COPD and Associated Comorbidities: A Review of Current Diagnosis and Treatment

References

• . Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global Strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. http://www.goldcopd.org. Updated December 2011. Accessed June 26, 2012
   Google Scholar
• . Menzin J, Boulanger L, Marton J, . The economic burden of chronic obstructive pulmonary disease (COPD) in a U.S. Medicare population. Respir Med. 2008;102(9):1248–1256
   PubMed Web of Science ®Google Scholar
• . National Heart, Lung, and Blood Institute. Morbidity and mortality: 2009 chartbook on cardiovascular, lung, and blood diseases. Washington, DC: US Dept of Health and Human Services, Public Health Service, National Institutes of Health; 2009
   Google Scholar
• . Donaldson GC, Seemungal TA, Bhowmik A, Wedzicha JA. Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease. Thorax. 2002;57(10): 847–852
   PubMed Web of Science ®Google Scholar
• . Spencer S, Jones PW. Time course of recovery of health status following an infective exacerbation of chronic bronchitis. Thorax. 2003;58(7):589–593
   PubMed Web of Science ®Google Scholar
• . Jones PW, Brusselle G, Dal Negro RW, . Health-related quality of life in patients by COPD severity within primary care in Europe. Respir Med. 2011;105(1):57–66
   PubMed Web of Science ®Google Scholar
• . Anderson G. Chronic care: making the case for ongoing care. Princeton, NJ: Robert Wood Johnson Foundation. http://www.rwjf.org/files/research/50968chronic.care.chartbook.pdf. Accessed June 2011
   Google Scholar
• . Martinez FJ, Raczek AE, Seifer FD, ; COPD-PS Clinician Working Group. Development and initial validation of a self-scored COPD Population Screener Questionnaire (COPD-PS). COPD. 2008;5(2):85–95
   PubMedGoogle Scholar
• . Yawn BP, Mapel DW, Mannino DM, ; Lung Function Questionnaire Working Group. Development of the Lung Function Questionnaire (LFQ) to identify airflow obstruction. Int J Chron Obstruct Pulmon Dis. 2010;5:1–10
   PubMedGoogle Scholar
• . ZuWallack R. How are you doing? What are you doing? Differing perspectives in the assessment of individuals with COPD. COPD. 2007;4(3):293–297
   PubMedGoogle Scholar
• . O'Donnell DE, Hernandez P, Kaplan A, . Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease—2008 update—highlights for primary care. Can Respir J. 2008;15( suppl A):1A–8A
   PubMed Web of Science ®Google Scholar
• . American Thoracic Society and European Respiratory Society. Standards for the diagnosis and management of patients with COPD. New York/Lausanne, Switzerland. http://www.copd-ats-ers.org/copddoc.pdf. Accessed May 2010
   Google Scholar
• . Ferguson GT, Enright PL, Buist AS, Higgins MW. Office spirometry for lung health assessment in adults: a consensus statement from the National Lung Health Education Program. Chest. 2000;117(4):1146–1161
   PubMed Web of Science ®Google Scholar
• . Bateman E, Boulet L, Cruz A, . Pocket guide for asthma prevention (for adults and children older than 5 years). A pocket guide for physicians and nurses. http://www.ginasthma.org/pdf/GINA_Pocket_2010a.pdf. Last updated 2010. Accessed September 28, 2011
   Google Scholar
• . Management of Asthma Working Group. VA/DoD clinical practice guideline for management of asthma in children and adults. Washington, DC: Department of Veterans Affairs, Department of Defense; 2009. http://www.guideline.gov/content.aspx?id=15706. Last updated 2009. Accessed September 28, 2011
   Google Scholar
• . Tinkelman DG, Price DB, Nordyke RJ, . Symptom-based questionnaire for differentiating COPD and asthma. Respiration. 2006;73(3):296–305
   PubMed Web of Science ®Google Scholar
• . McGoon M, Gutterman D, Steen V, ; American College of Chest Physicians. Screening, early detection, and diagnosis of pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines. Chest. 2004;126( 1 suppl):14S–34S
   PubMed Web of Science ®Google Scholar
• . Rich S. Primary pulmonary hypertension: executive summary from the World Symposium on Primary Pulmonary Hypertension. Evian, France: World Health Organization; 1998. http://www.who.int/ncd/cvd/pph.html. Accessed March 1, 2011
   Google Scholar
• . Qaseem A, Snow V, Barry P, ; Joint American Academy of Family Physicians/American College fo Physicians Panel on Deep Venous Thrombosis/Pulmonary Embolism. Current diagnosis of venous thromboembolism in primary care: a clinical practice guideline from the American Academy of Family Physicians and the American College of Physicians. Ann Fam Med. 2007;5(1):57–62
   PubMed Web of Science ®Google Scholar
• . Torbicki A, Perrier A, Konstantinides S, ; ESC Committee for Practice Guidelines (CPG). Guidelines on the diagnosis and management of acute pulmonary embolism: the Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC). Eur Heart J. 2008;29(18):2276–2315
   PubMed Web of Science ®Google Scholar
• . American College of Chest Physicians. Lung cancer…am I at risk? Patient education guide. Northbrook, IL. http://accpstorage.org/newOrganization/patients/lungCancer5045.pdf. Accessed February 24, 2011
   Google Scholar
• . National Guideline Clearinghouse (NGC-5930). Initial diagnosis of lung cancer: ACCP evidence-based clinical practice guidelines. Rockville, MD: US Department of Health and Human Services; 2007. http://www.guideline.gov/content.aspx?id=11411&search=lung+cancer. Accessed January 10, 2011
   Google Scholar
• . Antman EM, Cohen M, Bernink PJ, . The TIMI risk score for unstable angina/non-ST elevation MI: a method for prognostication and therapeutic decision making. JAMA. 2000;284(7):835–842
   PubMed Web of Science ®Google Scholar
• . National Guideline Clearinghouse (NGC-7228). Coronary artery disease (CAD) clinical practice guidelines. Oakland, CA: Kaiser Permanente Care Management Institute; 2008. http://www.guideline.gov/content.aspx?id=14438. Accessed March 2, 2011
   Google Scholar
• . Wilson PW, D'Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB. Prediction of coronary heart disease using risk factor categories. Circulation. 1998;97(18):1837–1847
   PubMed Web of Science ®Google Scholar
• . Wijeysundera HC, Tomlinson G, Norris CM, Ghali WA, Ko DT, Krahn MD. Predicting EQ-5D utility scores from the Seattle Angina Questionnaire in coronary artery disease: a mapping algorithm using a Bayesian framework. Med Decis Making. 2011;31(3):481–493
   PubMedGoogle Scholar
• . National Guideline Clearinghouse (NGC-8088). Institute for Clinical Systems Improvement guidelines for diagnosis and management of type 2 diabetes mellitus in adults. Bloomington, MN: US Dept of Health and Human Services; 2010. http://www.guideline.gov/content.aspx?id=24137. Last updated 2010. Accessed February 28, 2011
   Google Scholar
• . US Preventive Services Task Force. Screening for peripheral arterial disease: recommendation statement. Am Fam Physician. 2006;73(3):497–500
   PubMedGoogle Scholar
• . Leng GC, Fowkes FG. The Edinburgh Claudication Questionnaire: an improved version of the WHO/Rose Questionnaire for use in epidemiological surveys. J Clin Epidemiol. 1992;45(10):1101–1109
   PubMedGoogle Scholar
• . Rutten FH, Cramer MJ, Grobbee DE, . Unrecognized heart failure in elderly patients with stable chronic obstructive pulmonary disease. Eur Heart J. 2005;26(18):1887–1894
   PubMed Web of Science ®Google Scholar
• . Criteria Committee of the New York Heart Association. Nomenclature and criteria for diagnosis of diseases of the heart and great vessels. 9th ed. Boston, MA: Little, Brown, and Co; 2011. http://www.americanheart.org/. Accessed February 28, 2011
   Google Scholar
• . Le Jemtel TH, Padeletti M, Jelic S. Diagnostic and therapeutic challenges in patients with coexistent chronic obstructive pulmonary disease and chronic heart failure. J Am Coll Cardiol. 2007;49(2):171–180
   PubMed Web of Science ®Google Scholar
• . National Guideline Clearinghouse (NGC-7986). Heart failure in patients with reduced ejection fraction: HFSA 2010 comprehensive heart failure practice Guideline. Rockville, MD: US Department of Health and Human Services; 2010. http://www.guideline.gov/content.aspx?id=23903&search=heart+failure. Accessed January 8, 2011
   Google Scholar
• . Management of Overweight and Obesity Working Group. VA/DoD clinical practice guideline for screening and management of overweight and obesity. Washington, DC: Department of Veterans Affairs, Department of Defense; 2006. http://www.guideline.gov/content.aspx?id=10714. Accessed September 28, 2011
   Google Scholar
• . Rosenzweig JL, Ferrannini E, Grundy SM, ; Endocrine Society. Primary prevention of cardiovascular disease and type 2 diabetes in patients at metabolic risk: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2008;93(10):3671–3689
   PubMed Web of Science ®Google Scholar
• . Heikes KE, Eddy DM, Arondekar B, Schlessinger L. Diabetes Risk Calculator: a simple tool for detecting undiagnosed diabetes and pre-diabetes. Diabetes Care. 2008;31(5):1040–1045
   PubMedGoogle Scholar
• . Celli BR, Cote CG, Marin JM, . The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease. N Engl J Med. 2004;350(10):1005–1012
   PubMed Web of Science ®Google Scholar
• . Benton MJ, Wagner CL, Alexander JL. Relationship between body mass index, nutrition, strength, and function in elderly individuals with chronic obstructive pulmonary disease. J Cardiopulm Rehabil Prev. 2010;30(4):260–263
   PubMed Web of Science ®Google Scholar
• . Anker SD, Laviano A, Filippatos G, . ESPEN guidelines on parenteral nutrition: on cardiology and pneumology. Clin Nutr. 2009;28(4):455–460
   PubMedGoogle Scholar
• . Anker SD, John M, Pedersen PU, . ESPEN guidelines on enteral nutrition: cardiology and pulmonology. Clin Nutr. 2006; 25(2):311–318
   PubMedGoogle Scholar
• . National Osteoporosis Foundation. Clinician's guide to prevention and treatment of osteoporosis. Washington, DC: National Osteoporosis Foundation; 2010. http://www.nof.org/sites/default/files/pdfs/NOF_ClinicianGuide2009_v7.pdf. Accessed August 31, 2010
   Google Scholar
• . Kanis JA. FRAX® WHO fracture risk assessment tool. http://www.shef.ac.uk/FRAX/index.jsp. Accessed March 3, 2008
   Google Scholar
• . Adshead F, Cody DD, Pitt B. BASDEC: a novel screening instrument for depression in elderly medical inpatients. BMJ. 1992; 305(6850):397
   PubMedGoogle Scholar
• . Kunik ME, Azzam PN, Souchek J, . A practical screening tool for anxiety and depression in patients with chronic breathing disorders. Psychosomatics. 2007;48(1):16–21
   PubMed Web of Science ®Google Scholar
• . Incalzi RA, Corsonello A, Pedone C, Corica F, Carbonin P, Bernabei R. Construct validity of activities of daily living scale: a clue to distinguish the disabling effects of COPD and congestive heart failure. Chest. 2005;127(3):830–838
   PubMed Web of Science ®Google Scholar
• . Folstein MF, Folstein SE, McHugh PR. “Mini—mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189–198
   PubMed Web of Science ®Google Scholar
• . Mahoney FI, Barthel DW. Functional evaluation: the Barthel index. Md State Med J. 1965;14:61–65
   PubMedGoogle Scholar
• . National Guideline Clearinghouse (NGC-6350). Assessing cognitive function. In: Evidence-based geriatric nursing protocols for best practice. New York, NY: Springer Publishing Company; 2008. http://www.guideline.gov/content.aspx?id=12266. Accessed February 28, 2011
   Google Scholar
• . Rascon—Aguilar IE, Pamer M, Wludyka P, Cury J, Vega KJ. Poorly treated or unrecognized GERD reduces quality of life in patients with COPD. Dig Dis Sci. 2011;56(7):1976–1980
   PubMed Web of Science ®Google Scholar
• . Locke GR 3rd, Talley NJ, Fett SL, Zinsmeister AR, Melton LJ 3rd. Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmsted County, Minnesota. Gastroenterology. 1997;112(5):1448–1456
   PubMed Web of Science ®Google Scholar
• . Institute for Clinical Systems Improvement. Major depression in adults in primary care. 14th ed. Bloomington, MN: Institute for Clinical Systems Improvement. http://www.icsi.org/depression_5/depression__major__in_adults_in_primary_care_3.html. Last updated May 2011. Accessed July 29, 2011
   Google Scholar
• . National Guideline Clearinghouse (NGC-8118). Diagnosis and treatment of chest pain and acute coronary syndrome (ACS). Bloomington, MN: Institute for Clinical Systems Improvement; 2010. http://www.guideline.gov/content.aspx?id=24215&search=diagnosis+and+treatment+of+chest+pain+and+acute+coronary+syndrome. Accessed March 4, 2011
   Google Scholar
• . Irwin RS. Chronic cough due to gastroesophageal reflux disease: ACCP evidence-based clinical practice guidelines. Chest. 2006;129( 1 suppl):80S–94S
   PubMed Web of Science ®Google Scholar
• . Global Initiative for Asthma. Pocket guide for asthma prevention (for adults and children older than 5 years). Global Initiative for Asthma; 2010. http://www.ginasthma.org/pdf/GINA_Pocket_2010a.pdf. Accessed January 28, 2011
   Google Scholar
• . Casaburi R. Skeletal muscle dysfunction in chronic obstructive pulmonary disease. Med Sci Sports Exerc. 2001;33( 7 suppl): S662–S670
   PubMed Web of Science ®Google Scholar
• . Meador BM, Huey KA. Statin-associated myopathy and its exacerbation with exercise. Muscle Nerve. 2010;42(4):469–479
   PubMed Web of Science ®Google Scholar
• . Screening for peripheral arterial disease: recommendation statement. Am Fam Physician. 2006;73(3):497–500
   PubMedGoogle Scholar
• . Schneider C, Jick SS, Bothner U, Meier CR. COPD and the risk of depression. Chest. 2010;137(2):341–347
   PubMed Web of Science ®Google Scholar
• . Kulak CA, Borba VC, Jorgetti V, . Skeletal microstructural abnormalities in postmenopausal women with chronic obstructive pulmonary disease. J Bone Miner Res. 2010;25(9):1931–1940
   PubMedGoogle Scholar
• . Spiriva HandiHaler [package insert]. Ridgefield, CT: Boehringer Ingelheim. http://bidocs.boehringer-ingelheim.com/BIWebAccess/ViewServlet.ser?docBase=renetnt&folderPath=/Prescribing+Information/PIs/Spiriva/Spiriva.pdf. Last updated June 2010. Accessed February 17, 2011
   Google Scholar
• . Advair Diskus/Advair [package insert]. Research Triangle Park, NC: GlaxoSmithKline Inc. http://us.gsk.com/products/assets/us_advair.pdf. Last updated June 2010. Accessed February 17, 2011
   Google Scholar
• . Ries AL, Bauldoff GS, Carlin BW, . Pulmonary rehabilitation: joint ACCP/AACVPR evidence-based clinical practice guidelines. Chest. 2007;131( 5 suppl):4S–42S
   PubMed Web of Science ®Google Scholar
• . Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease: a clinical trial. Nocturnal Oxygen Therapy Trial Group. Ann Intern Med. 1980;93(3):391–398
   PubMed Web of Science ®Google Scholar
• . Criner GJ, Cordova F, Sternberg AL, Martinez FJ. The National Emphysema Treatment Trial (NETT). Part II: lessons learned about lung volume reduction surgery. Am J Respir Crit Care Med. 2011;184(8):881–893
   PubMed Web of Science ®Google Scholar
• . Todd JL, Palmer SM. Lung transplantation in advanced COPD: is it worth it? Semin Respir Crit Care Med. 2010;31(3):365–372
   PubMedGoogle Scholar
• . Fabbri LM, Luppi F, Beghé B, Rabe KF. Complex chronic comorbidities of COPD. Eur Respir J. 2008;31(1):204–212
   PubMed Web of Science ®Google Scholar
• . Benzo R, Wigle D, Novotny P, . Preoperative pulmonary rehabilitation before lung cancer resection: Results from two randomized studies. Lung Cancer. 2011;74(3):441–445
   PubMed Web of Science ®Google Scholar
• . Nauser TD, Stites SW. Diagnosis and treatment of pulmonary hypertension. Am Fam Physician. 2001;63(9):1789–1798
   PubMedGoogle Scholar
• . Macnee W. Right heart function in COPD. Semin Respir Crit Care Med. 2010;31(3):295–312
   PubMedGoogle Scholar
• . Lee R, McNicholas WT. Obstructive sleep apnea in chronic obstructive pulmonary disease patients. Curr Opin Pulm Med. 2011;17(2):79–83
   PubMedGoogle Scholar
• . Crowley K. Sleep and sleep disorders in older adults. Neuropsychol Rev. 2011;21(1):41–53
   PubMed Web of Science ®Google Scholar
• . Dancey DR, Hanly PJ, Soong C, Lee B, Shepard J Jr, Hoffstein V. Gender differences in sleep apnea: the role of neck circumference. Chest. 2003;123(5):1544–1550
   PubMed Web of Science ®Google Scholar
• . Soler—Cataluña JJ, Martinez—García MA, Román Sánchez P, Salcedo E, Navarro M, Ochando R. Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease. Thorax. 2005;60(11):925–931
   PubMed Web of Science ®Google Scholar
• . Seemungal TA, Donaldson GC, Paul EA, Bestall JC, Jeffries DJ, Wedzicha JA. Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1998;157(5 pt 1):1418–1422
   PubMed Web of Science ®Google Scholar
• . Niewoehner DE. The role of systemic corticosteroids in acute exacerbation of chronic obstructive pulmonary disease. Am J Respir Med. 2002;1(4):243–248
   PubMedGoogle Scholar
• . Calverley PM, Anderson JA, Celli B, ; TORCH investigators. Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease. N Engl J Med. 2007;356(8):775–789
   PubMed Web of Science ®Google Scholar
• . Hurst JR, Vestbo J, Anzueto A, ; Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators. Susceptibility to exacerbation in chronic obstructive pulmonary disease. N Engl J Med. 2010;363(12):1128–1138
   PubMed Web of Science ®Google Scholar
• . Donaldson GC, Hurst JR, Smith CJ, Hubbard RB, Wedzicha JA. Increased risk of myocardial infarction and stroke following exacerbation of COPD. Chest. 2010;137(5):1091–1097
   PubMed Web of Science ®Google Scholar
• . Gupta P, O'Mahony MS. Potential adverse effects of bronchodilators in the treatment of airways obstruction in older people: recommendations for prescribing. Drugs Aging. 2008;25(5):415–443
   PubMed Web of Science ®Google Scholar
• . Tashkin DP, Celli B, Senn S, ; UPLIFT Study Investigators. A 4-year trial of tiotropium in chronic obstructive pulmonary disease. N Engl J Med. 2008;359(15):1543–1554
   PubMed Web of Science ®Google Scholar
• . Michele TM, Pinheiro S, Iyasu S. The safety of tiotropium—the FDA's conclusions. N Engl J Med. 2010;363(12):1097–1099
   PubMed Web of Science ®Google Scholar
• . Benson MK, Berrill WT, Cruickshank JM, Sterling GS. A comparison of four beta-adrenoceptor antagonists in patients with asthma. Br J Clin Pharmacol. 1978;5(5):415–419
   PubMed Web of Science ®Google Scholar
• . Boudestein LC, Rutten FH, Cramer MJ, Lammers JW, Hoes AW. The impact of concurrent heart failure on prognosis in patients with chronic obstructive pulmonary disease. Eur J Heart Fail. 2009; 11(12):1182–1188
   PubMed Web of Science ®Google Scholar
• . Bashore TM, Granger CB, Hranitzky P, . Congestive heart failure. In: McPhee SJ, Papadakis MA, Rabow MW, eds. Current Medical Diagnosis and Treatment 2011. New York, NY: Lange Medical Books/McGraw-Hill; 2011:317–325
   Google Scholar
• . Kannel WB, Seidman JM, Fercho W, Castelli WP. Vital capacity and congestive heart failure. The Framingham study. Circulation. 1974;49(6):1160–1166
   PubMedGoogle Scholar
• . LeGatt DF. Theophylline toxicity—a consequence of congestive heart failure. Drug Intell Clin Pharm. 1983;17(1):59–60
   PubMedGoogle Scholar
• . Edner M, Jogestrand T, Dahlqvist R. Effect of salbutamol on digoxin pharmacokinetics. Eur J Clin Pharmacol. 1992;42(2):197–201
   PubMedGoogle Scholar
• . Mannino DM, Thorn D, Swensen A, Holguin F. Prevalence and outcomes of diabetes, hypertension and cardiovascular disease in COPD. Eur Respir J. 2008;32(4):962–969
   PubMed Web of Science ®Google Scholar
• . Loukides S, Polyzogopoulos D. The effect of diabetes mellitus on the outcome of patients with chronic obstructive pulmonary disease exacerbated due to respiratory infections. Respiration. 1996;63(3):170–173
   PubMed Web of Science ®Google Scholar
• . van der Molen T. Co-morbidities of COPD in primary care: frequency, relation to COPD, and treatment consequences. Prim Care Respir J. 2010;19(4):326–334
   PubMedGoogle Scholar
• . Howard C, Dupont S, Haselden B, Lynch J, Wills P. The effectiveness of a group cognitive-behavioural breathlessness intervention on health status, mood and hospital admissions in elderly patients with chronic obstructive pulmonary disease. Psychol Health Med. 2010;15(4):371–385
   PubMed Web of Science ®Google Scholar
• . Mannino DM, Homa DM, Akinbami LJ, Ford ES, Redd SC. Chronic obstructive pulmonary disease surveillance—United States, 1971–2000. MMWR Surveill Summ. 2002;51(6):1–16
   Google Scholar
• . Crisafulli E, Gorgone P, Vagaggini B, . Efficacy of standard rehabilitation in COPD outpatients with comorbidities. Eur Respir J. 2010;36(5):1042–1048
   PubMed Web of Science ®Google Scholar
• . Hanania NA, Sharma G, Sharafkhaneh A. COPD in the elderly patient. Semin Respir Crit Care Med. 2010;31(5):596–606
   PubMedGoogle Scholar
• . Biskobing DM. COPD and osteoporosis. Chest. 2002;121(2):609–620
   PubMed Web of Science ®Google Scholar
• . Kanis JA, Johnell O, Oden A, . Smoking and fracture risk: a meta-analysis. Osteoporos Int. 2005;16(2):155–162
   PubMed Web of Science ®Google Scholar
• . National Guideline Clearinghouse (NGC-5852). American Association of Clinical Endocrinologists medical guidelines for clinical practice for the management of diabetes mellitus. Prevention of type 2 diabetes mellitus. US Dept of Health and Human Services. http://www.guideline.gov/content.aspx?id=11093&search=diabetes. Accessed January 10, 2011
   Google Scholar
• . National Guideline Clearinghouse (NGC-7985). Nonpharmacologic management and health care maintenance of patients with chronic heart failure: HFSA 2010 comprehensive heart failure practice guideline. St. Paul, MN: Heart Failure Society of America. http://www.guideline.gov/content.aspx?id=23902. Last updated June 2010. Accessed March 4, 2011
   Google Scholar
• . Couillard A, Muir JF, Veale D. COPD recent findings: impact on clinical practice. COPD. 2010;7(3):204–213
   PubMedGoogle Scholar
• . Sava F, Laviolette L, Bernard S, Breton MJ, Bourbeau J, Maltais F. The impact of obesity on walking and cycling performance and response to pulmonary rehabilitation in COPD. BMC Pulm Med. 2010;10:55
   PubMed Web of Science ®Google Scholar
• . Evans RA, Singh SJ, Collier R, Loke I, Steiner MC, Morgan MD. Generic, symptom based, exercise rehabilitation; integrating patients with COPD and heart failure. Respir Med. 2010;104(10):1473–1481
   PubMed Web of Science ®Google Scholar
• . Fromer L, Barnes T, Garvey C, Ortiz G, Saver DF, Yawn B. Innovations to achieve excellence in COPD diagnosis and treatment in primary care. Postgrad Med. 2010;122(5):150–164
   PubMed Web of Science ®Google Scholar
• . National Committee for Quality Assurance. PCMH 2011 Standards. Washington, DC: National Committee for Quality Assurance; 2011
   Google Scholar
• . Steinhauser KE, Arnold RM, Olsen MK, . Comparing three life-limiting diseases: does diagnosis matter or is sick, sick? J Pain Symptom Manage. 2011;42(3):331–341
   PubMedGoogle Scholar
• . Katz P, Morris A, Gregorich S, . Valued life activity disability played a significant role in self-rated health among adults with chronic health conditions. J Clin Epidemiol. 2009;62(2):158–166
   PubMedGoogle Scholar
• . Corsonello A, Pedone C, Incalzi RA. Age-related pharmacokinetic and pharmacodynamic changes and related risk of adverse drug reactions. Curr Med Chem. 2010;17(6):571–584
   PubMed Web of Science ®Google Scholar
• . Geller DE. Comparing clinical features of the nebulizer, metered-dose inhaler, and dry powder inhaler. Respir Care. 2005;50(10):1313–1321; discussion 1321–1312
   PubMedGoogle Scholar
• . Melani AS, Bracci LS, Rossi M. Reduced peak inspiratory effort through the Diskus((R)) and the Turbuhaler((R)) due to mishandling is common in clinical practice. Clin Drug Investig. 2005; 25(8):543–549
   PubMed Web of Science ®Google Scholar
• . Jarvis S, Ind PW, Shiner RJ. Inhaled therapy in elderly COPD patients; time for re-evaluation? Age Ageing. 2007;36(2):213–218
   PubMed Web of Science ®Google Scholar
• . Gooneratne NS, Patel NP, Corcoran A. Chronic obstructive pulmonary disease diagnosis and management in older adults. J Am Geriatr Soc. 2010;58(6):1153–1162
   PubMedGoogle Scholar
• . Steinman MA, Hanlon JT. Managing medications in clinically complex elders: “There's got to be a happy medium.” JAMA. 2010;304(14):1592–1601
   PubMed Web of Science ®Google Scholar
• . Kronman AC, Ash AS, Freund KM, Hanchate A, Emanuel EJ. Can primary care visits reduce hospital utilization among Medicare beneficiaries at the end of life? J Gen Intern Med. 2008;23(9): 1330–1335
   PubMed Web of Science ®Google Scholar
• . Castaldi PJ, Rogers WH, Safran DG, Wilson IB. Inhaler costs and medication nonadherence among seniors with chronic pulmonary disease. Chest. 2010;138(3):614–620
   PubMed Web of Science ®Google Scholar
• . Lanken PN, Terry PB, Delisser HM, ; ATS End-of-Life Care Task Force. An official American Thoracic Society clinical policy statement: palliative care for patients with respiratory diseases and critical illnesses. Am J Respir Crit Care Med. 2008;177(8):912–927
   PubMed Web of Science ®Google Scholar