Mefenamic Acid-loaded Solid SMEDDS: An Innovative Aspect for Dose Reduction and Improved Pharmacodynamic Profile

References

• Amidon GL Lennernas H Shah VP Crison JR . A theoretical basis for a biopharmaceutic drug classification: the correlation in vitro drug product dissolution and in vivo bioavailability . Pharm. Res.12 , 413 – 420 ( 1995 ).
   PubMed Web of Science ®Google Scholar
• Shabbir A Arshad HM Shahzad M Shamsi S Ashraf MI . Immunomodulatory activity of mefenamic acid in mice models of cell-mediated and humoral immunity . Ind. J. Pharmacol.48 ( 2 ), 172 – 178 ( 2016 ).
   Google Scholar
• Rao KR Nagabhushanam MV Chowdary KP . In vitro dissolution studies on solid dispersions of mefenamic acid . Ind. J. Pharm. Sci.73 ( 2 ), 243 – 247 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Derle DV Bele M Kasilwal N Pandey F . In vitro and in vivo evaluation of mefenamic acid and its complexes . Asian J. Pharm.4 ( 2 ), 34 – 45 ( 2014 ).
   Google Scholar
• Ullah I Baloch MK Ullah I Mustaqeem M . Enhancement in aqueous solubility of mefenamic acid using micellar solutions of various surfactants . J. Solution Chem.43 ( 8 ), 1360 – 1373 ( 2014 ).
   Web of Science ®Google Scholar
• Gursoy RN Benita S . Self emulsifying drug delivery systems for improved oral delivery of lipophilic drugs . Biomed. Pharmacother.58 , 173 – 182 ( 2004 ).
   PubMed Web of Science ®Google Scholar
• Dokania S Joshi AK . Self-microemulsifying drug delivery system (SMEDDS)-challenges and road ahead . Drug Deliv.22 ( 6 ), 675 – 690 ( 2015 ).
   PubMed Web of Science ®Google Scholar
• Sriamornsak P Limmatvapirat S Piriyaprasarth S Mansukmanee P Huang Z . A new self-emulsifying formulation of mefenamic acid with enhanced drug dissolution . Asian. J. Pharm. Sci.10 , 121 – 127 ( 2014 ).
   Web of Science ®Google Scholar
• Mandic J Pobirk AZ Vrecer F Gasperlin M . Overview of solidification techniques for self-emulsifying drug delivery systems from industrial perspectives . Int. J. Pharm.533 ( 2 ), 335 – 345 ( 2017 ).
   PubMedGoogle Scholar
• Jaiswal Y Talete G Surana S . Application of HPLC for simulation determination of ethamsylate and mefenamic acid in bulk drug and tablets . J. Liq. Chromatogr. Relat. Technol.30 , 1115 – 1124 ( 2007 ).
   Web of Science ®Google Scholar
• Bali B Ali M Ali J . Study of surfactant combinations and development of a novel nanoemulsion for minimizing variations in bioavailability of ezetimibe . Colloids Surf. B. Biointerfaces76 , 410 – 420 ( 2010 ).
   PubMed Web of Science ®Google Scholar
• Singh D Tiwary AK Bedi N . Canagliflozin loaded SMEDDS: formulation optimization for improved solubility, permeability and pharmacokinetic performance . J. Pharm. Investig.1 – 19 ( 2018 ).
   Google Scholar
• Singh K Tiwary AK Rana V . Ethylenediaminediacetic acid bis (carbide amide chitosan): synthesis and evaluate as a solid carrier to fabricate nano-emulsion . Carbohydr. Polym.95 , 303 – 314 ( 2013 ).
   PubMed Web of Science ®Google Scholar
• Sinha A Sharma BP . Preparation of copper powder by glycerol process . Mater. Res. Bull.37 ( 3 ), 407 – 416 ( 2002 ).
   Web of Science ®Google Scholar
• Suthar V Shital B Gohel M . Solid self-emulsified nano-structures of lecanidipine hydrochloride: a potential approach to improve the fraction of dose absorbed . J. Drug. Del. Sci. Technol.31 , 11 – 21 ( 2016 ).
   Google Scholar
• Yeom DW Son HY Kim JH et al. Development of solidified self-microemulsifying drug delivery system (SMEDDS) for atorvastatin calcium with improved dissolution and bioavailability . Int. J. Pharm.506 ( 1–2 ), 302 – 311 ( 2016 ).
   PubMedGoogle Scholar
• Zhang Y He L Yue S Huang Q Zhang Y Yang J . Characterization and evaluation of a self-microemulsifying drug delivery system containing tectorigenin, an isoflavone with low aqueous solubility and permeability . Drug Deliv.24 ( 1 ), 632 – 640 ( 2017 ).
   PubMed Web of Science ®Google Scholar
• Gupta AK Parasar D Sagar A et al. Analgesic and Anti-inflammatory activity of gelsolin in acetic acid induced writhings, tail immersion and carrageenan induced paw edema in mice . PLoS ONE10 ( 9 ), 1 – 16 ( 2015 ).
   Google Scholar
• Jhawat V Gupta S Saini V . Formulation and evaluation of novel controlled release of topical pluronic lecithin organogel of mefenamic acid . Drug Deliv.23 ( 9 ), 3573 – 3581 ( 2016 ).
   PubMed Web of Science ®Google Scholar
• Pouton CW . Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and self-microemulsifying drug delivery systems . Eur. J. Pharm. Sci. Suppl. 2 , S93 – S98 ( 2000 ).
   PubMed Web of Science ®Google Scholar
• Mendes C Buttchevitz A Kruger JH Caon T . Self-nanoemulsified drug delivery system of hydrochlorothiazide for increasing dissolution rate and diuretic activity . AAPS Pharm. Sci Tech.18 ( 7 ), 2494 – 2504 ( 2017 ).
   PubMed Web of Science ®Google Scholar
• Senapati PC Sahoo SK Sahu AN . Mixed surfactant based (SMEDDS) self-nanoemulsifying drug delivery system presenting efavirenz for enhancement of oral bioavailability . Biomed. Pharmacother.80 , 42 – 51 ( 2016 ).
   PubMed Web of Science ®Google Scholar
• Khatri P Shao J . Mechanism and structural factors of lipid and surfactant in the formation of self-emulsified nanoemulsion . J. Pharm Sci.107 , 2198 – 2207 ( 2018 ).
   PubMed Web of Science ®Google Scholar
• Fahmy UA Ahmed AA Hosny KM . Development and evaluation of avanafil self-nanoemulsifying drug delivery system with rapid onset of action and enhanced bioavailability . AAPS PharmSciTech.16 ( 1 ), 53 – 58 ( 2015 ).
   PubMed Web of Science ®Google Scholar
• Michaelsen MH Wasan KM Sivak O Mullertz A Rades T . The effect of digestion and drug load on halofantrine absorption from self-nanoemulsifying drug delivery system (SMEDDS) . AAPS. J.18 ( 1 ), 180 – 186 ( 2014 ).
   Web of Science ®Google Scholar
• Park JB Choi BK Kang CY . Effect of adsorbent materials on a self-emulsifying drug delivery system for a poorly soluble drug . J. Pharm. Investig.45 , 529 – 539 ( 2015 ).
   Google Scholar
• Beg S Katare OP Saini S Garg B Khurana RK Singh B . Solid self-nanoemulsifying systems of olmesartan medoximil: formulation development, micromeretic characterization and in vivo evaluation . Powder Technol.294 , 93 – 104 ( 2016 ).
   Web of Science ®Google Scholar
• Agarwal V Siddiqui A Ali H Nazzal S . Dissolution and powder flow characterization of solid self-emulsified drug delivery system (SEDDS) . Int. J. Pharm.366 , 44 – 52 ( 2009 ).
   PubMed Web of Science ®Google Scholar
• Oh H Kang JH Kim DW et al. Comparison of solid self-microemulsifying drug delivery system (solid SMEDDS) compared with hydrophilic and hydrophobic solid carriers . Int. J. Pharm.420 , 412 – 418 ( 2014 ).
   Google Scholar
• Sun M Zhai X Xue K et al. Intestinal absorption and intestinal lymphatic transport of sirolimus from self-microemulsifying drug delivery systems assessed using the single-pass intestinal perfusion (SPIP) technique and a chylomicron flow blocking approach: linear correlation with oral bioavailabilities in rats . Eur. J. Pharm. Sci.43 , 132 – 140 ( 2011 ).
   PubMed Web of Science ®Google Scholar
• Chaurasiya A Singh AK Jain GK et al. Dual approach utilizing self-microemulsifying technique and effective p gp inhibitor for effective delivery of taxanes . J. Microencapsul.29 ( 6 ), 583 – 592 ( 2012 ).
   PubMed Web of Science ®Google Scholar
• Benet LZ Cummins CL Wu CY . Unmasking the dynamic interplay between efflux transporters and metabolic enzymes . Int. J. Pharm.277 , 3 – 9 ( 2004 ).
   PubMed Web of Science ®Google Scholar