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Editorial

Microspray and Microflow Liquid Chromatography: The Way Forward for LC–MS Bioanalysis

Pages 1935-1937 | Received 29 Sep 2017, Accepted 05 Oct 2017, Published online: 05 Dec 2017

References

  • Kebarle P , TangL. From ions in solution to ions in the gas phase: the mechanism of electrospray ionization mass spectrometry. Anal. Chem. 65, A972–A986 (1993).
  • Ishii D , AsaiK, HibiK, JonokuchiT, NagayaM. A study of micro-high-performance liquid chromatography. J. Chromatogr. A144 (2), 157–168 (1977).
  • Valaskovic GA , UtleyL, LeeMS, WuJT. Ultra-low flow nanospray for the normalization of conventional liquid chromatography/mass spectrometry through equimolar response: standard-free quantitative estimation of metabolite levels in drug discovery. Rapid Comm. Mass Spec. 20 (7), 1087–1096 (2006).
  • Johnson CJL , ChristiansonCD, NeedhamSR. The advantages of microflow LC–MS/MS compared with conventional HPLC–MS/MS for the analysis of methotrexate from human plasma. Bioanalysis5 (11), 1387–1396 (2013).
  • Needham SR , ValaskovicG. Peptide and protein bioanalysis using integrated column-to-source technology for high-flow nanospray. Chapter 5. In : Protein Analysis Using Mass Spectrometry: Accelerating Protein Biotherapeutics from Lab to Patient. LeeMS, LiQC ( Eds). John Wiley and Sons, Inc. (2017).
  • Stove C , SpoonerN. DBS and beyond. Bioanalysis7 (16), 1961–1962 (2015).
  • Covey TE , HenionJ. High-speed liquid chromatography/tandem mass spectrometry for the determination of drugs in biological samples. Anal Chem. 58, 2453–2460 (1986).
  • Emmett M , CaprioliR. Microspray-electrospray mass spectrometry: ultra-high-sensitivity analysis of peptides and proteins. J. Am. Soc. Mass Spectrom. 5 (7), 605–613 (1994).
  • Johnson CC , DeChenneCS, NeedhamS, ValaskovicG. Validation of an in-source micro flow LC–MS/MS method for bioanalysis. Presented at : The 62nd Conference on American Society for Mass Spectrometry. Baltimore, MD, 15–19 June 2014.
  • Kleinnijenhuis A , IngolaM, ToerscheJ, van HolthoonF, van DongenW. Quantitative bottom up analysis of infliximab in serum using protein A purification and integrated LC-electrospray chip IonKey MS/MS technology. Bioanalysis8 (9), 891–904 (2016).

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