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Therapeutic Delivery Volume 10, 2019 - Issue 11
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Editorial

How Can Microsphere-mediated Delivery of Small Molecules Serve As a Novel Tool for Engineering Tissues From Stem cells?

Stephanie Michelle Willerth1 Department of Mechanical Engineering & Division of Medical SciencesUniversity of Victoria; School of Biomedical Engineering & International Collaboration on Repair DiscoveriesUniversity of British ColumbiaVictoria, BC, V8W 2Y2 CanadaVancouverBCV5Z 1M9CanadaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-1665-7723
ORCID Icon
Pages 671-674 | Received 11 Sep 2019, Accepted 30 Sep 2019, Published online: 14 Oct 2019

References

  • Willerth SM , Sakiyama-ElbertSE. Combining stem cells and biomaterial scaffolds for constructing tissues and cell delivery (Updated from original 2008 article). StemJournal1(1), 1–25 (2019) ( Preprint).
  • Nirmalanandhan VS , SittampalamGS. Stem cells in drug discovery, tissue engineering and regenerative medicine: emerging opportunities and challenges. J. Biomol. Screen.14(7), 755–768 (2009).
  • Jyoti S , TandonS. Chemical and physical factors influencing the dynamics of differentiation in embryonic stem cells. Curr. Stem Cell Res. Ther.10(6), 477–491 (2015).
  • Aguilar LMC , SilvaSM , MoultonSE. Growth factor delivery: defining the next generation platforms for tissue engineering. J. Control. Release306, 40–58 (2019).
  • Yong SB , ChungJY , SongY , KimYH. Recent challenges and advances in genetically-engineered cell therapy. J. Pharm. Investig.48(2), 199–208 (2018).
  • Veber DF , JohnsonSR , ChengHY , SmithBR , WardKW , KoppleKD. Molecular properties that influence the oral bioavailability of drug candidates. J. Med. Chem.45(12), 2615–2623 (2002).
  • Lu B , AtalaA. Small molecules and small molecule drugs in regenerative medicine. Drug Discov. Today19(6), 801–808 (2014).
  • Zhang Y , LiW , LaurentT , DingS. Small molecules, big roles–the chemical manipulation of stem cell fate and somatic cell reprogramming. J. Cell Sci.125(23), 5609–5620 (2012).
  • Qin H , ZhaoA , FuX. Small molecules for reprogramming and transdifferentiation. Cell. Mol. Life Sci.74(19), 3553–3575 (2017).
  • Montgomery A , WongA , GabersN , WillerthSM. Engineering personalized neural tissue by combining induced pluripotent stem cells with fibrin scaffolds. Biomater. Sci.3(2), 401–413 (2015).
  • Robinson M , YauS , SunLet al. Optimizing differentiation protocols for producing dopaminergic neurons from human induced pluripotent stem cells for tissue engineering applications. Biomark. Insights10(Suppl.1), 61–70 (2015).
  • Gomez JC , EdgarJM , AgbayAMet al. Incorporation of retinoic acid releasing microspheres into pluripotent stem cell aggregates for inducing neuronal differentiation. Cell. Mol. Bioeng.8(3), 307–319 (2015).
  • Agbay A , DeLa Vega L , NixonG , WillerthSM. Guggulsterone-releasing microspheres direct the differentiation of human induced pluripotent stem cells into neural phenotypes. Biomed. Mater.13, 1–14 (2018).
  • De la Vega L , KarmirianK , WillerthSM. Engineering neural tissue from human pluripotent stem cells using novel small molecule releasing microspheres. Adv. Biosyst.2(12), 1800133 (2018).
  • Wang Y , ZhuG , LiN , SongJ , WangL , ShiX. Small molecules and their controlled release that induce the osteogenic/chondrogenic commitment of stem cells. Biotechnol. Adv.33(8), 1626–1640 (2015).
  • O’Neill E , RajpuraK , CarboneEJ , AwaleG , KanHM , LoKW. Repositioning tacrolimus: evaluation of the effect of short-term tacrolimus treatment on osteoprogenitor cells and primary cells for bone regenerative engineering. Assay Drug Dev. Technol.17(2), 77–88 (2019).
  • Cui ZK , SunJA , BaljonJJet al. Simultaneous delivery of hydrophobic small molecules and siRNA using sterosomes to direct mesenchymal stem cell differentiation for bone repair. Acta Biomater.58, 214–224 (2017).
  • Tsao CJ , TaraballiF , PandolfiLet al. Controlled release of small molecules for cardiac differentiation of pluripotent stem cells. Tissue Eng. Part A., 24(23-24), 1798–1807 (2018).
  • Li J , LeeWY , WuTet al. Near-infrared light-triggered release of small molecules for controlled differentiation and long-term tracking of stem cells in vivo using upconversion nanoparticles. Biomaterials110, 1–10 (2016).

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