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Review

Controlling Sources of Preanalytical Variability in Doping Samples: Challenges and Solutions

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Pages 1571-1582 | Published online: 24 Jun 2013

References

  • Lippi G , FranchiniM, GuidiGC. Doping in competition or doping in sport? Br. Med. Bull. 86, 95–107 (2008).
  • Lippi G , Sanchis-GomarF, BanfiG. Anti-‘negative-doping’ testing: a new perspective in anti-doping research? Eur. J. Appl. Physiol. 112, 2383–2384 (2012).
  • Lippi G , GuidiGC, MattiuzziC, PlebaniM. Preanalytical variability: the dark side of the moon in laboratory testing. Clin. Chem. Lab. Med. 44, 358–365 (2006).
  • Lippi G , BanfiG, MaffulliN. Preanalytical variability: the dark side of the moon in blood doping screening. Eur. J. Appl. Physiol. 109, 1003–1005 (2010).
  • Lippi G , MontagnanaM, SalvagnoGL, FranchiniM, GuidiGC. Glycaemic control in athletes. Int. J. Sports Med. 29, 7–10 (2008).
  • Lippi G , SchenaF, SalvagnoGL, MontagnanaM, BallestrieriF, GuidiGC. Comparison of the lipid profile and lipoprotein(a) between sedentary and highly trained subjects. Clin. Chem. Lab. Med. 44, 322–326 (2006).
  • Lippi G , BanfiG, Luca Salvagno G, Montagnana M, Franchini M, Cesare Guidi G. Comparison of creatinine-based estimations of glomerular filtration rate in endurance athletes at rest. Clin. Chem. Lab. Med. 46, 235–239 (2008).
  • Lippi G , PlebaniM. Athlete’s biological passport: to test or not to test? Clin. Chem. Lab. Med. 49, 1393–1395 (2011).
  • Lippi G , SchenaF, MontagnanaM, SalvagnoGL, BanfiG, GuidiGC. Significant variation of traditional markers of liver injury after a half-marathon run. Eur. J. Intern. Med. 22, e36–e38 (2011).
  • Lippi G , SchenaF, SalvagnoGLet al. Acute variation of estimated glomerular filtration rate following a half-marathon run. Int. J. Sports Med. 29, 948–951 (2008).
  • Lippi G , SchenaF, MontagnanaM, SalvagnoGL, BanfiG, GuidiGC. Acute variation of osteocalcin and parathyroid hormone in athletes after running a half-marathon. Clin. Chem. 54, 1093–1095 (2008).
  • Lippi G , BanfiG, MontagnanaM, SalvagnoGL, SchenaF, GuidiGC. Acute variation of leucocytes counts following a half-marathon run. Int. J. Lab. Hematol. 32, 117–121 (2010).
  • Banfi G , LundbyC, RobachP, LippiG. Seasonal variations of haematological parameters in athletes. Eur. J. Appl. Physiol. 111, 9–16 (2011).
  • Banfi G , Del Fabbro M, Lippi G. Creatinine values during a competitive season in elite athletes involved in different sport disciplines. J. Sports Med. Phys. Fitness48, 479–482 (2008).
  • Banfi G , Del Fabbro M, Lippi G. Relation between serum creatinine and body mass index in elite athletes of different sport disciplines. Br. J. Sports Med. 40, 675–678 (2006).
  • Banfi G , LombardiG, ColombiniA, LippiG. Bone metabolism markers in sports medicine. Sports Med. 40, 697–714 (2010).
  • Ahlgrim C , PottgiesserT, RobinsonN, SottasPE, RueckerG, SchumacherYO. Are 10 min of seating enough to guarantee stable haemoglobin and haematocrit readings for the athlete’s biological passport? Int. J. Lab. Hematol. 32, 506–511 (2010).
  • Lippi G , Lima-OliveiraG, SalvagnoGLet al. Influence of a light meal on routine haematological tests. Blood Transfus. 8, 94–99 (2010).
  • Lima-Oliveira G , SalvagnoGL, LippiGet al. Influence of a regular, standardized meal on clinical chemistry analytes. Ann. Lab. Med. 32, 250–256 (2012).
  • Schumacher YO , KlodtF, NonisDet al. The impact of long-haul air travel on variables of the athlete’s biological passport. Int. J. Lab. Hematol. doi: 10.1111/j.1751–553X.2012.01450.x (2012) (Epub ahead of print).
  • Lippi G , Becan-McBrideK, BehúlováDet al. Preanalytical quality improvement: in quality we trust. Clin. Chem. Lab. Med. 51, 229–241 (2013).
  • Lippi G , SonntagO, PlebaniM. Appropriate labelling of blood collection tubes: a step ahead towards patient’s safety. Clin. Chem. Lab. Med. 49, 1921–1923 (2011).
  • Lippi G , PlebaniM. Primary blood tubes mixing: time for updated recommendations. Clin. Chem. Lab. Med. 50, 599–600 (2012).
  • Banfi G , SalvagnoGL, LippiG. The role of ethylenediamine tetraacetic acid (EDTA) as in vitro anticoagulant for diagnostic purposes. Clin. Chem. Lab. Med. 45, 565–576 (2007).
  • Bull BS , FujimotoK, HouwenBet al. ICSH Expert Panel on Cytometry. International Council for Standardization in Haematology (ICSH) recommendations for ‘surrogate reference’ method for the packed cell volume. Lab. Hematol. 9, 1–9 (2003).
  • Lippi G , MattiuzziC, GuidiGC. Laboratory quality improvement by implementation of phlebotomy guidelines. MLO Med. Lab. Obs. 38, 6–7 (2006).
  • Lippi G , SalvagnoGL, MontagnanaM, FranchiniM, GuidiGC. Phlebotomy issues and quality improvement in results of laboratory testing. Clin. Lab. 52, 217–230 (2006).
  • Lippi G , SalvagnoGL, MontagnanaM, BroccoG, GuidiGC. Influence of short-term venous stasis on clinical chemistry testing. Clin. Chem. Lab. Med. 43, 869–875 (2005).
  • Lippi G , SalvagnoGL, MontagnanaM, GuidiGC. Short-term venous stasis influences routine coagulation testing. Blood Coagul. Fibrinolysis16, 453–458 (2005).
  • Lippi G , SalvagnoGL, MontagnanaM, FranchiniM, GuidiGC. Venous stasis and routine hematologic testing. Clin. Lab. Haematol. 28, 332–337 (2006).
  • Lippi G , SalvagnoGL, SoleroGP, GuidiGC. The influence of the tourniquet time on hematological testing for antidoping purposes. Int. J. Sports Med. 27, 359–362 (2006).
  • Banfi G . Limits and pitfalls of Athlete’s Biological Passport. Clin. Chem. Lab. Med. 49, 1417–1421 (2011).
  • Lima-Oliveira G , LippiG, SalvagnoGLet al. Transillumination: a new tool to eliminate the impact of venous stasis during the procedure for the collection of diagnostic blood specimens for routine haematological testing. Int. J. Lab. Hematol. 33, 457–462 (2011).
  • Lippi G , BlanckaertN, BoniniPet al. Haemolysis: an overview of the leading cause of unsuitable specimens in clinical laboratories. Clin. Chem. Lab. Med. 46, 764–772 (2008).
  • Lippi G , PlebaniM, Di Somma S, Cervellin G. Hemolyzed specimens: a major challenge for emergency departments and clinical laboratories. Crit. Rev. Clin. Lab. Sci. 48, 143–153 (2011).
  • Lippi G , AvanziniP, PavesiFet al. Studies on in vitro hemolysis and utility of corrective formulas for reporting results on hemolyzed specimens. Biochem. Med. (Zagreb)21, 297–305 (2011).
  • Lippi G , BanfiG, ButtarelloMet al. Recommendations for detection and management of unsuitable samples in clinical laboratories. Clin. Chem. Lab. Med. 45, 728–736 (2007).
  • Plebani M , LippiG. Hemolysis index: quality indicator or criterion for sample rejection? Clin. Chem. Lab. Med. 47, 899–902 (2009).
  • Lippi G , PavesiF, CattabianiC, AvanziniP, PipitoneS. Influence of in vitro hemolysis on nucleated red blood cells and reticulocyte counts. Int. J. Lab. Hematol. 35(2), 225–228. (2012).
  • Lippi G , MusaR, AvanziniP, AloeR, PipitoneS, SandeiF. Influence of in vitro hemolysis on hematological testing on Advia 2120. Int. J. Lab. Hematol. 34, 179–184 (2012).
  • Lippi G , PipitoneS, GennariD, FranchiniM. Identification of spurious hemolysis in anticoagulated blood with Sysmex XE-2100 and Siemens Advia 2120. Clin. Lab. 58, 801–804 (2012).
  • Lippi G , FranchiniM. Lipaemic donations: truth and consequences. Transfus. Apher. Sci. doi: 10.1016/j.transci.2012.10.001 (2012) (Epub ahead of print).
  • Lippi G , RomeroA, CervellinG, MercadantiM. Unusual false-positive case of urinary screening for buprenorphine. J. Clin. Lab. Anal. 25, 244–245 (2011).
  • Ventura R , SeguraJ. Masking and manipulation. Handb. Exp. Pharmacol. 195, 327–354 (2010).
  • Sanchis-Gomar F , Martinez-BelloVE, NascimentoALet al. Desmopresssin and hemodilution: implications in doping. Int. J. Sports Med. 31, 5–9 (2010).
  • Thevis M , MaurerJ, KohlerM, GeyerH, SchänzerW. Proteases in doping control analysis. Int. J. Sports Med. 28, 545–549 (2007).
  • Sanchis-Gomar F , Martinez-BelloVE, NascimentoAL, Gomez-CabreraMC, ViñaJ. Alternate methods to prevent protease use as a masking agent in sport. J. Sci. Med. Sport13, 473–474 (2010).
  • Tsivou M , GeorgakopoulosDG, DimopoulouHA, KoupparisMA, Atta-PolitouJ, GeorgakopoulosCG. Stabilization of human urine doping control samples: a current opinion. Anal. Bioanal. Chem. 401, 553–561 (2011).
  • Tsivou M , LivadaraD, GeorgakopoulosDG, KoupparisMA, Atta-PolitouJ, GeorgakopoulosCG. Stabilization of human urine doping control samples: II. microbial degradation of steroids. Anal. Biochem. 388, 146–154 (2009).
  • Tsivou M , LivadaraD, GeorgakopoulosDG, KoupparisMA, Atta-PolitouJ, GeorgakopoulosCG. Stabilization of human urine doping control samples. Anal. Biochem. 388, 179–191 (2009).
  • Lippi G , Lima-OliveiraG, NazerSCet al. Suitability of a transport box for blood sample shipment over a long period. Clin. Biochem. 44, 1028–1029 (2011).
  • Sanchis-Gomar F , Martínez-BelloVE, Olaso-GonzálezG, Gómez-CabreraMC, ViñaJ. Different types of storage devices for blood transportation in the anti-doping field. Clin. Biochem. 44, 1361 (2011).
  • Zaninotto M , TasinatoA, PadoanAet al. Effects of sample transportation on commonly requested laboratory tests. Clin. Chem. Lab. Med. 50, 1755–1760 (2012).
  • Lippi G , ChanceJJ, ChurchSet al. Preanalytical quality improvement: from dream to reality. Clin. Chem. Lab. Med. 49, 1113–1126 (2011).
  • Lippi G , SalvagnoGL, SoleroGP, FranchiniM, GuidiGC. Stability of blood cell counts, hematologic parameters and reticulocytes indexes on the Advia A120 hematologic analyzer. J. Lab. Clin. Med. 146, 333–340 (2005).
  • Lombardi G , LanteriP, ColombiniA, LippiG, BanfiG. Stability of haematological parameters and its relevance on the athlete’s biological passport model. Sports Med. 41, 1033–1042 (2011).
  • Ashenden M , ClarkeA, SharpeK, D’OnofrioG, PlowmanJ, GoreCJ. Stability of athlete passport parameters during extended storage. Int. J. Lab. Hematol. 35(2), 183–192 (2013).
  • Kouri T , SiloahoM, PohjavaaraSet al. Pre-analytical factors and measurement uncertainty. Scand. J. Clin. Lab. Invest. 65, 463–475 (2005).
  • Banfi G , LombardiG, ColombiniA, LippiG. Analytical variability in sport hematology: its importance in an antidoping setting. Clin. Chem. Lab. Med. 49, 779–782 (2011).
  • Sanchis-Gomar F , Cortell-BallesterJ, Pareja-GaleanoH, BanfiG, LippiG. Hemoglobin point-of-care testing: the HemoCue system. J. Lab. Autom. 18(3), 198–205 (2013).
  • Greene DN , SchmidtRL, KamerSM, GrenacheDG, HokeC, LoreyTS. Limitations in qualitative point of care hCG tests for detecting early pregnancy. Clin. Chim. Acta415, 317–321 (2013).
  • Atkinson KR , LoKR, PayneSR, MitchellJS, IngramJR. Rapid saliva processing techniques for near real-time analysis of salivary steroids and protein. J. Clin. Lab. Anal. 22, 395–402 (2008).
  • Sottas PE , SaudanC, SaugyM. Doping: a paradigm shift has taken place in testing. Nature455, 166 (2008).

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