2,606
Views
0
CrossRef citations to date
0
Altmetric
Editorial

Antibody–drug conjugates: Targeted Delivery and Future Prospects

Pages 279-282 | Received 05 Feb 2016, Accepted 02 Mar 2016, Published online: 14 Apr 2016

References

  • Miller DR . A tribute to Sidney Farber–the father of modern chemotherapy. Br. J. Haematol.134 (1), 20–26 (2006).
  • Frei III E . Combination cancer therapy: presidential address. Cancer Res.32, 2593–2607 (1972).
  • Kohler G Milstein C . Continuous cultures of fused cells secreting antibody of predefined specificity. Nature256, 495–497 (1975).
  • Jones TD Carter PJ Plűckthun A et al. The INNs and outs of antibody nonproprietary names. mAbs8 (1), 1–9 (2016).
  • Trail PA Willner D Lasch SJ et al. Cure of xenografted human carcinomas by BR96-doxorubicin immunoconjugates. Science261, 212–215 (1993).
  • Sedlacek H-H Seemann G Hoffmann D et al. Antibodies as carriers of cytotoxicity. In : Contributions to Oncology. HuberHQueisserW ( Eds). Karger, Basel (1992).
  • Chari RVJ Miller ML Widdison WC . Antibody–drug conjugates: an emerging concept in cancer therapy. Angew. Chem. Int. Ed.53, 3796–3827 (2014).
  • Bross PF Beitz J Chen G et al. Approval summary: gemtuzumab ozogamicin in relapsed acute myeloid leukemia. Clin. Cancer Res.7, 1490–1496 (2001).
  • Petersdorf SH Kopecky KJ Slovak M et al. A Phase 3 study of gemtuzumab ozogamicin during induction and post-consolidation therapy in younger patients with acute myeloid leukemia. Blood121, 4854–4860 (2013).
  • Senter PD Sievers EL . The discovery and development of brentuximab vedotin for use in relapsed Hodgkin lymphoma and systemic anaplastic large cell lymphoma. Nat. Biotechnol.30, 631–637 (2012).
  • Lambert JM Chari RVJ . Ado-trastuzumab emtansine (T-DM1): an antibody–drug conjugate (ADC) for HER2-positive breast cancer. J. Med. Chem.57, 6949–6964 (2014).
  • Damelin M Bankovich A Park A et al. Anti-EFNA4 calicheamicin conjugates effectively target triple-negative breast and ovarian tumor-initiating cells to result in sustained tumor regressions. Clin. Cancer Res.21, 4165–4173 (2015).
  • Saunders LR Bankovich AJ Anderson WC et al. A DLL3-targeted antibody–drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo. Sci. Transl. Med.7, 302ra136 (2015).
  • Whiteman KR Noordhuis P Walker R et al. The antibody–drug conjugate (ADC) IMGN779 is highly active in vitro and in vivo against myeloid leukemia (AML) with Flt3-ITD mutations. Blood124, Abstract 2321 (2014).
  • Elgersma RC Coumans RG Huijbregts T et al. Design, synthesis, and evaluation of linker-duocarmycin payloads: toward selection of HER2-targeting antibody–drug conjugate SYD985. Mol. Pharmaceutics12, 1813–1835 (2015).
  • Kelly KR Chanan-Khan A Somlo G et al. Indatuximab ravtansine (BT062) in combination with lenalidomide and low-dose dexamethasone in patients with relapsed and/or refractory multiple myeloma: clinical activity in len/dex-refractory patients. Blood122 (21), 758–758 (2013).
  • Ansell SM . Brentuximab vedotin. Blood124 (22), 3197–3200 (2014).
  • Műller P Martin K Theurich S et al. Microtubule-depolymerizing agents used in antibody–drug conjugates induce antitumor immunity by stimulation of dendritic cells. Cancer Immunol. Res.2 (8), 741–755 (2014).
  • Műller P Kreuzaler M Khan T et al. Trastuzumab emtansine (T-DM1) renders HER2+ breast cancer highly susceptible to CTLA-4/PD-1 blockade. Sci. Transl. Med.7, 315ra188 (2015).
  • Moore KN Martin LP Seward SM et al. Preliminary single agent activity of IMGN853, a folate receptor alpha (FRα)-targeting antibody–drug conjugate (ADC), in platinum-resistant epithelial ovarian cancer (EOC) patients (pts): Phase I trial. J. Clin. Oncol.33 (15 Suppl.), 5518 (2015).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.