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Future Science OA Volume 2, 2016 - Issue 2
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Company Profile

Company profile: BluePen Biomarkers LLC - integrated biomarker solutions

Ian A Blair1 BluePen Biomarkers LLC, 3401 Grays Ferry Avenue, Building 212, Suite 132, Philadelphia, PA19146-2701, USA;2 Penn SRP Center, University of Pennsylvania, Philadelphia, PA19104-6160, USA;3 Department of Systems Pharmacology & Translational Therapeutics, University of Pennsylvania, Philadelphia, PA19104-6160, USACorrespondence[email protected]
,
Clementina Mesaros2 Penn SRP Center, University of Pennsylvania, Philadelphia, PA19104-6160, USA;3 Department of Systems Pharmacology & Translational Therapeutics, University of Pennsylvania, Philadelphia, PA19104-6160, USA
,
Patrick Lilley4 Emerald Logic, Aliso Viejo, CA92656, USA;5 BluePrint Bio, Aliso Viejo, CA92656, USA
&
Matthew Nunez1 BluePen Biomarkers LLC, 3401 Grays Ferry Avenue, Building 212, Suite 132, Philadelphia, PA19146-2701, USA;5 BluePrint Bio, Aliso Viejo, CA92656, USA
Article: FSO124 | Accepted 06 May 2016, Published online: 09 Jun 2016

References

  • Poste G . Bring on the biomarkers. Nature469(7329), 156–157 (2011).
  • Basu SS , DeutschEC, SchmaierAA, LynchDR, BlairIA. Human platelets as a platform to monitor metabolic biomarkers using stable isotopes and LC-MS. Bioanalysis5(24), 3009–3021 (2013).
  • Worth AJ , BasuSS, DeutschECet al. Stable isotopes and LC-MS for monitoring metabolic disturbances in Friedreich’s ataxia platelets. Bioanalysis7(15), 1843–1855 (2015).
  • Worth AJ , MarchioneDM, ParryRCet al. LC-MS analysis of human platelets as a platform for studying mitochondrial metabolism. J. Vis. Exp.103(6), 612–617 (2016).
  • Yan Y , WeaverVM, BlairIA. Analysis of protein expression during oxidative stress in breast epithelial cells using a stable isotope labeled proteome internal standard. J. Proteome. Res.4(6), 2007–2014 (2005).
  • Snyder NW , KhezamM, MesarosCA, WorthA, BlairIA. Untargeted metabolomics from biological sources using ultraperformance liquid chromatography-high resolution mass spectrometry (UPLC-HRMS). J. Vis. Exp.75, e50433 (2013).
  • Snyder NW , MesarosC, BlairIA. Translational metabolomics in cancer research. Biomark. Med.9(9), 821–834 (2015).
  • Basu SS , MesarosC, GelhausSL, BlairIA. Stable isotope labeling by essential nutrients in cell culture for preparation of labeled coenzyme A and its thioesters. Anal. Chem.83(4), 1363–1369 (2011).
  • Basu SS , BlairIA. SILEC: a protocol for generating and using isotopically labeled coenzyme A mass spectrometry standards. Nat. Protoc.7(1), 1–12 (2012).
  • Snyder NW , TomblineG, WorthAJet al. Production of stable isotope-labeled acyl-coenzyme A thioesters by yeast stable isotope labeling by essential nutrients in cell culture. Anal. Biochem.474, 59–65 (2015).
  • Ciccimaro E , BlairIA. Stable-isotope dilution LC-MS for quantitative biomarker analysis. Bioanalysis2(2), 311–341 (2010).
  • Bansal S , DeStefanoA. Key elements of bioanalytical method validation for small molecules. AAPS J.9(1), E109–E114 (2007).
  • Wehr AY , HwangWT, BlairIA, YuKH. Relative quantification of serum proteins from pancreatic ductal adenocarcinoma patients by stable isotope dilution liquid chromatography-mass spectrometry. J. Proteome Res.11(3), 1749–1758 (2012).
  • Wehr AY , FurthEE, SangarV, BlairIA, YuKH. Analysis of the human pancreatic stellate cell secreted proteome. Pancreas40(4), 557–566 (2011).
  • Shah SJ , YuKH, SangarV, ParrySI, BlairIA. Identification and quantification of preterm birth biomarkers in human cervicovaginal fluid by liquid chromatography/tandem mass spectrometry. J. Proteome. Res.8(5), 2407–2417 (2009).
  • Ciccimaro E , HanksSK, YuKH, BlairIA. Absolute quantification of phosphorylation on the kinase activation loop of cellular focal adhesion kinase by stable isotope dilution liquid chromatography/mass spectrometry. Anal. Chem.81(9), 3304–3313 (2009).
  • Wang Q , ZhangS, GuoLet al. Serum apolipoprotein A-1 quantification by LC-MS with a SILAC internal standard reveals reduced levels in smokers. Bioanalysis7(22), 2895–2911 (2015).
  • Oe T , AckermannBL, InoueKet al. Quantitative analysis of amyloid beta peptides in cerebrospinal fluid of Alzheimer’s disease patients by immunoaffinity purification and stable isotope dilution liquid chromatography/negative electrospray ionization tandem mass spectrometry. Rapid Commun. Mass Spectrom.20(24), 3723–3735 (2006).
  • Mangal D , VudathalaD, ParkJH, LeeSH, PenningTM, BlairIA. Analysis of 7,8-dihydro-8-oxo-2′-deoxyguanosine in cellular DNA during oxidative stress. Chem. Res. Toxicol.22(5), 788–797 (2009).
  • Mesaros C , AroraJS, WholerA, VachaniA, BlairIA. 8-Oxo-2′-deoxyguanosine as a biomarker of tobacco-smoking-induced oxidative stress. Free Radic. Biol. Med.53(3), 610–617 (2012).

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