Chemical Genetics and Regeneration

References

• Maden M . A history of regeneration research. Milestones in the evolution of a science. Cell69 (5), 723–724 (1992).
   Google Scholar
• Nelson TJ , Martinez-FernandezA, TerzicA. Induced pluripotent stem cells: developmental biology to regenerative medicine. Nat. Rev. Cardiol.7 (12), 700–710 (2010).
   PubMed Web of Science ®Google Scholar
• El-Badawy A , El-BadriN. Regulators of pluripotency and their implications in regenerative medicine. Stem Cells Cloning8, 67–80 (2015).
   PubMedGoogle Scholar
• Yamakawa H , IedaM. Strategies for heart regeneration: approaches ranging from induced pluripotent stem cells to direct cardiac reprogramming. Int. Heart J.56 (1), 1–5 (2015).
   PubMed Web of Science ®Google Scholar
• Singh VK , KalsanM, KumarN, SainiA, ChandraR. Induced pluripotent stem cells: applications in regenerative medicine, disease modeling, and drug discovery. Front Cell Dev. Biol.3, 2 (2015).
   PubMed Web of Science ®Google Scholar
• Hirschi KK , LiS, RoyK. Induced pluripotent stem cells for regenerative medicine. Annu. Rev. Biomed. Eng.16, 277–294 (2014).
   PubMed Web of Science ®Google Scholar
• Green EM , LeeRT. Proteins and small molecules for cellular regenerative medicine. Physiol. Rev.93 (1), 311–325 (2013).
   PubMed Web of Science ®Google Scholar
• Li W , JiangK, WeiW, ShiY, DingS. Chemical approaches to studying stem cell biology. Cell Res.23 (1), 81–91 (2013).
   PubMed Web of Science ®Google Scholar
• Mitchison TJ . Towards a pharmacological genetics. Chem. Biol.1 (1), 3–6 (1994).
   PubMedGoogle Scholar
• Schreiber SL . Chemical genetics resulting from a passion for synthetic organic chemistry. Bioorganic Med. Chem.6 (8), 1127–1152 (1998).
   PubMed Web of Science ®Google Scholar
• Anighoro A , BajorathJ, RastelliG. Polypharmacology: challenges and opportunities in drug discovery. J. Med. Chem.57 (19), 7874–7887 (2014).
   PubMed Web of Science ®Google Scholar
• Dar AC , DasTK, ShokatKM, CaganRL. Chemical genetic discovery of targets and anti-targets for cancer polypharmacology. Nature486 (7401), 80–84 (2012).
   PubMed Web of Science ®Google Scholar
• Reddy AS , ZhangS. Polypharmacology: drug discovery for the future. Expert Rev. Clin. Pharmacol.6 (1), 41–47 (2013).
   PubMed Web of Science ®Google Scholar
• Alaimo PJ , Shogren-KnaakMA, ShokatKM. Chemical genetic approaches for the elucidation of signaling pathways. Curr. Opin. Chem. Biol.5 (4), 360–367 (2001).
   PubMed Web of Science ®Google Scholar
• Scannell JW , BlanckleyA, BoldonH, WarringtonB. Diagnosing the decline in pharmaceutical R&D efficiency. Nat. Rev. Drug Discov.11 (3), 191–200 (2012).
   PubMed Web of Science ®Google Scholar
• Swinney DC , AnthonyJ. How were new medicines discovered?Nat. Rev. Drug Discov.10 (7), 507–19 (2011).
   PubMed Web of Science ®Google Scholar
• Murphey RD , ZonLI. Small molecule screening in the zebrafish. Methods39 (3), 255–261 (2006).
   PubMed Web of Science ®Google Scholar
• Zon LI , PetersonRT. In vivo drug discovery in the zebrafish. Nat. Rev. Drug Discov.4 (1), 35–44 (2005).
   PubMed Web of Science ®Google Scholar
• Wheeler GN , BrändliAW. Simple vertebrate models for chemical genetics and drug discovery screens: lessons from zebrafish and Xenopus. Dev. Dyn.238 (6), 1287–308 (2009).
   PubMed Web of Science ®Google Scholar
• Goessling W , NorthTE. Repairing quite swimmingly: advances in regenerative medicine using zebrafish. Dis. Model. Mech.7 (7), 769–76 (2014).
   PubMed Web of Science ®Google Scholar
• Rennekamp AJ , PetersonRT. 15 years of zebrafish chemical screening. Curr. Opin. Chem. Biol.24, 58–70 (2015).
   PubMed Web of Science ®Google Scholar
• Taylor KL , GrantNJ, TemperleyND, PattonEE. Small molecule screening in zebrafish: an in vivo approach to identifying new chemical tools and drug leads. Cell Commun. Signal.8, 11 (2010).
   PubMed Web of Science ®Google Scholar
• Wang J , ConboyI. Embryonic vs. adult myogenesis: challenging the “regeneration recapitulates development” paradigm. J. Mol. Cell Biol.2 (1), 1–4 (2010).
   PubMed Web of Science ®Google Scholar
• Agata K , WatanabeK. Molecular and cellular aspects of planarian regeneration. Semin. Cell Dev. Biol.10 (4), 377–383 (1999).
   PubMed Web of Science ®Google Scholar
• Wagner DE , WangIE, ReddienPW. Clonogenic neoblasts are pluripotent adult stem cells that underlie planarian regeneration. Science332 (6031), 811–816 (2011).
   PubMed Web of Science ®Google Scholar
• Sánchez Alvarado A , NewmarkPA. The use of planarians to dissect the molecular basis of metazoan regeneration. Wound Repair Regen.6 (4), 413–420.
   PubMedGoogle Scholar
• Br⊘ndsted HV . Planarian Regeneration (International Series of Monographs in Pure and Applied Biology), (1st Edition). Pergamon Press, Scotland (1969).
   Google Scholar
• Elliott SA , Sánchez AlvaradoA. The history and enduring contributions of planarians to the study of animal regeneration. Wiley Interdiscip. Rev. Dev. Biol.2 (3), 301–326 (2013).
   PubMed Web of Science ®Google Scholar
• Fraguas S , BarberánS, CebriàF. EGFR signaling regulates cell proliferation, differentiation and morphogenesis during planarian regeneration and homeostasis. Dev. Biol.354 (1), 87–101 (2011).
   PubMed Web of Science ®Google Scholar
• Reddien PW , BermangeAL, KiczaAM, Sánchez AlvaradoA. BMP signaling regulates the dorsal planarian midline and is needed for asymmetric regeneration. Development134 (22), 4043–4051 (2007).
   PubMed Web of Science ®Google Scholar
• Tasaki J , ShibataN, NishimuraOet al. ERK signaling controls blastema cell differentiation during planarian regeneration. Development138 (12), 2417–2427 (2011).
   PubMed Web of Science ®Google Scholar
• Umesono Y , TasakiJ, NishimuraYet al. The molecular logic for planarian regeneration along the anterior-posterior axis. Nature500 (7460), 73–76 (2013).
   PubMed Web of Science ®Google Scholar
• Ermakov AM , ErmakovaON, ErmolaevaSA. Study of possible involvement of MEK mitogen-activated protein kinase and TGF-β receptor in planarian regeneration processes using pharmacological inhibition analysis. Ontogenez45 (5), 355–360 (2014).
   PubMedGoogle Scholar
• Peiris TH , OviedoNJ. Gap junction proteins: master regulators of the planarian stem cell response to tissue maintenance and injury. Biochim. Biophys. Acta1828 (1), 109–117 (2013).
   PubMed Web of Science ®Google Scholar
• Nogi T , LevinM. Characterization of innexin gene expression and functional roles of gap-junctional communication in planarian regeneration. Dev. Biol.287 (2), 314–335 (2005).
   PubMed Web of Science ®Google Scholar
• Oviedo NJ , MorokumaJ, WalentekPet al. Long-range neural and gap junction protein-mediated cues control polarity during planarian regeneration. Dev. Biol.339 (1), 188–199 (2010).
   PubMed Web of Science ®Google Scholar
• Balestrini L , IsolaniME, PietraDet al. Berberine exposure triggers developmental effects on planarian regeneration. Sci. Rep.4, 4914 (2014).
   PubMed Web of Science ®Google Scholar
• Beane WS , MorokumaJ, AdamsDS, LevinM. A chemical genetics approach reveals H,K-ATPase-mediated membrane voltage is required for planarian head regeneration. Chem. Biol.18 (1), 77–89 (2011).
   PubMedGoogle Scholar
• Nogi T , ZhangD, ChanJD, MarchantJS. A novel biological activity of praziquantel requiring voltage-operated Ca2+ channel beta subunits: subversion of flatworm regenerative polarity. PLoS Negl. Trop. Dis.3 (6), e464 (2009).
   PubMed Web of Science ®Google Scholar
• Nogi T , YuanYE, SoroccoD, Perez-TomasR, LevinM. Eye regeneration assay reveals an invariant functional left-right asymmetry in the early bilaterian, Dugesia japonica. Laterality10 (3), 193–205 (2005).
   PubMed Web of Science ®Google Scholar
• Beane WS , MorokumaJ, LemireJM, LevinM. Bioelectric signaling regulates head and organ size during planarian regeneration. Development140 (2), 313–322 (2013).
   PubMed Web of Science ®Google Scholar
• Tanaka EM , ReddienPW. The cellular basis for animal regeneration. Dev. Cell21 (1), 172–185 (2011).
   PubMed Web of Science ®Google Scholar
• Brockes JP , KumarA. Appendage regeneration in adult vertebrates and implications for regenerative medicine. Science310 (5756), 1919–1923 (2005).
   PubMed Web of Science ®Google Scholar
• Yokoyama H , Yonei-TamuraS, EndoT, Izpisúa BelmonteJC, TamuraK, IdeH. Mesenchyme with fgf-10 expression is responsible for regenerative capacity in Xenopus limb buds. Dev. Biol.219 (1), 18–29 (2000).
   PubMed Web of Science ®Google Scholar
• Tseng A-S , BeaneWS, LemireJM, MasiA, LevinM. Induction of vertebrate regeneration by a transient sodium current. J. Neurosci.30 (39), 13192–13200 (2010).
   PubMed Web of Science ®Google Scholar
• Johnson SL , WestonJA. Temperature-sensitive mutations that cause stage-specific defects in Zebrafish fin regeneration. Genetics141 (4), 1583–1595 (1995).
   PubMed Web of Science ®Google Scholar
• Stoick-Cooper CL , WeidingerG, RiehleKJet al. Distinct Wnt signaling pathways have opposing roles in appendage regeneration. Development134 (3), 479–489 (2007).
   PubMed Web of Science ®Google Scholar
• Poss KD , ShenJ, NechiporukAet al. Roles for Fgf signaling during zebrafish fin regeneration. Dev. Biol.222 (2), 347–358 (2000).
   PubMed Web of Science ®Google Scholar
• Münch J , González-RajalA, de la PompaJL. Notch regulates blastema proliferation and prevents differentiation during adult zebrafish fin regeneration. Development140 (7), 1402–1411 (2013).
   PubMed Web of Science ®Google Scholar
• Koshiba K , KuroiwaA, YamamotoH, TamuraK, IdeH. Expression of Msx genes in regenerating and developing limbs of axolotl. J. Exp. Zool.282 (6), 703–714 (1998).
   PubMedGoogle Scholar
• Akimenko MA , JohnsonSL, WesterfieldM, EkkerM. Differential induction of four msx homeobox genes during fin development and regeneration in zebrafish. Development121 (2), 347–357 (1995).
   PubMed Web of Science ®Google Scholar
• McCusker CD , GardinerDM. Understanding positional cues in salamander limb regeneration: implications for optimizing cell-based regenerative therapies. Dis. Model. Mech.7 (6), 593–599 (2014).
   PubMed Web of Science ®Google Scholar
• Kikuchi K , HoldwayJE, MajorRJet al. Retinoic acid production by endocardium and epicardium is an injury response essential for zebrafish heart regeneration. Dev. Cell20 (3), 397–404 (2011).
   PubMed Web of Science ®Google Scholar
• Mathew LK , SenguptaS, FranzosaJAet al. Comparative expression profiling reveals an essential role for raldh2 in epimorphic regeneration. J. Biol. Chem.284 (48), 33642–33653 (2009).
   PubMed Web of Science ®Google Scholar
• Rojas-Muñoz A , RajadhykshaS, GilmourDet al. ErbB2 and ErbB3 regulate amputation-induced proliferation and migration during vertebrate regeneration. Dev. Biol.327 (1), 177–190 (2009).
   PubMed Web of Science ®Google Scholar
• Einhorn TA . The cell and molecular biology of fracture healing. Clin. Orthop. Relat. Res. (355 Suppl.), S7–S21 (1998).
   PubMed Web of Science ®Google Scholar
• Dimitriou R , JonesE, McGonagleD, GiannoudisPV. Bone regeneration: current concepts and future directions. BMC Med.9 (1), 66 (2011).
   PubMed Web of Science ®Google Scholar
• Dallas SL , BonewaldLF. Dynamics of the transition from osteoblast to osteocyte. Ann. NY Acad. Sci.1192, 437–443 (2010).
   PubMed Web of Science ®Google Scholar
• Long F . Building strong bones: molecular regulation of the osteoblast lineage. Nat. Rev. Mol. Cell Biol.13 (1), 27–38 (2012).
   Web of Science ®Google Scholar
• Rosen V . BMP2 signaling in bone development and repair. Cytokine Growth Factor Rev.20 (5–6), 475–480 (2009).
   PubMed Web of Science ®Google Scholar
• Chen D , JiX, HarrisMAet al. Differential roles for bone morphogenetic protein (BMP) receptor type IB and IA in differentiation and specification of mesenchymal precursor cells to osteoblast and adipocyte lineages. J. Cell Biol.142 (1), 295–305 (1998).
   PubMed Web of Science ®Google Scholar
• Bessa PC , CasalM, ReisRL. Bone morphogenetic proteins in tissue engineering: the road from laboratory to clinic, part II (BMP delivery). J. Tissue Eng. Regen. Med.2 (2–3), 81–96 (2008).
   PubMed Web of Science ®Google Scholar
• Carbone EJ , RajpuraK, JiangT, LaurencinCT, LoKW-H. Regulation of bone regeneration with approved small molecule compounds. Adv. Regen. Biol.1, 25276 (2014).
   Google Scholar
• Lo KW-H , AsheKM, KanHM, LaurencinCT. The role of small molecules in musculoskeletal regeneration. Regen. Med.7 (4), 535–549 (2012).
   PubMed Web of Science ®Google Scholar
• Metz JR , de VriezeE, LockE-J, SchultenIE, FlikG. Elasmoid scales of fishes as model in biomedical bone research. J. Appl. Ichthyol.28 (3), 382–387 (2012).
   Web of Science ®Google Scholar
• Stewart S , GomezAW, ArmstrongBE, HennerA, StankunasK. Sequential and opposing activities of Wnt and BMP coordinate zebrafish bone regeneration. Cell Rep.6 (3), 482–498 (2014).
   PubMed Web of Science ®Google Scholar
• De Vrieze E , ZethofJ, Schulte-MerkerS, FlikG, MetzJR. Identification of novel osteogenic compounds by an ex-vivo sp7: luciferase zebrafish scale assay. Bone74, 106–113 (2015).
   PubMed Web of Science ®Google Scholar
• Singh BN , Koyano-NakagawaN, GarryJP, WeaverCV. Heart of newt: a recipe for regeneration. J. Cardiovasc. Transl. Res.3 (4), 397–409 (2010).
   PubMed Web of Science ®Google Scholar
• Poss KD , WilsonLG, KeatingMT. Heart regeneration in zebrafish. Science298 (5601), 2188–2190 (2002).
   PubMed Web of Science ®Google Scholar
• Jopling C , SleepE, RayaM, MartíM, RayaA, Izpisúa BelmonteJC. Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation. Nature.464 (7288), 606–609 (2010).
   PubMed Web of Science ®Google Scholar
• Kikuchi K , HoldwayJE, WerdichAAet al. Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes. Nature464 (7288), 601–605 (2010).
   PubMed Web of Science ®Google Scholar
• Porrello ER , MahmoudAI, SimpsonEet al. Transient regenerative potential of the neonatal mouse heart. Science331 (6020), 1078–1080 (2011).
   PubMed Web of Science ®Google Scholar
• Bergmann O , BhardwajRD, BernardSet al. Evidence for cardiomyocyte renewal in humans. Science324 (5923), 98–102 (2009).
   PubMed Web of Science ®Google Scholar
• Choi W-Y , GemberlingM, WangJet al. In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration. Development140 (3), 660–666 (2013).
   PubMed Web of Science ®Google Scholar
• Huang Y , HarrisonMR, OsorioAet al. Igf signaling is required for cardiomyocyte proliferation during zebrafish heart development and regeneration. PLoS ONE8 (6), e67266 (2013).
   PubMed Web of Science ®Google Scholar
• Kikuchi K , PossKD. Cardiac regenerative capacity and mechanisms. Annu. Rev. Cell Dev. Biol.28, 719–741 (2012).
   PubMed Web of Science ®Google Scholar
• Chablais F , JazwinskaA. The regenerative capacity of the zebrafish heart is dependent on TGFβ signaling. Development139 (11), 1921–1930 (2012).
   PubMed Web of Science ®Google Scholar
• Baines CP , MolkentinJD. STRESS signaling pathways that modulate cardiac myocyte apoptosis. J. Mol. Cell. Cardiol.38 (1), 47–62 (2005).
   PubMed Web of Science ®Google Scholar
• Cuevas P , ReimersD, CarcellerFet al. Fibroblast growth factor-1 prevents myocardial apoptosis triggered by ischemia reperfusion injury. Eur. J. Med. Res.2 (11), 465–408 (1997).
   PubMedGoogle Scholar
• Engel FB , HsiehPCH, LeeRT, KeatingMT. FGF1/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction. Proc. Natl Acad. Sci. USA.103 (42), 15546–15551 (2006).
   PubMed Web of Science ®Google Scholar
• Golub JS , TongL, NgyuenTBet al. Hair cell replacement in adult mouse utricles after targeted ablation of hair cells with diphtheria toxin. J. Neurosci.32 (43), 15093–15105 (2012).
   PubMed Web of Science ®Google Scholar
• Cox BC , ChaiR, LenoirAet al. Spontaneous hair cell regeneration in the neonatal mouse cochlea in vivo. Development141 (4), 816–829 (2014).
   PubMed Web of Science ®Google Scholar
• Stawicki TM , EsterbergR, HaileyDW, RaibleDW, RubelEW. Using the zebrafish lateral line to uncover novel mechanisms of action and prevention in drug-induced hair cell death. Front. Cell. Neurosci.9, 46 (2015).
   PubMed Web of Science ®Google Scholar
• J⊘rgensen JM , MathiesenC. The avian inner ear. Continuous production of hair cells in vestibular sensory organs, but not in the auditory papilla. Naturwissenschaften75 (6), 319–320 (1988).
   Google Scholar
• López-Schier H , HudspethAJ. A two-step mechanism underlies the planar polarization of regenerating sensory hair cells. Proc. Natl Acad. Sci. USA103 (49), 18615–18620 (2006).
   PubMed Web of Science ®Google Scholar
• Roberson DW , AlosiJA, CotancheDA. Direct transdifferentiation gives rise to the earliest new hair cells in regenerating avian auditory epithelium. J. Neurosci. Res.78 (4), 461–471 (2004).
   PubMed Web of Science ®Google Scholar
• Stone JS , RubelEW. Temporal, spatial, and morphologic features of hair cell regeneration in the avian basilar papilla. J. Comp. Neurol.417 (1), 1–16 (2000).
   PubMed Web of Science ®Google Scholar
• Warchol ME , CorwinJT. Regenerative proliferation in organ cultures of the avian cochlea: identification of the initial progenitors and determination of the latency of the proliferative response. J. Neurosci.16 (17), 5466–77 (1996).
   PubMed Web of Science ®Google Scholar
• Ma EY , RubelEW, RaibleDW. Notch signaling regulates the extent of hair cell regeneration in the zebrafish lateral line. J. Neurosci.28 (9), 2261–2273 (2008).
   PubMed Web of Science ®Google Scholar
• Coffin AB , OuH, OwensKNet al. Chemical screening for hair cell loss and protection in the zebrafish lateral line. Zebrafish7 (1), 3–11 (2010).
   PubMed Web of Science ®Google Scholar
• Mackenzie SM , RaibleDW. Proliferative regeneration of zebrafish lateral line hair cells after different ototoxic insults. PLoS ONE7 (10), e47257 (2012).
   PubMed Web of Science ®Google Scholar
• He Y , CaiC, TangD, SunS, LiH. Effect of histone deacetylase inhibitors trichostatin A and valproic acid on hair cell regeneration in zebrafish lateral line neuromasts. Front. Cell. Neurosci.8, 382 (2014).
   PubMed Web of Science ®Google Scholar
• Head JR , GaciochL, PennisiM, MeyersJR. Activation of canonical Wnt/β-catenin signaling stimulates proliferation in neuromasts in the zebrafish posterior lateral line. Dev. Dyn.242 (7), 832–846 (2013).
   PubMed Web of Science ®Google Scholar
• Lenkowski JR , RaymondPA. Müller glia: stem cells for generation and regeneration of retinal neurons in teleost fish. Prog. Retin. Eye Res.40, 94–123 (2014).
   PubMed Web of Science ®Google Scholar
• Lamba D , KarlM, RehT. Neural regeneration and cell replacement: a view from the eye. Cell Stem Cell.2 (6), 538–549 (2008).
   PubMed Web of Science ®Google Scholar
• Polosukhina A , LittJ, TochitskyIet al. Photochemical restoration of visual responses in blind mice. Neuron75 (2), 271–282 (2012).
   PubMed Web of Science ®Google Scholar
• Tochitsky I , PolosukhinaA, DegtyarVEet al. Restoring visual function to blind mice with a photoswitch that exploits electrophysiological remodeling of retinal ganglion cells. Neuron81 (4), 800–813 (2014).
   PubMed Web of Science ®Google Scholar
• Dyer MA , CepkoCL. Control of Müller glial cell proliferation and activation following retinal injury. Nat. Neurosci.3 (9), 873–880 (2000).
   PubMed Web of Science ®Google Scholar
• Jayaram H , JonesMF, EastlakeKet al. Transplantation of photoreceptors derived from human Muller glia restore rod function in the P23H rat. Stem Cells Transl. Med.3 (3), 323–333 (2014).
   PubMed Web of Science ®Google Scholar
• Singhal S , BhatiaB, JayaramHet al. Human Müller glia with stem cell characteristics differentiate into retinal ganglion cell (RGC) precursors in vitro and partially restore RGC function in vivo following transplantation. Stem Cells Transl. Med.1 (3), 188–199 (2012).
   PubMed Web of Science ®Google Scholar
• Lawrence JM , SinghalS, BhatiaBet al. MIO-M1 cells and similar muller glial cell lines derived from adult human retina exhibit neural stem cell characteristics. Stem Cells25 (8), 2033–2043 (2007).
   PubMed Web of Science ®Google Scholar
• Craig SEL , CalinescuA-A, HitchcockPF. Identification of the molecular signatures integral to regenerating photoreceptors in the retina of the zebra fish. J. Ocul. Biol. Dis. Infor.1 (2–4), 73–84 (2008).
   PubMedGoogle Scholar
• Wan J , ZhaoX-F, VojtekA, GoldmanD. Retinal injury, growth factors, and cytokines converge on β-catenin and pStat3 signaling to stimulate retina regeneration. Cell Rep.9 (1), 285–297 (2014).
   PubMed Web of Science ®Google Scholar
• Zhao X-F , EllingsenS, FjoseA. Labelling and targeted ablation of specific bipolar cell types in the zebrafish retina. BMC Neurosci.10, 107 (2009).
   PubMed Web of Science ®Google Scholar
• Montgomery JE , ParsonsMJ, HydeDR. A novel model of retinal ablation demonstrates that the extent of rod cell death regulates the origin of the regenerated zebrafish rod photoreceptors. J. Comp. Neurol.518 (6), 800–814 (2010).
   PubMed Web of Science ®Google Scholar
• Ariga J , WalkerSL, MummJS. Multicolor time-lapse imaging of transgenic zebrafish: visualizing retinal stem cells activated by targeted neuronal cell ablation. J. Vis. Exp.43, pii: 2093 (2010).
   Google Scholar
• Walker SL , ArigaJ, MathiasJRet al. Automated reporter quantification in vivo: high-throughput screening method for reporter-based assays in zebrafish. PLoS ONE7 (1), e29916 (2012).
   PubMed Web of Science ®Google Scholar
• Fausett BV , GoldmanD. A role for alpha1 tubulin-expressing Müller glia in regeneration of the injured zebrafish retina. J. Neurosci.26 (23), 6303–6313 (2006).
   PubMed Web of Science ®Google Scholar
• Bernardos RL , BarthelLK, MeyersJR, RaymondPA. Late-stage neuronal progenitors in the retina are radial Müller glia that function as retinal stem cells. J. Neurosci.27 (26), 7028–7040 (2007).
   PubMed Web of Science ®Google Scholar
• Fimbel SM , MontgomeryJE, BurketCT, HydeDR. Regeneration of inner retinal neurons after intravitreal injection of ouabain in zebrafish. J. Neurosci.27 (7), 1712–1724 (2007).
   PubMed Web of Science ®Google Scholar
• Fischer AJ , RehTA. Müller glia are a potential source of neural regeneration in the postnatal chicken retina. Nat. Neurosci.4 (3), 247–252 (2001).
   PubMed Web of Science ®Google Scholar
• Gorsuch RA , HydeDR. Regulation of Müller glial dependent neuronal regeneration in the damaged adult zebrafish retina. Exp. Eye Res.123, 131–140 (2014).
   PubMed Web of Science ®Google Scholar
• Goldman D . Müller glial cell reprogramming and retina regeneration. Nat. Rev. Neurosci.15 (7), 431–442 (2014).
   PubMed Web of Science ®Google Scholar
• Ramachandran R , ZhaoX-F, GoldmanD. Ascl1a/Dkk/beta-catenin signaling pathway is necessary and glycogen synthase kinase-3beta inhibition is sufficient for zebrafish retina regeneration. Proc. Natl Acad. Sci. USA108 (38), 15858–15863 (2011).
   PubMed Web of Science ®Google Scholar
• Huang S-MA , MishinaYM, LiuSet al. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature461 (7264), 614–620 (2009).
   PubMed Web of Science ®Google Scholar
• Meyers JR , HuL, MosesA, KaboliK, PapandreaA, RaymondPA. β-Catenin/Wnt signaling controls progenitor fate in the developing and regenerating zebrafish retina. Neural Dev.7, 30 (2012).
   PubMed Web of Science ®Google Scholar
• Zhu J , Luz-MadrigalA, HaynesT, ZavadaJ, BurkeAK, Del Rio-TsonisK. β-Catenin inactivation is a pre-requisite for chick retina regeneration. PLoS ONE9 (7), e101748 (2014).
   PubMed Web of Science ®Google Scholar
• Wan J , RamachandranR, GoldmanD. HB-EGF is necessary and sufficient for Müller Glia dedifferentiation and retina regeneration. Dev. Cell22 (2), 334–347 (2012).
   PubMed Web of Science ®Google Scholar
• Lemmon MA , SchlessingerJ. Cell signaling by receptor tyrosine kinases. Cell.141 (7), 1117–1134 (2010).
   PubMed Web of Science ®Google Scholar
• Conner C , AckermanKM, LahneM, HobgoodJS, HydeDR. Repressing notch signaling and expressing TNFα are sufficient to mimic retinal regeneration by inducing Müller glial proliferation to generate committed progenitor cells. J. Neurosci.34 (43), 14403–14419 (2014).
   PubMed Web of Science ®Google Scholar
• Nelson BR , UekiY, ReardonSet al. Genome-wide analysis of Müller glial differentiation reveals a requirement for Notch signaling in postmitotic cells to maintain the glial fate. PLoS ONE6 (8), e22817 (2011).
   PubMed Web of Science ®Google Scholar
• Ramachandran R , ZhaoX-F, GoldmanD. Insm1a-mediated gene repression is essential for the formation and differentiation of Müller glia-derived progenitors in the injured retina. Nat. Cell Biol.14 (10), 1013–1023 (2012).
   PubMed Web of Science ®Google Scholar
• Nelson CM , GorsuchRA, BaileyTJ, AckermanKM, KassenSC, HydeDR. Stat3 defines three populations of Müller glia and is required for initiating maximal müller glia proliferation in the regenerating zebrafish retina. J. Comp. Neurol.520 (18), 4294–4311 (2012).
   PubMed Web of Science ®Google Scholar
• Bailey TJ , FossumSL, FimbelSM, MontgomeryJE, HydeDR. The inhibitor of phagocytosis, O-phospho-L-serine, suppresses Müller glia proliferation and cone cell regeneration in the light-damaged zebrafish retina. Exp. Eye Res.91 (5), 601–612 (2010).
   PubMed Web of Science ®Google Scholar
• Mathew LK , SenguptaS, KawakamiAet al. Unraveling tissue regeneration pathways using chemical genetics. J. Biol. Chem.282 (48), 35202–35210 (2007).
   PubMed Web of Science ®Google Scholar
• Oppedal D , GoldsmithMI. A chemical screen to identify novel inhibitors of fin regeneration in zebrafish. Zebrafish7 (1), 53–60 (2010).
   PubMed Web of Science ®Google Scholar
• Mundy G , GarrettR, HarrisSet al. Stimulation of bone formation in vitro and in rodents by statins. Science286 (5446), 1946–1949 (1999).
   PubMed Web of Science ®Google Scholar
• Darcy A , MeltzerM, MillerJet al. A novel library screen identifies immunosuppressors that promote osteoblast differentiation. Bone50 (6), 1294–1303 (2012).
   PubMed Web of Science ®Google Scholar
• Yuldashev MP , BatirovEK, VdovinAD, AbdullaevND. Structural study of glabrisoflavone, a novel isoflavone from Glycyrrhiza glabra L. Russ. J. Bioorganic Chem.26 (8), 784–786 (2000).
   Google Scholar
• Alves H , DecheringK, Van BlitterswijkC, De BoerJ. High-throughput assay for the identification of compounds regulating osteogenic differentiation of human mesenchymal stromal cells. PLoS ONE6 (10), e26678 (2011).
   PubMed Web of Science ®Google Scholar
• Brey DM , MotlekarNA, DiamondSL, MauckRL, GarinoJP, BurdickJA. High-throughput screening of a small molecule library for promoters and inhibitors of mesenchymal stem cell osteogenic differentiation. Biotechnol. Bioeng.108 (1), 163–174 (2011).
   PubMed Web of Science ®Google Scholar
• Sadek H , HannackB, ChoeEet al. Cardiogenic small molecules that enhance myocardial repair by stem cells. Proc. Natl Acad. Sci. USA105 (16), 6063–6068 (2008).
   PubMed Web of Science ®Google Scholar
• Uosaki H , MagadumA, SeoKet al. Identification of chemicals inducing cardiomyocyte proliferation in developmental stage-specific manner with pluripotent stem cells. Circ. Cardiovasc. Genet.6 (6), 624–633 (2013).
   PubMedGoogle Scholar
• Willems E , SpieringS, DavidovicsHet al. Small-molecule inhibitors of the Wnt pathway potently promote cardiomyocytes from human embryonic stem cell-derived mesoderm. Circ. Res.109 (4), 360–364 (2011).
   PubMed Web of Science ®Google Scholar
• Namdaran P , ReinhartKE, OwensKN, RaibleDW, RubelEW. Identification of modulators of hair cell regeneration in the zebrafish lateral line. J. Neurosci.32 (10), 3516–3528 (2012).
   PubMed Web of Science ®Google Scholar
• Moon IS , SoJ-H, JungY-Met al. Fucoidan promotes mechanosensory hair cell regeneration following amino glycoside-induced cell death. Hear. Res.282 (1–2), 236–242 (2011).
   PubMed Web of Science ®Google Scholar
• Ku Y-C , RenaudNA, VeileRAet al. The transcriptome of utricle hair cell regeneration in the avian inner ear. J. Neurosci.34 (10), 3523–3535 (2014).
   PubMed Web of Science ®Google Scholar
• McCullagh KJA , PerlingeiroRCR. Coaxing stem cells for skeletal muscle repair. Adv. Drug Deliv. Rev.84, 198–207 (2014).
   PubMed Web of Science ®Google Scholar
• Rahimov F , KunkelLM. The cell biology of disease: cellular and molecular mechanisms underlying muscular dystrophy. J. Cell Biol.201 (4), 499–510 (2013).
   PubMed Web of Science ®Google Scholar
• Tennyson CN , KlamutHJ, WortonRG. The human dystrophin gene requires 16 hours to be transcribed and is cotranscriptionally spliced. Nat. Genet.9 (2), 184–190 (1995).
   PubMed Web of Science ®Google Scholar
• Dumont NA , WangYX, RudnickiMA. Intrinsic and extrinsic mechanisms regulating satellite cell function. Development142 (9), 1572–1581 (2015).
   PubMed Web of Science ®Google Scholar
• Waugh TA , HorstickE, HurJet al. Fluoxetine prevents dystrophic changes in a zebrafish model of Duchenne muscular dystrophy. Hum. Mol. Genet.23 (17), 4651–4662 (2014).
   PubMed Web of Science ®Google Scholar
• Kawahara G , KunkelLM. Zebrafish based small molecule screens for novel DMD drugs. Drug Discov. Today. Technol.10 (1), e91–e96 (2013).
   Google Scholar
• Bouwens L , RoomanI. Regulation of pancreatic beta-cell mass. Physiol. Rev.85 (4), 1255–1270 (2005).
   PubMed Web of Science ®Google Scholar
• Andersson O , AdamsBA, YooDet al. Adenosine signaling promotes regeneration of pancreatic β cells in vivo. Cell Metab.15 (6), 885–894 (2012).
   PubMed Web of Science ®Google Scholar
• Curado S , AndersonRM, JungblutB, MummJ, SchroeterE, StainierDYR. Conditional targeted cell ablation in zebrafish: a new tool for regeneration studies. Dev. Dyn.236 (4), 1025–1035 (2007).
   PubMed Web of Science ®Google Scholar
• Pisharath H , RheeJM, SwansonMA, LeachSD, ParsonsMJ. Targeted ablation of beta cells in the embryonic zebrafish pancreas using E. coli nitroreductase. Mech. Dev.124 (3), 218–229 (2007).
   PubMed Web of Science ®Google Scholar
• Annes JP , RyuJH, LamKet al. Adenosine kinase inhibition selectively promotes rodent and porcine islet β-cell replication. Proc. Natl Acad. Sci. USA109 (10), 3915–3920 (2012).
   PubMed Web of Science ®Google Scholar
• Fredholm BB . Adenosine, an endogenous distress signal, modulates tissue damage and repair. Cell Death Differ.14 (7), 1315–1323 (2007).
   PubMed Web of Science ®Google Scholar
• Rovira M , HuangW, YusuffSet al. Chemical screen identifies FDA-approved drugs and target pathways that induce precocious pancreatic endocrine differentiation. Proc. Natl Acad. Sci. USA108 (48), 19264–19269 (2011).
   PubMed Web of Science ®Google Scholar
• Tsuji N , NinovN, DelawaryMet al. Whole organism high content screening identifies stimulators of pancreatic beta-cell proliferation. PLoS ONE9 (8), e104112 (2014).
   PubMed Web of Science ®Google Scholar
• Wang G , RajpurohitSK, DelaspreaFet al. First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass. Elife4, e08261 (2015).
   PubMed Web of Science ®Google Scholar
• Inglese J , AuldDS, JadhavAet al. Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries. Proc. Natl Acad. Sci. USA103 (31), 11473–11478 (2006).
   PubMed Web of Science ®Google Scholar
• Samara C , RohdeCB, GillelandCL, NortonS, HaggartySJ, YanikMF. Large-scale in vivo femtosecond laser neurosurgery screen reveals small-molecule enhancer of regeneration. Proc. Natl Acad. Sci. USA107 (43), 18342–18347 (2010).
   PubMed Web of Science ®Google Scholar
• Franzini RM , NeriD, ScheuermannJ. DNA-encoded chemical libraries: advancing beyond conventional small-molecule libraries. Acc. Chem. Res.47 (4), 1247–1255 (2014).
   PubMed Web of Science ®Google Scholar
• Hojo H , IgawaK, OhbaSet al. Development of high-throughput screening system for osteogenic drugs using a cell-based sensor. Biochem. Biophys. Res. Commun.376 (2), 375–379 (2008).
   PubMed Web of Science ®Google Scholar
• Sylvia G , LenhoffAT. Hydra and the Birth of Experimental Biology, 1744: Abraham Trembley's Memoirs Concerning the Natural History of a Type of Freshwater Polyp with Arms Shaped Like Horns. Boxwood Press, CA, USA (1986).
   Google Scholar
• Morgan T . Regeneration: Columbia University Biological Series VII. OsbornHF, WilsonEB ( Eds). Macmillan Publishers, New York, USA (1901).
   Google Scholar
• Worley MI , SetiawanL, HariharanIK. Regeneration and transdetermination in drosophila imaginal discs. Annu. Rev. Genet.46, 289–310 (2012).
   PubMed Web of Science ®Google Scholar
• Kunkel JG . Cockroach molting. II. The nature of regeneration-induced delay of molting hormone secretion. Biol. Bull.153 (1), 145–162 (1977).
   PubMed Web of Science ®Google Scholar
• Sánchez Alvarado A , TsonisPA. Bridging the regeneration gap: genetic insights from diverse animal models. Nat. Rev. Genet.7 (11), 873–884 (2006).
   PubMed Web of Science ®Google Scholar
• Slack JMW , LinG, ChenY. Molecular and cellular basis of regeneration and tissue repair: the Xenopus tadpole: a new model for regeneration research. Cell Mol. Life Sci.65 (1), 54–63 (2008).
   PubMedGoogle Scholar
• Gemberling M , BaileyT, HydeD, PossK. The zebrafish as a model for complex tissue regeneration. Trends Genet.29 (11), 611–620 (2013).
   PubMed Web of Science ®Google Scholar
• Stone JS , CotancheDA. Hair cell regeneration in the avian auditory epithelium. Int. J. Dev. Biol.51 (6–7), 633–647 (2007).
   PubMed Web of Science ®Google Scholar
• Lehoczky JA , RobertB, TabinCJ. Mouse digit tip regeneration is mediated by fate-restricted progenitor cells. Proc. Natl Acad. Sci. USA108 (51), 20609–20614 (2011).
   PubMed Web of Science ®Google Scholar
• Yimlamai D , ChristodoulouC, GalliGGet al. Hippo pathway activity influences liver cell fate. Cell157 (6), 1324–1338 (2014).
   PubMed Web of Science ®Google Scholar
• Nieto-Diaz M , Pita-ThomasDW, Munoz-GaldeanoTet al. Deer antler innervation and regeneration. Front. Biosci. (Landmark Ed.)17, 1389–1401 (2012).
   PubMed Web of Science ®Google Scholar