132
Views
0
CrossRef citations to date
0
Altmetric
Drug Evaluation

Calcipotriene Betamethasone Dipropionate Aerosol Foam in the Treatment of Plaque Psoriasis: A Review of the Literature

, &
Pages 737-746 | Received 03 May 2017, Accepted 07 Jun 2017, Published online: 29 Jun 2017

References

  • Parisi R Symmons DP Griffiths CE et al. Global epidemiology of psoriasis: a systematic review of incidence and prevalence. J. Invest. Dermatol.133 (2), 377–385 (2013).
  • World Health Organization: Global report on psoriasis (2016). http://apps.who.int/iris/bitstream/10665/204417/1/9789241565189_eng.pdf.
  • Korman NJ Zhao Y Pike J Roberts J . Relationship between psoriasis severity, clinical symptoms, quality of life and work productivity among patients in the USA. Clin. Exp. Dermatol.41 (5), 514–521 (2016).
  • Kirby B Richards HL Mason DL Fortune DG Main CJ Griffiths CE . Alcohol consumption and psychological distress in patients with psoriasis. Br. J. Dermatol.158 (1), 138–140 (2008).
  • Gelfand JM Troxel AB Lewis JD et al. The risk of mortality in patients with psoriasis: results from a population-based study. Arch. Dermatol.143 (12), 1493–1499 (2007).
  • Abuabara K Azfar RS Shin DB Neimann AL Troxel AB Gelfand JM . Cause-specific mortality in patients with severe psoriasis: a population-based cohort study in the U.K. Br. J. Dermatol.163 (3), 586–592 (2010).
  • Neimann AL Shin DB Wang X Margolis DJ Troxel AB Gelfand JM . Prevalence of cardiovascular risk factors in patients with psoriasis. J. Am. Acad. Dermatol.55 (5), 829–835 (2006).
  • Gottlieb A Korman NJ Gordon KB et al. Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 2. Psoriatic arthritis: overview and guidelines of care for treatment with an emphasis on the biologics. J. Am. Acad. Dermatol.58 (5), 851–864 (2008).
  • Najarian DJ Gottlieb AB . Connections between psoriasis and Crohn's disease. J. Am. Acad. Dermatol.48 (6), 805–821 ; quiz 822–804 (2003).
  • Davidovici BB Sattar N Prinz J et al. Psoriasis and systemic inflammatory diseases: potential mechanistic links between skin disease and co-morbid conditions. J. Invest. Dermatol.130 (7), 1785–1796 (2010).
  • Armstrong AW Voyles SV Armstrong EJ Fuller EN Rutledge JC . Angiogenesis and oxidative stress: common mechanisms linking psoriasis with atherosclerosis. J. Dermatol. Sci.63 (1), 1–9 (2011).
  • Alexander H Nestle FO . Pathogenesis and immunotherapy in cutaneous psoriasis: what can rheumatologists learn?Curr. Opin. Rheumatol.29 (1), 71–78 (2017).
  • American Academy of Dermatology Work G , MenterAKormanNJet al.Guidelines of care for the management of psoriasis and psoriatic arthritis: section 6. Guidelines of care for the treatment of psoriasis and psoriatic arthritis: case-based presentations and evidence-based conclusions. J. Am. Acad. Dermatol.65 (1), 137–174 (2011).
  • Menter A Gottlieb A Feldman SR et al. Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 1. Overview of psoriasis and guidelines of care for the treatment of psoriasis with biologics. J. Am. Acad. Dermatol.58 (5), 826–850 (2008).
  • Bewley A Page B . Maximizing patient adherence for optimal outcomes in psoriasis. J. Eur. Acad. Dermatol. Venereol.25 (Suppl. 4), 9–14 (2011).
  • Lind M Nielsen KT Schefe LH et al. Supersaturation of calcipotriene and betamethasone dipropionate in a novel aerosol foam formulation for topical treatment of psoriasis provides enhanced bioavailability of the active ingredients. Dermatol. Ther. (Heidelb.)6 (3), 413–425 (2016).
  • Milde P Hauser U Simon T et al. Expression of 1,25-dihydroxyvitamin D3 receptors in normal and psoriatic skin. J. Invest. Dermatol.97 (2), 230–239 (1991).
  • Jensen T Sorensen S Solvsten H Kragballe K . The vitamin D3 receptor and retinoid X receptors in psoriatic skin: the receptor levels correlate with the receptor binding to DNA. Br. J. Dermatol.138 (2), 225–228 (1998).
  • Bartosik-Psujek H Tabarkiewicz J Pocinska K Stelmasiak Z Rolinski J . Immunomodulatory effects of vitamin D on monocyte-derived dendritic cells in multiple sclerosis. Mult. Scler.16 (12), 1513–1516 (2010).
  • Gorman S Kuritzky LA Judge MA et al. Topically applied 1,25-dihydroxyvitamin D3 enhances the suppressive activity of CD4+CD25+ cells in the draining lymph nodes. J. Immunol.179 (9), 6273–6283 (2007).
  • Boonstra A Barrat FJ Crain C Heath VL Savelkoul HF O'garra A . 1alpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells. J. Immunol.167 (9), 4974–4980 (2001).
  • Chen ML Perez A Sanan DK Heinrich G Chen TC Holick MF . Induction of vitamin D receptor mRNA expression in psoriatic plaques correlates with clinical response to 1,25-dihydroxyvitamin D3. J. Invest. Dermatol.106 (4), 637–641 (1996).
  • Colin EM Asmawidjaja PS Van Hamburg JP et al. 1,25-dihydroxyvitamin D3 modulates Th17 polarization and interleukin-22 expression by memory T cells from patients with early rheumatoid arthritis. Arthritis Rheum.62 (1), 132–142 (2010).
  • Uva L Miguel D Pinheiro C et al. Mechanisms of action of topical corticosteroids in psoriasis. Int. J. Endocrinol.2012, 561018 (2012).
  • Mcmanus R . Mechanisms of steroid action and resistance in inflammation and disease. J. Endocrinol.178 (1), 1–4 (2003).
  • Ahluwalia A . Topical glucocorticoids and the skin--mechanisms of action: an update. Mediators Inflamm.7 (3), 183–193 (1998).
  • Barnes PJ . Anti-inflammatory actions of glucocorticoids: molecular mechanisms. Clin. Sci. (Lond.)94 (6), 557–572 (1998).
  • Lovato P Norsgaard H Tokura Y Ropke MA . Calcipotriol and betamethasone dipropionate exert additive inhibitory effects on the cytokine expression of inflammatory dendritic cell-Th17 cell axis in psoriasis. J. Dermatol. Sci.81 (3), 153–164 (2016).
  • Huang X Tanojo H Lenn J Deng CH Krochmal L . A novel foam vehicle for delivery of topical corticosteroids. J. Am. Acad. Dermatol.53 (1 Suppl. 1), S26–S38 (2005).
  • Williams AC Barry BW . Skin absorption enhancers. Crit. Rev. Ther. Drug Carrier Syst.9 (3–4), 305–353 (1992).
  • Queille-Roussel C Bang B Clonier F Lacour JP . Enhanced vasoconstrictor potency of the fixed combination calcipotriol plus betamethasone dipropionate in an innovative aerosol foam formulation vs. other corticosteroid psoriasis treatments. J. Eur. Acad. Dermatol. Venereol.30 (11), 1951–1956 (2016).
  • Basse Lh OM Lacour Jp Queille-Roussel C . Enhanced in vitro skin penetration and antipsoriatic effect of fixed combination calcipotriol plus betamethasone dipropionate in an innovative foam vehicle. J. Invest. Dermatol.134 (S33), Abstract 192 (2014).
  • Queille-Roussel C Olesen M Villumsen J Lacour JP . Efficacy of an innovative aerosol foam formulation of fixed combination calcipotriol plus betamethasone dipropionate in patients with psoriasis vulgaris. Clin. Drug Investig.35 (4), 239–245 (2015).
  • LEO Pharma . Enstilar® (calcipotriene and betamethasone dipropionate) foam: US prescribing information (2016).
  • LEO Pharma . Enstilar® (calcipotriol/betamethasone dipropionate) cutaneous foam: UK summary of product characteristics (2016).
  • Taraska V Tuppal R Olesen M Bang Pedersen C Papp K . A novel aerosol foam formulation of calcipotriol and betamethasone has no impact on HPA axis and calcium homeostasis in patients with extensive psoriasis vulgaris. J. Cutan. Med. Surg.20 (1), 44–51 (2016).
  • Koo J Tyring S Werschler WP et al. Superior efficacy of calcipotriene and betamethasone dipropionate aerosol foam versus ointment in patients with psoriasis vulgaris--a randomized Phase II study. J. Dermatolog. Treat.27 (2), 120–127 (2016).
  • Lebwohl M Tyring S Bukhalo M et al. Fixed combination aerosol foam calcipotriene 0.005% (Cal) plus betamethasone dipropionate 0.064% (BD) is more efficacious than Cal or BD aerosol foam alone for psoriasis vulgaris: a randomized, double-blind, multicenter, three-arm, Phase II study. J. Clin. Aesthet. Dermatol.9 (2), 34–41 (2016).
  • Leonardi C Bagel J Yamauchi P et al. Efficacy and safety of calcipotriene plus betamethasone dipropionate aerosol foam in patients with psoriasis vulgaris--a randomized Phase III study (PSO-FAST). J. Drugs Dermatol.14 (12), 1468–1477 (2015).
  • Stein Gold L Villumsen J Rosen M . Calcipotriol plus betamethasone dipropionate aerosol foam is effective, independent of body mass index and the extent and severity of psoriasis. Dermatol. Ther. (Heidelb.)6 (4), 667–673 (2016).
  • Paul C Stein Gold L Cambazard F et al. Calcipotriol plus betamethasone dipropionate aerosol foam provides superior efficacy vs. gel in patients with psoriasis vulgaris: randomized, controlled PSO-ABLE study. J. Eur. Acad. Dermatol. Venereol.31 (1), 119–126 (2017).
  • Paul C Leonardi C Menter A et al. Calcipotriol plus betamethasone dipropionate aerosol foam in patients with moderate-to-severe psoriasis: sub-group analysis of the PSO-ABLE study. Am. J. Clin. Dermatol.18 (3), 405–441 (2017).
  • Stein Gold L Lebwohl M Menter A Villumsen J Rosen M Koo J . Aerosol foam formulation of fixed combination calcipotriene plus betamethasone dipropionate is highly efficacious in patients with psoriasis vulgaris: pooled data from three randomized controlled studies. J. Drugs Dermatol.15 (8), 951–957 (2016).
  • Finlay AY Khan GK . Dermatology life quality index (DLQI)--a simple practical measure for routine clinical use. Clin. Exp. Dermatol.19 (3), 210–216 (1994).
  • Leonardi C Bagel J Yamauchi P et al. The aerosol foam formulation of the fixed combination calcipotriene plus betamethasone dipropionate improves the health-related quality of life in patients with psoriasis vulgaris: results from the randomized PSO-FAST study. J. Drugs Dermatol.15 (8), 981–987 (2016).
  • Pickard AS Gooderham M Hartz S Nicolay C . EQ-5D health utilities: exploring ways to improve upon responsiveness in psoriasis. J. Med. Econ.20 (1), 19–27 (2017).
  • Paul C Gold LS Cambazard F et al. More rapid improvement in quality of life with fixed combination calcipotriene plus betamethasone dipropionate aerosol foam versus topical suspension (PSO-ABLE study in patients with psoriasis vulgaris). J. Am. Acad. Dermatol.74 (5), AB260 (2016).
  • Housman TS Mellen BG Rapp SR Fleischer AB, Jr Feldman SR . Patients with psoriasis prefer solution and foam vehicles: a quantitative assessment of vehicle preference. Cutis70 (6), 327–332 (2002).
  • Gottlieb AB Ford RO Spellman MC . The efficacy and tolerability of clobetasol propionate foam 0.05% in the treatment of mild to moderate plaque-type psoriasis of nonscalp regions. J. Cutan. Med. Surg.7 (3), 185–192 (2003).
  • Andreassi L Giannetti A Milani M , Scale Investigators G. Efficacy of betamethasone valerate mousse in comparison with standard therapies on scalp psoriasis: an open, multicentre, randomized, controlled, cross-over study on 241 patients. Br. J. Dermatol.148 (1), 134–138 (2003).
  • Queille-Roussel C . Phase I evaluation of the dermal safety of the fixed combination calcipotriene plus betamethasone dipropionate aerosol foam and foam vehicle. J. Am. Acad. Dermatol.72 (5 Suppl. 1), AB211 (2015).
  • Menter A Stein Gl Koo J et al. Fixed combination calcipotriene plus betamethasone dipropionate aerosol foam is well tolerated in patients with psoriasis vulgaris (pooled data from three randomized controlled studies). Skinmed15 (2), 119–124 (2016).
  • Clinical Trials Database: NCT02899962. https://clinicaltrials.gov/ct2/show/NCT02899962.
  • Napolitano M Megna M Balato A et al. Systemic treatment of pediatric psoriasis: a review. Dermatol. Ther. (Heidelb.)6 (2), 125–142 (2016).
  • Clinical Trials Database: NCT02387853. https://clinicaltrials.gov/ct2/show/NCT02387853.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.