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Clinical Focus: Protocols and Treatment Options for Cardiovascular Disease

Antiplatelet Drug Use in Patients with Non-ST-Segment Elevation Acute Coronary Syndromes

, MD, FACC, FAHA
Pages 51-58 | Published online: 13 Mar 2015

References

  • . Théroux P, Lidón R. Unstable angina: pathogenesis, diagnosis, and treatment. Curr Probl Cardiol. 1993;18(3):157–231
  • . Chesebro JH, Fuster V. Thrombosis in unstable angina. N Engl J Med. 1992;327(3):192–194
  • . Rizik D, Healy S, Margulis A, . A new clinical classification for hospital prognosis of unstable angina pectoris. Am J Cardiol. 1995;75(15):993–997
  • . Braunwald E, Antman EM, Beasley JW, . ACC/AHA guidelines for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction: executive summary and recommendations. A report of the American College of Cardiology/American Heart Association task force on practice guidelines (committee on the management of patients with unstable angina). Circulation. 2000;102(10):1193–1209
  • . Hardisty RM, Powling MJ, Nokes TJ. The action of ticlopidine on human platelets. Studies on aggregation, secretion, calcium mobilization and membrane glycoproteins. Thromb Haemost. 1990;64(1):145–150
  • . Lewis HD Jr, Davis JW, Archibald DG, . Protective effects of aspirin against acute myocardial infarction and death in men with unstable angina. Results of a Veterans Administration Cooperative Study. N Engl J Med. 1983;309(7):396–403
  • . Cairns JA, Gent M, Singer J, . Aspirin, sulfinpyrazone, or both in unstable angina. Results of a Canadian multicenter trial. N Engl J Med. 1985;313(22):1369–1375
  • . Théroux P, Ouimet H, McCans J, . Aspirin, heparin, or both to treat acute unstable angina. N Engl J Med. 1988;319(17):1105–1111
  • . Wallentin LC. Aspirin (75 mg/day) after an episode of unstable coronary artery disease: long-term effects on the risk for myocardial infarction, occurrence of severe angina and the need for revascularization. Research Group on Instability in Coronary Artery Disease in Southeast Sweden. J Am Coll Cardiol. 1991;18(7):1587–1593
  • . Borzak S, Cannon CP, Kraft PL, . Effects of prior aspirin and anti-ischemic therapy on outcome of patients with unstable angina. TIMI 7 Investigators. Thrombin Inhibition in Myocardial Ischemia. Am J Cardiol. 1998;81(6):678–681
  • . Alexander JH, Harrington RA, Tuttle RH, . Prior aspirin use predicts worse outcomes in patients with non-ST-elevation acute coronary syndromes. PURSUIT Investigators. Platelet IIb/IIIa in Unstable angina: Receptor Suppression Using Integrum Therapy. Am J Cardiol. 1999;83(8):1147–1151
  • . Antithrombotic Trialists' Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ. 2002;324(7329):71–86
  • . Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. ISIS-2 (Second International Study of Infarct Survival) Collaborative Group. Lancet. 1988;2(8607):349–360
  • . Wright RS, Anderson JL, Adams CD, . 2011 ACCF/AHA focused update of the Guidelines for the Management of Patients with Unstable Angina/Non-ST-Elevation Myocardial Infarction (updating the 2007 guideline): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines developed in collaboration with the American College of Emergency Physicians, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. J Am Coll Cardiol. 2011;57(19):1920–1959
  • . Ibáñez L, Vidal X, Vendrell L, Moretti U, Laporte JR; Spanish-Italian Collaborative Group for the Epidemiology of Gastrointestinal Bleeding. Upper gastrointestinal bleeding associated with antiplatelet drugs. Aliment Pharmacol Ther. 2006;23(2):235–242
  • . Hollopeter G, Jantzen HM, Vincent D, . Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature. 2001;409(6817):202–207
  • . Savi P, Pereillo JM, Uzabiaga MF, . Identification and biological activity of the active metabolite of Clopidogrel. Thromb Haemost. 2000;84(5):891–896
  • . Balsano F, Rizzon P, Violi F, . Antiplatelet treatment with ticlopidine in unstable angina. A controlled multicenter clinical trial. The Studio della Ticlopidina nell' Angina Instabile Group. Circulation. 1990;82(1):17–26
  • . Yusuf S, Zhao F, Mehta SR, Chrolavicius S, Tognoni G, Fox KK; Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators. Effects of Clopidogrel in addition to aspirin inpatients with acute coronary syndromes without ST-segment elevation. N Engl J Med. 2001;345(7):494–502
  • . Peters RJ, Mehta SR, Fox KA, ; Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) Trial Investigators. Effects of aspirin dose when used alone or in combination with Clopidogrel in patients with acute coronary syndromes: observations from the Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) study. Circulation. 2003;108(14):1682–1687
  • . Budaj A, Yusuf S, Mehta SR, ; Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) Trial Investigators. Benefit of Clopidogrel in patients with acute coronary syndromes without ST-segment elevation in various risk groups. Circulation. 2002;106(13):1622–1626
  • . Mehta SR, Yusuf S, Peters RJ, ; Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) Trial Investigators. Effects of pretreatment with Clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. Lancet. 2001;358(9281):527–533
  • . Steinhubl SR, Berger PB, Mann JT 3rd, ; CREDO Investigators; Clopidogrel for the Reduction of Events During Observation. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial. JAMA. 2002;288(19):2411–2420
  • . Mehta SR, Bassand JP, Chrolavicius S, ; CURRENT-OASIS 7 Investigators. Dose comparisons of Clopidogrel and aspirin in acute coronary syndromes. N Engl J Med. 2010;363(10):930–942
  • . Pierre—Louis B, Aronow WS, Yoon JH, . Risk factors for major bleeding and for minor bleeding after percutaneous coronary intervention in 634 consecutive patients with acute coronary syndromes. Am J Ther. 2010;17(4):e74–e77
  • . Feldman DN, Fakorede F, Minutello RM, Bergman G, Moussa I, Wong SC. Efficacy of high-dose Clopidogrel treatment (600 mg) less than two hours before percutaneous coronary intervention in patients with non-ST-segment elevation acute coronary syndromes. Am J Cardiol. 2010;105(3):323–332
  • . Paré G, Mehta SR, Yusuf S, . Effects of CYP2C19 genotype on outcomes of Clopidogrel treatment. N Engl J Med. 2010;363(18):1704–1714
  • . Wiviott SD, Trenk D, Frelinger AL, ; PRINCIPLE-TIMI 44 Investigators. Prasugrel compared with high loading- and maintenance-dose Clopidogrel in patients with planned percutaneous coronary intervention: the Prasugrel in Comparison to Clopidogrel for Inhibition of Platelet Activation and Aggregation-Thrombolysis in Myocardial Infarction 44 trial. Circulation. 2007;116(25):2923–2932
  • . Wiviott SD, Braunwald E, McCabe CH, ; TRITON-TIMI 38 Investigators. Prasugrel versus Clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2007;357(20):2001–2015
  • . Wiviott SD, Braunwald E, McCabe CH, ; TRITON-TIMI 38 Invesitgators. Intensive oral antiplatelet therapy for reduction of ischaemic events including stent thrombosis in patients with acute coronary syndromes treated with percutaneous coronary intervention and stenting in the TRITON-TIMI 38 trial: a subanalysis of a randomised trial. Lancet. 2008;371(9621):1353–1363
  • . Wiviott SD, Braunwald E, Angiolillo DJ, ; TRITON-TIMI 38 Investigators. Greater clinical benefit of more intensive oral antiplatelet therapy with prasugrel in patients with diabetes mellitus in the trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with prasugrel-Thrombolysis in Myocardial Infarction 38. Circulation. 2008;118(16):1626–1636
  • . Fuster V, Farkouh ME. Acute coronary syndromes and diabetes mellitus: a winning ticket for prasugrel [editorial]. Circulation. 2008;118(16):1607–1608
  • . O'Donoghue ML, Braunwald E, Antman EM, . Pharmacodynamic effect and clinical efficacy of Clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials. Lancet. 2009;374(9694):989–997
  • . Husted S, Emanuelsson H, Heptinstall S, Sandset PM, Wickens M, Peters G. Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: a double-blind comparison to Clopidogrel with aspirin. Eur Heart J. 2006;27(9):1038–1047
  • . Nawarskas JJ, Clark SM. Ticagrelor: a novel reversible oral antiplatelet agent. Cardiol Rev. 2011;19(2):95–100
  • . Gurbel PA, Bliden KP, Butler K, . Randomized double-blind assessment of the ONSET and OFFSET of the antiplatelet effects of ticagrelor versus Clopidogrel in patients with stable coronary artery disease: the ONSET/OFFSET study. Circulation. 2009;120(25):2577–2585
  • . Wallentin L, Becker RC, Budaj A, ; PLATO Investigators. Ticagrelor versus Clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2009;361(11):1045–1057
  • . Armstrong PW, Siha H, Fu Y, . ST-elevation acute coronary syndromes in the Platelet Inhibition and Patient Outcomes (PLATO) trial: insights from the ECG substudy. Circulation. 2012;125(3):514–521
  • . Gaglia MA Jr, Waksman R. Overview of the 2010 Food and Drug Administration Cardiovascular and Renal Drugs Advisory Committee meeting regarding ticagrelor. Circulation. 2011;123(4):451–456
  • . Cannon CP, Harrington RA, James S, ; PLATelet inhibition and patient Outcomes Investigators. Comparison of ticagrelor with Clopidogrel in patients with a planned invasive strategy for acute coronary syndromes (PLATO): a randomised double-blind study. Lancet. 2010;375(9711):283–293
  • . Held C, Asenblad N, Bassand JP, . Ticagrelor versus Clopidogrel in patients with acute coronary syndromes undergoing coronary artery bypass surgery: results from the PLATO (Platelet Inhibition and Patient Outcomes) trial. J Am Coll Cardiol. 2011;57(6):672–684
  • . James S, Budaj A, Aylward P, . Ticagrelor versus Clopidogrel in acute coronary syndromes in relation to renal function: results from the Platelet Inhibition and Patient Outcomes (PLATO) trial. Circulation. 2010;122(11):1056–1067
  • . Gurbel PA, Bliden KP, Butler K, . Response to ticagrelor in Clopidogrel nonresponders and responders and effect of switching therapies: the RESPOND study. Circulation. 2010;121(10):1188–1199
  • . Boersma E, Harrington RA, Moliterno DJ, . Platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes: a meta-analysis of all major randomised clinical trials. Lancet. 2002;359(9302):189–198
  • . Giugliano RP, White JA, Bode C, ; EARLY ACS Investigators. Early versus delayed, provisional eptifibatide in acute coronary syndromes. N Engl J Med. 2009;360(21):2176–2190
  • . Stone GW, Bertrand ME, Moses JW, ; ACUITY Investigators. Routine upstream initiation vs deferred selective use of glycoprotein IIb/IIIa inhibitors in acute coronary syndromes: the ACUITY Timing trial. JAMA. 2007;297(6):591–602
  • . Harrington RA, Stone GW, McNulty S, . Platelet inhibition with cangrelor in patients undergoing PCI. N Engl J Med. 2009;361(24):2318–2329
  • . Bhatt DL, Lincoff AM, Gibson CM, ; CHAMPION PLATFORM Investigators. Intravenous platelet blockade with cangrelor during PCI. N Engl J Med. 2009;361(24):2330–2341
  • . Tricoci P, Huang Z, Held C, ; TRACER Investigators. Thrombin-receptor antagonist vorapaxar in acute coronary syndromes. N Engl J Med. 2012;366(1):20–33
  • . Peters RJ, Mehta SR, Fox KA, ; Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) Trial Investigators. Effects of aspirin dose when used alone or in combination with Clopidogrel in patients with acute coronary syndromes: observations from the Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) study. Circulation. 2003;108(14):1682–1687

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