Attention Benefits after a Single Dose of Metadoxine Extended Release in Adults with Predominantly Inattentive ADHD

References

• . Wilens TE, Faraone SV, Biederman J. Attention-deficit/hyperactivity disorder in adults. JAMA. 2004;292(5):619–623
   PubMed Web of Science ®Google Scholar
• . Biederman J, Faraone SV. Attention-deficit hyperactivity disorder [published correction appears in Lancet. 2006;367(9506):210]. Lancet. 2005;366(9481):237–248
   PubMed Web of Science ®Google Scholar
• . Faraone SV, Biederman J, Mick E. The age-dependent decline of attention deficit hyperactivity disorder: a meta-analysis of follow-up studies. Psychol Med. 2006;36(2):159–165
   PubMed Web of Science ®Google Scholar
• . Kessler RC, Adler L, Barkley R, . The prevalence and correlates of adult ADHD in the United States: results from the National Comorbidity Survey Replication. Am J Psychiatry. 2006;163(4):716–723
   PubMed Web of Science ®Google Scholar
• . American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 5th Edition. Arlington, VA: American Psychiatric Publishing; 2013
   Google Scholar
• . Adler LA, Cohen J. Diagnosis and evaluation of adults with attention-deficit/hyperactivity disorder. Psychiatr Clin North Am. 2004;27(2):187–201
   PubMed Web of Science ®Google Scholar
• . Kooij SJ, Bejerot S, Blackwell A, . European consensus statement on diagnosis and treatment of adult ADHD: the European Network Adult ADHD. BMC Psychiatry. 2010;10:67
   PubMed Web of Science ®Google Scholar
• . Greydanus DE, Pratt HD, Patel DR. Attention deficit hyperactivity disorder across the lifespan: the child, adolescent, and adult. Dis Mon. 2007;53(2):70–131
   PubMed Web of Science ®Google Scholar
• . Kessler RC, Green JG, Adler LA, . Structure and diagnosis of adult attention-deficit/hyperactivity disorder: analysis of expanded symptom criteria from the Adult ADHD Clinical Diagnostic Scale. Arch Gen Psychiatry. 2010;67(11):1168–1178
   PubMed Web of Science ®Google Scholar
• . Biederman J, Petty CR, Woodworth KY, Lomedico A, Hyder LL, Faraone SV. Adult outcome of attention-deficit/hyperactivity disorder: a controlled 16-year follow-up study. J Clin Psychiatry. 2012;73(7):941–950
   PubMed Web of Science ®Google Scholar
• . Murphy K, Barkley RA. Attention deficit hyperactivity disorder adults: comorbidities and adaptive impairments. Compr Psychiatry. 1996;37(6):393–401
   PubMed Web of Science ®Google Scholar
• . Biederman J, Fried R, Monuteaux MC, . A laboratory driving simulation for assessment of driving behavior in adults with ADHD: a controlled study. Ann Gen Psychiatry. 2007;6:4
   PubMedGoogle Scholar
• . Michelson D, Adler L, Spencer T, . Atomoxetine in adults with ADHD: two randomized, placebo-controlled studies. Biol Psychiatry. 2003;53(2):112–120
   PubMed Web of Science ®Google Scholar
• . Weisler RH, Biederman J, Spencer TJ, . Mixed amphetamine salts extended-release in the treatment of adult ADHD: a randomized, controlled trial. CNS Spectr. 2006;11(8):625–639
   PubMed Web of Science ®Google Scholar
• . Medori R, Ramos-Quiroga JA, Casas M, . A randomized, placebo-controlled trial of three fixed dosages of prolonged-release OROS methylphenidate in adults with attention-deficit/hyperactivity disorder. Biol Psychiatry. 2008;63(10):981–989
   PubMed Web of Science ®Google Scholar
• . Biederman J, Arnsten AF, Faraone SV, . New developments in the treatment of ADHD. J Clin Psychiatry. 2006;67(1):148–159
   PubMed Web of Science ®Google Scholar
• . Wilens TE, Hammerness PG, Biederman J, . Blood pressure changes associated with medication treatment of adults with attention-deficit/hyperactivity disorder. J Clin Psychiatry. 2005;66(2):253–259
   PubMed Web of Science ®Google Scholar
• . Adler LA, Nierenberg A. Review of medication adherence in children and adults with ADHD. Postgrad Med. 2010;122(1):184–191
   PubMed Web of Science ®Google Scholar
• . Wilens TE, Adler LA, Adams J, . Misuse and diversion of stimulants prescribed for ADHD: a systematic review of the literature. J Am Acad Child Adolesc Psychiatry. 2008;47(1):21–31
   PubMed Web of Science ®Google Scholar
• . Strattera [package insert]. Indianapolis, IN: Eli Lilly and Company; 2014
   Google Scholar
• . Bushe CJ, Savill NC. Systematic review of atomoxetine data in childhood and adolescent attention-deficit hyperactivity disorder 2009–2011: focus on clinical efficacy and safety. J Psychopharmacol. 2014;28(3):204–211
   PubMed Web of Science ®Google Scholar
• . Adler LA, Spencer T, Brown TE, . Once-daily atomoxetine for adult attention-deficit/hyperactivity disorder: a 6-month, double-blind trial. J Clin Psychopharmacol. 2009;29(1):44–50
   PubMed Web of Science ®Google Scholar
• . Leuchter AF, McGough JJ, Korb AS, . Neurophysiologic predictors of response to atomoxetine in young adults with attention deficit hyperactivity disorder: a pilot project. J Psychiatric Research. 2014;54:11–18
   PubMed Web of Science ®Google Scholar
• . Caballería J, Parés A, Brú C, . Metadoxine accelerates fatty liver recovery in alcoholic patients: results of a randomized double-blind, placebo-control trial. Spanish Group for the Study of Alcoholic Fatty Liver. J Hepatol. 1998;28(1):54–60
   PubMed Web of Science ®Google Scholar
• . Bono G, Sinforiani E, Merlo P, Belloni G, Soldati M, Gelso E. Alcoholic abstinence syndrome: short-term treatment with metadoxine. Int J Clin Pharmacol Res. 1991;11(1):35–40
   PubMedGoogle Scholar
• . Shpilenya LS, Muzychenko AP, Gasbarrini G, Addolorato G. Metadoxine in acute alcohol intoxication: a double-blind, randomized, placebo-controlled study. Alcohol Clin Exp Res. 2002;26(3):340–346
   PubMed Web of Science ®Google Scholar
• . Addolorato G, Ancona C, Capristo E, Gasbarrini G. Metadoxine in the treatment of acute and chronic alcoholism: a review. Int J Immunopathol Pharmacol. 2003;16(3):207–214
   PubMed Web of Science ®Google Scholar
• . Rubin J, Daniely Y, Manor I, Schumann J, Cogram P, Adler L. Metadoxine in ADHD and fragile X syndrome: a novel mechanism of action [abstract]. Presented at Society of Biological Psychiatry 69th Annual Scientific Meeting; May 8–10, 2014; New York, NY. Abstract 446
   Google Scholar
• . Adler L. Preferential Effects of Metadoxine Extended-Release on Inattentive Subtype ADHD. Symposium presentation 16.3 at the 60th Annual Meeting of the American Academy of Child and Adolescent Psychiatry; October 19–27, 2013; Orlando, FL
   Google Scholar
• . Manor I, Ben-Hayun R, Aharon-Peretz J, . A randomized, double-blind, placebo-controlled, multicenter study evaluating the efficacy, safety, and tolerability of extended-release metadoxine in adults with attention-deficit/hyperactivity disorder. J Clin Psychiatry. 2012;73(12):1517–1523
   PubMed Web of Science ®Google Scholar
• . Manor I, Newcorn JH, Faraone SV, Adler LA. Efficacy of metadoxine extended release in patients with predominantly inattentive subtype attention-deficit/hyperactivity disorder. Postgrad Med. 2013;125(4):181–190
   PubMed Web of Science ®Google Scholar
• . American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision. Washington, DC: American Psychiatric Association; 2000
   Google Scholar
• . First MB, Williams JBW, Spitzer RL, Gibbon M. Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Clinical Trials Version (SCID-CT). New York City, NY: Biometrics Research, New York State Psychiatric Institute; 2007
   Google Scholar
• . Posner K, Brown GK, Stanley B, . The Columbia-Suicide Severity Rating Scale: initial validity and internal consistency findings from three multisite studies with adolescents and adults. Am J Psychiatry. 2011;168(12):1266–1277
   PubMed Web of Science ®Google Scholar
• . Spielberger CD, Gorsuch RL, Lushene R, Vagg PR, Jacobs GA. Manual for the State-Trait Anxiety Inventory. Palo Alto, CA: Consulting Psychologists Press; 1983
   Google Scholar
• . Beck AT, Steer RA, Brown GK. Manual for the Beck Depression Inventory-II (BDI-II). San Antonio, TX: Psychological Corporation; 1996
   Google Scholar
• . Greenberg LM. Attention Deficit Disorders and the Test of Variables of Attention (TOVA). http://www.tovatest.com/adhd. Accessed August 21, 2014
   Google Scholar
• . Chamberlain SR, Robbins TW, Winder-Rhodes S, . Translational approaches to frontostriatal dysfunction in attention-deficit/hyperactivity disorder using a computerized neuropsychological battery. Biol Psychiatry. 2011;69:1192–1203
   PubMed Web of Science ®Google Scholar
• . Guy W, ed. ECDEU Assessment Manual for Psychopharmacology. Rockville, MD; US Department of Health, Education, and Welfare; 1976
   Google Scholar
• . Greenberg LM, Kindschi CL, Dupuy TR, Hughes SJ. TOVA Clinical Manual. Test of Variables of Attention Continuous Performance Test. Los Alamitos, CA: The TOVA Company; 2007. http://mail.uad.com/manuals/tova_7_3_Clinical_Manual_2007_02_27.pdf. Accessed August 22, 2014
   Google Scholar
• . Roth RM, Isquith PK, Gioia GA. Behavior Rating Inventory of Executive Functioning-Adult Version. Lutz, FL: Psychological Assessment Resources, Inc; 2006
   Google Scholar
• . Kuntsi J, Pinto R, Price TS, van der Meere JJ, Frazier-Wood AC, Asherson P. The separation of ADHD inattention and hyperactivity-impulsivity symptoms: pathways from genetic effects to cognitive impairments and symptoms. J Abnorm Child Psychol. 2014;42(1):127–136
   PubMed Web of Science ®Google Scholar
• . Braverman ER, Chen AL, Chen TJ, . Test of variables of attention (TOVA) as a predictor of early attention complaints, an antecedent to dementia. Neuropsychiatr Dis Treat. 2010;6:681–690
   PubMed Web of Science ®Google Scholar
• . Huang YS, Wang LJ, Chen CK. Long-term neurocognitive effects of methylphenidate in patients with attention deficit hyperactivity disorder, even at drug-free status. BMC Psychiatry. 2012;12:194
   PubMed Web of Science ®Google Scholar