Alternative Matrices for Therapeutic Drug Monitoring of Immunosuppressive Agents Using LC–MS/MS

References

• Schiff J , ColeE, CantarovichM. Therapeutic monitoring of calcineurin inhibitors for the nephrologist. Clin. J. Am. Soc. Nephrol. 2 (2), 374–384 (2007).
   PubMed Web of Science ®Google Scholar
• Johnston A , HoltDW. Ther. Drug Monit. of immunosuppressant drugs. Br. J. Clin. Pharmacol. 47 (4), 339–350 (1999).
   PubMedGoogle Scholar
• Staatz CE , TettSE. Clinical pharmacokinetics and pharmacodynamics of tacrolimus in solid organ transplantation. Clin. pharmacokinet. 43 (10), 623–653 (2004).
   PubMed Web of Science ®Google Scholar
• Staatz CE , TettSE. Clinical pharmacokinetics and pharmacodynamics of mycophenolate in solid organ transplant recipients. Clin. pharmacokinet. 46 (1), 13–58 (2007).
   PubMed Web of Science ®Google Scholar
• Mohammadpour N , ElyasiS, VahdatiN, MohammadpourAH, ShamsaraJ. A review on Ther. Drug Monit. of immunosuppressant drugs. Iran. J. Basic Med. Sci. 14 (6), 485–498 (2011).
   PubMed Web of Science ®Google Scholar
• Korecka M , ShawLM. Review of the newest HPLC methods with mass spectrometry detection for determination of immunosuppressive drugs in clinical practice. Ann. Transplant. 14 (2), 61–72 (2009).
   PubMed Web of Science ®Google Scholar
• Sallustio BC . LC–MS/MS for immunosuppressant therapeutic drug monitoring. Bioanalysis2 (6), 1141–1153 (2010).
   PubMed Web of Science ®Google Scholar
• Vogeser M , KirchhoffF. Progress in automation of LC–MS in laboratory medicine. Clin. Biochem. 44 (1), 4–13 (2011).
   PubMed Web of Science ®Google Scholar
• Marinova M , ArtusiC, BrugnoloL, AntonelliG, ZaninottoM, PlebaniM. Immunosuppressant Ther. Drug Monit. by LC–MS/MS: workflow optimization through automated processing of whole blood samples. Clin. Biochem. 46 (16–17), 1723–1727 (2013).
   PubMed Web of Science ®Google Scholar
• Spooner N , LadR, BarfieldM. Dried blood spots as a sample collection technique for the determination of pharmacokinetics in clinical studies: considerations for the validation of a quantitative bioanalytical method. Analy. Chem. 81 (4), 1557–1563 (2009).
   PubMed Web of Science ®Google Scholar
• Webb NJ , CoulthardMG, TrompeterRSet al. Correlation between finger-prick and venous ciclosporin levels: association with gingival overgrowth and hypertrichosis. Pediatr. Nephrol. 22 (12), 2111–2118 (2007).
   PubMed Web of Science ®Google Scholar
• Yonan N , MartyszczukR, MachaalA, BaynesA, KeevilBG. Monitoring of cyclosporine levels in transplant recipients using self-administered fingerprick sampling. Clin. Transplant. 20 (2), 221–225 (2006).
   PubMed Web of Science ®Google Scholar
• Keevil BG , TierneyDP, CooperDP, MorrisMR, MachaalA, YonanN. Simultaneous and rapid analysis of cyclosporin A and creatinine in finger prick blood samples using liquid chromatography tandem mass spectrometry and its application in C2 monitoring. Ther. Drug Monit. 24 (6), 757–767 (2002).
   PubMed Web of Science ®Google Scholar
• Webb NJ , RobertsD, PreziosiR, KeevilBG. Fingerprick blood samples can be used to accurately measure tacrolimus levels by tandem mass spectrometry. Pediatr. Transplant. 9 (6), 729–733 (2005).
   PubMed Web of Science ®Google Scholar
• Leichtle AB , CeglarekU, WitzigmannH, GabelG, ThieryJ, FiedlerGM. Potential of dried blood self-sampling for cyclosporine c(2) monitoring in transplant outpatients. J. Transplant. 2010, 201918 (2010).
   PubMedGoogle Scholar
• Murthy JN , YatscoffRW, SoldinSJ. Cyclosporine metabolite cross-reactivity in different cyclosporine assays. Clin. Biochem. 31 (3), 159–163 (1998).
   PubMed Web of Science ®Google Scholar
• Murthy JN , DavisDL, YatscoffRW, SoldinSJ. Tacrolimus metabolite cross-reactivity in different tacrolimus assays. Clin. Biochem. 31 (8), 613–617 (1998).
   PubMed Web of Science ®Google Scholar
• Dietemann J , BerthouxP, Gay-MontchampJP, BatieM, BerthouxF. Comparison of ELISA method versus MEIA method for daily practice in the therapeutic monitoring of tacrolimus. Nephrol. Dialysis Transplant. 16 (11), 2246–2249 (2001).
   PubMed Web of Science ®Google Scholar
• Napoli KL . Is microparticle enzyme-linked immunoassay (MEIA) reliable for use in tacrolimus TDM? Comparison of MEIA to liquid chromatography with mass spectrometric detection using longitudinal trough samples from transplant recipients. Ther. Drug Monit. 28 (4), 491–504 (2006).
   PubMed Web of Science ®Google Scholar
• Moes DJ , PressRR, de FijterJW, GuchelaarHJ, den HartighJ. Liquid chromatography-tandem mass spectrometry outperforms fluorescence polarization immunoassay in monitoring everolimus therapy in renal transplantation. Ther. Drug Monit. 32 (4), 413–419 (2010).
   PubMed Web of Science ®Google Scholar
• Buchwald A , WinklerK, EptingT. Validation of an LC–MS/MS method to determine five immunosuppressants with deuterated internal standards including MPA. BMC Clin. Pharmacol. 12, 2 (2012).
   PubMedGoogle Scholar
• Zimmer D . Introduction to Quantitative Liquid Chromatography-Tandem Mass Spectrometry. Chromatographia57 (Suppl.), S325–S332 (2003).
   Google Scholar
• Holcapek M , KolarovaL, NobilisM. High-performance liquid chromatography-tandem mass spectrometry in the identification and determination of phase I and phase II drug metabolites. Anal. Bioanal. Chem. 391 (1), 59–78 (2008).
   PubMed Web of Science ®Google Scholar
• Belostotsky V , AdawayJ, KeevilBG, CohenDR, WebbNJ. Measurement of saliva tacrolimus levels in pediatric renal transplant recipients. Pediatr. Nephrol. 26 (1), 133–138 (2011).
   PubMed Web of Science ®Google Scholar
• Shen B , LiS, ZhangYet al. Determination of total, free and saliva mycophenolic acid with a LC–MS/MS method: application to pharmacokinetic study in healthy volunteers and renal transplant patients. J. Pharm. Biomed. Anal. 50 (3), 515–521 (2009).
   PubMed Web of Science ®Google Scholar
• Dams R , HuestisMA, LambertWE, MurphyCM. Matrix effect in bio-analysis of illicit drugs with LC–MS/MS: influence of ionization type, sample preparation, and biofluid. J. Am. Soc. Mass Spectrom. 14 (11), 1290–1294 (2003).
   PubMed Web of Science ®Google Scholar
• Mei H , HsiehY, NardoCet al. Investigation of matrix effects in bioanalytical high-performance liquid chromatography/tandem mass spectrometric assays: application to drug discovery. Rapid Commun. Mass Spectrom. 17 (1), 97–103 (2003).
   PubMed Web of Science ®Google Scholar
• Chambers E , Wagrowski-DiehlDM, LuZ, MazzeoJR. Systematic and comprehensive strategy for reducing matrix effects in LC/MS/MS analyses. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 852 (1–2), 22–34 (2007).
   PubMed Web of Science ®Google Scholar
• Feller K , le PetitG. On the distribution of drugs in saliva and blood plasma. Int. J. Clin. Pharmacol. Biopharm. 15 (10), 468–469 (1977).
   PubMedGoogle Scholar
• Horning MG , BrownL, NowlinJ, LertratanangkoonK, KellawayP, ZionTE. Use of saliva in therapeutic drug monitoring. Clin. Chem. 23 (2 Pt. 1), 157–164 (1977).
   PubMed Web of Science ®Google Scholar
• Mucklow JC , BendingMR, KahnGC, DolleryCT. Drug concentration in saliva. Clin. Pharmacol. Ther. 24 (5), 563–570 (1978).
   PubMed Web of Science ®Google Scholar
• Drobitch RK , SvenssonCK. Ther. Drug Monit. in saliva. An update. Clin. pharmacokinet. 23 (5), 365–379 (1992).
   PubMed Web of Science ®Google Scholar
• Gorodischer R , KorenG. Salivary excretion of drugs in children: theoretical and practical issues in therapeutic drug monitoring. Dev. Pharmacol. Ther. 19 (4), 161–177 (1992).
   PubMedGoogle Scholar
• Haeckel R . Factors influencing the saliva/plasma ratio of drugs. Ann. NY Acad. Sci. 694, 128–142 (1993).
   PubMed Web of Science ®Google Scholar
• Jusko WJ , MilsapRL. Pharmacokinetic principles of drug distribution in saliva. Ann. NY Acad. Sci. 694, 36–47 (1993).
   PubMed Web of Science ®Google Scholar
• Coates JE , LamSF, McGawWT. Radioimmunoassay of salivary cyclosporine with use of 125I-labeled cyclosporine. Clin. Chem. 34 (8), 1545–1551 (1988).
   PubMed Web of Science ®Google Scholar
• Wiesen MH , FarowskiF, FeldkotterM, HoppeB, MullerC. Liquid chromatography-tandem mass spectrometry method for the quantification of mycophenolic acid and its phenolic glucuronide in saliva and plasma using a standardized saliva collection device. J. Chromatogr. A, 1241, 52–59 (2012).
   PubMed Web of Science ®Google Scholar
• Mendonza AE , GohhRY, AkhlaghiF. Analysis of mycophenolic acid in saliva using liquid chromatography tandem mass spectrometry. Ther. Drug Monit. 28 (3), 402–406 (2006).
   PubMed Web of Science ®Google Scholar
• Mendonza A , GohhR, AkhlaghiF. Determination of cyclosporine in saliva using liquid chromatography-tandem mass spectrometry. Ther. Drug Monit. 26 (5), 569–575 (2004).
   PubMed Web of Science ®Google Scholar
• Swallow V , HughesJ, RobertsD, WebbNJ. Assessing children’s and parents’ opinions on salivary sampling for therapeutic drug monitoring. Nurse Res. 19 (3), 32–37 (2012).
   PubMedGoogle Scholar
• Tennison M , AliI, MilesMV, D’CruzO, VaughnB, GreenwoodR. Feasibility and acceptance of salivary monitoring of antiepileptic drugs via the US Postal Service. Ther. Drug Monit. 26 (3), 295–299 (2004).
   PubMed Web of Science ®Google Scholar
• Gorodischer R , BurtinP, HwangP, LevineM, KorenG. Saliva versus blood sampling for Ther. Drug Monit. in children: patient and parental preferences and an economic analysis. Ther. Drug Monit. 16 (5), 437–443 (1994).
   PubMed Web of Science ®Google Scholar
• Zahir H , McCaughanG, GleesonM, NandRA, McLachlanAJ. Changes in tacrolimus distribution in blood and plasma protein binding following liver transplantation. Ther. Drug Monit. 26 (5), 506–515 (2004).
   PubMed Web of Science ®Google Scholar
• Akhlaghi F , AshleyJ, KeoghA, BrownK. Cyclosporine plasma unbound fraction in heart and lung transplantation recipients. Ther. Drug Monit. 21 (1), 8–16 (1999).
   PubMed Web of Science ®Google Scholar
• Haeckel R , HaneckeP. Application of saliva for drug monitoring. An in vivo model for transmembrane transport. Eur. J. Clin. Chem. Clin. Biochem. 34 (3), 171–191 (1996).
   PubMedGoogle Scholar
• Kaufman E , LamsterIB. The diagnostic applications of saliva--a review. Crit. Rev. Oral Biol. Med. 13 (2), 197–212 (2002).
   PubMedGoogle Scholar
• Lipinski CA , LombardoF, DominyBW, FeeneyPJ. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev. 46 (1–3), 3–26 (2001).
   PubMed Web of Science ®Google Scholar
• Liu H , DelgadoMR. Therapeutic drug concentration monitoring using saliva samples. Focus on anticonvulsants. Clin. Pharmacokinet. 36 (6), 453–470 (1999).
   PubMed Web of Science ®Google Scholar
• Lindholm A , HenricssonS. Intra- and interindividual variability in the free fraction of cyclosporine in plasma in recipients of renal transplants. Ther. Drug Monit. 11 (6), 623–630 (1989).
   PubMed Web of Science ®Google Scholar
• Kovarik JM , SabiaHD, FigueiredoJet al. Influence of hepatic impairment on everolimus pharmacokinetics: implications for dose adjustment. Clin. Pharmacol. Ther. 70 (5), 425–430 (2001).
   PubMed Web of Science ®Google Scholar
• Peveling-Oberhag J , ZeuzemS, YongWPet al. Effects of hepatic impairment on the pharmacokinetics of everolimus: a single-dose, open-label, parallel-group study. Clin. Ther. 35 (3), 215–225 (2013).
   PubMed Web of Science ®Google Scholar
• Ionita IA , OgasawaraK, GohhRY, AkhlaghiF. Pharmacokinetics of total and unbound prednisone and prednisolone in stable kidney transplant recipients with diabetes mellitus. Ther. Drug Monit. 36 (4), 448–455 (2014).
   PubMed Web of Science ®Google Scholar
• Reece PA , DisneyAP, StaffordI, ShastryJC. Prednisolone protein binding in renal transplant patients. Br. J. Clin. Pharmacol. 20 (2), 159–162 (1985).
   PubMed Web of Science ®Google Scholar
• MacDonald A , ScarolaJ, BurkeJT, ZimmermanJJ. Clinical pharmacokinetics and thererapeutic drug monitoring of sirolimus. Clin. Ther. 22 (Suppl. B), B101–B121 (2000).
   PubMedGoogle Scholar
• ChemSpider . http://www.chemspider.com.
   Google Scholar
• DrugBank . http://www.drugbank.ca.
   Google Scholar
• Idkaidek NM . Interplay of biopharmaceutics, biopharmaceutics drug disposition and salivary excretion classification systems. Saudi Pharm. J. 22 (1), 79–81 (2014).
   PubMed Web of Science ®Google Scholar
• Idkaidek N , ArafatT. Saliva versus plasma pharmacokinetics: theory and application of a salivary excretion classification system. Mol. Pharm. 9 (8), 2358–2363 (2012).
   PubMedGoogle Scholar
• Drummer OH . Introduction and review of collection techniques and applications of drug testing of oral fluid. Ther. Drug Monit. 30 (2), 203–206 (2008).
   PubMed Web of Science ®Google Scholar
• Granger DA , ShirtcliffEA, BoothA, KivlighanKT, SchwartzEB. The “trouble” with salivary testosterone. Psychoneuroendocrinology29 (10), 1229–1240 (2004).
   PubMed Web of Science ®Google Scholar
• Groschl M , KohlerH, TopfHG, RupprechtT, RauhM. Evaluation of saliva collection devices for the analysis of steroids, peptides and therapeutic drugs. J. Pharm. Biomed. Anal. 47 (3), 478–486 (2008).
   PubMed Web of Science ®Google Scholar
• Shaefer MS , CollierDS, HavenMCet al. Falsely elevated FK-506 levels caused by sampling through central venous catheters. Transplantation56 (2), 475–476 (1993).
   PubMed Web of Science ®Google Scholar
• Blifeld C , EttengerRB. Measurement of cyclosporine levels in samples obtained from peripheral sites and indwelling lines. N. Engl. J. Med. 317 (8), 509 (1987).
   PubMed Web of Science ®Google Scholar
• Lillsunde P . Analytical techniques for drug detection in oral fluid. Ther. Drug Monit. 30 (2), 181–187 (2008).
   PubMed Web of Science ®Google Scholar
• Langel K , EngblomC, PehrssonA, GunnarT, AriniemiK, LillsundeP. Drug testing in oral fluid-evaluation of sample collection devices. J. Anal. Toxicol. 32 (6), 393–401 (2008).
   PubMed Web of Science ®Google Scholar
• Kivlighan KT , GrangerDA, SchwartzEB, NelsonV, CurranM, ShirtcliffEA. Quantifying blood leakage into the oral mucosa and its effects on the measurement of cortisol, dehydroepiandrosterone, and testosterone in saliva. Horm. Behav. 46 (1), 39–46 (2004).
   PubMed Web of Science ®Google Scholar
• Akhlaghi F , TrullAK. Distribution of cyclosporin in organ transplant recipients. Clin. pharmacokinet. 41 (9), 615–637 (2002).
   PubMed Web of Science ®Google Scholar
• Akhlaghi F , McLachlanAJ, KeoghAM, BrownKF. Effect of simvastatin on cyclosporine unbound fraction and apparent blood clearance in heart transplant recipients. Br. J. Clin. Pharmacol. 44 (6), 537–542 (1997).
   PubMed Web of Science ®Google Scholar
• Akhlaghi F , KeoghAM, BrownKF. Unbound cyclosporine and allograft rejection after heart transplantation. Transplantation67 (1), 54–59 (1999).
   PubMed Web of Science ®Google Scholar
• Zahir H , McCaughanG, GleesonM, NandRA, McLachlanAJ. Factors affecting variability in distribution of tacrolimus in liver transplant recipients. Br. J. Clin. Pharmacol. 57 (3), 298–309 (2004).
   PubMed Web of Science ®Google Scholar
• Vogeser M , ZachovalR, SpohrerU, JacobK. Potential lack of specificity using electrospray tandem-mass spectrometry for the analysis of mycophenolic acid in serum. Ther. Drug Monit. 23 (6), 722–724 (2001).
   PubMed Web of Science ®Google Scholar
• Spies CM , StrehlC, van der GoesMC, BijlsmaJW, ButtgereitF. Glucocorticoids. Best Pract. Res. Clin. Rheumatol. 25 (6), 891–900 (2011).
   PubMed Web of Science ®Google Scholar
• Bergmann TK , BarracloughKA, LeeKJ, StaatzCE. Clinical pharmacokinetics and pharmacodynamics of prednisolone and prednisone in solid organ transplantation. Clin. Pharmacokinet. 51 (11), 711–741 (2012).
   PubMed Web of Science ®Google Scholar
• Meffin PJ , BrooksPM, SallustioBC. Alterations in prednisolone disposition as a result of time of administration, gender and dose. Br. J. Clin. Pharmacol. 17 (4), 395–404 (1984).
   PubMed Web of Science ®Google Scholar
• Teeninga N , GuanZ, FreijerJet al. Monitoring prednisolone and prednisone in saliva: a population pharmacokinetic approach in healthy volunteers. Ther. Drug Monit. 35 (4), 485–492 (2013).
   PubMed Web of Science ®Google Scholar
• Ruiter AF , TeeningaN, NautaJ, EndertE, AckermansMT. Determination of unbound prednisolone, prednisone and cortisol in human serum and saliva by on-line solid-phase extraction liquid chromatography tandem mass spectrometry and potential implications for drug monitoring of prednisolone and prednisone in saliva. Biomed. Chromatogr. 26 (7), 789–796 (2012).
   PubMed Web of Science ®Google Scholar
• den Burger JC , WilhelmAJ, ChahbouniA, VosRM, SinjewelA, SwartEL. Analysis of cyclosporin A, tacrolimus, sirolimus, and everolimus in dried blood spot samples using liquid chromatography tandem mass spectrometry. Anal. Bioanal. Chem. 404 (6–7), 1803–1811 (2012).
   PubMed Web of Science ®Google Scholar
• Hinchliffe E , AdawayJE, KeevilBG. Simultaneous measurement of cyclosporin A and tacrolimus from dried blood spots by ultra high performance liquid chromatography tandem mass spectrometry. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 883–884, 102–107 (2012).
   PubMed Web of Science ®Google Scholar
• Hoogtanders K , van der HeijdenJ, ChristiaansM, van de PlasA, van HooffJ, StolkL. Dried blood spot measurement of tacrolimus is promising for patient monitoring. Transplantation83 (2), 237–238 (2007).
   PubMed Web of Science ®Google Scholar
• Koop DR , BleyleLA, MunarM, CheralaG, Al-UzriA. Analysis of tacrolimus and creatinine from a single dried blood spot using liquid chromatography tandem mass spectrometry. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 926, 54–61 (2013).
   PubMed Web of Science ®Google Scholar
• Sadilkova K , BusbyB, DickersonJA, RutledgeJC, JackRM. Clinical validation and implementation of a multiplexed immunosuppressant assay in dried blood spots by LC–MS/MS. Clin. Chim. Acta421, 152–156 (2013).
   PubMed Web of Science ®Google Scholar
• van der Heijden J , de BeerY, HoogtandersKet al. Therapeutic Drug Monitoring of everolimus using the dried blood spot method in combination with liquid chromatography-mass spectrometry. J. Pharm. Biomed. Anal. 50 (4), 664–670 (2009).
   PubMed Web of Science ®Google Scholar
• Wilhelm AJ , den BurgerJC, VosRM, ChahbouniA, SinjewelA. Analysis of cyclosporin A in dried blood spots using liquid chromatography tandem mass spectrometry. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 877 (14–15), 1595–1598 (2009).
   PubMed Web of Science ®Google Scholar
• Lampe D , ScholzD, PrumkeHJ, BlankW, HullerH. Capillary blood, dried on filter paper, as sample for monitoring cyclosporin A concentrations. Clin. Chem. 33 (9), 1643–1644 (1987).
   PubMed Web of Science ®Google Scholar
• Cheung CY , van der HeijdenJ, HoogtandersKet al. Dried blood spot measurement: application in tacrolimus monitoring using limited sampling strategy and abbreviated AUC estimation. Transplant Int. 21 (2), 140–145 (2008).
   PubMed Web of Science ®Google Scholar
• Keevil BG . The analysis of dried blood spot samples using liquid chromatography tandem mass spectrometry. Clin. Biochem. 44 (1), 110–118 (2011).
   PubMed Web of Science ®Google Scholar
• Acott PD . Home fingerprick sampling for immunosuppressant drug monitoring in pediatric renal transplant patients. Nat. Clin. Pract. Nephrol. 2 (6), 304–305 (2006).
   PubMedGoogle Scholar
• Hoogtanders K , van der HeijdenJ, ChristiaansM, EdelbroekP, van HooffJP, StolkLM. Ther. Drug Monit. of tacrolimus with the dried blood spot method. J. Pharm. Biomed. Anal. 44 (3), 658–664 (2007).
   PubMed Web of Science ®Google Scholar
• Li Q , CaoD, HuangY, XuH, YuC, LiZ. Development and validation of a sensitive LC–MS/MS method for determination of tacrolimus on dried blood spots. Biomed. Chromatogr. 27 (3), 327–334 (2013).
   PubMed Web of Science ®Google Scholar
• Bowen CL , DopsonW, KempDC, LewisM, LadR, OvervoldC. Investigations into the environmental conditions experienced during ambient sample transport: impact to dried blood spot sample shipments. Bioanalysis3 (14), 1625–1633 (2011).
   PubMed Web of Science ®Google Scholar
• Holub M , TuschlK, RatschmannRet al. Influence of hematocrit and localisation of punch in dried blood spots on levels of amino acids and acylcarnitines measured by tandem mass spectrometry. Clin. Chim. Acta373 (1–2), 27–31 (2006).
   PubMed Web of Science ®Google Scholar
• Koster RA , AlffenaarJW, GreijdanusB, UgesDR. Fast LC–MS/MS analysis of tacrolimus, sirolimus, everolimus and cyclosporin A in dried blood spots and the influence of the hematocrit and immunosuppressant concentration on recovery. Talanta115, 47–54 (2013).
   PubMed Web of Science ®Google Scholar
• Heinig K , BucheliF, HartenbachR, Gajate-PerezA. Determination of mycophenolic acid and its phenyl glucuronide in human plasma, ultrafiltrate, blood, DBS and dried plasma spots. Bioanalysis2 (8), 1423–1435 (2010).
   PubMed Web of Science ®Google Scholar
• LifeSciences GH . Grade 31ET Chr Cellulose Chromatography Papers). www.gelifesciences.com/webapp/wcs/stores/servlet/productById/en/GELifeSciences/28419331.
   Google Scholar
• Li W , TseFL. Dried blood spot sampling in combination with LC–MS/MS for quantitative analysis of small molecules. Biomed. Chromatogr. 24 (1), 49–65 (2010).
   PubMed Web of Science ®Google Scholar
• PerkinElmer . PerkinElmer 226 Sample Collection Devices – Clinical. www.perkinelmer.com/pages/060/newbornscreening/customdevices.xhtml.
   Google Scholar
• Besarab A , BoltonWK, BrowneJKet al. The effects of normal as compared with low hematocrit values in patients with cardiac disease who are receiving hemodialysis and epoetin. N. Engl. J. Med. 339 (9), 584–590 (1998).
   PubMed Web of Science ®Google Scholar
• Wilhelm AJ , den BurgerJC, ChahbouniA, VosRM, SinjewelA. Analysis of mycophenolic acid in dried blood spots using reversed phase high performance liquid chromatography. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 877 (30), 3916–3919 (2009).
   PubMed Web of Science ®Google Scholar
• Spooner N , DenniffP, MichielsenLet al. A device for dried blood microsampling in quantitative bioanalysis: overcoming the issues associated blood hematocrit. Bioanalysis1–7 (2014) ( Epub ahead of print).
   PubMed Web of Science ®Google Scholar
• Denniff P , SpoonerN. Volumetric absorptive microsampling: a dried sample collection technique for quantitative bioanalysis. Analy. Chem. 86 (16), 8489–8495 (2014).
   PubMed Web of Science ®Google Scholar
• Merton G , JonesK, LeeM, JohnstonA, HoltDW. Accuracy of cyclosporin measurements made in capillary blood samples obtained by skin puncture. Ther. Drug Monit. 22 (5), 594–598 (2000).
   PubMed Web of Science ®Google Scholar
• Wallemacq P , ArmstrongVW, BrunetMet al. Opportunities to optimize tacrolimus therapy in solid organ transplantation: report of the European consensus conference. Ther. Drug Monit. 31 (2), 139–152 (2009).
   PubMed Web of Science ®Google Scholar
• Batiuk TD , PazderkaF, EnnsJ, DeCastroL, HalloranPF. Cyclosporine inhibition of calcineurin activity in human leukocytes in vivo is rapidly reversible. J. Clin. Invest. 96 (3), 1254–1260 (1995).
   PubMed Web of Science ®Google Scholar
• Thomson AW , BonhamCA, ZeeviA. Mode of action of tacrolimus (FK506): molecular and cellular mechanisms. Ther. Drug Monit. 17 (6), 584–591 (1995).
   PubMed Web of Science ®Google Scholar
• Dumont FJ , SuQ. Mechanism of action of the immunosuppressant rapamycin. Life Sci. 58 (5), 373–395 (1996).
   PubMed Web of Science ®Google Scholar
• Kemnitz J , UysalA, HaverichAet al. Multidrug resistance in heart transplant patients: a preliminary communication on a possible mechanism of therapy-resistant rejection. J. Heart Lung Transplant. 10 (2), 201–210 (1991).
   PubMed Web of Science ®Google Scholar
• Albermann N , Schmitz-WinnenthalFH, Z’GraggenKet al. Expression of the drug transporters MDR1/ABCB1, MRP1/ABCC1, MRP2/ABCC2, BCRP/ABCG2, and PXR in peripheral blood mononuclear cells and their relationship with the expression in intestine and liver. Biochem. Pharmacol. 70 (6), 949–958 (2005).
   PubMed Web of Science ®Google Scholar
• Chaudhary PM , MechetnerEB, RoninsonIB. Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes. Blood80 (11), 2735–2739 (1992).
   PubMed Web of Science ®Google Scholar
• Cattaneo D , RuggenentiP, BaldelliSet al. ABCB1 genotypes predict cyclosporine-related adverse events and kidney allograft outcome. J. Am. Soc. Nephrol. 20 (6), 1404–1415 (2009).
   PubMed Web of Science ®Google Scholar
• Crettol S , VenetzJP, FontanaMet al. Influence of ABCB1 genetic polymorphisms on cyclosporine intracellular concentration in transplant recipients. Pharmacogenet. Genomics18 (4), 307–315 (2008).
   PubMed Web of Science ®Google Scholar
• Ansermot N , RebsamenM, ChabertJet al. Influence of ABCB1 gene polymorphisms and P-glycoprotein activity on cyclosporine pharmacokinetics in peripheral blood mononuclear cells in healthy volunteers. Drug Metabol. Lett. 2 (2), 76–82 (2008).
   PubMedGoogle Scholar
• Capron A , MouradM, De MeyerMet al. CYP3A5 and ABCB1 polymorphisms influence tacrolimus concentrations in peripheral blood mononuclear cells after renal transplantation. Pharmacogenomics11 (5), 703–714 (2010).
   PubMed Web of Science ®Google Scholar
• Chen N , WeissD, ReyesJet al. No clinically significant drug interactions between lenalidomide and Pglycoprotein substrates and inhibitors: results from controlled phase I studies in healthy volunteers. Cancer Chemother. Pharmacol. 73 (5), 1031–1039 (2014).
   PubMed Web of Science ®Google Scholar
• Anglicheau D , PalletN, RabantMet al. Role of P-glycoprotein in cyclosporine cytotoxicity in the cyclosporine-sirolimus interaction. Kidney Int. 70 (6), 1019–1025 (2006).
   PubMed Web of Science ®Google Scholar
• Laplante A , DemeuleM, MurphyGF, BeliveauR. Interaction of immunosuppressive agents rapamycin and its analogue SDZ-RAD with endothelial P-gp. Transplant. Proc. 34 (8), 3393–3395 (2002).
   PubMed Web of Science ®Google Scholar
• Grude P , BoleslawskiE, ContiF, ChouzenouxS, CalmusY. MDR1 gene expression in peripheral blood mononuclear cells after liver transplantation. Transplantation73 (11), 1824–1828 (2002).
   PubMed Web of Science ®Google Scholar
• Goto M , MasudaS, KiuchiTet al. Relation between mRNA expression level of multidrug resistance 1/ABCB1 in blood cells and required level of tacrolimus in pediatric living-donor liver transplantation. J. Pharmacol. Exp. Ther. 325 (2), 610–616 (2008).
   PubMed Web of Science ®Google Scholar
• Robertsen I , FalckP, AndreassenAKet al. Endomyocardial, intralymphocyte, and whole blood concentrations of ciclosporin A in heart transplant recipients. Transplant. Res. 2 (1), 5 (2013).
   PubMedGoogle Scholar
• Lemaitre F , AntignacM, FernandezC. Monitoring of tacrolimus concentrations in peripheral blood mononuclear cells: Application to cardiac transplant recipients. Clin. Biochem. 46 (15), 1538–1541 (2013).
   PubMed Web of Science ®Google Scholar
• Ansermot N , FathiM, VeutheyJL, DesmeulesJ, HochstrasserD, RudazS. Quantification of cyclosporine A in peripheral blood mononuclear cells by liquid chromatography-electrospray mass spectrometry using a column-switching approach. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 857 (1), 92–99 (2007).
   PubMed Web of Science ®Google Scholar
• Falck P , GuldsethH, AsbergA, MidtvedtK, ReubsaetJL. Determination of ciclosporin A and its six main metabolites in isolated T-lymphocytes and whole blood using liquid chromatography-tandem mass spectrometry. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 852 (1–2), 345–352 (2007).
   PubMed Web of Science ®Google Scholar
• Brozmanova H , PerinovaI, HalvovaP, GrundmannM. Liquid chromatography-tandem mass spectrometry method for simultaneous determination of cyclosporine A and its three metabolites AM1, AM9 and AM4N in whole blood and isolated lymphocytes in renal transplant patients. J. Sep. Sci. 33 (15), 2287–2293 (2010).
   PubMed Web of Science ®Google Scholar
• Capron A , LerutJ, LatinneD, RahierJ, HaufroidV, WallemacqP. Correlation of tacrolimus levels in peripheral blood mononuclear cells with histological staging of rejection after liver transplantation: preliminary results of a prospective study. Transplant Int. 25 (1), 41–47 (2012).
   PubMed Web of Science ®Google Scholar
• Capron A , MusuambaF, LatinneDet al. Validation of a liquid chromatography-mass spectrometric assay for tacrolimus in peripheral blood mononuclear cells. Ther. Drug Monit. 31 (2), 178–186 (2009).
   PubMed Web of Science ®Google Scholar
• Gustafsson F , BarthD, DelgadoDH, NsouliM, SheedyJ, RossHJ. The impact of everolimus versus mycophenolate on blood and lymphocyte cyclosporine exposure in heart-transplant recipients. Eur. J. Clin. Pharmacol. 65 (7), 659–665 (2009).
   PubMed Web of Science ®Google Scholar
• Falck P , AsbergA, GuldsethHet al. Declining intracellular T-lymphocyte concentration of cyclosporine a precedes acute rejection in kidney transplant recipients. Transplantation85 (2), 179–184 (2008).
   PubMed Web of Science ®Google Scholar
• Lepage JM , Lelong-BoulouardV, LecoufA, DebruyneD, Hurault de LignyB, CoquerelA. Cyclosporine monitoring in peripheral blood mononuclear cells: feasibility and interest. A prospective study on 20 renal transplant recipients. Transplant. Proc. 39 (10), 3109–3110 (2007).
   PubMed Web of Science ®Google Scholar
• Barbari A , StephanA, MasriMet al. Cyclosporine lymphocyte level and lymphocyte count: new guidelines for tailoring immunosuppressive therapy. Transplant. Proc. 35 (7), 2742–2744 (2003).
   PubMed Web of Science ®Google Scholar
• Barbari A , MasriMA, StephanAet al. Cyclosporine lymphocyte versus whole blood pharmacokinetic monitoring: correlation with histological findings. Transplant. Proc. 33 (5), 2782–2785 (2001).
   PubMed Web of Science ®Google Scholar
• Masri MA , BarbariA, StephanA, RizkS, KilanyH, KamelG. Measurement of lymphocyte cyclosporine levels in transplant patients. Transplant. Proc. 30 (7), 3561–3562 (1998).
   PubMed Web of Science ®Google Scholar
• Masri M , RizkS, BarbariA, StephanA, KamelG, RostM. An assay for the determination of sirolimus levels in the lymphocyte of transplant patients. Transplant. Proc. 39 (4), 1204–1206 (2007).
   PubMed Web of Science ®Google Scholar
• Roullet-Renoleau F , LemaitreF, AntignacM, ZahrN, FarinottiR, FernandezC. Everolimus quantification in peripheral blood mononuclear cells using ultra high performance liquid chromatography tandem mass spectrometry. J. Pharm. Biomed. Anal. 66, 278–281 (2012).
   PubMed Web of Science ®Google Scholar
• Starkel P , SempouxC, Van Den BergeVet al. CYP 3A proteins are expressed in human neutrophils and lymphocytes but are not induced by rifampicin. Life Sci. 64 (8), 643–653 (1999).
   PubMed Web of Science ®Google Scholar
• Dey A , YadavS, DhawanA, SethPK, ParmarD. Evidence for cytochrome P450 3A expression and catalytic activity in rat blood lymphocytes. Life Sci. 79 (18), 1729–1735 (2006).
   PubMed Web of Science ®Google Scholar
• Hesselink DA , van SchaikRH, van der HeidenIPet al. Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus. Clin. Pharmacol. Ther. 74 (3), 245–254 (2003).
   PubMed Web of Science ®Google Scholar
• Kamdem LK , StreitF, ZangerUMet al. Contribution of CYP3A5 to the in vitro hepatic clearance of tacrolimus. Clin. Chem. 51 (8), 1374–1381 (2005).
   PubMed Web of Science ®Google Scholar
• Miura M , NiiokaT, KagayaHet al. Pharmacogenetic determinants for interindividual difference of tacrolimus pharmacokinetics 1 year after renal transplantation. J. Clin. Pharm. Ther. 36 (2), 208–216 (2011).
   PubMed Web of Science ®Google Scholar
• Uesugi M , MasudaS, KatsuraT, OikeF, TakadaY, InuiK. Effect of intestinal CYP3A5 on postoperative tacrolimus trough levels in living-donor liver transplant recipients. Pharmacogenet. Genomics16 (2), 119–127 (2006).
   PubMed Web of Science ®Google Scholar
• Lensmeyer GL , WiebeDA, CarlsonIH, SubramanianR. Concentrations of cyclosporin A and its metabolites in human tissues postmortem. J. Anal. Toxicol. 15 (3), 110–115 (1991).
   PubMed Web of Science ®Google Scholar
• Sandborn WJ , LawsonGM, CodyTJet al. Early cellular rejection after orthotopic liver transplantation correlates with low concentrations of FK506 in hepatic tissue. Hepatology21 (1), 70–76 (1995).
   PubMed Web of Science ®Google Scholar
• Sandborn WJ , LawsonGM, KromRA, WiesnerRH. Hepatic allograft cyclosporine concentration is independent of the route of cyclosporine administration and correlates with the occurrence of early cellular rejection. Hepatology15 (6), 1086–1091 (1992).
   PubMed Web of Science ®Google Scholar
• Capron A , LerutJ, VerbaandertCet al. Validation of a liquid chromatography-mass spectrometric assay for tacrolimus in liver biopsies after hepatic transplantation: correlation with histopathologic staging of rejection. Ther. Drug Monit. 29 (3), 340–348 (2007).
   PubMed Web of Science ®Google Scholar
• Noll BD , CollerJK, SomogyiAAet al. Measurement of cyclosporine A in rat tissues and human kidney transplant biopsies--a method suitable for small (<1 mg) samples. Ther. Drug Monit. 33 (6), 688–693 (2011).
   PubMed Web of Science ®Google Scholar
• Noll BD , CollerJK, SomogyiAAet al. Validation of an LC–MS/MS Method to Measure Tacrolimus in Rat Kidney and Liver Tissue and its Application to Human Kidney Biopsies. Ther. Drug Monit. (2013).
   PubMed Web of Science ®Google Scholar
• Ting LS , PartoviN, LevyRD, RiggsKW, EnsomMH. Pharmacokinetics of mycophenolic acid and its phenolic-glucuronide and ACYl glucuronide metabolites in stable thoracic transplant recipients. Ther. Drug Monit. 30 (3), 282–291 (2008).
   PubMed Web of Science ®Google Scholar
• Elens L , CapronA, KerckhoveVVet al. 1199G>A and 2677G>T/A polymorphisms of ABCB1 independently affect tacrolimus concentration in hepatic tissue after liver transplantation. Pharmacogenet. Genomics17 (10), 873–883 (2007).
   PubMed Web of Science ®Google Scholar
• Smans L , LentjesE, HermusA, ZelissenP. Salivary cortisol day curves in assessing glucocorticoid replacement therapy in Addison’s disease. Hormones12 (1), 93–100 (2013).
   PubMedGoogle Scholar