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Research Article

Hair Analysis for Opiates: Hydromorphone and Hydrocodone as Indicators of Heroin Use

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Pages 953-964 | Received 27 Jan 2016, Accepted 09 Mar 2016, Published online: 12 Apr 2016

References

  • European drug report: Trends and developments. www.emcdda.europa.eu/publications/edr/trends-developments/2014.
  • Dart RC , SevertsonSG, Bucher-BartelsonB. Trends in opioid analgesic abuse and mortality in the United States. N. Engl. J. Med. 372 (16), 1573–1574 (2015).
  • Cicero TJ , EllisMS, HarneyJ. Shifting patterns of prescription opioid and heroin abuse in the United States. N. Engl. J. Med. 373 (18), 1789–1790 (2015).
  • Pragst F , BalikovaMA. State of the art in hair analysis for detection of drug and alcohol abuse. Clin. Chim. Acta370 (1–2), 17–49 (2006).
  • Moosmann B , RothN, AuwärterV. Hair analysis for THCA-A, THC and CBN after passive in vivo exposure to marijuana smoke. Drug Test. Anal. 6 (1–2), 119–125 (2014).
  • Pragst F , BroeckerS, HastedtMet al. Methadone and illegal drugs in hair from children with parents in maintenance treatment or suspected for drug abuse in a German community. Ther. Drug Monit. 35 (6), 737–752 (2013)
  • Moosmann B , RothN, AuwärterV. Finding cannabinoids in hair does not prove cannabis consumption. Sci. Rep. 5, 14906 (2015).
  • Society of Hair Testing: recommendations for hair testing in forensic cases. Forensic Sci. Int. 145 (2–3), 83–84 (2004).
  • Society of Hair Testing: Statement of the Society of Hair Testing concerning the examination of drugs in human hair. Forensic Sci. Int. 84, 3–6 (1997).
  • Cooper G , KronstrandR, KintzP. Society of Hair Testing guidelines for drug testing in hair. Forensic Sci. Int. 218 (1–3), 20–24 (2012).
  • Blank DL , KidwellDA. Decontamination procedures for drugs of abuse in hair: are they sufficient. Forensic Sci. Int. 70, 13–38 (1995).
  • Blank DL , KidwellDA. External contamination of hair by cocaine: an issue in forensic interpretation. Forensic Sci. Int. 63 (1–3), 145–156; discussion ; 157–160 (1993).
  • Schaffer M , HillV, CairnsT. Hair analysis for cocaine: the requirement for effective wash procedures and effects of drug concentration and hair porosity in contamination and decontamination. J. Anal. Toxicol. 29 (5), 319–326 (2005).
  • Cairns T , HillV, SchafferM, ThistleW. Removing and identifying drug contamination in the analysis of human hair. Forensic Sci. Int. 145 (2–3), 97–108 (2004).
  • Schaffer MI , WangW-L, IrvingJ. An evaluation of two wash procedures for the differentiation of external contamination versus ingestion in the analysis of human hair samples for cocaine. J. Anal. Toxicol. 26 (7), 485–488 (2002).
  • Tsanaclis L , WicksJFC. Differentiation between drug use and environmental contamination when testing for drugs in hair. Forensic Sci. Int. 176 (1), 19–22 (2008).
  • Madry MM , RustKY, GuglielmelloR, BaumgartnerMR, KraemerT. Metabolite to parent drug concentration ratios in hair for the differentiation of tramadol intake from external contamination and passive exposure. Forensic Sci. Int. 223 (1–3), 330–334 (2012).
  • Tsanaclis L , NuttJ, BagleyK, BevanS, WicksJ. Differentiation between consumption and external contamination when testing for cocaine and cannabis in hair samples. Drug Test. Anal. 6 (S1), 37–41 (2014).
  • Baumgartner MR , BinzTM, KraemerT. Statistical evaluation of cocaine metabolic ratios in hair and application for discrimination between external contamination and incorporation after a single cocaine intake: a unique case. Presented at : 52nd Annual Meeting of the International Association of Forensic Toxicologists, Buenos Aires, Argentina, 9–13November 2014.
  • Cairns T , HillV, SchafferM, ThistleW. Levels of cocaine and its metabolites in washed hair of demonstrated cocaine users and workplace subjects. Forensic Sci. Int. 145 (2–3), 175–181 (2004).
  • Han E , ParkY, YangWet al. The study of metabolite-to-parent drug ratios of methamphetamine and methylenedioxymethamphetamine in hair. Forensic Sci. Int. 161 (2–3), 124–129 (2006).
  • Morris-Kukoski CL , MontgomeryMA, HammerRL. Analysis of extensively washed hair from cocaine users and drug chemists to establish new reporting criteria. J. Anal. Toxicol. 38 (9), 628–636 (2014).
  • Hoelzle C , ScheuflerF, UhlM, SachsH, ThiemeD. Application of discriminant analysis to differentiate between incorporation of cocaine and its congeners into hair and contamination. Forensic Sci. Int. 176 (1), 13–18 (2008).
  • Ropero-Miller JD , HuestisMA, StoutPR. Cocaine analytes in human hair: evaluation of concentration ratios in different cocaine sources, drug-user populations and surface-contaminated specimens. J. Anal. Toxicol. 36 (6), 390–398 (2012).
  • Romano G , BarberaN, SpadaroG, ValentiV. Determination of drugs of abuse in hair: evaluation of external heroin contamination and risk of false positives. Forensic Sci. Int. 131 (2–3), 98–102 (2003).
  • Stefanidou M , AthanaselisS, SpiliopoulouC, DonaA, MaraveliasC. Biomarkers of opiate use. Int. J. Clin. Pract. 64 (12), 1712–1718 (2010).
  • Cone EJ , HeitHA, CaplanYH, GourlayD. Evidence of morphine metabolism to hydromorphone in pain patients chronically treated with morphine. J. Anal. Toxicol. 30 (1), 1–5 (2006).
  • Cone EJ , CaplanYH, MoserF, RobertT, BlackD. Evidence that morphine is metabolized to hydromorphone but not to oxymorphone. J. Anal. Toxicol. 32 (4), 319–323 (2008).
  • Hughes MM , AtayeeRS, BestBM, PesceAJ. Observations on the metabolism of morphine to hydromorphone in pain patients. J. Anal. Toxicol. 36 (4), 250–256 (2012).
  • Wasan AD , MichnaE, JanfazaD, GreenfieldS, TeterCJ, JamisonRN. Interpreting urine drug tests: prevalence of morphine metabolism to hydromorphone in chronic pain patients treated with morphine. Pain Med. 9 (7), 918–923 (2008).
  • Mcdonough PC , LevineB, VorceS, JuferRA, FowlerD. The detection of hydromorphone in urine specimens with high morphine concentrations. J. Forensic Sci. 53 (3), 752–754 (2008).
  • Reisfield GM , ChronisterCW, GoldbergerBA, BertholfRL. Unexpected urine drug testing results in a hospice patient on high-dose morphine therapy. Clin. Chem. 55 (10), 1765–1768 (2009).
  • Hailes AM , BruceNC. Biological synthesis of the analgesic hydromorphone, an intermediate in the metabolism of morphine, by Pseudomonas putida M10. Appl. Environ. Microbiol. 59 (7), 2166–2170 (1993).
  • Yamano S , TakahashiA, TodakaT, TokiS. In vivo and in vitro formation of morphinone from morphine in rat. Xenobiotica27 (7), 645–656 (1997).
  • Coller J , ChristrupL, SomogyiA. Role of active metabolites in the use of opioids. Eur. J. Clin. Pharmacol. 65 (2), 121–139 (2009).
  • Cone EJ , DarwinWD, GorodetzkyCW, TanT. Comparative metabolism of hydrocodone in man, rat, guinea pig, rabbit, and dog. Drug Metab. Disposition6 (4), 488–493 (1978).
  • Barakat NH , AtayeeRS, BestBM, PesceAJ. Relationship between the concentration of hydrocodone and its conversion to hydromorphone in chronic pain patients using urinary excretion data. J. Anal. Toxicol. 36 (4), 257–264 (2012).
  • Oyler JM , ConeEJ, JosephREJr, HuestisMA. Identification of hydrocodone in human urine following controlled codeine administration. J. Anal. Toxicol. 24 (7), 530–535 (2000).
  • Yee DA , AtayeeRS, BestBM, MaJD. Observations on the urine metabolic profile of codeine in pain patients. J. Anal. Toxicol. 38 (2), 86–91 (2014).
  • Girod C , StaubC. Acetylcodeine as a marker of illicit heroin in human hair: method validation and results of a pilot study. J. Anal. Toxicol. 25 (2), 106–111 (2001).
  • Kintz P , JameyC, CirimeleV, BrenneisenR, LudesB. Evaluation of acetylcodeine as a specific marker of illicit heroin in human hair. J. Anal. Toxicol. 22 (6), 425–429 (1998).
  • Vree TB , Verwey-Van WissenCP. Pharmacokinetics and metabolism of codeine in humans. Biopharm. Drug Dispos. 13 (6), 445–460 (1992).
  • De Kesel PM , LambertW, StoveC. Alternative sampling strategies for cytochrome P450 phenotyping. Clin. Pharmacokinet. 55 (2), 169–184 (2015).
  • Musshoff F , LachenmeierK, TrafkowskiJ, MadeaB, NauckF, StamerU. Determination of opioid analgesics in hair samples using liquid chromatography/tandem mass spectrometry and application to patients under palliative care. Ther. Drug Monit. 29 (5), 655–661 (2007).
  • Moore C , FeldmanM, HarrisonEet al. Disposition of hydrocodone in hair. J. Anal. Toxicol. 30 (6), 353–359 (2006).
  • Brehmer C , ItenPX. Medical prescription of heroin to chronic heroin addicts in Switzerland – a review. Forensic Sci. Int. 121 (1–2), 23–26 (2001).
  • Baumgartner MR , GuglielmelloR, FangerM, KraemerT. Analysis of drugs of abuse in hair: evaluation of the immunochemical method VMA-T vs. LC–MS/MS or GC–MS. Forensic Sci. Int. 215 (1–3), 56–59 (2012).
  • Delano K , WalasekP, AleksaK, KorenG. Metabolic ratio of opioids in hair: a novel method to study population genetic polymorphism (Abstract). 17th Annual Meeting of the Society of Hair Testing (SoHT) Presented at : Toronto, Canada, 25–28June 2012
  • Bland JM , AltmanDG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet1 (8476), 307–310 (1986).

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