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Commentary

Gabaergic Drugs and Alzheimer’s Disease

, &
Pages 149-153 | Published online: 11 Feb 2011

Bibliography

  • Orgogozo JM , GilmanS, DartiguesJFet al. Subacute meningoencephalitis in a subset of patients with Alzheimer’s disease (AD) after Aβ42 immunization. Neurology 61(1), 46–54 (2003).
  • Extance A . Alzheimer’s failure raises questions about disease-modifying strategies.Nat. Rev. Drug Discov.9(10), 749–751 (2010).
  • LaFerla FM , GreenKN, OddoS. Intracellular amyloid-β in Alzheimer’s disease.Nat. Rev. Neurosci.8(7), 499–509 (2007).
  • Palop JJ , ChinJ, RobersonEDet al. Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer’s disease. Neuron 55(5), 697–711 (2007).
  • Scarmeas N , HonigLS, ChoiHet al. Seizures in Alzheimer disease: who, when, and how common? Arch. Neurol. 66(8), 992–997 (2009).
  • Ittner LM , KeYD, DelerueFet al. Dendritic function of tau mediates amyloid-β toxicity in Alzheimer’s disease mouse models. Cell 142(3), 387–397 (2010).
  • Parodi J , SepúlvedaFJ, RoaJ, OpazoC, InestrosaNC, AguayoLG. β-Amyloid causes depletion of synaptic vesicles leading to neurotransmission failure.J. Biol. Chem.285(4), 2506–2514 (2010).
  • Querfurth HW , LaFerlaFM. Alzheimer’s disease.N. Engl. J. Med.362(4), 329–344 (2010).
  • Raina P , SantaguidaP, IsmailaAet al. Effectiveness of cholinesterase inhibitors and memantine for treating dementia: evidence review for a clinical practice guideline. Ann. Intern. Med. 148(5), 379–397 (2008).
  • Rissman RA , De Blas AL, Armstrong DM. GABA(A) receptors in aging and Alzheimer’s disease. J. Neurochem.103(4), 1285–1292 (2007).
  • Lawrence JJ . Cholinergic control of GABA release: emerging parallels between neocortex and hippocampus.Trends Neurosci.31(7), 317–327 (2008).
  • Ellender TJ , PaulsenO. The many tunes of perisomatic targeting interneurons in the hippocampal network.Front Cell Neurosci.30(4), pii: 26 (2010).
  • Somogyi P , KlausbergerT. Defined types of cortical interneurone structure space and spike timing in the hippocampus.J. Physiol.562(Pt 1), 9–26 (2005).
  • Sernagor E , ChabrolF, BonyG, CanceddaL. GABAergic control of neurite outgrowth and remodeling during development and adult neurogenesis: general rules and differences in diverse systems.Front. Cell Neurosci.4, 11 (2010).
  • Olsen RW , SieghartW. International Union of Pharmacology. LXX. Subtypes of γ-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. Update.Pharmacol. Rev.60(3), 243–260 (2008).
  • Marczynski TJ . GABAergic deafferentation hypothesis of brain aging and Alzheimer’s disease revisited.Brain Res. Bull.45(4), 341–379 (1998).
  • Dawson GR , MaubachKA, CollinsonNet al. An inverse agonist selective for α5 subunit-containing GABAA receptors enhances cognition. J. Pharmacol. Exp. Ther. 316(3), 1335–1345 (2006).
  • Martin LJ , BoninRP, OrserBA. The physiological properties and therapeutic potential of α5-GABAA receptors. BioChemSoc Trans.37(Pt 6), 1334–1337 (2009).
  • Atack JR . Preclinical and clinical pharmacology of the GABAA receptor α5 subtype-selective inverse agonist α5IA. Pharmacol. Ther.125(1), 11–26 (2010).
  • Farrant M , NusserZ. Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors.Nat. Rev. Neurosci.6(3), 215–229 (2005).
  • Glykys J , MannEO, ModyI. Which GABA(A) receptor subunits are necessary for tonic inhibition in the hippocampus?J. Neurosci.28(6), 1421–1426 (2008).
  • Lee S , YoonBE, BerglundKet al. Channel-mediated tonic GABA release from glia. Science 330(6005), 790–796 (2010).
  • Li G , Bien-LyN, Andrews-ZwillingYet al. GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice. Cell Stem Cell 5(6), 634–645 (2009).
  • Mestas J , HughesCC. Of mice and not men: differences between mouse and human immunology.J. Immunol.172(5), 2731–2738 (2004).
  • Maloney B , GeYW, AlleyGM, LahiriDK. Important differences between human and mouse APOE gene promoters: limitation of mouse APOE model in studying Alzheimer’s disease.J. Neurochem.103(3), 1237–1257 (2007).
  • Iwakiri M , MizukamiK, IkonomovicMD, IshikawaM, AbrahamsonEE, DeKoskyST. An immunohistochemical study of GABAA receptor γ subunits in Alzheimer’s disease hippocampus: relationship to neurofibrillary tangle progression. Neuropathology29(3), 263–269 (2009).
  • Limon A , Reyes-RuizJM, VaswaniRG, ChamberlinAR, MilediR. Kaitocephalin antagonism of glutamate receptors expressed in Xenopus oocytes. ACS Chem. Neurosci.1(3), 175–181 (2010).
  • Inoue S . In situ Aβ pores in AD brain are cylindrical assembly of Aβ protofilaments. Amyloid15(4), 223–233 (2008).
  • Shankar GM , BloodgoodBL, TownsendM, WalshDM, SelkoeDJ, SabatiniBL. Natural oligomers of the Alzheimer amyloid-β protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway.J. Neurosci.27(11), 2866–2875 (2007).
  • Small DH , MakselD, KerrMLet al. The β-amyloid protein of Alzheimer’s disease binds to membrane lipids but does not bind to the α7 nicotinic acetylcholine receptor. J. Neurochem. 101(6), 1527–1538 (2007).
  • Yang X , AskarovaS, LeeJC. Membrane biophysics and mechanics in Alzheimer’s disease.Mol. Neurobiol.41(2–3), 138–148 (2010).
  • Miledi R , DueñasZ, Martinez-TorresA, KawasCH, EusebiF. Microtransplantation of functional receptors and channels from the Alzheimer’s brain to frog oocytes.Proc. Natl Acad. Sci. USA101(6), 1760–1763 (2004).
  • Bernareggi A , DueñasZ, Reyes-RuizJM, RuzzierF, MilediR. Properties of glutamate receptors of Alzheimer’s disease brain transplanted to frog oocytes.Proc. Natl. Acad. Sci. USA104(8), 2956–2960 (2007).
  • Palma E , TorchiaG, LimatolaCet al. BDNF modulates GABAA receptors microtransplanted from the human epileptic brain to Xenopus oocytes. Proc. Natl Acad. Sci. USA 102(5), 1667–1672 (2005).
  • Limon A , Reyes-RuizJM, MilediR. Microtransplantation of neurotransmitter receptors from postmortem autistic brains to Xenopus oocytes. Proc. Natl Acad. Sci. USA105(31), 10973–10977 (2008).
  • Spitzer NC . A Rosetta stone for analysis of human membrane protein function.Proc. Natl Acad. Sci. USA105(31), 10641–10642 (2008).
  • Eusebi F , PalmaE, AmiciM, MilediR. Microtransplantation of ligand-gated receptor-channels from fresh or frozen nervous tissue into Xenopus oocytes: a potent tool for expanding functional information. Prog. Neurobiol.88(1), 32–40 (2009).

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