, Moroz G, Biederman J,. Clomipramine hydrochloride in childhood and adolescent obsessive-compulsive disorder—a multicenter trial. J Am Acad Child Adolesc Psychiatry. 1992;31(1):45–49
   PubMed Web of Science ®Google Scholar
• . Stein DJ, Spadaccini E, Hollander E. Meta-analysis of pharmacotherapy trials for obsessive-compulsive disorder. Int Clin Psychopharmacol. 1995;10(1):11–18
   PubMed Web of Science ®Google Scholar
• . Freeman CP, Trimble MR, Deakin JF, Stokes TM, Ashford JJ. Fluvoxamine versus clomipramine in the treatment of obsessive compulsive disorder: a multicenter, randomized, double-blind, parallel group comparison. J Clin Psychiatry. 1994;55(7):301–305
   PubMed Web of Science ®Google Scholar
• . Koran LM, McElroy SL, Davidson JR, Rasmussen SA, Hollander E, Jenike MA. Fluvoxamine versus clomipramine for obsessive-compulsive disorder: a double-blind comparison. J Clin Psychopharmacol. 1996; 16(2):121–129
   PubMed Web of Science ®Google Scholar
• . Geller DA, Wagner KD, Emslie G,. Paroxetine treatment in children and adolescents with obsessive-compulsive disorder: a randomized, multicenter, double-blind, placebo-controlled trial. J Am Acad Child Adolesc Psychiatry. 2004;43(11):1387–1396
   PubMed Web of Science ®Google Scholar
• . Jenike MA, Baer L, Minichiello WE, Rauch SL, Buttolph ML. Placebo-controlled trial of fluoxetine and phenelzine for obsessive-compulsive disorder. Am J Psychiatry. 1997;154(9):1261–1264
   PubMed Web of Science ®Google Scholar
• . Zohar J, Judge R. Paroxetine versus clomipramine in the treatment of obsessive-compulsive disorder. OCD Paroxetine Study Investigators. Br J Psychiatry. 1996;169(4):468–474
   PubMed Web of Science ®Google Scholar
• . Soomro GM, Altman D, Rajagopal S, Oakley–Browne M. Selective serotonin re-uptake inhibitors (SSRIs) versus placebo for obsessive compulsive disorder (OCD). Cochrane Database Syst Rev. 2008;(1):CD001765
   Google Scholar
• . Kaplan A, Hollander E. Review of pharmacologic treatments for obsessive-compulsive disorder. Psychiatr Serv. 2003;54(8):1111–1118
   PubMed Web of Science ®Google Scholar
• . Bloch MH, McGuire J, Landeros–Weisenberger A, Leckman JF, Pittenger C. Meta-analysis of the dose-response relationship of SSRI in obsessive-compulsive disorder. Mol Psychiatry. 2010;15(8): 850–855
   PubMed Web of Science ®Google Scholar
• . Goodman WK, Murphy TK, Storch EA. Risk of adverse behavioral effects with pediatric use of antidepressants. Psychopharmacology (Berl). 2007;191(1):87–96
   PubMed Web of Science ®Google Scholar
• . Murphy TK, Segarra A, Storch EA, Goodman WK. SSRI adverse events: how to monitor and manage. Int Rev Psychiatry. 2008;20(2): 203–208
   PubMed Web of Science ®Google Scholar
• . Bridge JA, Iyengar S, Salary CB,. Clinical response and risk for reported suicidal ideation and suicide attempts in pediatric antidepressant treatment: a meta-analysis of randomized controlled trials. JAMA. 2007;297(15):1683–1696
   PubMed Web of Science ®Google Scholar
• . Goodman WK, McDougle CJ, Barr LC, Aronson SC, Price LH. Biological approaches to treatment-resistant obsessive compulsive disorder. J Clin Psychiatry. 1993;54( suppl):16–26
   PubMed Web of Science ®Google Scholar
• . Simpson HB, Huppert JD, Petkova E, Foa EB, Liebowitz MR. Response versus remission in obsessive-compulsive disorder. J Clin Psychiatry. 2006;67(2):269–276
   PubMed Web of Science ®Google Scholar
• . McDougle CJ, Goodman WK, Leckman JF, Lee NC, Heninger GR, Price LH. Haloperidol addition in fluvoxamine-refractory obsessive-compulsive disorder: a double-blind, placebo-cotrolled study in patients with and without tics. Arch Gen Psychiatry. 1994;51(4):302–308
   PubMed Web of Science ®Google Scholar
• . Muscatello MR, Bruno A, Pandolfo G,. Effect of aripiprazole augmentation of serotonin reuptake inhibitors or clomipramine in treatment-resistant obsessive-compulsive disorder: a double-blind, placebo-controlled study. J Clin Psychopharmacol. 2011;31(2): 174–179
   PubMed Web of Science ®Google Scholar
• . Masi G, Pfanner C, Millepiedi S, Berloffa S. Aripiprazole augmentation in 39 adolescents with medication-resistant obsessive-compulsive disorder. J Clin Psychopharmacol. 2010;30(6):688–693
   PubMed Web of Science ®Google Scholar
• . Denys D, de Geus F, van Megen HJ, Westenberg HG. A double-blind, randomized, placebo-controlled trial of quetiapine addition in patients with obsessive-compulsive disorder refractory to serotonin reuptake inhibitors. J Clin Psychiatry. 2004;65(8):1040–1048
   PubMed Web of Science ®Google Scholar
• . Fineberg NA, Sivakumaran T, Roberts A, Gale T. Adding quetiapine to SRI in treatment-resistant obsessive-compulsive disorder: a randomized controlled treatment study. Int Clin Psychopharmacol. 2005;20(4):223–226
   PubMed Web of Science ®Google Scholar
• . Kordon A, Wahl K, Koch N,. Quetiapine addition to serotonin reuptake inhibitors in patients with severe obsessive-compulsive disorder: a double-blind, randomized, placebo-controlled study. J Clin Psychopharmacol. 2008;28(5):550–554
   PubMed Web of Science ®Google Scholar
• . Vulink NC, Denys D, Fluitman SB, Meinardi JC, Westenberg HG. Quetiapine augments the effect of citalopram in non-refractory obsessive-compulsive disorder: a randomized, double-blind, placebo-controlled study of 76 patients. J Clin Psychiatry. 2009;70(7):1001–1008
   PubMed Web of Science ®Google Scholar
• . McDougle CJ, Epperson CN, Pelton GH, Wasylink S, Price LH. A double-blind, placebo-controlled study of risperidone addition in serotonin reuptake inhibitor-refractory obsessive-compulsive disorder. Arch Gen Psychiatry. 2000;57(8):794–801
   PubMed Web of Science ®Google Scholar
• . Diniz JB, Shavitt RG, Pereira CA,. Quetiapine versus clomipramine in the augmentation of selective serotonin reuptake inhibitors for the treatment of obsessive-compulsive disorder: a randomized, open-label trial. J Psychopharmacol. 2010;24(3):297–307
   PubMed Web of Science ®Google Scholar
• . Crockett BA, Churchill E, Davidson JR. A double-blind combination study of clonazepam with sertraline in obsessive-compulsive disorder. Ann Clin Psychiatry. 2004;16(3):127–132
   PubMedGoogle Scholar
• . Komossa K, Depping AM, Meyer M, Kissling W, Leucht S. Second-generation antipsychotics for obsessive compulsive disorder. Cochrane Database Syst Rev. 2010;(12):CD008141
   Google Scholar
• . Pessina E, Albert U, Bogetto F, Maina G. Aripiprazole augmentation of serotonin reuptake inhibitors in treatment-resistant obsessive-compulsive disorder: a 12-week open-label preliminary study. Int Clin Psychopharmacol. 2009;24(5):265–269
   PubMed Web of Science ®Google Scholar
• . Lewin AB, Storch EA, Storch HD. Risks from antipsychotic medications in children and adolescents. JAMA. 2010;303(8):729–730
   PubMedGoogle Scholar
• . Matsunaga H, Nagata T, Hayashida K, Ohya K, Kiriike N, Stein DJ. A long-term trial of the effectiveness and safety of atypical antipsychotic agents in augmenting SSRI-refractory obsessive-compulsive disorder. J Clin Psychiatry. 2009;70(6):863–868
   PubMed Web of Science ®Google Scholar
• . Hezel DM, Beattie K, Stewart SE. Memantine as an augmenting agent for severe pediatric OCD. Am J Psychiatry. 2009;166(2):237
   PubMed Web of Science ®Google Scholar
• . Lafleur DL, Pittenger C, Kelmendi B,. N-acetylcysteine augmentation in serotonin reuptake inhibitor refractory obsessive-compulsive disorder. Psychopharmacology (Berl). 2006;184(2):254–256
   PubMed Web of Science ®Google Scholar
• . Hollander E, Kwon JH, Stein DJ, Broatch J, Rowland CT, Himelein CA. Obsessive-compulsive and spectrum disorders: overview and quality of life issues. J Clin Psychiatry. 1996;57( suppl 8):3–6
   PubMed Web of Science ®Google Scholar
• . Chowdhury U, Frampton I, Heyman I. Clinical characteristics of young people referred to an obsessive compulsive disorder clinic in the United Kingdom. Clin Child Psychol Psychiatry. 2004;9(3):395–401
   Google Scholar
• . Blanco C, Olfson M, Stein DJ, Simpson HB, Gameroff MJ, Narrow WH. Treatment of obsessive-compulsive disorder by U.S. psychiatrists. J Clin Psychiatry. 2006;67(6):946–951
   PubMed Web of Science ®Google Scholar
• . Stewart SE, Stack DE, Farrell C, Pauls DL, Jenike MA. Effectiveness of intensive residential treatment (IRT) for severe, refractory obsessive-compulsive disorder. J Psychiatr Res. 2005;39(6):603–609
   PubMed Web of Science ®Google Scholar
• . Mundo E, Maina G, Uslenghi C. Multicentre, double-blind, comparison of fluvoxamine and clomipramine in the treatment of obsessive-compulsive disorder. Int Clin Psychopharmacol. 2000;15(2): 69–76
   PubMed Web of Science ®Google Scholar
• . Goodman WK, Price LH, Rasmussen SA, Delgado PL, Heninger GR, Charney DS. efficacy of fluvoxamine in obsessive-compulsive disorder: a double-blind comparison with placebo. Arch Gen Psychiatry. 1989;46(1):36–44
   PubMed Web of Science ®Google Scholar
• . Goodman WK, Kozak MJ, Liebowitz M, White KL. Treatment of obsessive-compulsive disorder with fluvoxamine: a multicentre, double-blind, placebo-controlled trial. Int Clin Psychopharmacol. 1996;11(1):21–29
   PubMed Web of Science ®Google Scholar
• . Hollander E, Koran LM, Goodman WK,. A double-blind, placebo-controlled study of the efficacy and safety of controlled-release fluvoxamine in patients with obsessive-compulsive disorder. J Clin Psychiatry. 2003;64(6):640–647
   PubMed Web of Science ®Google Scholar
• . Jenike MA, Hyman S, Baer L,. A controlled trial of fluvoxamine in obsessive-compulsive disorder: implications for a serotonergic theory. Am J Psychiatry. 1990;147(9):1209–1215
   PubMed Web of Science ®Google Scholar
• . Riddle MA, Reeve EA, Yaryura–Tobias JA,. Fluvoxamine for children and adolescents with obsessive-compulsive disorder: a randomized, controlled, multicenter trial. J Am Acad Child Adolesc Psychiatry. 2001;40(2):222–229
   PubMed Web of Science ®Google Scholar
• . Kamijima K, Murasaki M, Asai M,. Paroxetine in the treatment of obsessive-compulsive disorder: randomized, double-blind, placebo-controlled study in Japanese patients. Psychiatry Clin NeuroSci. 2004;58(4):427–433
   PubMed Web of Science ®Google Scholar
• . Koran LM, Hackett E, Rubin A, Wolkow R, Robinson D. efficacy of sertraline in the long-term treatment of obsessive-compulsive disorder. Am J Psychiatry. 2002;159(1):88–95
   PubMed Web of Science ®Google Scholar
• . Greist JH, Jefferson JW, Kobak KA,. A 1 year double-blind placebo-controlled fixed dose study of sertraline in the treatment of obsessive-compulsive disorder. Int Clin Psychopharmacol. 1995; 10(2):57–65
   PubMed Web of Science ®Google Scholar
• . Jenike MA, Baer L, Summergrad P, Minichiello WE, Holland A, Seymour R. Sertraline in obsessive-compulsive disorder: a double-blind comparison with placebo. Am J Psychiatry. 1990;147(7): 923–928
   PubMed Web of Science ®Google Scholar
• . Kronig MH, Apter J, Asnis G,. Placebo-controlled, multicenter study of sertraline treatment for obsessive-compulsive disorder. J Clin Psychopharmacol. 1999;19(2):172–176
   PubMed Web of Science ®Google Scholar
• . Bergeron R, Ravindran AV, Chaput Y,. Sertraline and fluoxetine treatment of obsessive-compulsive disorder: results of a double-blind, 6-month treatment study. J Clin Psychopharmacol. 2002;22(2): 148–154
   PubMed Web of Science ®Google Scholar
• . March JS, Biederman J, Wolkow R,. Sertraline in children and adolescents with obsessive-compulsive disorder: a multicenter randomized controlled trial. JAMA. 1998;280(20):1752–1756
   PubMed Web of Science ®Google Scholar
• . Montgomery SA, Kasper S, Stein DJ, Bang Hedegaard K, Lemming OM. Citalopram 20 mg, 40 mg and 60 mg are all effective and well tolerated compared with placebo in obsessive-compulsive disorder. Int Clin Psychopharmacol. 2001;16(2):75–86
   PubMed Web of Science ®Google Scholar
• . Alaghband–Rad J, Hakimshooshtary M. A randomized controlled clinical trial of citalopram versus fluoxetine in children and adolescents with obsessive-compulsive disorder (OCD). Eur Child Adolesc Psychiatry. 2009;18(3):131–135
   PubMed Web of Science ®Google Scholar
• . Stein DJ, Andersen EW, Tonnoir B, Fineberg N. Escitalopram in obsessive-compulsive disorder: a randomized, placebo-controlled, paroxetine-referenced, fixed-dose, 24-week study. Curr Med Res Opin. 2007;23(4):701–711
   PubMed Web of Science ®Google Scholar
• . Montgomery SA, McIntyre A, Osterheider M,. A double-blind, placebo-controlled study of fluoxetine in patients with DSM-III-R obsessive-compulsive disorder. The Lilly European OCD Study Group. Eur Neuropsychopharmacol. 1993;3(2):143–152
   PubMedGoogle Scholar
• . Tollefson GD, Rampey AH, Potvin JH,. A multicenter investigation of fixed-dose fluoxetine in the treatment of obsessive-compulsive disorder. Arch Gen Psychiatry. 1994;51(7):559–567
   PubMed Web of Science ®Google Scholar
• . Liebowitz MR, Turner SM, Piacentini J,. Fluoxetine in children and adolescents with OCD: a placebo-controlled trial. J Am Acad Child Adolesc Psychiatry. 2002;41(12):1431–1438
   PubMed Web of Science ®Google Scholar
• . Riddle MA, Scahill L, King RA,. Double-blind, crossover trial of fluoxetine and placebo in children and adolescents with obsessive-compulsive disorder. J Am Acad Child Adolesc Psychiatry. 1992;31(6): 1062–1069
   PubMed Web of Science ®Google Scholar
• . Geller DA, Hoog SL, Heiligenstein JH,; Fluoxetine Pediatric OCD Study Team. Fluoxetine treatment for obsessive-compulsive disorder in children and adolescents: a placebo-controlled clinical trial. J Am Acad Child Adolesc Psychiatry. 2001;40(7):773–779
   PubMed Web of Science ®Google Scholar
• . Barrett P, Healy–Farrell L, March JS. Cognitive-behavioral family treatment of childhood obsessive-compulsive disorder: a controlled trial. J Am Acad Child Adolesc Psychiatry. 2004;43(1):46–62
   PubMed Web of Science ®Google Scholar
• . de Haan E, Hoogduin KA, Buitelaar JK, Keijsers GP. Behavior therapy versus clomipramine for the treatment of obsessive-compulsive disorder. J Am Acad Child Adolesc Psychiatry. 1998;37(10):1022–1029
   PubMed Web of Science ®Google Scholar
• . Vogel PA, Stiles TC, Götestam KG. Adding cognitive therapy elements to exposure therapy for obsessive compulsive disorder: a controlled study. Behav Cogn Psychother. 2004;32(3):275–290
   Web of Science ®Google Scholar
• . Greist JH, Marks IM, Baer L,. Behavior therapy for obsessive-compulsive disorder guided by a computer or by a clinician compared with relaxation as a control. J Clin Psychiatry. 2002;63(2):138–145
   PubMed Web of Science ®Google Scholar
• . Freeman JB, Garcia AM, Coyne L,. Early childhood OCD: preliminary findings from a family-based cognitive-behavioral approach. J Am Acad Child Adolesc Psychiatry. 2008;47(5):593–602
   PubMed Web of Science ®Google Scholar
• . Whittal ML, Thordarson DS, McLean PD. Treatment of obsessive-compulsive disorder: Cognitive behavior therapy vs. exposure and response prevention. Behav Res Ther. 2005;43(12):1559–1576
   PubMed Web of Science ®Google Scholar
• . Cottraux J, Note I, Yao SN,. A randomized controlled trial of cognitive therapy versus intensive behavior therapy in obsessive compulsive disorder. Psychother Psychosom. 2001;70(6):288–297
   PubMed Web of Science ®Google Scholar
• . Lindsay M, Crino R, Andrews G. Controlled trial of exposure and response prevention in obsessive-compulsive disorder. Br J Psychiatry. 1997;171:135–139
   PubMed Web of Science ®Google Scholar
• . Fals–Stewart W, Marks AP, Schafer J. A comparison of behavioral group therapy and individual behavior therapy in treating obsessive-compulsive disorder. J Nerv Ment Dis. 1993;181(3):189–193
   PubMed Web of Science ®Google Scholar
• . van Balkom AJ, de Haan E, van Oppen P, Spinhoven P, Hoogduin KA, van Dyck R. Cognitive and behavioral therapies alone versus in combination with fluvoxamine in the treatment of obsessive compulsive disorder. J Nerv Ment Dis. 1998;186(8):492–499
   PubMed Web of Science ®Google Scholar