659
Views
0
CrossRef citations to date
0
Altmetric
Commentary

The Potential Use of Gabaergic Drugs in the Treatment of Asthma

Pages 145-147 | Published online: 11 Feb 2011

Bibliography

  • Xiang YY , WangS, LiuMet al. A GABAergic system in airway epithelium is essential for mucus overproduction in asthma. Nat. Med. 13, 862–867 (2007).
  • Mizuta K , XuD, PanYet al. GABAA receptors are expressed and facilitate relaxation in airway smooth muscle. Am. J. Physiol. Lung Cell Mol. Physiol. 294, L1206–L1206 (2008).
  • Reyes-García MG , Hernández-HernándezF, Hernández-TéllezB, García-TamayoF. GABA(A) receptor subunits RNA expression in mice peritoneal macrophages modulate their IL-6/IL-12 production.J. Neuroimmunol.188, 64–68 (2007).
  • Gladkevich A , KorfJ, HakobyanVP, MelkonyanKV. The peripheral GABAergic system as a target in endocrine disorders.Auton. Neurosci.124, 1–8 (2006).
  • Andäng M , Hjerling-LefflerJ, MolinerAet al. Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation. Nature 451, 460–464 (2008).
  • Rogers DF . Airway goblet cell hyperplasia in asthma: hypersecretory and anti-inflammatory?Clin. Exp. Allergy32, 1124–1127 (2002).
  • Rogers DF . Airway mucus hypersecretion in asthma: an undervalued pathology?Curr. Opin. Pharmacol.4, 241–250 (2004).
  • Danahay H , AthertonH, JonesG, BridgesRJ, PollCT. Interleukin-13 induces a hypersecretory ion transport phenotype in human bronchial epithelial cells.Am. J. Physiol. Lung Cell Mol. Physiol.282, L226–L236 (2002).
  • Danahay H , AthertonHC, JacksonAD, KreindlerJL, PollCT, BridgesRJ. Membrane capacitance and conductance changes parallel mucin secretion in the human airway epithelium.Am. J. Physiol Lung Cell Mol. Physiol.290, L558–L569 (2006).
  • Hakonarson H , HerrickDJ, GrunsteinMM. Mechanism of impaired β-adrenoceptor responsiveness in atopic sensitized airway smooth muscle.Am. J. Physiol.269, L645–L652 (1995).
  • Osawa Y , XuD, SternbergDet al., Functional expression of the GABAB receptor in human airway smooth muscle. Am. J. Physiol Lung Cell Mol. Physiol.291, L923–L931 (2006).
  • Moore CT , WilsonCG, MayerCA, AcquahSS, MassariVJ, HaxhiuMA. A GABAergic inhibitory microcircuit controlling cholinergic outflow to the airways.J. Appl. Physiol.96, 260–270 (2004).
  • Tamaoki J , GrafPD, NadelJA. Effect of γ-aminobutyric acid on neurally mediated contraction of guinea pig trachealis smooth muscle.J. Pharmacol. Exp. Ther.243, 86–90 (1987).
  • Hakonarson H , GrunsteinMM. Autocrine regulation of airway smooth muscle responsiveness.Respir. Physiol. Neurobiol.137, 263–276 (2003).
  • Taniguchi H , OkadaY, SeguchiHet al. High concentration of γ-aminobutyric acid in pancreatic β cells. Diabetes 28, 629–633 (1979).
  • Kataoka Y , GutmanY, GuidottiAet al. Intrinsic GABAergic system of adrenal chromaffincells. Proc. Natl Acad. Sci. USA 81, 3218–3222 (1984).
  • Tian J , ChauC, HalesTG, KaufmanDL. GABA(A) receptors mediate inhibition of T cell responses.J. Neuroimmunol.96, 21–28 (1999).
  • Parramón M , GonzálezMP, Oset-GasqueMJ. Pharmacological modulation of adrenal medullary GABAA receptor: consistent with its subunit composition. Br. J. Pharmacol.116, 1875–1881 (1995).
  • Ren XB , LiuCT, ZhuT. [Investigation of effect of bicuculline on expression of α-smooth muscle actin and airway remodeling in asthmatic mice].Sichuan Da Xue Xue Bao Yi Xue Ban41, 626–629 (2010).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.