Bibliography
- Park BK , KitteringhamNR, MaggsJL, PirmohamedM, WilliamsDP. The role of metabolic activation in drug-induced hepatotoxicity. Annu. Rev. Pharmacol. Toxicol. 45, 177–202 (2005).
- Jan BMD , NicoNMC, VermeulenPE. Mercapturic acids as biomarkers of exposure to electrophilic chemicals: applications to environmental and industrial chemicals. Biomarkers3, 239–303 (1998).
- Kuiper HC , MirandaCL, SowellJD, StevensJF. Mercapturic acid conjugates of 4-hydroxy-2-nonenal and 4-oxo-2-nonenal metabolites are in vivo markers of oxidative stress. J. Biol. Chem. 283, 17131–17138 (2008).
- Seutter-Berlage F , van Dorp HL, Kosse HG, Henderson PT. Urinary mercapturic acid excretion as a biological parameter of exposure to alkylating agents. Int. Arch. Occup. Environ. Health39, 45–51 (1977).
- Inoue O , KannoE, KasaiK, UkaiH, OkamotoS, IkedaM. Benzylmercapturic acid is superior to hippuric acid and o-cresol as a urinary marker of occupational exposure to toluene. Toxicol. Lett. 147, 177–186 (2004).
- Hinchman CA , BallatoriN. Glutathione conjugation and conversion to mercapturic acids can occur as an intrahepatic process. J. Toxicol. Environ. Health41, 387–409 (1994).
- Teichert J , SohrR, HennigLet al. Identification and quantitation of the N-acetyl-L-cysteine S-conjugates of bendamustine and its sulfoxides in human bile after administration of bendamustine hydrochloride. Drug Metab. Dispos. 37, 292–301 (2009).
- Siegers CP , LoeserW, GieselmannJ, OltmannsD. Biliary and renal excretion of paracetamol in man. Pharmacology29, 301–303 (1984).
- Hinchman CA , RebbeorJF, BallatoriN. Efficient hepatic uptake and concentrative biliary excretion of a mercapturic acid. Am. J. Physiol. 275, G612–G619 (1998).
- Amore BM , KalhornTF, SkilesGLet al. Characterization of carbamazepine metabolism in a mouse model of carbamazepine teratogenicity. Drug Metab. Dispos. 25, 953–962 (1997).
- Madden S , MaggsJL, ParkBK. Bioactivation of carbamazepine in the rat in vivo. Evidence for the formation of reactive arene oxide(s). Drug Metab. Dispos. 24, 469–479 (1996).
- Maggs JL , PirmohamedM, KitteringhamNR, ParkBK. Characterization of the metabolites of carbamazepine in patient urine by liquid chromatography/mass spectrometry. Drug Metab. Dispos. 25, 275–280 (1997).
- Dieckhaus CM , Fernandez-MetzlerCL, KingR, KrolikowskiPH, BaillieTA. Negative ion tandem mass spectrometry for the detection of glutathione conjugates. Chem. Res. Toxicol. 18, 630–638 (2005).
- Gopaul S , FarrellK, AbbottF. Effects of age and polytherapy, risk factors of valproic acid (VPA) hepatotoxicity, on the excretion of thiol conjugates of (E)-2,4-diene VPA in people with epilepsy taking VPA. Epilepsia44, 322–328 (2003).
- Srivastava A , LianLY, MaggsJLet al. Quantifying the metabolic activation of nevirapine in patients by integrated applications of NMR and mass spectrometries. Drug Metab. Dispos. 38(1), 122–132 (2010).
- Espina R , YuL, WangJet al. Nuclear magnetic resonance spectroscopy as a quantitative tool to determine the concentrations of biologically produced metabolites: implications in metabolites in safety testing. Chem. Res. Toxicol. 22, 299–310 (2009).
- Shenton JM , TeranishiM, bu-AsabMS, YagerJA, UetrecJP. Characterization of a potential animal model of an idiosyncratic drug reaction: nevirapine-induced skin rash in the rat. Chem. Res. Toxicol. 16, 1078–1089 (2003).
- Kumar S , KassahunK, Tschirret-GuthRA, MitraK, BaillieTA. Minimizing metabolic activation during pharmaceutical lead optimization: progress, knowledge gaps and future directions. Curr. Opin. Drug Discov. Devel. 11, 43–52 (2008).
- Bauman JN , KellyJM, TripathySet al. Can in vitro metabolism-dependent covalent binding data distinguish hepatotoxic from nonhepatotoxic drugs? An analysis using human hepatocytes and liver S-9 fraction. Chem. Res. Toxicol. 22, 332–340 (2009).
- Obach RS , KalgutkarAS, SogliaJR, and Zhao SX. Can in vitro metabolism-dependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose. Chem. Res. Toxicol. 21, 1814–1822 (2008).
- Takakusa H , MasumotoH, YukinagaHet al. Covalent binding and tissue distribution/retention assessment of drugs associated with idiosyncratic drug toxicity. Drug. Metab. Dispos. 36, 1770–1779 (2008).
- Teichert J , SohrR, HennigLet al. In vitro screening of 50 highly prescribed drugs for thiol adduct formation-comparison of potential for drug-induced toxicity and extent of adduct formation. Chem. Res. Toxicol. 22, 690–698 (2009).
- Levesque JF , DaySH, ChauretNet al. Metabolic activation of indole-containing prostaglandin D2 receptor 1 antagonists: impacts of glutathione trapping and glucuronide conjugation on covalent binding. Bioorg. Med. Chem. Lett. 17, 3038–3043 (2007).