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Clinical Focus: Respiratory Disorders, Allergies, and Infectious Diseases

Community-Associated Methicillin-Resistant Staphylococcus aureus and Athletes

, PhD, , PhD & , PhD
Pages 13-21 | Published online: 13 Mar 2015

References

  • . Gorwitz RJ, Kruszon-Moran D, McAllister SK, . Changes in the prevalence of nasal colonization with Staphylococcus aureus in the United States, 2001–2004. J Infect Dis. 2008; 197(9):1226–1234
  • . Ogston A. Report upon micro-organisms in surgical diseases. Br Med J. 1881; 1(1054):369–375
  • . Chambers HF, DeLeo FR. Waves of resistance: Staphylococcus aureus in the antibiotic era. Nat Rev Micro. 2009; 7(9):629–641
  • . Jevons MP, Coe AW, Parker MT. Methicillin resistance in staphylococci. Lancet. 1963; 281(7287):904–907
  • . DeLeo FR, Chambers HF. Reemergence of antibiotic-resistant Staphylococcus aureus in the genomics era. J Clin Invest. 2009; 119(9): 2464–2474
  • . Stefani S, Chung DR, Lindsay JA, . Meticillin-resistant Staphylococcus aureus (MRSA): Global epidemiology and harmonisation of typing methods. Int J Antimicrob Agents. 2012; 39(4):273–282
  • . DeLeo FR, Otto M, Kreiswirth BN, Chambers HF. Community-associated meticillin-resistant Staphylococcus aureus. Lancet. 2010; 375(9725):1557–1568
  • . Ito T, Katayama Y, Asada K, . Structural comparison of three types of staphylococcal cassette chromosome mec integrated in the chromosome in methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2001; 45(5):1323–1336
  • . Severin A, Wu SW, Tabei K, Tomasz A. High-level β-Lactam resistance and cell wall synthesis catalyzed by the mecA homologue of Staphylococcus sciuri introduced into Staphylococcus aureus. J Bacteriol. 2005; 187(19):6651–6658
  • . Wu S, Piscitelli C, de Lencastre H, Tomasz A. Tracking the evolutionary origin of the methicillin resistance gene: Cloning and sequencing of a homologue of mecA from a methicillin susceptible strain of Staphylococcus sciuri. Microb Drug Resist. 1996; 2(4):435–441
  • . Tsubakishita S, Kuwahara-Arai K, Sasaki T, Hiramatsu K. Origin and molecular evolution of the determinant of methicillin resistance in staphylococci. Antimicrob Agents Chemother. 2010; 54(10):4352–4359
  • . Shore AC, Deasy EC, Slickers P, . Detection of staphylococcal cassette chromosome mec type XI carrying highly divergent mecA, mecI, mecR1, blaZ, and ccr genes in human clinical isolates of clonal complex 130 methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2011; 55(8):3765–3773
  • . International Working Group on the Staphylococcal Cassette Chromosome elements (IWG-SCC). Currently identified SCCmec types in S aureus strains. http://www.sccmec.org/Pages/SCC_TypesEN.html. Accessed March 2, 2012
  • . Chongtrakool P, Ito T, Ma XX, . Staphylococcal cassette chromosome mec (SCCmec) typing of methicillin-resistant Staphylococcus aureus strains isolated in 11 asian countries: A proposal for a new nomenclature for SCCmec elements. Antimicrob Agents Chemother. 2006; 50(3):1001–1012
  • . Ma XX, Ito T, Tiensasitorn C, . Novel type of staphylococcal cassette chromosome mec identified in community-acquired methicillin-resistant Staphylococcus aureus strains. Antimicrob Agents Chemother. 2002; 46(4):1147–1152
  • . Yamamoto T, Nishiyama A, Takano T, . Community-acquired methicillin-resistant Staphylococcus aureus: Community transmission, pathogenesis, and drug resistance. J Infect Chemother. 2010; 16(4):225–254
  • . Lee SM, Ender M, Adhikari R, Smith JM, Berger-Bächi B, Cook GM. Fitness cost of staphylococcal cassette chromosome mec in methicillin-resistant Staphylococcus aureus by way of continuous culture. Antimicrob Agents Chemother. 2007; 51(4):1497–1499
  • . Okuma K, Iwakawa K, Turnidge JD, . Dissemination of new methicillin-resistant Staphylococcus aureus clones in the community. J Clin Microbiol. 2002; 40(11):4289–4294
  • . Diep BA, Stone GG, Basuino L, . The arginine catabolic mobile element and staphylococcal chromosomal cassette mec linkage: Convergence of virulence and resistance in the USA300 clone of methicillin-resistant Staphylococcus aureus. J Infect Dis. 2008; 197(11):1523–1530
  • . Nichol KA, Adam HJ, Hussain Z, . Comparison of community-associated and health care-associated methicillin-resistant Staphylococcus aureus in Canada: Results of the CANWARD 2007–2009 study. Diagn Microbiol Infect Dis. 2011; 69(3):320–325
  • . Baba T, Takeuchi F, Kuroda M, . Genome and virulence determinants of high virulence community-acquired MRSA. Lancet. 2002; 359(9320):1819–1827
  • . Fridkin SK, Hageman JC, Morrison M, . Methicillin-resistant Staphylococcus aureus disease in three communities. N Engl J Med. 2005; 352(14):1436–1444
  • . Diep BA, Gill SR, Chang RF, . Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus. Lancet. 2006; 367(9512):731–739
  • . Maree CL, Daum RS, Boyle-Vavra S, Matayoshi K, Miller LG. Community-associated methicillin-resistant Staphylococcus aureus isolates causing healthcare-associated infections. Emerg Infect Dis. 2007; 13(2):236–242
  • . Otter JA, French GL. Community-associated meticillin-resistant Staphylococcus aureus strains as a cause of healthcare-associated infection. J Hosp Infect. 2011; 79(3):189–193
  • . Seybold U, Kourbatova EV, Johnson JG, . Emergence of community-associated methicillin-resistant Staphylococcus aureus USA300 genotype as a major cause of health care-associated blood stream infections. Clin Infect Dis. 2006; 42(5):647–656
  • . Herold BC, Immergluck LC, Maranan MC, . Community-acquired methicillin-resistant Staphylococcus aureus in children with no identified predisposing risk. JAMA. 1998; 279(8):593–598
  • . From the Centers for Disease Control and Prevention. Four pediatric deaths from community-acquired methicillin-resistant Staphylococcus aureus—Minnesota and North Dakota, 1997–1999. JAMA. 1999; 282(12):1123–1125
  • . King MD, Humphrey BJ, Wang YF, Kourbatova EV, Ray SM, Blumberg HM. Emergence of community-acquired methicillin-resistant Staphylococcus aureus USA300 clone as the predominant cause of skin and soft-tissue infections. Ann Intern Med. 2006; 144(5):309–317
  • . Moran GJ, Krishnadasan A, Gorwitz RJ, . Methicillin-resistant S aureus infections among patients in the emergency department. N Engl J Med. 2006; 355(7):666–674
  • . Klevens RM, Morrison MA, Nadle J, . Invasive methicillin-resistant Staphylococcus aureus infections in the United States. JAMA. 2007; 298(15):1763–1771
  • . Daum RS. Skin and soft-tissue infections caused by methicillin-resistant Staphylococcus aureus. N Engl J Med. 2007; 357(4):380–390
  • . Purcell K, Fergie J. Epidemic of community-acquired methicillin-resistant Staphylococcus aureus infections: A 14-year study at Driscoll Children's Hospital. Arch Pediatr Adolesc Med. 2005; 159(10):980–985
  • . Kaplan SL, Hulten KG, Gonzalez BE, . Three-year surveillance of community-acquired Staphylococcus aureus infections in children. Clin Infect Dis. 2005; 40(12):1785–1791
  • . Liu C, Graber CJ, Karr M, . A population-based study of the incidence and molecular epidemiology of methicillin-resistant Staphylococcus aureus disease in San Francisco, 2004–2005. Clin Infect Dis. 2008; 46(11):1637–1646
  • . Cohen PR, Kurzrock R. Community-acquired methicillin-resistant Staphylococcus aureus skin infection: An emerging clinical problem. J Am Acad Dermatol. 2004; 50(2):277–280
  • . Dominguez TJ. It's not a spider bite, it's community-acquired methicillin-resistant Staphylococcus aureus. J Am Board Fam Pract. 2004; 17(3):220–226
  • . Forcade NA, Parchman ML, Jorgensen JH, . Prevalence, severity, and treatment of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) skin and soft tissue infections in 10 medical clinics in Texas: A South Texas Ambulatory Research Network (STARNet) study. J Am Board Fam Med. 2011; 24(5):543–550
  • . Naimi TS, LeDell KH, Como-Sabetti K, . Comparison of community- and health care-associated methicillin-resistant Staphylococcus aureus infection. JAMA. 2003; 290(22):2976–2984
  • . Kirkland EB, Adams BB. Methicillin-resistant Staphylococcus aureus and athletes. J Am Acad Dermatol. 2008; 59(3):494–502
  • . Centers for Disease Control and Prevention (CDC). MRSA and the workplace. http://www.cdc.gov/mrsa. Accessed March 2, 2012
  • . Centers for Disease Control and Prevention (CDC). Methicillin-resistant Staphylococcus aureus infections among competitive sports participants—Colorado, Indiana, Pennsylvania, and Los Angeles County, 2000–2003. MMWR Morb Mortal Wkly Rep. 2003; 52: 793–795
  • . Kazakova SV, Hageman JC, Matava M, . A clone of methicillin-resistant Staphylococcus aureus among professional football players. N Engl J Med. 2005; 352(5):468–475
  • . Rihn JA, Michaels MG, Harner CD. Community-acquired methicillin-resistant Staphylococcus aureus. Am J Sports Med. 2005; 33(12): 1924–1929
  • . Begier EM, Frenette K, Barrett NL, . A high-morbidity outbreak of methicillin-resistant Staphylococcus aureus among players on a college football team, facilitated by cosmetic body shaving and turf burns. Clin Infect Dis. 2004; 39(10):1446–1453
  • . Barr B, Felkner M, Diamond PM. High school athletic departments as sentinel surveillance sites for community-associated methicillin-resistant staphylococcal infections. Tex Med. 2006; 102(4):56–61
  • . Lindenmayer JM, Schoenfeld S, O'Grady R, Carney JK. Methicillin-resistant Staphylococcus aureus in a high school wrestling team and the surrounding community. Arch Intern Med. 1998; 158(8):895–899
  • . Cohen PR. Cutaneous community-acquired methicillin-resistant Staphylococcus aureus infection in participants of athletic activities. South Med J. 2005; 98(6):596–602
  • . Huijsdens XW, Van Lier AM, Van Kregten E, . Methicillin-resistant Staphylococcus aureus in Dutch soccer team. Emerg Infect Dis. 2006; 12(10):1584–1586
  • . Stacey AR, Endersby KE, Chan PC, Marples RR. An outbreak of methicillin resistant Staphylococcus aureus infection in a rugby football team. Br J Sports Med. 1998; 32(2):153–154
  • . Creech CB, Saye E, McKenna BD, . One-year surveillance of methicillin-resistant Staphylococcus aureus nasal colonization and skin and soft tissue infections in collegiate athletes. Arch Pediatr Adolesc Med. 2010; 164(7):615–620
  • . Kobayashi SD, DeLeo FR. An update on community-associated MRSA virulence. Curr Opin Pharmacol. 2009; 9(5):545–551
  • . Bubeck Wardenburg J, Bae T, Otto M, DeLeo FR, Schneewind O. Poring over pores: Alpha-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia. Nat Med. 2007; 13(12): 1405–1406
  • . Walev I, Martin E, Jonas D, . Staphylococcal alpha-toxin kills human keratinocytes by permeabilizing the plasma membrane for monovalent ions. Infect Immun. 1993; 61(12):4972–4979
  • . Bernheimer AW. Staphylococcal alpha toxin. Ann N Y Acad Sci. 1965; 128(1):112–123
  • . Bartlett AH, Foster TJ, Hayashida A, Park PW. Alpha-toxin facilitates the generation of CXC chemokine gradients and stimulates neutrophil homing in Staphylococcus aureus pneumonia. J Infect Dis. 2008; 198(10):1529–1535
  • . Gillet Y, Issartel B, Vanhems P, . Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patients. Lancet. 2002; 359(9308):753–759
  • . Hidron AI, Low CE, Honig EG, Blumberg HM. Emergence of community-acquired meticillin-resistant Staphylococcus aureus strain USA300 as a cause of necrotising community-onset pneumonia. Lancet Infect Dis. 2009; 9(6):384–392
  • . Cribier B, Prévost G, Couppie P, Finck-Barbancon V, Grosshans E, Piemont Y. Staphylococcus aureus leukocidin: A new virulence factor in cutaneous infections? Dermatology. 1992; 185(3):175–180
  • . Couppie P, Cribier B, Prévost G. Leukocidin from Staphylococcus aureus and cutaneous infections: An epidemiologic study. Arch Dermatol. 1994; 130(9):1208–1209
  • . Sharma-Kuinkel BK, Ahn SH, Rude TH, . Presence of genes encoding Panton-Valentine leukocidin is not the primary determinant of outcome in patients with hospital-acquired pneumonia due to Staphylococcus aureus. J Clin Microbiol. 2012; 50(3):848–856
  • . Bae IG, Tonthat GT, Stryjewski ME, . Presence of genes encoding the Panton-Valentine leukocidin exotoxin is not the primary determinant of outcome in patients with complicated skin and skin structure infections due to methicillin-resistant Staphylococcus aureus: Results of a multinational trial. J Clin Microbiol. 2009; 47(12): 3952–3957
  • . Panton PN, Valentine FCO. Staphylococcal toxin. Lancet. 1932; 219(5662):506–508
  • . Szmigielski S, Prévost G, Monteil H, Colin DA, Jeljaszewicz J. Leukocidal toxins of staphylococci. Zentralbl Bakteriol. 1999; 289(2): 185–201
  • . Voyich Jovanka M, Otto M, Mathema B, . Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease? J Infect Dis. 2006; 194(12):1761–1770
  • . Kobayashi SD, Malachowa N, Whitney AR, . Comparative analysis of USA300 virulence determinants in a rabbit model of skin and soft tissue infection. J Infect Dis. 2011; 204(6):937–941
  • . Bubeck Wardenburg J, Palazzolo-Ballance AM, Otto M, Schneewind O, DeLeo FR. Panton-Valentine leukocidin is not a virulence determinant in murine models of community-associated methicillin-resistant Staphylococcus aureus disease. J Infect Dis. 2008; 198(8): 1166–1170
  • . Montgomery CP, Daum RS. Transcription of inflammatory genes in the lung after infection with community-associated methicillin-resistant Staphylococcus aureus: A role for Panton-Valentine leukocidin? Infect Immun. 2009; 77(5):2159–2167
  • . Olsen RJ, Kobayashi SD, Ayeras AA, . Lack of a major role of Staphylococcus aureus Panton-Valentine leukocidin in lower respiratory tract infection in nonhuman primates. Am J Pathol. 2010; 176(3): 1346–1354
  • . Yoong P, Pier GB. Antibody-mediated enhancement of community-acquired methicillin-resistant Staphylococcus aureus infection. Proc Natl Acad Sci U S A. 2010; 107(5):2241–2246
  • . Malachowa N, Whitney AR, Kobayashi SD, . Global changes in Staphylococcus aureus gene expression in human blood. PLoS One. 2011; 6(4):e18617
  • . Otto M. Basis of virulence in community-associated methicillin-resistant Staphylococcus aureus. Annu Rev Microbiol. 2010; 64(1): 143–162
  • . Ventura CL, Malachowa N, Hammer CH, . Identification of a novel Staphylococcus aureus two-component leukotoxin using cell surface proteomics. PLoS One. 2010; 5(7):e11634
  • . Wang R, Braughton KR, Kretschmer D, . Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA. Nat Med. 2007; 13(12):1510–1514
  • . Löffler B, Hussain M, Grundmeier M, . Staphylococcus aureus Panton-Valentine leukocidin is a very potent cytotoxic factor for human neutrophils. PLoS Pathog. 2010; 6(1):e1000715
  • . Queck SY, Jameson-Lee M, Villaruz AE, . RNAIII-independent target gene control by the agr quorum-sensing system: Insight into the evolution of virulence regulation in Staphylococcus aureus. Mol Cell. 2008; 32(1):150–158
  • . Li M, Diep BA, Villaruz AE, . Evolution of virulence in epidemic community-associated methicillin-resistant Staphylococcus aureus. Proc Natl Acad Sci U SA. 2009; 106(14):5883–5888
  • . Liu C, Bayer A, Cosgrove SE, . Clinical practice guidelines by the Infectious Diseases Society of America for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children. Clin Infect Dis. 2011; 52(3):e18–e55
  • . Centers for Disease Control and Prevention (CDC). Outpatient management of skin and soft tissue infections (SSTIs). http://www.cdc.gov/mrsa/treatment/. Published 2007. Accessed March 2, 2012
  • . Fitch MT, Manthey DE, McGinnis HD, Nicks BA, Pariyadath M. Videos in clinical medicine. Abscess incision and drainage. N Engl J Med. 2007; 357(19):e20
  • . Duong M, Markwell S, Peter J, Barenkamp S. Randomized, controlled trial of antibiotics in the management of community-acquired skin abscesses in the pediatric patient. Ann Emerg Med. 2010; 55(5):401–407
  • . Daly JM, Levy BT, Ely JW, . Management of skin and soft tissue infections in community practice before and after implementing a “best practice” approach: An Iowa Research Network (IRENE) Intervention study. J Am Board Fam Med. 2011; 24(5):524–533
  • . Lee MC, Rios AM, Aten MF, . Management and outcome of children with skin and soft tissue abscesses caused by community-acquired methicillin-resistant Staphylococcus aureus. Pediatr Infect Dis J. 2004; 23(2):123–127
  • . Krishnan PU, Miles K, Shetty N. Detection of methicillin and mupirocin resistance in Staphylococcus aureus isolates using conventional and molecular methods: A descriptive study from a burns unit with high prevalence of MRSA. J Clin Pathol. 2002; 55(10):745–748
  • . Fiebelkorn KR, Crawford SA, McElmeel ML, Jorgensen JH. Practical disk diffusion method for detection of inducible clindamycin resistance in Staphylococcus aureus and coagulase-negative staphylococci. J Clin Microbiol. 2003; 41(10):4740–4744
  • . Popovich KJ, Hota B. Treatment and prevention of community-associated methicillin-resistant Staphylococcus aureus skin and soft tissue infections. Dermatol Ther. 2008; 21(3):167–179
  • . LaPlante KL, Leonard SN, Andes DR, Craig WA, Rybak MJ. Activities of clindamycin, daptomycin, doxycycline, linezolid, trimethoprim-sulfamethoxazole, and vancomycin against community-associated methicillin-resistant Staphylococcus aureus with inducible clindamycin resistance in murine thigh infection and in vitro pharmacodynamic models. Antimicrob Agents Chemother. 2008; 52(6):2156–2162
  • . LoVecchio F, Perera N, Casanova L, Mulrow M, Pohl A. Board-certified emergency physicians' treatment of skin and soft tissue infections in the community-acquired methicillin-resistant Staphylococcus aureus era. Am J Emerg Med. 2009; 27(1):68–70
  • . Mandell GL, Moorman DR. Treatment of experimental staphylococcal infections: Effect of rifampin alone and in combination on development of rifampin resistance. Antimicrob Agents Chemother. 1980; 17(4):658–662
  • . Kluytmans JA, Manders MJ, van Bommel, Verbrugh H. Elimination of nasal carriage of Staphylococcus aureus in hemodialysis patients. Infect Control Hosp Epidemiol. 1996; 17(12):793–797
  • . Dryden MS, Dailly S, Crouch M. A randomized, controlled trial of tea tree topical preparations versus a standard topical regimen for the clearance of MRSA colonization. J Hosp Infect. 2004; 56(4):283–286
  • . Parras F, Guerrero MC, Bouza E, . Comparative study of mupirocin and oral co-trimoxazole plus topical fusidic acid in eradication of nasal carriage of methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 1995; 39(1):175–179
  • . Crossley K. Review: Intranasal mupirocin ointment reduces Staphylococcus aureus infections in nasal carriers/Review: Intranasal mupirocin ointment reduces Staphylococcus aureus infections in nasal carriers. Evid Based Med. 2009; 14(4):110
  • . Miller LG, Tan J, Eells SJ, Benitez E, Radner AB. Prospective investigation of nasal mupirocin, hexachlorophene body wash, and systemic antibiotics for prevention of recurrent community-associated methicillin-resistant Staphylococcus aureus infections. Antimicrob Agents Chemother. 2012; 56(2):1084–1086
  • . Deshpande LM, Fix AM, Pfaller MA, Jones RN; SENTRY Antimicrobial Surveillance Program Participants Group. Emerging elevated mupirocin resistance rates among staphylococcal isolates in the SENTRY Antimicrobial Surveillance Program (2000): Correlations of results from disk diffusion, Etest and reference dilution methods. Diagn Microbiol Infect Dis. 2002; 42(4):283–290
  • . Jones JC, Rogers TJ, Brookmeyer P, . Mupirocin resistance in patients colonized with methicillin-resistant Staphylococcus aureus in a surgical intensive care unit. Clin Infect Dis. 2007; 45(5): 541–547
  • . Miller MA, Dascal A, Portnoy J, Mendelson J. Development of mupirocin resistance among methicillin-resistant Staphylococcus aureus after widespread use of nasal mupirocin ointment. Infect Control Hosp Epidemiol. 1996; 17(12):811–813
  • . Patel JB, Gorwitz RJ, Jernigan JA. Mupirocin resistance. Clin Infect Dis. 2009; 49(6):935–941
  • . Edgeworth JD. Has decolonization played a central role in the decline in UK methicillin-resistant Staphylococcus aureus transmission? A focus on evidence from intensive care. J Antimicrob Chemother. 2011; 66( suppl 2):ii41–ii47
  • . Batra R, Cooper BS, Whiteley C, Patel AK, Wyncoll D, Edgeworth JD. Efficacy and limitation of a chlorhexidine-based decolonization strategy in preventing transmission of methicillin-resistant Staphylococcus aureus in an intensive care unit. Clin Infect Dis. 2010; 50(2):210–217
  • . Golding G, Quinn B, Bergstrom K, . Community-based educational intervention to limit the dissemination of community-associated methicillin-resistant Staphylococcus aureus in Northern Saskatchewan, Canada. BMC Public Health. 2012; 12(1):15
  • . National Athletic Trainers' Association (NATA). Official statement on community-acquired MRSA infections. http://www.nata.org/NR031605. Published 2005. Accessed April 7, 2012
  • . Oller AR, Province L, Curless B. Staphylococcus aureus recovery from environmental and human locations in 2 collegiate athletic teams. J Athl Train. 2010; 45(3):222–229

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