Microfluidic Cell Chips for High-Throughput Drug Screening

References

• FDA Issues Advice to Make Earliest Stages Of Clinical Drug Development More Efficient . www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2006/ucm108576.htm.
   Google Scholar
• Macarron R , BanksMN, BojanicDet al. Impact of high-throughput screening in biomedical research. Nat. Rev. Drug Discov. 10 (3), 188–195 (2011).
   PubMed Web of Science ®Google Scholar
• AIM Biotech . www.aimbiotech.com/chips.html.
   Google Scholar
• 3D Biotek Perfusion Bioreactor System with Pump www.sigmaaldrich.com/catalog/product/aldrich/z755354?lang=en^®ion=US.
   Google Scholar
• Sung JH , ShulerML. A micro cell culture analog (mu CCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs. Lab Chip9 (10), 1385–1394 (2009).
   PubMed Web of Science ®Google Scholar
• Dereli-Korkut Z , AkaydinHD, AhmedAHR, JiangXJ, WangSH. Three dimensional microfluidic cell arrays for ex vivo drug screening with mimicked vascular flow. Anal. Chem. 86 (6), 2997–3004 (2014).
   PubMed Web of Science ®Google Scholar
• Niu Y , BaiJ, KammRD, WangY, WangC. Validating antimetastatic effects of natural products in an engineered microfluidic platform mimicking tumor microenvironment. Mol. Pharm. 11 (7), 2022–2029 (2014).
   PubMedGoogle Scholar
• Mehta G , MehtaK, SudDet al. Quantitative measurement and control of oxygen levels in microfluidic poly(dimethylsiloxane) bioreactors during cell culture. Biomed. Microdevices9 (2), 123–134 (2007).
   PubMed Web of Science ®Google Scholar
• Zheng B , RoachLS, IsmagilovRF. Screening of protein crystallization conditions on a microfluidic chip using nanoliter-size droplets. J. Am. Chem. Soc. 125 (37), 11170–11171 (2003).
   PubMed Web of Science ®Google Scholar
• Yamashita T , TanakaY, IdotaN, SatoK, MawatariK, KitamoriT. Cultivation and recovery of vascular endothelial cells in microchannels of a separable micro-chemical chip. Biomaterials32 (10), 2459–2465 (2011).
   PubMed Web of Science ®Google Scholar
• Zheng XT , YuL, LiPWet al. On-chip investigation of cell-drug interactions. Adv. Drug Del. Rev. 65 (11–12), 1556–1574 (2013).
   PubMed Web of Science ®Google Scholar
• Gates BD , XuQB, StewartM, RyanD, WillsonCG, WhitesidesGM. New approaches to nanofabrication: molding, printing, and other techniques. Chem. Rev. 105 (4), 1171–1196 (2005).
   PubMed Web of Science ®Google Scholar
• Byun I , ParkJ, KimJ, KimB. Fabrication of PDMS Nano-stamp by replicating Si Nano-moulds fabricated by interference lithography. Proc. Prec. Eng. Nanotechnol. (Aspen2011)516, 25–29 (2012).
   Google Scholar
• Lei KF . Materials and fabrication techniques for nano- and microfluidic devices. In : Microfluidics in Detection Science: Lab-on-a-chip Technologies. The Royal Society of Chemistry, Cambridge, UK, 1–28 (2015).
   Google Scholar
• Palchesko RN , ZhangL, SunY, FeinbergAW. Development of polydimethylsiloxane substrates with tunable elastic modulus to study cell mechanobiology in muscle and nerve. PLoS ONE7 (12), e51499 (2012).
   PubMed Web of Science ®Google Scholar
• Zhou JW , KhodakovDA, EllisAV, VoelckerNH. Surface modification for PDMS-based microfluidic devices. Electrophoresis33 (1), 89–104 (2012).
   PubMed Web of Science ®Google Scholar
• Vickers JA , CaulumMM, HenryCS. Generation of hydrophilic poly(dimethylsiloxane) for high-performance microchip electrophoresis. Anal. Chem. 78 (21), 7446–7452 (2006).
   PubMed Web of Science ®Google Scholar
• Park JY , AhnD, ChoiYYet al. Surface chemistry modification of PDMS elastomers with boiling water improves cellular adhesion. Sensors and Actuators B-Chemical173, 765–771 (2012).
   Web of Science ®Google Scholar
• Wang L , SunB, ZiemerKS, BarabinoGA, CarrierRL. Chemical and physical modifications to poly(dimethylsiloxane) surfaces affect adhesion of Caco-2 cells. J. Biomed. Mater. Res. A93a (4), 1260–1271 (2010).
   Web of Science ®Google Scholar
• Zhang HB , ChiaoM. Anti-fouling coatings of poly(dimethylsiloxane) devices for biological and biomedical applications. J. Med. Biol. Eng. 35 (2), 143–155 (2015).
   PubMed Web of Science ®Google Scholar
• Wang J , BettingerCJ, LangerRS, BorensteinJT. Biodegradable microfluidic scaffolds for tissue engineering from amino alcohol-based poly(ester amide) elastomers. Organogenesis6 (4), 212–216 (2010).
   PubMed Web of Science ®Google Scholar
• Domachuk P , TsiorisK, OmenettoFG, KaplanDL. Bio-microfluidics: biomaterials and biomimetic designs. Adv. Mater. 22 (2), 249–260 (2010).
   PubMed Web of Science ®Google Scholar
• Waldbaur A , RappH, LangeK, RappBE. Let there be chip-towards rapid prototyping of microfluidic devices: one-step manufacturing processes. Anal. Methods3 (12), 2681–2716 (2011).
   Web of Science ®Google Scholar
• Ren K , ZhouJ, WuH. Materials for microfluidic chip fabrication. Acc. Chem. Res. 46 (11), 2396–2406 (2013).
   PubMed Web of Science ®Google Scholar
• Cabodi M , ChoiNW, GleghornJP, LeeCSD, BonassarLJ, StroockAD. A microfluidic biomaterial. J. Am. Chem. Soc. 127 (40), 13788–13789 (2005).
   PubMed Web of Science ®Google Scholar
• Tseng P , MurrayC, KimD, Di CarloD. Research highlights: printing the future of microfabrication. Lab Chip14 (9), 1491–1495 (2014).
   PubMedGoogle Scholar
• Rodriguez-Rivera V , WeidnerJW, YostMJ. Three-dimensional biomimetic technology: novel biorubber creates defined micro- and macro-scale architectures in collagen hydrogels. J. Vis. Exp. 12 (108), e53578 (2016).
   Google Scholar
• Bettinger CJ , WeinbergEJ, KuligKMet al. Three-dimensional microfluidic tissue-engineering scaffolds using a flexible biodegradable polymer. Adv. Mater. (Deerfield Beach, Fla.)18 (2), 165–169 (2005).
   PubMed Web of Science ®Google Scholar
• Yetisen AK , AkramMS, LoweCR. Paper-based microfluidic point-of-care diagnostic devices. Lab Chip13 (12), 2210–2251 (2013).
   PubMed Web of Science ®Google Scholar
• Cate DM , AdkinsJA, MettakoonpitakJ, HenryCS. Recent developments in paper-based microfluidic devices. Anal. Chem. 87 (1), 19–41 (2015).
   PubMed Web of Science ®Google Scholar
• Hansson J , YasugaH, HaraldssonT, Van Der WijngaartW. Synthetic microfluidic paper: high surface area and high porosity polymer micropillar arrays. Lab Chip16 (2), 298–304 (2016).
   PubMed Web of Science ®Google Scholar
• Paguirigan A , BeebeDJ. Gelatin based microfluidic devices for cell culture. Lab Chip6 (3), 407–413 (2006).
   PubMed Web of Science ®Google Scholar
• Zhang W , LinS, WangCet al. PMMA/PDMS valves and pumps for disposable microfluidics. Lab Chip9 (21), 3088–3094 (2009).
   PubMed Web of Science ®Google Scholar
• Au AK , LeeW, FolchA. Mail-order microfluidics: evaluation of stereolithography for the production of microfluidic devices. Lab Chip14 (7), 1294–1301 (2014).
   PubMed Web of Science ®Google Scholar
• Kang HW , ChoDW. Development of an indirect stereolithography technology for scaffold fabrication with a wide range of biomaterial selectivity. Tissue Eng. C Methods18 (9), 719–729 (2012).
   PubMed Web of Science ®Google Scholar
• Khalil S , SunW. Bioprinting endothelial cells with alginate for 3D tissue constructs. J. Biomech. Eng. 131 (11), 111002 (2009).
   PubMed Web of Science ®Google Scholar
• Au AK , LaiHY, UtelaBR, FolchA. Microvalves and micropumps for BioMEMS. Micromachines-Basel2 (2), 179–220 (2011).
   Web of Science ®Google Scholar
• King KR , WangSH, IrimiaD, JayaramanA, TonerM, YarmushML. A high-throughput microfluidic real-time gene expression living cell array. Lab Chip7 (1), 77–85 (2007).
   PubMed Web of Science ®Google Scholar
• Wu MH , HuangSB, CuiZF, CuiZ, LeeGB. A high throughput perfusion-based microbioreactor platform integrated with pneumatic micropumps for three-dimensional cell culture. Biomed. Microdevices10 (2), 309–319 (2008).
   PubMed Web of Science ®Google Scholar
• Lau ATH , YipHM, NgKCC, CuiX, LamRHW. Dynamics of microvalve operations in integrated microfluidics. Micromachines-Basel5 (1), 50–65 (2014).
   Web of Science ®Google Scholar
• Walker GM , BeebeDJ. A passive pumping method for microfluidic devices. Lab Chip2 (3), 131–134 (2002).
   PubMed Web of Science ®Google Scholar
• Pedro JR , DavidJB, JustinCW. A review of tubeless microfluidic devices. In : Microfluidics and Nanotechnology. CRC Press, FL, USA, 221–264 (2014).
   Google Scholar
• Chen YL , GaoD, LiuHX, LinS, JiangYY. Drug cytotoxicity and signaling pathway analysis with three-dimensional tumor spheroids in a microwell-based microfluidic chip for drug screening. Anal. Chim. Acta898, 85–92 (2015).
   PubMed Web of Science ®Google Scholar
• Park J , YoonTH. Microfluidic image cytometry (mu FIC) assessments of silver nanoparticle cytotoxicity. Bull. Korean Chem. Soc. 33 (12), 4023–4027 (2012).
   Web of Science ®Google Scholar
• Ye NN , QinJH, ShiWW, LiuX, LinBC. Cell-based high content screening using an integrated microfluidic device. Lab Chip7 (12), 1696–1704 (2007).
   PubMed Web of Science ®Google Scholar
• Hung PJ , LeePJ, SabounchiP, LinR, LeeLP. Continuous perfusion microfluidic cell culture array for high-throughput cell-based assays. Biotechnol. Bioeng. 89 (1), 1–8 (2005).
   PubMed Web of Science ®Google Scholar
• Flaim CJ , ChienS, BhatiaSN. An extracellular matrix microarray for probing cellular differentiation. Nat. Methods2 (2), 119–125 (2005).
   PubMed Web of Science ®Google Scholar
• Englert DL , MansonMD, JayaramanA. Flow-based microfluidic device for quantifying bacterial chemotaxis in stable, competing gradients. Appl. Environ. Microbiol. 75 (13), 4557–4564 (2009).
   PubMed Web of Science ®Google Scholar
• An D , KimK, KimJ. Microfluidic system based high throughput drug screening system for Curcumin/TRAIL combinational chemotherapy in human prostate cancer PC3 cells. Biomol. Ther. (Seoul)22 (4), 355–362 (2014).
   PubMed Web of Science ®Google Scholar
• Liu D , WangL, ZhongRet al. Parallel microfluidic networks for studying cellular response to chemical modulation. J. Biotechnol. 131 (3), 286–292 (2007).
   PubMed Web of Science ®Google Scholar
• Lau C , NygardS, FureHet al. CD14 and complement crosstalk and largely mediate the transcriptional response to escherichia coli in human whole blood as revealed by DNA microarray. PLoS ONE10 (2), (2015).
   Web of Science ®Google Scholar
• Lao YH , ChiangHY, YangDK, PeckK, ChenLC. Selection of aptamers targeting the sialic acid receptor of hemagglutinin by epitope-specific SELEX. Chem. Commun. 50 (63), 8719–8722 (2014).
   PubMed Web of Science ®Google Scholar
• Lee MY , KumarRA, SukumaranSM, HoggMG, ClarkDS, DordickJS. Three-dimensional cellular microarray for high-throughput toxicology assays. Proc. Natl Acad. Sci. USA105 (1), 59–63 (2008).
   PubMed Web of Science ®Google Scholar
• Yeon JH , ParkJK. Cytotoxicity test based on electrochemical impedance measurement of HepG2 cultured in microfabricated cell chip. Anal. Biochem. 341 (2), 308–315 (2005).
   PubMed Web of Science ®Google Scholar
• Caviglia C , ZorK, MontiniLet al. Impedimetric toxicity assay in microfluidics using free and liposome-encapsulated anticancer drugs. Anal. Chem. 87 (4), 2204–2212 (2015).
   PubMed Web of Science ®Google Scholar
• Caviglia C , ZorK, CanepaSet al. Interdependence of initial cell density, drug concentration and exposure time revealed by real-time impedance spectroscopic cytotoxicity assay. Analyst140 (10), 3623–3629 (2015).
   PubMed Web of Science ®Google Scholar
• Pihl J , SinclairJ, SahlinEet al. Microfluidic gradient-generating device for pharmacological profiling. Anal. Chem. 77 (13), 3897–3903 (2005).
   PubMed Web of Science ®Google Scholar
• Mao SF , GaoD, LiuW, WeiHB, LinJM. Imitation of drug metabolism in human liver and cytotoxicity assay using a microfluidic device coupled to mass spectrometric detection. Lab Chip12 (1), 219–226 (2012).
   PubMed Web of Science ®Google Scholar
• Berthuy OI , BlumLJ, MarquetteCA. Cancer-cells on a chip for label-free optic detection of secreted molecules. Biosensors (Basel). 6 (1), pii: E2 (2016).
   PubMedGoogle Scholar
• Lee K , KimC, AhnBet al. Generalized serial dilution module for monotonic and arbitrary microfluidic gradient generators. Lab Chip9 (5), 709–717 (2009).
   PubMed Web of Science ®Google Scholar
• Wang H , ChenCH, XiangZL, WangM, LeeC. A convection-driven long-range linear gradient generator with dynamic control. Lab Chip15 (6), 1445–1450 (2015).
   PubMed Web of Science ®Google Scholar
• Abhyankar VV , LokutaMA, HuttenlocherA, BeebeDJ. Characterization of a membrane-based gradient generator for use in cell-signaling studies. Lab Chip6 (3), 389–393 (2006).
   PubMed Web of Science ®Google Scholar
• Ziauddin J , SabatiniDM. Microarrays of cells expressing defined cDNAs. Nature411 (6833), 107–110 (2001).
   PubMed Web of Science ®Google Scholar
• Lee PJ , HungPJ, RaoVM, LeeLP. Nanoliter scale microbioreactor array for quantitative cell biology. Biotechnol. Bioeng. 94 (1), 5–14 (2006).
   PubMed Web of Science ®Google Scholar
• Baker BM , ChenCS. Deconstructing the third dimension - how 3D culture microenvironments alter cellular cues. J. Cell Sci. 125 (13), 3015–3024 (2012).
   PubMed Web of Science ®Google Scholar
• Walsh CL , BabinBM, KasinskasRW, FosterJA, McgarryMJ, ForbesNS. A multipurpose microfluidic device designed to mimic microenvironment gradients and develop targeted cancer therapeutics. Lab Chip9 (4), 545–554 (2009).
   PubMed Web of Science ®Google Scholar
• Lee PJ , HungPJ, LeeLP. An artificial liver sinusoid with a microfluidic endothelial-like barrier for primary hepatocyte culture. Biotechnol. Bioeng. 97 (5), 1340–1346 (2007).
   PubMed Web of Science ®Google Scholar
• Huh D , MatthewsBD, MammotoA, Montoya-ZavalaM, HsinHY, IngberDE. Reconstituting organ-level lung functions on a chip. Science328 (5986), 1662–1668 (2010).
   PubMed Web of Science ®Google Scholar
• Kim HJ , HuhD, HamiltonG, IngberDE. Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow. Lab Chip12 (12), 2165–2174 (2012).
   PubMed Web of Science ®Google Scholar
• Torisawa YS , SpinaCS, MammotoTet al. Bone marrow-on-a-chip replicates hematopoietic niche physiology in vitro. Nat. Methods11 (6), 663–+ (2014).
   PubMed Web of Science ®Google Scholar
• Yasotharan S , PintoS, SledJG, BolzSS, GuntherA. Artery-on-a-chip platform for automated, multimodal assessment of cerebral blood vessel structure and function. Lab Chip15 (12), 2660–2669 (2015).
   PubMed Web of Science ®Google Scholar
• Huh D , LeslieDC, MatthewsBDet al. A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice. Sci. Transl. Med. 4 (159), 159ra147 (2012).
   PubMed Web of Science ®Google Scholar
• Jang KJ , SuhKY. A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells. Lab Chip10 (1), 36–42 (2010).
   PubMed Web of Science ®Google Scholar
• Jang KJ , MehrAP, HamiltonGAet al. Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment. Integrative Biology5 (9), 1119–1129 (2013).
   PubMed Web of Science ®Google Scholar
• Agarwal A , GossJA, ChoA, MccainML, ParkerKK. Microfluidic heart on a chip for higher throughput pharmacological studies. Lab Chip13 (18), 3599–3608 (2013).
   PubMed Web of Science ®Google Scholar
• Bhatia SN , IngberDE. Microfluidic organs-on-chips. Nat. Biotechnol. 32 (8), 760–772 (2014).
   PubMed Web of Science ®Google Scholar
• Booth R , KimH. Characterization of a microfluidic in vitro model of the blood–brain barrier (mu BBB). Lab Chip12 (10), 1784–1792 (2012).
   PubMed Web of Science ®Google Scholar
• Kim J , TaylorD, AgrawalNet al. A programmable microfluidic cell array for combinatorial drug screening. Lab Chip12 (10), 1813–1822 (2012).
   PubMed Web of Science ®Google Scholar
• Occhetta P , CentolaM, TonnarelliB, RedaelliA, MartinI, RasponiM. High-throughput microfluidic platform for 3D cultures of mesenchymal stem cells, towards engineering developmental processes. Sci. Rep. 5, 10288 (2015).
   PubMed Web of Science ®Google Scholar
• Huang SB , WangSS, HsiehCH, LinYC, LaiCS, WuMH. An integrated microfluidic cell culture system for high-throughput perfusion three-dimensional cell culture-based assays: effect of cell culture model on the results of chemosensitivity assays dagger. Lab Chip13 (6), 1133–1143 (2013).
   PubMed Web of Science ®Google Scholar
• Wen Y , ZhangX, YangS-T. Microplate-reader compatible perfusion microbioreactor array for modular tissue culture and cytotoxicity assays. Biotechnol. Prog. 26 (4), 1135–1144 (2010).
   PubMed Web of Science ®Google Scholar
• Montanez-Sauri SI , SungKE, PuccinelliJP, PehlkeC, BeebeDJ. Automation of three-dimensional cell culture in arrayed microfluidic devices. J. Lab. Autom. 16 (3), 171–185 (2011).
   PubMedGoogle Scholar
• List of microfluidics companies . http://fluidicmems.com/list-of-microfluidics-lab-on-a-chip-and-biomems-companies.
   Google Scholar
• ACEA Biosciences . www.aceabio.com/about/.
   Google Scholar
• Bell Brook Labs . www.bellbrooklabs.com/products-services/iuvo-microconduit-array-platform/microchannel-5250/.
   Google Scholar
• Cellasic bought by Millipore . www.emdmillipore.com/US/en/life-science-research/cell-culture-systems/cellASIC-live-cell-analysis/microfluidic-plates/68eb.qB.wfkAAAFBWmVb3.sJ,nav.
   Google Scholar
• Cytoo . http://cytoo.com/about-us.
   Google Scholar
• Celsee Diagnostics . http://celsee.com/about-us/.
   Google Scholar
• Fluxion Biosciences . http://fluxionbio.com/bioflux/.
   Google Scholar
• Xona mcirofluidics http://xonamicrofluidics.com/.
   Google Scholar