Conservative Treatment Modalities and Outcomes for Osteoarthritis: The Concomitant Pyramid of Treatment

References

• . Felson DT, Zhang Y. An update on the epidemiology of knee and hip osteoarthritis with a view to prevention. Arthritis Rheum. 1998;41(8):1343–1355
   PubMed Web of Science ®Google Scholar
• . Hootman JM, Helmick CG. Projections of US prevalence of arthritis and associated activity limitations. Arthritis Rheum. 2006;54(1):226–229
   PubMed Web of Science ®Google Scholar
• . Buckwalter JA, Lappin DR. The disproportionate impact of chronic arthralgia and arthritis among women. Clin Orthop Relat Res. 2000;372:159–168
   PubMedGoogle Scholar
• . Langworthy MJ, Nelson F, Coutts R. The basic science of cartilage. In: Cole BJ, Malek MM, eds. Articular Cartilage Lesions. New York, NY: Springer; 2004:1–11
   Google Scholar
• . Kraus VG. Pathogenesis and treatment of osteoarthritis. Med Clin North Am. 1997;81(1):85–112
   PubMed Web of Science ®Google Scholar
• . Kurtz S, Ong K, Lau E, Mowat F, Halpern M. Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. J Bone Joint Surg Am. 2007;89(4):780–785
   PubMed Web of Science ®Google Scholar
• . DeGroot J, Verzijl N, Jacobs KM, . Accumulation of advanced glycation endproducts reduces chondrocyte-mediated extracellular matrix turnover in human articular cartilage. Osteoarthritis Cartilage. 2001;9(8):720–726
   PubMed Web of Science ®Google Scholar
• . Barbero A, Grogan S, Schäfer D, Heberer M, Mainil-Varlet P, Martin I. Age related changes in human articular chondrocyte yield, proliferation and post-expansion chondrogenic capacity. Osteoarthritis Cartilage. 2004;12(6):476–484
   PubMed Web of Science ®Google Scholar
• . Claassen H, Hassenpflug J, Schünke M, Sierralta W, Thole H, Kurz B. Immunohistochemical detection of estrogen receptor alpha in articular chondrocytes from cows, pigs and humans: in situ and in vitro results. Ann Anat. 2001;183(3):223–227
   PubMed Web of Science ®Google Scholar
• . DeGroot J, Verzijl N, Jacobs KM, . Accumulation of advanced glycation end products reduces chondrocyte-mediated extracellular matrix turnover in human articular cartilage. Osteoarthritis Cartilage. 2001;9(8):720–726
   PubMed Web of Science ®Google Scholar
• . Watterson JR, Esdaile JM. Viscosupplementation: therapeutic mechanisms and clinical potential in osteoarthritis of the knee. J Am Acad Orthop Surg. 2000;8(5):277–284
   PubMedGoogle Scholar
• . Felson DT, Zhang Y, Anthony JM, Naimark A, Anderson JJ. Weight loss reduces the risk for symptomatic knee osteoarthritis in women. The Framingham Study. Ann Intern Med. 1992;116(7):535–539
   PubMed Web of Science ®Google Scholar
• . Slemenda C, Brandt KD, Heilman DK, . Quadriceps weakness and osteoarthritis of the knee. Ann Intern Med. 1997;127(2):97–104
   PubMed Web of Science ®Google Scholar
• . Ettinger WH Jr, Burns R, Messier SP, . A randomized trial comparing aerobic exercise and resistance exercise with a health education program in older adults with knee osteoarthritis. The Fitness Arthritis and Seniors Trial (FAST). JAMA. 1997;277(1):25–31
   PubMed Web of Science ®Google Scholar
• . Creamer P, Hochberg MC. Osteoarthritis. Lancet. 1997;350(9076):503–508
   PubMed Web of Science ®Google Scholar
• . Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update. American College of Rheumatology Subcommittee on Osteoarthritis Guidelines. Arthritis Rheum. 2000;43(9):1905–1915
   PubMed Web of Science ®Google Scholar
• . Krenzelok EP. The FDA Acetaminophen Advisory Committee Meeting—what is the future of acetaminophen in the United States? The perspective of a committee member. Clin Toxicol (Phila). 2009;47(8):784–789
   PubMed Web of Science ®Google Scholar
• . Devos-Comby L, Cronan T, Roesch SC. Do exercise and self-management interventions benefit patients with osteoarthritis of the knee? A metaanalytic review. J Rheumatol. 2006;33(4):744–756
   PubMed Web of Science ®Google Scholar
• . Woodcock J. A difficult balance—pain management, drug safety, and the FDA. N Engl J Med. 2009;361(22):2105–2107
   PubMed Web of Science ®Google Scholar
• . Singh G, Triadafilopoulos G. Epidemiology of NSAID induced gastrointestinal complications. J Rheumatol Suppl. 1999;56:18–24
   PubMedGoogle Scholar
• . Goldstein JL, Aisenberg J, Lanza F, . A multicenter, randomized, double-blind, active-comparator, placebo-controlled, parallel-group comparison of the incidence of endoscopic gastric and duodenal ulcer rates with valdecoxib or naproxen in healthy subjects aged 65 to 75 years. Clin Ther. 2006;28(3):340–351
   PubMed Web of Science ®Google Scholar
• . Hollenz M, Stolte M, Leodolter A, Labenz J. NSAID-associated dyspepsia and ulcers: a prospective cohort study in primary care. Dig Dis. 2006;24(1–2):189–194
   PubMed Web of Science ®Google Scholar
• . Wolfe MM, Lichtenstein DR, Singh G. Gastrointestinal toxicity of nonsteroidal anti-inflammatory drugs. N Engl J Med. 1999;340(24):1888–1899
   PubMed Web of Science ®Google Scholar
• . Hunt RH, Lanas A, Stichtenoth DO, Scarpignato C. Myths and facts in the use of anti-inflammatory drugs [published online ahead of print May 8, 2009]. Ann Med.
   Google Scholar
• . Lanas A, Perez-Aisa MA, Feu F, ; Investigators of the Asociación Española de Gastroenterología (AEG). A nationwide study of mortality associated with hospital admission due to severe gastrointestinal events and those associated with nonsteroidal antiinflammatory drug use. GI related mortality and nsaid use. Am J Gastroenterol. 2005;100(8):1685–1693
   PubMed Web of Science ®Google Scholar
• . Urban MK. COX-2 specific inhibitors offer improved advantages over traditional NSAIDs. Orthopedics. 2000;23( 7 suppl):S761–S764
   PubMed Web of Science ®Google Scholar
• . Gabriel SE, Jaakkimainen L, Bombardier C. Risk for serious gastrointestinal complications related to use of nonsteroidal anti-inflammatory drugs. A meta analysis. Ann Intern Med. 1991;115(10):787–796
   PubMed Web of Science ®Google Scholar
• . Hollenz M, Stolte M, Leodolter A, Labenz J. NSAID-associated dyspepsia and ulcers: a prospective cohort study in primary care. Dig Dis. 2006;24(1–2):189–194
   PubMed Web of Science ®Google Scholar
• . Neumaier J. Therapy of joint pain in arthrosis and arthritis. Classical nonsteroidal anti-inflammatory agents, coxibs—or opioids? [in German]. MMW Fortschr Med. 2009;151(34–35):22–23
   PubMedGoogle Scholar
• . Simon LS, Weaver AL, Graham DY, . Anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis: a randomized controlled trial. JAMA. 1999;282(20):1921–1928
   PubMed Web of Science ®Google Scholar
• . Layton D, Hughes K, Harris S, Shakir SA. Comparison of the incidence rates of selected gastrointestinal events reported for patients prescribed celecoxib and meloxicam in general practice in England using prescription-event monitoring (PEM) data. Rheumatology (Oxford). 2003;42(11):1332–1341
   PubMed Web of Science ®Google Scholar
• . White WB. Cyclooxygenase-2 inhibitors and cardiovascular thromboembolic events. J Am Coll Cardiol. 2002;40(3):577–578
   PubMed Web of Science ®Google Scholar
• . Whelton A, Fort JG, Puma JA, Normandin D, Bello AE, Verburg KM; SUCCESS VI Study Group. Cyclooxygenase-2-specific inhibitors and cardiorenal function: a randomized, controlled trial of celecoxib and rofecoxib in older hypertensive osteoarthritis patients. Am J Ther. 2001;8(2):85–95
   PubMedGoogle Scholar
• . Solomon DH, Schneeweiss S, Glynn RJ, . Relationship between selective cyclooxygenase-2 inhibitors and acute myocardial infarction in older adults. Circulation. 2004;109(17):2068–2073
   PubMed Web of Science ®Google Scholar
• . White WB, West CR, Borer JS, . Risk of cardiovascular events in patients receiving celecoxib: a meta-analysis of randomized clinical trials. Am J Cardiol. 2007;99(1):91–98
   PubMed Web of Science ®Google Scholar
• . Dahners LE, Mullis BH. Effects of nonsteroidal anti-inflammatory drugs on bone formation and soft-tissue healing. J Am Acad Orthop Surg. 2004;12(3):139–143
   PubMed Web of Science ®Google Scholar
• . Vielpeau C, Joubert JM, Hulet C. Naproxen in the prevention of heterotopic ossification after total hip replacement. Clin Orthop Relat Res. 1999;(369):279–288
   Google Scholar
• . Langman MJ, Jensen DM, Watson DJ, . Adverse upper gastrointestinal effects of rofecoxib compared with NSAIDs. JAMA. 1999;282(20):1929–1933
   PubMed Web of Science ®Google Scholar
• . Gambaro G, Perazella MA. Adverse renal effects of anti-inflammatory agents: evaluation of selective and nonselective cyclooxygenase inhibitors. J Intern Med. 2003;253(6):643–652
   PubMed Web of Science ®Google Scholar
• . Goodwin JL, Kraemer JJ, Bajwa ZH. The use of opioids in the treatment of osteoarthritis: when, why, and how? Curr Rheumatol Rep. 2009;11(1):5–14
   PubMedGoogle Scholar
• . Tramodol hydrochloride. In: Physicians Desk Reference. Ed 64. Montvale, NJ: PDR Network, LLC; 2009:2813–2817
   Google Scholar
• . Pyne D, Ioannou Y, Mootoo R, Bhanji A. Intra-articular steroids in knee osteoarthritis: a comparative study of triamcinolone hexacetonide and methylprednisolone acetate. Clin Rheumatol. 2004;23(2):116–120
   PubMed Web of Science ®Google Scholar
• . Raynauld JP, Buckland-Wright C, Ward R, . Safety and efficacy of long-term intraarticular steroid injections in osteoarthritis of the knee: a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2003;48(2):370–377
   PubMed Web of Science ®Google Scholar
• . Fubini SL, Todhunter RJ, Burton-Wurster N, Vernier-Singer M, MacLeod JN. Corticosteroids alter the differentiated phenotype of articular chondrocytes. J Orthop Res. 2001;19(4):688–695
   PubMed Web of Science ®Google Scholar
• . Genovese MC. Joint and soft-tissue injection. A useful adjuvant to systemic and local treatment. Postgrad Med. 1998;103(2):125–134
   PubMed Web of Science ®Google Scholar
• . Lippiello L, Woodward J, Karpman R, Hammad TA. In vivo chondroprotection and metabolic synergy of glucosamine and chondroitin sulfate. Clin Orthop Relat Res. 2000;381:229–240
   PubMed Web of Science ®Google Scholar
• . Piperno M, Reboul P, Hellio Le Graverand MP, . Glucosamine sulfate modulates dysregulated activities of human osteoarthritic chondrocytes in vitro. Osteoarthritis Cartilage. 2000;8(3):207–212
   PubMed Web of Science ®Google Scholar
• . Clegg DO, Reda DJ, Harris CL, . Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med. 2006;354(8):795–808
   PubMed Web of Science ®Google Scholar
• . Soeken KL, Lee WL, Bausell RB, Agelli M, Berman BM. Safety and efficacy of S-adenosylmethionine (SAMe) for osteoarthritis. J Fam Pract. 2002;51(5):425–430
   PubMed Web of Science ®Google Scholar
• . Nicolas P, Tod M, Padoin C, Petitjean O. Clinical pharmacokinetics of diacerein. Clin Pharmacokinet. 1998;35(5):347–359
   PubMed Web of Science ®Google Scholar
• . Lualdi P. Bioavailability of oral chondroitin sulfate. Rheumatol Int. 1993;13(1):39–43
   PubMed Web of Science ®Google Scholar
• . Parnham MJ. Antirheumatic agents and leukocyte recruitment. New light on the mechanism of action of oxaceprol. Biochem Pharmacol. 1999;58(2):209–215
   PubMed Web of Science ®Google Scholar
• . Mills SY, Jacoby RK, Chacksfield M, Willoughby M. Effect of a proprietary herbal medicine on the relief of chronic arthritic pain: a double-blind study. Br J Rheumatol. 1996;35(9):874–878
   PubMedGoogle Scholar
• . Ahmed S, Rahman A, Hasnain A, . Green tea polyphenol epigallocatechin-3-gallate inhibits the IL-1 beta-induced activity and expression of cyclooxygenase-2 and nitric oxide synthase-2 in human chondrocytes. Free Radic Biol Med. 2002;33(8):1097–1105
   PubMed Web of Science ®Google Scholar
• . Baker W. Vitamin D. Bone benefits and beyond. Mayo Clin Health Lett. 2009;27(9):4–5
   Google Scholar
• . Felson DT, Niu J, Clancy M, . Low levels of vitamin D and worsening of knee osteoarthritis: results of two longitudinal studies. Arthritis Rheum. 2007;56(1):129–136
   PubMedGoogle Scholar
• . Herrmann G, Steeger D, Klasser M, . Oxaceprol is a well-tolerated therapy for osteoarthritis with efficacy equivalent to diclofenac. Clin Rheumatol. 2000;19(2):99–104
   PubMed Web of Science ®Google Scholar
• . Bliddal H, Rosetzsky A, Schlichting P, . A randomized, placebo-controlled, cross-over study of ginger extracts and ibuprofen in osteoarthritis. Osteoarthritis Cartilage. 2000;8(1):9–12
   PubMed Web of Science ®Google Scholar
• . Goldberg H, Avins A, Bent S. Chondroitin for osteoarthritis of the knee or hip. Ann Intern Med. 2007;147(12):883
   PubMedGoogle Scholar
• . Ramsey DK, Briem K, Axe MJ, Snyder-Mackler L. A mechanical theory for the effectiveness of bracing for medial compartment osteoarthritis of the knee. J Bone Joint Surg Am. 2007;89(11):2398–2407
   PubMedGoogle Scholar
• . Barnes CL, Cawley PW, Hederman B. Effect of CounterForce brace on symptomatic relief in a group of patients with symptomatic unicompartmental osteoarthritis: a prospective 2-year investigation. Am J Orthop (Belle Mead NJ). 2002;31(7):396–401
   PubMedGoogle Scholar
• . Pollo FE, Otis JC, Backus SI, Warren RF, Wickiewicz TL. Reduction of medial compartment loads with valgus bracing of the osteoarthritic knee. Am J Sports Med. 2002;30(3):414–421
   PubMed Web of Science ®Google Scholar
• . Giori NJ. Load-shifting brace treatment for osteoarthritis of the knee: a minimum 2 1/2-year follow-up study. J Rehabil Res Dev. 2004;41(2):187–194
   PubMedGoogle Scholar
• . Kerrigan DC, Lelas JL, Goggins J, Merriman GJ, Kaplan RJ, Felson DT. Effectiveness of a lateral-wedge insole on knee varus torque in patients with knee osteoarthritis. Arch Phys Med Rehabil. 2002;83(7):889–893
   PubMed Web of Science ®Google Scholar
• . Zhang W, Moskowitz RW, Nuki G, . OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis Cartilage. 2008;16(2):137–162
   PubMed Web of Science ®Google Scholar
• . Simon LS, Grierson LM, Naseer Z, Bookman AA, Zev Shainhouse J. Efficacy and safety of topical diclofenac containing dimethyl sulfoxide (DMSO) compared with those of topical placebo, DMSO vehicle and oral diclofenac for knee osteoarthritis. Pain. 2009;143(3):238–245
   PubMed Web of Science ®Google Scholar
• . Selfe TK, Taylor AG. Acupuncture and osteoarthritis of the knee: a review of randomized, controlled trials. Fam Community Health. 2008;31(3):247–254
   PubMed Web of Science ®Google Scholar
• . Ezzo J, Hadhazy V, Birch S, . Acupuncture for osteoarthritis of the knee: a systematic review. Arthritis Rheum. 2001;44(4):819–825
   PubMedGoogle Scholar
• . Brighton CT, Unger AS, Stambough JL. In vitro growth of bovine articular cartilage chondrocytes in various capacitively coupled electrical fields. J Orthop Res. 1984;2(1):15–22
   PubMedGoogle Scholar
• . Zizic TM, Hoffman KC, Holt PA, . The treatment of osteoarthritis of the knee with pulsed electrical stimulation. J Rheumatol. 1995;22(9):1757–1761
   PubMed Web of Science ®Google Scholar
• . Minns Lowe CJ, Barker KL, Dewey ME, Sackley CM. Effectiveness of physiotherapy exercise following hip arthroplasty for osteoarthritis: a systematic review of clinical trials. BMC Musculoskelet Disord. 2009;10:98
   PubMed Web of Science ®Google Scholar
• . Fransen M, McConnell S, Hernandez-Molina G, Reichenbach S. Exercise for osteoarthritis of the hip. Cochrane Database Syst Rev. 2009;(3):CD007912
   Google Scholar
• . Fransen M, McConnell S. Land-based exercise for osteoarthritis of the knee: a metaanalysis of randomized controlled trials. J Rheumatol. 2009;36(6):1109–1117
   PubMed Web of Science ®Google Scholar
• . Edmonds S. Therapeutic targets for osteoarthritis. Maturitas. 2009;63(3):191–194
   PubMed Web of Science ®Google Scholar
• . Hochberg MC, Perlmutter DL, Hudson JI, Altman RD. Preferences in the management of osteoarthritis of the hip and knee: results of a survey of community-based rheumatologists in the United States. Arthritis Care Res. 1996;9(3):170–176
   PubMedGoogle Scholar
• . Fransen M, McConnell S. Exercise for osteoarthritis of the knee. Cochrane Database Syst Rev. 2008;(4):CD004376
   Google Scholar
• . Lange AK, Vanwanseele B, Fiatarone Singh MA. Strength training for treatment of osteoarthritis of the knee: a systematic review. Arthritis Rheum. 2008;59(10):1488–1494
   PubMed Web of Science ®Google Scholar
• . Hernández-Molina G, Reichenbach S, Zhang B, Lavalley M, Felson DT. Effect of therapeutic exercise for hip osteoarthritis pain: results of a meta-analysis. Arthritis Rheum. 2008;59(9):1221–1228
   PubMed Web of Science ®Google Scholar
• . Blackham J, Garry JP, Cummings DM, Russell RG, Dealleaume L. Does regular exercise reduce the pain and stiffness of osteoarthritis? J Fam Pract. 2008;57(7):476–477
   PubMed Web of Science ®Google Scholar
• . Delarue Y, de Branche B, Anract P, Revel M, Rannou F. Supervised or unsupervised exercise for the treatment of hip and knee osteoarthritis. Clinical practice recommendations. Ann Readapt Med Phys. 2007;50(9):759–768
   PubMedGoogle Scholar
• . Tiffreau V, Mulleman D, Coudeyre E, Lefevre-Colau MM, Revel M, Rannou F. The value of individual or collective group exercise programs for knee or hip osteoarthritis. Clinical practice recommendations. Ann Readapt Med Phys. 2007;50(9):734–746
   Google Scholar
• . Bartels EM, Lund H, Hagen KB, Dagfinrud H, Christensen R, Danneskiold-Samsøe B. Aquatic exercise for the treatment of knee and hip osteoarthritis. Cochrane Database Syst Rev. 2007;(4):CD005523
   Google Scholar
• . Focht BC. Effectiveness of exercise interventions in reducing pain symptoms among older adults with knee osteoarthritis: a review. J Aging Phys Act. 2006;14(2):212–235
   PubMed Web of Science ®Google Scholar
• . Snibbe JC, Gambardella RA. Treatment options for osteoarthritis. Oththopedics. 2005;28( 2 suppl):S215–S220
   PubMed Web of Science ®Google Scholar
• . Balazs EA, Denlinger JL. Viscosupplementation: a new concept in the treatment of osteoarthritis. J Rheumatol Suppl. 1993;39:3–9
   PubMedGoogle Scholar
• . Divine JG, Zazulak BT, Hewett TE. Viscosupplementation for knee osteoarthritis: a systematic review. Clin Orthop Relat Res. 2007;455:113–122
   PubMedGoogle Scholar
• . Bagga H, Burkhardt D, Sambrook P, March L. Longterm effects of intraarticular hyaluronan on synovial fluid in osteoarthritis of the knee. J Rheumatol. 2006;33(5):946–950
   PubMed Web of Science ®Google Scholar
• . Huin-Amargier C, Marchal P, Payan E, Netter P, Dellacherie E. New physically and chemically crosslinked hyaluronate (HA)-based hydrogels for cartilage repair. J Biomed Mater Res A. 200676(2):416–424
   PubMed Web of Science ®Google Scholar
• . Balazs EA, Watson D, Duff IF, Roseman S. Hyaluronic acid in synovial fluid. Molecular parameters of hyaluronic acid in normal and arthritic human fluids. Arthritis Rheum. 1967;10(4):357–376
   PubMed Web of Science ®Google Scholar
• . Gomis A. Effects of different molecular weight elastoviscous hyaluronan solutions on articular nociceptive afferents. Arthritis Rheum. 2004;50:314–326
   PubMed Web of Science ®Google Scholar
• . Weiss C, Band P. Basic principles underlying the development of viscosupplementation for the treatment of osteoarthritis. J Clin Rheumatol. 1999;5( 6 suppl):S2–S11
   Web of Science ®Google Scholar
• . Waddell DD. Viscosupplements affect on IL-1 mediated MMP activity. Clin Orthop Rel Res. 2007;465:241–248
   PubMedGoogle Scholar
• . Wang CT, Lin J, Chang CJ, Lin YT, Hou SM. Therapeutic effects of hyaluronic acid on osteoarthritis of the knee: a meta-analysis of randomized controlled trials. J Bone Joint Surg. 2004;86–A:538–545
   PubMed Web of Science ®Google Scholar
• . Strauss EJ, Hart JA, Miller MD, Altman RD, Rosen JE. Hyaluronic acid viscosupplementation and osteoarthritis: current uses and future directions. Am J Sports Med. 2009;37(8):1636–1644
   PubMed Web of Science ®Google Scholar
• . Williams NH, Amoakwa E, Burton K, . The Hip and Knee Book: developing an active management booklet for hip and knee osteoarthritis. Br J Gen Pract. 2010;60(571):64–82
   PubMed Web of Science ®Google Scholar
• . Jackson DW, Evans NA, Thomas BM. Accuracy of needle placement into the intra-articular space of the knee. J Bone Joint Surg. 2002;84-A(9):1522–1527
   PubMed Web of Science ®Google Scholar
• . Langworthy MJ. A review of the first 100 office Synvysc One injections. Physician Rev. 2008;( suppl):A1–A6
   Google Scholar
• . Mathieu P, Conrozier T, Vignon E, Rozand Y, Rinaudo M. Rheologic behavior of osteoarthritic synovial fluid after addition of hyaluronic acid: a pilot study. Clin Orthop Relat Res. 2009;467(11):3002–3009
   PubMed Web of Science ®Google Scholar
• . Hochberg MC, Altman RD, Brandt KD, . Guidelines for the medical management of osteoarthritis. Part II. Osteoarthritis of the knee. American College of Rheumatology. Arthritis Rheum. 1995;38(11):1541–1546
   PubMed Web of Science ®Google Scholar
• . Raynauld JP, Torrance GW, Band PA, ; Canadian Knee OA Study Group. A prospective, randomized, pragmatic, health outcomes trial evaluating the incorporation of hylan G-F-20 into the treatment paradigm with knee osteoarthritis (part 1 of 2): clinical results. Osteoarthritis Cartilage. 2002;10(7):506–517
   PubMed Web of Science ®Google Scholar
• . Caligaris M, Canal CE, Ahmad CS, Gardner TR, Ateshian GA. Investigation of the frictional response of osteoarthritic human tibiofemoral joints and the potential beneficial tribological effect of healthy synovial fluid. Osteoarthritis Cartilage. 2009;17(10):1327–1332
   PubMed Web of Science ®Google Scholar
• . Doherty M, Dieppe P. The “placebo” response in osteoarthritis and its implications for clinical practice. Osteoarthritis Cartilage. 2009;17(10):1255–1262
   PubMed Web of Science ®Google Scholar