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Editorial

Application of Emerging Toxicity Screens in Drug Discovery: Challenges and Implications

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Pages 1201-1205 | Published online: 21 Oct 2009

Bibliography

  • Wiebel FJ , AnderssonTB, CascianoDAet al. Genetically engineered cell lines: characterisation and applications in toxicity testing. The report and recommendations of ECVAM workshop 26. Altern. Lab. Anim. 25, 625–639 (1997).
  • Hasspieler BM , HaffnerGD, AdeliK. In vitro toxicological methods for environmental health testing. Rev. Environ. Health.11, 213–227 (1996).
  • Adams CP , BrantnerVV. Estimating the cost of new drug development: is it really 802 million dollars?Health Aff.25, 420–428 (2006).
  • Helma C , CramerT, KramerS, De Raedt L. Data mining and machine learning techniques for the identification of mutagenicity inducing substructures and structure activity relationships of noncongeneric compounds. J. Chem. Inf. Comput. Sci.44, 1402–1411 (2004).
  • Helma C . Data mining and knowledge discovery in predictive toxicology.SAR QSAR Environ. Res.15, 367–383 (2004).
  • Dearden JC . In silico prediction of drug toxicity. J. Comput. Aided Mol. Des.17, 119–127 (2003).
  • Judson R , RichardA, DixDJet al. The toxicity data landscape for environmental chemicals. Environ Health Perspect. 117, 685–695 (2009).
  • Kohen R , NyskaA. Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification.Toxicol. Pathol.30, 620–650 (2002).
  • Apel K , HirtH. Reactive oxygen species: metabolism, oxidative stress, and signal transduction.Annu. Rev. Plant Biol.55, 373–399 (2004).
  • Spector A . Review: Oxidative stress and disease.J. Ocul. Pharmacol. Ther.16, 193–201 (2000).
  • Will Y , HynesJ, OgurtsovVI, PapkovskyDB. Analysis of mitochondrial function using phosphorescent oxygen-sensitive probes.Nat. Protoc.1, 2563–2572 (2006).
  • Neupert W , HerrmannJM. Translocation of proteins into mitochondria.Annu. Rev. Biochem.76, 723–749 (2007).
  • Ernster L , SchatzG. Mitochondria: a historical review.J. Cell Biol.91(Suppl.), S227–S255 (1981).
  • Schroder M . Endoplasmic reticulum stress responses.Cell Mol. Life Sci.65, 862–894 (2008).
  • Marciniak SJ , RonD. Endoplasmic reticulum stress signaling in disease.Physiol. Rev.86, 1133–1149 (2006).
  • Xu C , Bailly-MaitreB, ReedJC. Endoplasmic reticulum stress: cell life and death decisions.J. Clin. Invest.115, 2656–2664 (2005).
  • Kultz D . Molecular and evolutionary basis of the cellular stress response.Annu. Rev. Physiol.67, 225–257 (2005).
  • Hartwell LH , WeinertTA. Checkpoints: controls that ensure the order of cell cycle events.Science246, 629–634 (1989).
  • Hartwell LH , KastanMB. Cell cycle control and cancer.Science266, 1821–1828 (1994).
  • Kaufmann WK , PaulesRS. DNA damage and cell cycle checkpoints.FASEB J.10, 238–247 (1996).
  • Hiom K . DNA repair: a riddle at a double-strand break.Curr. Biol.19, R331–R333 (2009).
  • Cohn MA , D‘AndreaAD. Chromatin recruitment of DNA repair proteins: lessons from the fanconi anemia and double-strand break repair pathways.Mol. Cell.32, 306–312 (2008).
  • Altieri F , GrilloC, MaceroniM, ChichiarelliS. DNA damage and repair: from molecular mechanisms to health implications.Antioxid. Redox Signal.10, 891–937 (2008).
  • Sheikh MS , HollanderMC, FornanceAJ Jr. Role of Gadd45 in apoptosis. Biochem. Pharmacol.59, 43–45 (2000).
  • Wible BA , HawrylukP, FickerE, KuryshevYA, KirschG, BrownAM. HERG-Lite: a novel comprehensive high-throughput screen for drug-induced hERG risk.J. Pharmacol. Toxicol. Methods.52, 136–145 (2005).
  • Priest BT , BellIM, GarciaML. Role of hERG potassium channel assays in drug development.Channels2(2) (2008).
  • Yao X , AndersonDL, RossSAet al. Predicting QT prolongation in humans during early drug development using hERG inhibition and an anaesthetized guinea-pig model. Br. J. Pharmacol. 154, 1446–1456 (2008).
  • Giguere V . Orphan nuclear receptors: from gene to function,Endocr. Rev.20, 689–725 (1999).
  • Kliewer SA , WillsonTM. Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor,J. Lipid Res.43, 359–364 (2002).
  • Nebert DW . Drug-metabolizing enzymes in ligand-modulated transcription.Biochem. Pharmacol.47, 25–37 (1994).
  • Elcombe CR , OdumJ, FosterJRet al. Prediction of rodent nongenotoxic carcinogenesis: evaluation of biochemical and tissue changes in rodents following exposure to nine nongenotoxic NTP carcinogens. Environ. Health Perspect. 110, 363–375 (2002).
  • Hoel DG , HasemanJK, HoganMD, HuffJ, McConnellEE. The impact of toxicity on carcinogenicity studies: implications for risk assessment.Carcinogenesis9, 2045–2052 (1988).
  • Tennant RW , ElwellMR, SpaldingJW, GriesemerRA. Evidence that toxic injury is not always associated with induction of chemical carcinogenesis.Mol. Carcinog.4, 420–440 (1991).
  • Aranda A , PascualA. Nuclear hormone receptors and gene expression.Physiol. Rev.81, 1269–1304 (2001).
  • Coecke S , AhrH, BlaauboerBJet al. Metabolism: a bottleneck in in vitro toxicological test development. The report and recommendations of ECVAM workshop 54. Altern. Lab Anim. 34, 49–84 (2006).
  • Olson H , BettonG, RobinsonDet al. Concordance of the toxicity of pharmaceuticals in humans and in animals. Regul. Toxicol. Pharmacol. 32, 56–67 (2000).
  • Zambrowicz BP , SandsAT. Knockouts model the 100 best-selling drugs – will they model the next 100?Nat. Rev. Drug Discov.2, 38–51 (2003).
  • MacDonald J , FrenchJE, GersonRJet al. The utility of genetically modified mouse assays for identifying human carcinogens: a basic understanding and path forward. The Alternatives to Carcinogenicity Testing Committee ILSI HESI. Toxicol. Sci. 77, 188–194 (2004).
  • Baryla UM , FlemingJS, StantonHC. The anesthetized ferret, an in vivo model for evaluating inotropic activity: effects of milrinone and anagrelide.J. Pharmacol. Methods.20, 299–306 (1988).
  • Faiola B , FallsJG, PetersonRAet al. PPAR α, more than PPAR δ, mediates the hepatic and skeletal muscle alterations induced by the PPAR agonist GW0742. Toxicol. Sci. 105, 384–394 (2008).
  • Mannisto PT , KirklandD, VilukselaM, TikkanenL. Toxicological studies with dithranol and its 10-acyl analogues.Arch. Toxicol.59, 180–185 (1986).
  • Preston J , HoffmannG. Casarett and Doull’s Toxicology. McGraw Hill, Berkshire, UK (2001).

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