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Bioanalysis Volume 5, 2013 - Issue 12
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Preliminary Communication

Determination of Artemether and Dihydroartemisinin in Human Plasma with A New Hydrogen Peroxide Stabilization Method

Liusheng Huangb Drug Research Unit, Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, CA94110, USA. [email protected]Correspondence[email protected]
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,
Alexander Olsona Drug Research Unit, Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, CA94110, USAView further author information
,
David Gingricha Drug Research Unit, Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, CA94110, USAView further author information
&
Francesca T Aweekaa Drug Research Unit, Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, CA94110, USAView further author information
Pages 1501-1506 | Published online: 24 Jun 2013

References

  • Peys E , VandenkerckhoveJ, Van Hemel J, Sas B. Simultaneous determination of β-artemether and its metabolite dihydroartemisinin in human plasma and urine by a high-performance liquid chromatography-mass spectrometry assay using electrospray ionisation. Chromatographia61, 637–641 (2005).
  • Shi B , YUY, LiZet al. Quantitative analysis of artemether and its metabolite dihydroartemisinin in human plasma by LC with tandem mass spectrometry. Chromatographia64, 523–530 (2006).
  • Souppart C , GauducheauN, SandrenanN, RichardF. Development and validation of a high-performance liquid chromatography–mass spectrometry assay for the determination of artemether and its metabolite dihydroartemisinin in human plasma. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 774, 195–203 (2002)
  • Hanpithakpong W , KamanikomB, SinghasivanonP, WhiteNJ, DayNPJ, LindegardhN. A liquid chromatographic–tandem mass spectrometric method for determination of artemether and its metabolite dihydroartemisinin in human plasma. Bioanalysis1, 37–46 (2009).
  • Huang L , JayewardeneAL, LiX, MarzanF, LizakPS, AweekaFT. Development and validation of a high-performance liquid chromatography-tandem mass spectrometry method for determination of artemether and its active metabolite dihydroartemisinin in human plasma. J. Pharm. Biomed. Anal. 50, 959–965 (2009).
  • Wiesner L , GovenderK, MeredithSA, NormanJ, SmithPJ. A liquid-liquid LC/MS/MS assay for the determination of artemether and DHA in malaria patient samples. J. Pharm. Biomed. Anal. 55, 373–8 (2011).
  • Lindegardh N , HanpithakpongW, KamanikomBet al. Major pitfalls in the measurement of artemisinin derivatives in plasma in clinical studies. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 876, 54–60 (2008).
  • Keiser J , GruyerMS, PerrottetN, ZanolariB, MercierT, DecosterdLA. Pharmacokinetics parameters of artesunate and dihydroartemisinin in rats infected or not by Fasciola hepatica. J. Antimicrob. Chemother. 63, 543–549 (2009).
  • Hodel EM , ZanolariB, MercierTet al. A single LC tandem mass spectrometry method for the simultaneous determination of 14 antimalarial drugs and their metabolites in human plasma. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 877, 867–886 (2009).
  • AIDS Clinical Trials Group network guidelines for method development and validation based on (and including) FDA guidelines dated by 2001. Version 2 (2005).
  • Colussi D , ParisotC, LegayF, LefèvreG. Binding of artemether and lumefantrine to plasma proteins and Erythrocytes. Eur. J. Pharm. Sci. 9, 9–16 (1999).
  • Batty KT , IlettKF, DavisTM. Protein binding and α:β anomer ratio of dihydroartemisinin in vivo. Br. J. Clin. Pharmacol. 57, 529–533 (2004).
  • Blessborn D , SköldK, ZeebergD, KaewkhaoK, SköldO Ahnoff M. Heat stabilization of blood spot samples for determination of metabolically unstable drug compounds. Bioanalysis5(1), 31–39 (2013).

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