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Research Article

Formulation Design and Evaluation of Aceclofenac Nanogel for Topical Application

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Pages 767-778 | Received 15 Jun 2020, Accepted 05 Nov 2020, Published online: 23 Nov 2020

References

  • Allen KD , GolightlyYM. State of the evidence. Curr. Opin. Rheumatol.27(3), 276–283 (2015).
  • Mccurry SM , Von KorffM , VitielloMVet al. Frequency of comorbid insomnia, pain, and depression in older adults with osteoarthritis: predictors of enrollment in a randomized treatment trial. J. Psychosom. Res.71(5), 296–299 (2011).
  • Maniar KH , JonesIA , GopalakrishnaR , VangsnessCTJr. Lowering side effects of NSAID usage in osteoarthritis: recent attempts at minimizing dosage. Expert Opin. Pharmacother.19(2), 93–102 (2018).
  • Crofford LJ . Use of NSAIDs in treating patients with arthritis. Arthritis Res. Ther.15(Suppl. 3), S2 (2013).
  • Rannou F , PelletierJP , Martel-PelletierJ. Efficacy and safety of topical NSAIDs in the management of osteoarthritis: evidence from real-life setting trials and surveys. Semin. Arthritis Rheum.45(Suppl. 4), S18–S21 (2016).
  • Pelletier JP , Martel-PelletierJ , RannouF , CooperC. Efficacy and safety of oral NSAIDs and analgesics in the management of osteoarthritis: evidence from real-life setting trials and surveys. Semin. Arthritis Rheum.45(Suppl. 4), S22–S27 (2016).
  • Thakur S , RiyazB , PatilA , KaurA , KapoorB , MishraV. Novel drug delivery systems for NSAIDs in management of rheumatoid arthritis: an overview. Biomed. Pharmacother.106, 1011–1023 (2018).
  • Lee J , LeeY , KimJ , YoonM , ChoiYW. Formulation of microemulsion systems for transdermal delivery of aceclofenac. Arch. Pharm. Res.28(9), 1097–1102 (2005).
  • Nasr M , MansourS , MortadaND , ElshamyAA. Vesicular aceclofenac systems: a comparative study between liposomes and niosomes. J. Microencapsul.25(7), 499–512 (2008).
  • Dasgupta S , DeyS , ChoudhuryS , MazumderB. Topical delivery of aceclofenac as nanoemulsion comprising excipients having optimum emulsification capabilities: preparation, characterization and in vivo evaluation. Expert Opin. Drug Deliv.10(4), 411–420 (2013).
  • Dasgupta S , GhoshSK , RayS , MazumderB. Solid lipid nanoparticles (SLNs) gels for topical delivery of aceclofenac in vitro and in vivo evaluation. Curr. Drug Deliv.10(6), 656–666 (2013).
  • Nasr M , MansourS , MortadaND , ElShamy AA. Lipospheres as carriers for topical delivery of aceclofenac: preparation, characterization and in vivo evaluation. AAPS Pharm. Sci. Tech.9(1), 154–162 (2008).
  • Algahtani MS , AhmadMZ , AhmadJ. Nanoemulsion loaded polymeric hydrogel for topical delivery of curcumin in psoriasis. J. Drug Deliv. Sci. Technol.59, 101847 (2020).
  • Khurana B , AroraD , NarangRK. FbD supported development and in vitro evaluation of carbomer based resveratrol loaded topical antipsoriatic nanoemulgel for its targeted skin delivery. Pharm.Nanotechnol.8(2), 91–107 (2020).
  • Arora D , NandaS. Quality by design driven development of resveratrol loaded ethosomal hydrogel for improved dermatological benefits via enhanced skin permeation and retention. Int. J. Pharm.567, 118448 (2019).
  • Shafiq-Un-Nabi S , ShakeelF , TalegaonkarSet al. Formulation development and optimization using nanoemulsion technique: a technical note. AAPS Pharm. Sci. Tech.8(2), E12–E28 (2007).
  • Ahmad J , KohliK , MirSR , AminS. Formulation of self-nanoemulsifying drug delivery system for telmisartan with improved dissolution and oral bioavailability. J. Dispers. Sci. Technol.32(7), 958–968 (2011).
  • Algahtani MS , AhmadMZ , AhmadJ. Nanoemulgel for improved topical delivery of retinyl palmitate: formulation design and stability evaluation. Nanomaterials (Basel, Switzerland)10(5), E848 (2020).
  • Gupta SK . Formulation and evaluation of nanoemulsion based nanoemulgel of aceclofenac. J. Pharm. Sci. Res.12(4), 524–532 (2020).
  • Modi JD , PatelJK. Nanoemulsion-based gel formulation of aceclofenac for topical delivery. Int. J. Sci. Res. Methodol.1(1), 6–12 (2011).
  • Kotta S , KhanAW , AnsariSH , SharmaRK , AliJ. Formulation of nanoemulsion: a comparison between phase inversion composition method and high-pressure homogenization method. Drug Deliv.22(4), 455–466 (2015).
  • Izquierdo P , FengJ , EsquenaJet al. The influence of surfactant mixing ratio on nano-emulsion formation by the pit method. J. Colloid Interface Sci.285(1), 388–394 (2005).
  • Jafari SM , HeY , BhandariB. Optimization of nano-emulsions production by microfluidization. Eur. Food Res. Technol.225(5-6), 733–741 (2007).
  • Akhter S , AnwarM , SiddiquiMAet al. Improving the topical ocular pharmacokinetics of an immunosuppressant agent with mucoadhesive nanoemulsions: formulation development, in-vitro and in-vivo studies. Colloids Surf. B Biointerfaces148, 19–29 (2016).
  • Algahtani MS , AhmadMZ , NoureinIH , AhmadJ. Co-delivery of imiquimod and curcumin by nanoemugel for improved topical delivery and reduced psoriasis-like skin lesions. Biomolecules10(7), 968 (2020).
  • Ahmad J , GautamA , KomathS , BanoM , GargA , JainK. Topical nano-emulgel for skin disorders: formulation approach and characterization. Recent Pat. Antiinfect Drug Discov.14(1), 36–48 (2019).
  • Alam S , AlgahtaniMS , AhmadMZ , AhmadJ. Investigation utilizing the HLB concept for the development of moisturizing cream and lotion: in-vitro characterization and stability evaluation. Cosmetics7(2), 43 (2020).
  • Hajjar B , ZierK-I , KhalidN , AzarmiS , LöbenbergR. Evaluation of a microemulsion-based gel formulation for topical drug delivery of diclofenac sodium. Int. J. Pharm. Investig.48(3), 351–362 (2018).
  • Md S , AlhakamyNA , AldawsariHMet al. Improved analgesic and anti-inflammatory effect of diclofenac sodium by topical nanoemulgel: formulation development-in vitro and in vivo studies. J.Chem.2020, (2020).
  • Shakeel F , BabootaS , AhujaA , AliJ , AqilM , ShafiqS. Nanoemulsions as vehicles for transdermal delivery of aceclofenac. AAPS Pharm. Sci. Tech.8(4), E104 (2007).
  • Ahmad J , MirSR , KohliKet al. Solid-nanoemulsion preconcentrate for oral delivery of paclitaxel: formulation design, biodistribution, and γ scintigraphy imaging. Biomed. Res. Int.2014, 984756 (2014).
  • Yuan Y , GaoY , ZhaoJ , MaoL. Characterization and stability evaluation of β-carotene nanoemulsions prepared by high pressure homogenization under various emulsifying conditions. Food Res. Int.41(1), 61–68 (2008).
  • Gupta A , EralHB , HattonTA , DoylePS. Nanoemulsions: formation, properties and applications. Soft Matter12(11), 2826–2841 (2016).
  • Mao L , XuD , YangJ , YuanF , GaoY , ZhaoJ. Effects of small and large molecule emulsifiers on the characteristics of β-carotene nanoemulsions prepared by high pressure homogenization. Food Technol. Biotechnol.47(3), 336–342 (2009).
  • Qian C , McclementsDJ. Formation of nanoemulsions stabilized by model food-grade emulsifiers using high-pressure homogenization: factors affecting particle size. Food Hydrocoll.25(5), 1000–1008 (2011).
  • Azeem A , RizwanM , AhmadFJ , KharRK , IqbalZ , TalegaonkarS. Components screening and influence of surfactant and cosurfactant on nanoemulsion formation. Curr. Nanosci.5(2), 220–226 (2009).
  • Khurana B , AroraD , NarangR. Topical delivery of nanoemulsion for antipsoriatic drugs. J. Drug Deliv. Ther.8(5-s), 1–11 (2018).
  • Baspinar Y , KeckCM , BorchertHH. Development of a positively charged prednicarbate nanoemulsion. Int. J. Pharm.383(1-2), 201–208 (2010).
  • Mustafa G , BabootaS , AliJet al. Effect of homogenization on the fate of true nanoemulsion in brain translocation: a gamma scintigraphic evaluation. Sci. Adv. Materials4(7), 739–748 (2012).
  • Marie P , Perrier-CornetJ , GervaisP. Influence of major parameters in emulsification mechanisms using a high-pressure jet. J. Food Eng.53(1), 43–51 (2002).
  • Kumar M , BishnoiRS , ShuklaAK , JainCP. Techniques for formulation of nanoemulsion drug delivery system: a review. Prev. Nutr. Food Sci.24(3), 225–234 (2019).
  • Sobhani H , TarighiP , OstadSN , ShafaatiA , Nafissi-VarchehN , AboofazeliR. Formulation development and toxicity assessment of triacetin mediated nanoemulsions as novel delivery systems for rapamycin. Iran. J. Pharm. Res.14(Suppl.), 3–21 (2015).
  • Bali V , AliM , AliJ. Nanocarrier for the enhanced bioavailability of a cardiovascular agent: in vitro, pharmacodynamic, pharmacokinetic and stability assessment. Int. J. Pharm.403(1-2), 46–56 (2011).
  • Khurana S , JainNK , BediPM. Nanoemulsion based gel for transdermal delivery of meloxicam: physico-chemical, mechanistic investigation. Life Sci.92(6-7), 383–392 (2013).
  • Rai VK , MishraN , YadavKS , YadavNP. Nanoemulsion as pharmaceutical carrier for dermal and transdermal drug delivery: formulation development, stability issues, basic considerations and applications. J. Control. Rel.270, 203–225 (2018).
  • Sinko PJ , SinghY. Martin's physical pharmacy and pharmaceutical sciences: physical chemical and biopharmaceutical principles in the pharmaceutical sciences. Walter Kluer (2011).
  • Lee CH , MoturiV , LeeY. Thixotropic property in pharmaceutical formulations. J. Control. Rel.136(2), 88–98 (2009).
  • Mastropietro DJ , NimrooziR , OmidianH. Rheology in pharmaceutical formulations – a perspective. J. Dev. Drugs2(2), 1–6 (2013).
  • Owen DH , PetersJJ , KatzDF. Rheological properties of contraceptive gels. Contraception62(6), 321–326 (2000).
  • Chen MX , AlexanderKS , BakiG. Formulation and evaluation of antibacterial creams and gels containing metal ions for topical application. J Pharm.2016, 5754349 (2016).
  • Neupane R , BodduSHS , RenukuntlaJ , BabuRJ , TiwariAK. Alternatives to biological skin in permeation studies: current trends and possibilities. Pharmaceutics12(2), (2020).

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