Patent Highlights February–March 2023

References

• Lim S , HonekJ , XueYet al. Cold-induced activation of brown adipose tissue and adipose angiogenesis in mice. Nat. Protoc.7(3), 606–615 (2012).
   PubMed Web of Science ®Google Scholar
• Blondin DP , NielsenS , KuipersENet al. Human brown adipocyte thermogenesis is driven by β2-AR stimulation. Cell Metab.32(2), 287–300.e7 (2020).
   PubMed Web of Science ®Google Scholar
• Hu M , ZhangX , HuC , TengT , TangQ-Z. A brief overview about the adipokine: isthmin-1. Front. Cardiovasc. Med.9 (2022). https://www.frontiersin.org/articles/10.3389/fcvm.2022.939757
   Web of Science ®Google Scholar
• Shakhawat HM , HazratZ , ZhouZ. Isthmin – a multifaceted protein family. Cells12(1), 17 (2023).
   Web of Science ®Google Scholar
• Jiang Z , ZhaoM , VoilquinLet al. Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis. Cell Metab.33(9), 1836–1852.e11 (2021).
   PubMed Web of Science ®Google Scholar
• Lee C . Griffithsin, a highly potent broad-spectrum antiviral lectin from red algae: from discovery to clinical application. Mar. Drugs17(10), 567 (2019).
   PubMed Web of Science ®Google Scholar
• Nabeta HW , KouokamJC , LasnikAB , FuquaJL , PalmerKE. Novel antifungal activity of Q-Griffithsin, a broad-spectrum antiviral lectin. Microbiol. Spectr.9(2), e00957–21 (2021).
   PubMed Web of Science ®Google Scholar
• Nabeta HW , LasnikAB , FuquaJL , WangL , RohanLC , PalmerKE. Antiviral lectin Q-Griffithsin suppresses fungal infection in murine models of vaginal candidiasis. Front. Cell. Infect. Microbiol.12 (2022). https://www.frontiersin.org/articles/10.3389/fcimb.2022.976033
   Web of Science ®Google Scholar
• Huet P , BurgS , GuludecDL , HyafilF , BuvatI. Variability and uncertainty of 18F-FDG PET imaging protocols for assessing inflammation in atherosclerosis: suggestions for improvement. J. Nucl. Med.56(4), 552–559 (2015).
   PubMed Web of Science ®Google Scholar
• Li X , ChenW , LiPet al. Follicular stimulating hormone accelerates atherogenesis by increasing endothelial VCAM-1 expression. Theranostics.7(19), 4671–4688 (2017).
   PubMed Web of Science ®Google Scholar
• Wen Y , YangS , WakabayashiKet al. RPTPα phosphatase activity is allosterically regulated by the membrane-distal catalytic domain. J. Biol. Chem.295(15), 4923–4936 (2020).
   PubMed Web of Science ®Google Scholar
• Jiang G , den HertogJ , SuJ , NoelJ , SapJ , HunterT. Dimerization inhibits the activity of receptor-like protein-tyrosine phosphatase-α. Nature401(6753), 606–610 (1999).
   PubMed Web of Science ®Google Scholar
• Liao Q , HeH , MaoY , DingX , ZhangX , XuJ. Engineering T cells with hypoxia-inducible chimeric antigen receptor (HiCAR) for selective tumor killing. Biomark. Res.8(1), 56 (2020).
   PubMed Web of Science ®Google Scholar
• Metzger E , WangS , UrbanSet al. KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells. Nat. Struct. Mol. Biol.26(5), 361–371 (2019).
   PubMed Web of Science ®Google Scholar
• Berlin C , CottardF , WillmannDet al. KMT9 controls stemness and growth of colorectal cancer. Cancer Res.82(2), 210–220 (2022).
   PubMed Web of Science ®Google Scholar
• Baumert HM , MetzgerE , FahrnerMet al. Depletion of histone methyltransferase KMT9 inhibits lung cancer cell proliferation by inducing non-apoptotic cell death. Cancer Cell Int.20(1), 52 (2020).
   PubMed Web of Science ®Google Scholar
• Koll FJ , MetzgerE , HamannJet al. Overexpression of KMT9α Is associated with aggressive basal-like muscle-invasive bladder cancer. Cells12(4), 589 (2023).
   PubMed Web of Science ®Google Scholar
• Fowler VG , DasAF , Lipka-DiamondJet al. Exebacase for patients with Staphylococcus aureus bloodstream infection and endocarditis. J. Clin. Invest.130(7), 3750–3760 (2020).
   PubMed Web of Science ®Google Scholar
• Mensel B , KühnJ-P , KrachtFet al. Prevalence of renal cysts and association with risk factors in a general population: an MRI-based study. Abdom. Radiol.43(11), 3068–3074 (2018).
   PubMed Web of Science ®Google Scholar
• Rangaswami J , BhallaV , BlairJEAet al. Cardiorenal syndrome: classification, pathophysiology, diagnosis, and treatment strategies: a scientific statement from the american heart association. Circulation139(16), e840–e878 (2019).
   PubMed Web of Science ®Google Scholar
• Patel KP , KatsuradaK , ZhengH. Cardiorenal syndrome: the role of neural connections between the heart and the kidneys. Circ. Res.130(10), 1601–1617 (2022).
   PubMed Web of Science ®Google Scholar
• Schena G , CarmosinoM , ChiurliaSet al. β3 adrenergic receptor as potential therapeutic target in ADPKD. Physiol. Rep.9(20), e15058 (2021).
   PubMed Web of Science ®Google Scholar
• Cannavo A , KochWJ. Targeting β3-adrenergic receptors in the heart: selective agonism and β-blockade. J. Cardiovasc. Pharmacol.69(2), 71–78 (2017).
   PubMed Web of Science ®Google Scholar
• Mora Barthelmess R , StijlemansB , Van GinderachterJA. Hallmarks of cancer affected by the MIF cytokine family. Cancers15(2), 395 (2023).
   PubMed Web of Science ®Google Scholar
• Tilstam PV , PantourisG , CormanMet al. A selective small-molecule inhibitor of macrophage migration inhibitory factor-2 (MIF-2), a MIF cytokine superfamily member, inhibits MIF-2 biological activity. J. Biol. Chem.294(49), 18522–18531 (2019).
   PubMed Web of Science ®Google Scholar
• Xiao Z , OsipyanA , SongSet al. Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione derivative inhibits d-dopachrome tautomerase activity and suppresses the proliferation of non-small cell lung cancer cells. J. Med. Chem.65(3), 2059–2077 (2022).
   PubMed Web of Science ®Google Scholar
• Jia W , YaoZ , ZhaoJ , GuanQ , GaoL. New perspectives of physiological and pathological functions of nucleolin (NCL). Life Sci.186, 1–10 (2017).
   PubMed Web of Science ®Google Scholar
• Perry RB-T , RishalI , Doron-MandelEet al. Nucleolin-mediated RNA localization regulates neuron growth and cycling cell size. Cell Rep.16(6), 1664–1676 (2016).
   PubMed Web of Science ®Google Scholar
• Gawali NB , BulaniVD , GursahaniMS , DeshpandePS , KothavadePS , JuvekarAR. Agmatine attenuates chronic unpredictable mild stress-induced anxiety, depression-like behaviours and cognitive impairment by modulating nitrergic signalling pathway. Brain Res.1663, 66–77 (2017).
   PubMed Web of Science ®Google Scholar
• Taksande BG , FalduDS , DixitMPet al. Agmatine attenuates chronic unpredictable mild stress induced behavioral alteration in mice. Eur. J. Pharmacol.720(1), 115–120 (2013).
   PubMed Web of Science ®Google Scholar
• Rahangdale S , FatingR , GajbhiyeMet al. Involvement of agmatine in antidepressant-like effect of HMG-CoA reductase inhibitors in mice. Eur. J. Pharmacol.892, 173739 (2021).
   PubMed Web of Science ®Google Scholar
• Yan S , XuC , YangMet al. The expression of agmatinase manipulates the affective state of rats subjected to chronic restraint stress. Neuropharmacology229, 109476 (2023).
   PubMed Web of Science ®Google Scholar
• Piletz JE , KlenotichS , LeeKSet al. Putative agmatinase inhibitor for hypoxic-ischemic new born brain damage. Neurotox. Res.24(2), 176–190 (2013).
   PubMed Web of Science ®Google Scholar
• Aye Y , LiM , LongMJC , WeissRS. Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies. Oncogene34(16), 2011–2021 (2015).
   PubMed Web of Science ®Google Scholar
• Huff SE , WinterJM , DealwisCG. Inhibitors of the cancer target ribonucleotide reductase, past and present. Biomolecules12(6), 815 (2022).
   PubMed Web of Science ®Google Scholar