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Bioanalysis Volume 5, 2013 - Issue 12
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Review

Salting-Out Assisted Liquid–Liquid Extraction for Bioanalysis

Yong Q Tang1 Department of Drug metabolism & Pharmacokinetics, Arena Pharmaceuticals Inc., 6154 Nancy Ridge Drive, San Diego, CA92121, USA. [email protected]Correspondence[email protected]
&
Naidong Weng2 Janssen Research & Development, 1000 US Highway 202, Raritan, NJ08869, USA
Pages 1583-1598 | Published online: 24 Jun 2013

References

  • Xu RN , FanL, RieserMJ, El-ShourbagyTA. Recent advances in high-throughput quantitative bioanalysis by LC–MS. J. Pharm. Biomed. Anal. 44, 342–355 (2007).
  • Zhou S , SongQ, TangY, WengN. Critical review of development, validation, and transfer for high throughput bioanalytical LC–MS/MS methods. Curr. Pharm. Anal. 1, 3–14 (2005).
  • Guillarme D , SchapplerJ, RudazS, VeutheyJL. Coupling ultra-high-pressure liquid chromatography with mass spectrometry. Trends Anal. Chem. 29, 15–27 (2010).
  • Badman ER , BeardsleyRL, LiangZ, BansalS. Accelerating high quality bioanalytical LC/MS/MS assays using fused-core columns. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 878, 2307–2313 (2010).
  • Jian W , EdomRW, XuY, WengN. Recent advances in application of hydrophilic interaction chromatography for quantitative bioanalysis. J. Sep. Sci. 33, 1–17 (2010).
  • Al-Dirbashi OY , Aboul-EneinHY, JacobM, Al-QahtaniK, RashedMS. UPLC–MS/MS determination of doxazosine in human plasma. Anal. Bioanal. Chem. 385, 1439–1443 (2006).
  • Yadav M , RaoR, Kurani1Het al. Validated ultra-performance liquid chromatography tandem mass spectrometry method for the determination of pramipexole in human plasma. J. Chromatogr. Sci. 48, 811–818 (2010).
  • Zang X , LuoR, SongN, ChenTK, BozigianH. A novel on-line solid-phase extraction approach integrated with a monolithic column and tandem mass spectrometry for direct plasma analysis of multiple drugs and metabolites. Rapid Commun. Mass Spectrom. 19, 3259–3268 (2005).
  • Frigerio E , CenacchiV, JamesCA. Determination of PNU-248686A, a novel matrix metalloproteinase inhibitor, in human plasma by liquid chromatography-tandem mass spectrometry, following protein precipitation in the 96-well plate format. J. Chromatogr. A987, 249–256 (2003).
  • Shou WZ , JiangX, BeatoBD, WengN. A highly automated 96-well solid phase extraction and liquid chromatography/tandem mass spectrometry method for the determination of fentanyl in human plasma. Rapid Commun. Mass Spectrom. 15, 466–476 (2001).
  • Ramos L , BakhtiarR, TseFL. Liquid–liquid extraction using 96-well plate format in conjunction with liquid chromatography/tandem mass spectrometry for quantitative determination of methylphenidate (Ritalin) in human plasma. Rapid Commun. Mass Spectrom. 14, 740–745 (2000).
  • Wang PG , WeiJS, KimG, ChangM, El-ShourbagyT. Validation and application of a high-performance liquid chromatography–tandem mass spectrometric method for simultaneous quantification of lopinavir and ritonavir in human plasma using semi-automated 96-well liquid–liquid extraction. J. Chromatogr. A1130, 302–307 (2006).
  • Zhang J , WuH, KimE, El-ShourbagyTA. Salting-out assisted liquid/liquid extraction with acetonitrile: a new high throughput sample preparation technique for good laboratory practice bioanalysis using liquid chromatography-mass spectroscopy. Biomed. Chromatogr. 23, 419–425 (2009).
  • Wu H , ZhangJ, NoremK, El-ShourbagyTA. Simultaneous determination of a hydrophobic drug candidate and its methabolite in human plasma with salting-out assisted liquid/liquid extraction using a mass spectrometry friendly salt. J. Pharm Biomed. Anal. 48, 1243–1248 (2008).
  • Myasein F , KimE, ZhangJ, WuH, El-ShourbagyTA. Rapid, simultaneous determination of lopinavir and ritonavir in human plasma by stacking protein precipitations and salting-out assisted liquid/liquid extraction, and ultrafast LC–MS/MS. Anal. Chim. Acta651, 112–116 (2009).
  • Zhang J , MyaseinF, WuH, El-ShourbagyTA. High-throughput salting-out assisted liquid–liquid extraction and ultrafast LC for the same day delivery of bioanalytical data in a first-in-human study. Bioanalysis1, 715–719 (2009).
  • Zhang J , RamonaR, GageEet al. High-throughput salting-out assisted liquid/liquid extraction with acetonitrile for the simultaneous determination of simvastatin and simvastatin acid in human plasma with liquid chromatography. Anal. Chim. Acta661, 167–172 (2010).
  • Yanes EG , LovettDP. High-throughput bioanalytical method for analysis of synthetic cannabinoid metabolites in urine using salting-out sample preparation and LC–MS/MS. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 909, 42–50 (2012).
  • Rustum AM , HoffmanNE. Determination of cyclophosphamide in whole blood and plasma by reversed-phase high-performance liquid chromatography. J.Chromatogr. 422, 125–134 (1987).
  • Rustum AM . Determination of cadralazine in human whole blood using reversed-phase high-performance liquid chromatography: utilizing a salting-out extraction procedure. J.Chromatogr. 489, 345–352 (1989).
  • Rustum AM , Determination of diltiazem in human whole blood and plasma by high performance liquid chromatography using a polymeric reverse-phase column and utilizing a salting out extraction procedure. J. Chromatogr. 490, 365–375 (1989).
  • Rustum AM . Estimation of cyclosporin-A in whole blood by simple and rapid reversed-phase HPLC utilizing a salting-out extraction procedure. J. Chromatogr. Sci. 28, 594–598 (1990).
  • Cociglio M , AlricR, BouvierO. Performance analysis of a reversed-phase liquid chromatographic assay of lamotrigine in plasma using solvent-demixing extraction. J. Chromatogr. 572, 269–276 (1991).
  • Alric R , CocigloM, BlayacJP, PuechR. Performance evaluation of a reversed-phase, high-performance liquid chromatographic assay of valproic acid involving a ‘solvent demixing’ extraction procedure and precolumn derivatization. J. Chromatogr. 224, 289–299 (1981).
  • Cociglio M , Hillaire-BuysD, PeyriereH, AlricR. Performance analysis of a rapid HPLC determination with the solvent demixing extraction of HIV antiproteases and efavirenz in plasma. J. Chromatogr. Sci. 41, 80–86 (2003).
  • Yoshida M , AkaneA, NishikawaM, WatabikiT, TsuchihashiH. Extraction of thiamylal in serum using hydrophilic acetonitrile with subzero-temperature and salting-out methods. Anal. Chem. 76, 4672–4675 (2004).
  • Matkovich CE , ChristianGD. Salting-out of acetone from water-basis of a new solvent extraction system. Anal. Chem. 45, 1915–1921 (1973).
  • Chuang NH , TabataM. Salting-out phase separation of the mixture of 2-propanol and water for selective extraction of colbalt(II) in the presence of manganese(II), nickel(II), and copper(II). Hydrometallurgy73, 81–89 (2004).
  • Tabata M , KumamotoM, NishimotoJ. Chemical properties of water miscible solvents separated by salt-out and their application to solvent extraction. Anal. Sci. 10, 383–388 (1994).
  • Horning MG , BoucherEA, StaffordM, HorningEC. A rapid procedure for the isolation of drugs and drugs and metabolites from plasma. Clin. Chim. Acta37, 381–386 (1972).
  • Horning MG , GregoryP, NowlinJet al. Isolation of drugs and drug metabolites from biological fluids by use of salt-solvent pairs. Clin. Chem. 20, 282–287 (1974).
  • Jenkins TF , MiyaresPH. Nonevaporative preconcentration technique for volatile and semi-volatile solutes in certain polar solvent. Anal. Chem. 63, 1341–1343 (1991).
  • Chen GG , TureckiG, MamerOA. A novel liquid–liquid extraction and stable isotope dilution NCI-GC–MS method for quantitation of agmatine in postmortem brain cortex. J. Mass Spectrom. 45, 560–565 (2010).
  • So TSK , HuieCW. Salting-out solvent extraction for the off-line preconcentration of benzalkonium chloride in capillary electrophoresis. Electrophoresis22, 2143–2149 (2001).
  • Li Q , HuieCW. Coupling of acetonitrile deproteinization and salting-out extraction with acetonitrile stacking for biological sample clean-up and the enrichment of hydrophobic compounds (porphyrins) in capillary electrophoresis. Electrophoresis27, 4219–4229 (2006).
  • Choy TMH , ChanWH, LeeAWM, HuieCW. Stacking and separation of enantiomers by acetonitrile-salt mixtures in micellarelectrokinetic chromatography. Electrophoresis24, 3116–3123 (2003).
  • Leggett DC , JenkinsTF, MiyaresPH. Salting-out solvent extraction for preconcentration of neutral polar organic solutes from water. Anal. Chem. 62, 1355–1356 (1990).
  • Nagosa Y , TaniguchiM, MiuraJ. Hydrophobic salt-induced phase-separation and extraction for sample preparation in chromatographic determination of heavy metal ions as dibenzyldithiocarbamates. Anal. Chem. Acta356, 135–140 (1997).
  • Wang H , ZhouX, ZhangYet al. Dynamic microwave-assistant extraction coupled with salting-out liquid–liquid extraction for determination of steroid hormones in fish tissues. J. Agric. Food Chem. 60, 10343–10351 (2012).
  • Song S , EdiageEN, WuA, SaegerSD. Development and application of salting-out assisted liquid/liquid extraction for multi-mycotoxin biomarkers analysis in pig urine with high performance liquid chromatography/tandem mass spectrometry. J. Chromatogr. A1292, 111–120 (2013).
  • Bastos ML , KananenGE, YoungRM, MonforteJR, SunshineI. Detection of basic organic drugs and their metabolites in urine. Clin. Chem. 16, 931–940 (1970).
  • Zhang J , MyaseinF, WuH, El-ShourbagyTA. Sugaring-out assisted liquid/liquid extraction with acetonitrile for bioanalysis using liquid chromatography-mass spectroscopy. Microchem. J. 108, 198–202 (2013).
  • Majors RE . Salting-out liquid–liquid extraction (SALLE). LCGC North America27, 526–533 (2009).
  • Kole PL , VenkateshG, KotechaJ, SheshalaR. Recent advances in sample preparation techniques for effective bioanalytical methods. Biomed. Chromatogr. 25, 199–217 (2011).
  • Chandewar AV , DewaniAP, WadhwaniNG, PawarAA. A review: developments in extraction procedures of analytes from biological samples. Int. J. Univ. Pharm. Life Sci. 2, 64–91 (2012).
  • Ma M , TangYQ. High throughput bioanalysis of lorcaserin in human plasma using salting-out assisted liquid/liquid extraction (SALLE) and LC–MS/MS. Presented at:The 60th ASMS Conference on Mass Spectrometry and Allied Topics. Vancouver, Canada, 20–24 May 2012.
  • Zhao FJ , TangH, ZhangQH, YangJ, DaveyAK, WangJP. Salting-out homogeneous liquid–liquid extraction approach applied in sample pre-processing for the quantitative determination of entecavir in human plasma by LC–MS. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 881–882, 119–125 (2012).
  • Anastassiades M , LehotaySJ, StajnbaherD, SchenckFJ. Fast and easy multiresidue method employing acetonitrile extraction/partitioning and ‘dispersive solid-phase extraction’ for the determination of pesticide residues in produce. J. AOAC Int. 86, 412–431 (2003).
  • Li AC , LiY, GuirguisMS, CaldwellRG, ShouWZ. Advantages of using tetrahydrofuran-water as mobile phase in the quantitation of cyclosporine A in monkey and rat plasma by liquid chromatography–tandem mass spectroscopy. J. Pharm. Biomed. Anal. 43, 277–284 (2007).
  • Karatapanis AE , FiamegosYC, StalikasCD. HILIC separation and quantitation of water-soluble vitamins using diol column. J. Sep. Sci. 32(7), 909–917 (2009).
  • Polson C , SarkarP, IncledonB, RaguvaranV, GrantR. Optimization of protein precipitation based upon effectiveness of protein removal and ionization effect in liquid chromatography–tandem mass spectrometry. J. Chromatogr. B785, 263–275 (2003).
  • Li CH . Recovery of aniline from wastewater by nitrobenzene extraction enhanced with salting-out effect. Biomed. Environ. Sci. 23, 208–212 (2010).
  • Tsai WH , HuangTC, ChenHH, WuYW, HuangJJ, ChuangHY. Determination of sulfonamides in swine muscle after salting-out assisted liquid extraction with acetonitrile coupled with back-extraction by a water/dichloromethane ternary component system prior to high-performance liquid chromatography. J. Chromatogr. A1217, 250–255 (2010).
  • Tsai WH , HuangTC, HuangJJ, HsueYH, ChuangHY. Dispersive solid-phase microextraction method for sample extraction in the analysis of four tetracyclines in water and milk samples by high-performance liquid chromatography with diode-array detection. J. Chromatogr. A1216, 2263–2269 (2009).
  • Wang B , EzejiT, FengH, BlaschekH. Sugaring-out : A novel phase separation and extraction system. Chem. Eng. Sci. 63, 2595–2600 (2008).
  • Tsai WH , ChuangHY, ChenHH, WuYW, ChengSH, HuangTC. Application of sugaring-out extraction for determination of sulfonamides in honey by high-performance liquid chromatography with fluorescence detection. J. Chromatogr. A1217, 7812–7815 (2010).
  • Jones LA , PrabelJB, GlennonJJ, CopelandMF, KavlockRJ. Extraction of phenol and its metabolites from aqueous solution. J. Agric. Food Chem. 41, 735–741 (1993).
  • Hendriks G , UgesDRA, FrankeJP. Reconsideration of sample pH adjustment in bioanalytical liquid–liquid extraction of ionisable compounds. J. Chromatogr. B853, 234–241 (2007).
  • Wang M , CaiZ, XuL. Coupling of acetonitrile deproteinization and salting-out extraction with acetonitrile stacking in chiral capillary electrophoresis for the determination of warfarin enantiomers. J. Chromatogr. A1218, 4045–4051 (2011).
  • Liu G , ZhouN, ZhangMet al. Hydrophobic solvent induced phase transition extraction to extract drugs from plasma for high performance liquid chromatography-mass spectrometric analysis. J. Chromatogr. A1217, 243–249 (2010).
  • Garofolo F , BergeronM, MiltonF, MathieuL. Selection of buffer additives for liquid–liquid extraction(LLE) procedure to remove matrix effect. Presented at:2010 AAPS Annual Meeting and Exposition. New Orleans, LA, USA, 14–18 November 2010.
  • Tan B , NegahbanA, McDonaldT, ZhangY, HollimanC. Utilization of hydrophilic-interaction LC to minimize matrix effects caused by phospholipids. Bioanalysis4(16), 2049–2058 (2012).
  • Bu W , NguyenM, XuC, LinCC, YehLT, BorgesV. Determination of N-acetylretigabine in dog plasma by LC/MS/MS following off-line microelution 96-well solid phase extraction. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 852(1–2), 465–472 (2007).
  • Weng N . Bioanalytical liquid chromatography tandem mass spectrometry methods on underivatized silica columns with aqueous/organic mobile phases. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 796, 209–224 (2003).
  • Weng N , ShouWZ, AddisonT, MalekiS, JiangX. Direct injection of solid-phase extraction eluents onto silica columns for the analysis of polar compounds isoniazid and cetirizine in plasma using hydrophilic interaction chromatography with tandem mass spectrometry. Rapid Commun. Mass Spectrom. 18, 2343–2350 (2004).
  • Song Q , WengN. Analysis of omeprazole and 5-OH omeprazole in human plasma using hydrophilic interaction chromatography with tandem mass spectrometry (HILIC–MS/MS) – eliminating evaporation and reconstitution steps in 96-well liquid/liquid extraction. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 830, 135–142 (2006).
  • Xue YJ , LiuJ, UngerS. A 96-well single-pot liquid–liquid extraction, hydrophilic interaction liquid chromatography-mass spectrometry method for the determination of muraglitazar in human plasma. J. Pharm. Biomed. Anal. 41, 979–988 (2006).

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