5,466
Views
0
CrossRef citations to date
0
Altmetric
Editorial

The Role of Pharmacokinetic Studies in Drug Discovery: Where are We Now, How Did We Get Here and Where are We Going?

Pages 1233-1235 | Published online: 27 Aug 2014

References

  • Jamei M , MarciniakS, FengK, BarnettA, TuckerG, Rostami-HodjeganA. The Simcyp population-based ADME simulator. Expert Opin. Drug Metab. Toxicol.5 (2), 211–223 (2009).
  • Kuentz M , NickS, ParrottN, RöthlisbergerD. A strategy for preclinical formulation development using GastroPlus as pharmacokinetic simulation tool and a statistical screening design applied to a dog study. Eur. J. Pharm. Sci.27 (1), 91–99 (2006).
  • Wagner JG . History of pharmacokinetics. Pharmacol. Ther.12 (3), 537–562 (1981).
  • Clark B , SmithDA. Pharmacokinetics and toxicity testing. Crit. Rev. Toxicol.12 (4), 343–385 (1984).
  • Henion JD , MaylinGA. Drug analysis by direct liquid introduction micro liquid chromatography mass spectrometry. Biomed. Mass Spectrom.7 (3), 115–121 (1980).
  • Rowland M , BenetLZ, GrahamGG. Clearance concepts in pharmacokinetics. J. Pharmacokinet Biopharm.1 (2), 123–136 (1973).
  • Houston JB . Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance. Biochem. Pharmacol.47 (9), 1469–1479 (1994).
  • Smith DA . Evolution of ADME science: where else can modeling and simulation contribute?Mol. Pharm.10 (4), 1162–1170 (2013).
  • Ballard P , BrassilP, BuiKHet al.. The right compound in the right assay at the right time: an integrated discovery DMPK strategy. Drug Metab. Rev.44 (3),  224–252  (2012).
  • Riley RJ , McGinnityDF, AustinRP. A unified model for predicting human hepatic, metabolic clearance from in vitro intrinsic clearance data in hepatocytes and microsomes. Drug Metab. Dispos.33 (9), 1304–1311 (2005).
  • Peck CC . Quantitative clinical pharmacology is transforming drug regulation. J. Pharmacokinet Pharmacodyn.37 (6), 617–628 (2010).
  • Gessel MM , NorrisJL, CaprioliRM. MALDI imaging mass spectrometry: spatial molecular analysis to enable a new age of discovery. J. Proteomics107C, 71–82  (2014).
  • Ellis SR , BruinenAL, HeerenRM. A critical evaluation of the current state-of-the-art in quantitative imaging mass spectrometry. Anal. Bioanal. Chem.406 (5), 1275–1289 (2014).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.