Advanced search
Publication Cover
Bioanalysis Volume 2, 2010 - Issue 9
Submit an article Journal homepage
1,407
Views
0
CrossRef citations to date
0
Altmetric
Bioanalytical Challenge

Challenges in Urine Bioanalytical Assays: Overcoming Nonspecific Binding

Allena Ji Ji1 Bioanalytical Services, XenoBiotic Laboratories, Inc., 107 Morgan Lane, Plainsboro, NJ08536, USA;2 Bioanalytical R&D, Drug Safety & Metabolism, Pfizer, NY, USACorrespondence[email protected]
,
Zhiping Jiang1 Bioanalytical Services, XenoBiotic Laboratories, Inc., 107 Morgan Lane, Plainsboro, NJ08536, USA;3 Hoffman-La Roche, NJ, USA
,
Yuliya Livson2 Bioanalytical R&D, Drug Safety & Metabolism, Pfizer, NY, USA;3 Hoffman-La Roche, NJ, USA
,
Jennifer Ann Davis2 Bioanalytical R&D, Drug Safety & Metabolism, Pfizer, NY, USA;4 Novartis Pharmaceuticals Corp., NJ, USA
,
Jasper Xuegong Chu2 Bioanalytical R&D, Drug Safety & Metabolism, Pfizer, NY, USA;5 Pfizer, CT, USA
&
Naidong Weng6 Johnson & Johnson Pharmaceutical Research & Development, NJ, USA
Pages 1573-1586 | Published online: 20 Aug 2010

Bibliography

  • Li W , LuoS, SmithH, TseF. Quantitative determination of baf312, a s1p-r modulator,in human urine by LC–MS/MS: prevention and recovery of lost analyte due to container surface adsorption. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 878(5–6), 583–589 (2010).
  • Hoffman B , BhadresaS, ZhaoLet al. Adsorptive losses in a bioanalyticalLC–MS/MS urine assay. Poster Presented at:American Society For Mass Spectrometry, Seattle, WA, USA 8 May– 2 June 2006.
  • Viswanathan CT , BansalS, BoothBet al. Quantitative bioanalytical methods validation and implementation: best practices for chromatographic and ligand binding assays. Pharm. Res. 24(10), 1962–1973 (2007).
  • Gotoh A , UchidaK, HamanoY, MashibaS, KawabataI, ItohY. Evaluation of adsorption of urine cystatin c to thepolymer materials on the microplate by an antigen capture enzyme-linked immunosorbent assay. Clin. Chim. Acta397(1–2), 13–17 (2008).
  • Fisher AL , DepuyE, ShihTet al. Liquid chromatographic–tandem mass spectrometric urine assay for a highly metabolized cyclic ureidobenzenesulfonamide: issues concerning assay specificity and quality control preparation. J. Pharm. Biomed. Anal. 26(5–6), 739–752 (2001).
  • Groff M , RiffelK, SongH, LoMW. Stabilization and determination of a PPAR agonist in human urine using automated 96-well liquid–liquid extraction and liquid chromatography/tandem mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 842(2), 122–130 (2006).
  • Rodila R , KimGE, FanLet al. HPLC–MS/MS determination of a hardly soluble drug in human urine through drug-albumin binding assisted dissolution. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 872(1–2), 128–132 (2008).
  • Rose MJ , MerschmanSA, WoolfEJ, MatuszewskiBK. Determination of l-756 423, a novel HIV protease inhibitor, in human plasma and urine using high-performance liquid chromatography with fluorescence detection. J. Chromatogr. B Biomed. Sci. Appl. 732(2), 425–435 (1999).
  • Schwartz M , KlineW, MatuszewskiB. Determination of a cyclic hexapeptide (l-743 872), a novel pneumocandin antifungal agent in human plasma and urine by high-performance liquid chromatography with fluorescencedetection. Anal. Chim. Acta352(1–3), 299–307 (1997).
  • Chen C , BajpaiL, MollovaN, LeungK. Sensitive and cost-effective LC–MS/MS method for quantitation of cvt-6883 in human urine using sodium dodecylbenzenesulfonate additive toeliminate adsorptive losses. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 877(10), 943–947 (2009).
  • Xu Y , DuL, RoseMJ, FuI, WoolfEJ, MussonDG. Concerns in the development of an assay for determination of a highly conjugated adsorption-prone compound in human urine. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 818(2), 241–248 (2005).
  • Vittinghus E . Preanalytical handling of stored urine samples, and measurement of β2-microglobulin, orosomucoid, albumin, transferrin and immunoglobulin g in urine by enzyme-linked immunosorbent assays (ELISA). Scand. J. Clin. Lab. Invest. 50(8), 843–849 (1990).
  • Xu RN , BoydB, RieserMJ, El-ShourbagyTA. Simultaneous LC–MS/MS quantitation of a highly hydrophobic pharmaceutical compound and its metabolite in urine online monolithic phase-based extraction. J. Sep. Sci. 30(17), 2943–2949 (2007).
  • Palmgren JJ , MonkkonenJ, KorjamoT, HassinenA, AuriolaS. Drug adsorption to plastic containers and retention of drugs in cultured cells under in vitro conditions. Eur. J. Pharm. Biopharm. 64(3), 369–378 (2006).
  • Davis ME , BrewsterME. Cyclodextrin-based pharmaceutics: past, present and future. Drug Discovery3(12), 1023–1035 (2004).

Patent

  • Amshey J, Donn R. US patent 606020 – methods for reducing adsorption in an assay. PatentStorm (2000).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.