References
- Bidwell GL 3rd, Raucher D. Therapeutic peptides for cancer therapy. Part I - peptide inhibitors of signal transduction cascades. Expert Opin. Drug Deliv.6(10), 1033–1047 (2009).
- Raucher D , MoktanS, MassodiI, BidwellGL 3rd. Therapeutic peptides for cancer therapy. Part II – cell cycle inhibitory peptides and apoptosis-inducing peptides. Expert Opin. Drug Deliv.6(10), 1049–1064 (2009).
- Draeger LJ , MullenGP. Interaction of the bHLH-zip domain of c-Myc with H1-type peptides. Characterization of helicity in the H1 peptides by NMR. J. Biol. Chem.269(3), 1785–1793 (1994).
- Chen IT , AkamatsuM, SmithMLet al. Characterization of p21Cip1/Waf1 peptide domains required for cyclin E/Cdk2 and PCNA interaction. Oncogene 12(3), 595–607 (1996).
- Ladner RC , SatoAK, GorzelanyJ, De Souza M. Phage display-derived peptides as therapeutic alternatives to antibodies. Drug Discov. Today9(12), 525–529 (2004).
- Li Y , MaoY, RosalRVet al. Selective induction of apoptosis through the FADD/caspase-8 pathway by a p53 C-terminal peptide in human pre-malignant and malignant cells. Int. J. Cancer 115(1), 55–64 (2005).
- Carvalho G , FabreC, BraunTet al. Inhibition of NEMO, the regulatory subunit of the IKK complex, induces apoptosis in high-risk myelodysplastic syndrome and acute myeloid leukemia. Oncogene 26(16), 2299–2307 (2007).
- Fahraeus R , LainS, BallKL, LaneDP. Characterization of the cyclin-dependent kinase inhibitory domain of the INK4 family as a model for a synthetic tumour suppressor molecule. Oncogene16(5), 587–596 (1998).
- Adams PD , SellersWR, SharmaSK, WuAD, NalinCM, KaelinWG Jr. Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors. Mol. Cell. Biol.16(12), 6623–6633 (1996).
- Widakowich C , De Castro G Jr, De Azambuja E, Dinh P, Awada A. Review: side effects of approved molecular targeted therapies in solid cancers. Oncologist12(12), 1443–1455 (2007).
- Wee S , JaganiZ, XiangKXet al. PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers. Cancer Res. 69(10), 4286–4293 (2009).
- Smalley KS , HaassNK, BraffordPA, LioniM, FlahertyKT, HerlynM. Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases. Mol. Cancer Ther.5(5), 1136–1144 (2006).
- Talmadge JE . Pharmacodynamic aspects of peptide administration biological response modifiers. Adv. Drug Deliv. Rev.33(3), 241–252 (1998).
- Lipka E , CrisonJ, AmidonGL. Transmembrane transport of peptide type compounds: prospects for oral delivery. J. Control. Release39(2–3), 121–129 (1996).
- Gregoriadis G , JainS, PapaioannouI, LaingP. Improving the therapeutic efficacy of peptides and proteins: a role for polysialic acids. Int. J. Pharm.300(1–2), 125–130 (2005).
- Adler V , PincusMR, Brandt-RaufPW, RonaiZ. Complexes of p21RAS with JUN N-terminal kinase and JUN proteins. Proc. Natl Acad. Sci. USA92(23), 10585–10589 (1995).
- Chie L , ChenJM, FriedmanFKet al. Identification of the site of inhibition of oncogenic ras-p21-induced signal transduction by a peptide from a ras effector domain. J. Protein Chem. 18(8), 881–884 (1999).
- Chie L , ChenJM, FriedmanFKet al. Inhibition of oncogenic and activated wild-type ras-p21 protein-induced oocyte maturation by peptides from the guanine-nucleotide exchange protein, SOS, identified from molecular dynamics calculations. Selective inhibition of oncogenic ras-p21. J. Protein Chem. 18(8), 875–879 (1999).
- Chung D , AmarS, GlozmanAet al. Inhibition of oncogenic and activated wild-type ras-p21 protein-induced oocyte maturation by peptides from the ras-binding domain of the raf-p74 protein, identified from molecular dynamics calculations. J. Protein Chem. 16(6), 631–635 (1997).
- Clark GJ , DruganJK, TerrellRSet al. Peptides containing a consensus Ras binding sequence from Raf-1 and the GTPase activating protein NF1 inhibit Ras function. Proc. Natl Acad. Sci. USA 93(4), 1577–1581 (1996).
- Kelemen BR , HsiaoK, GoueliSA. Selective in vivo inhibition of mitogen-activated protein kinase activation using cell-permeable peptides. J. Biol. Chem.277(10), 8741–8748 (2002).
- Agou F , CourtoisG, ChiaravalliJet al. Inhibition of NF-kappa B activation by peptides targeting NF-kappa B essential modulator (nemo) oligomerization. J. Biol. Chem. 279(52), 54248–54257 (2004).
- Agou F , TraincardF, VinoloEet al. The trimerization domain of NEMO is composed of the interacting C-terminal CC2 and LZ coiled-coil subdomains. J. Biol. Chem. 279(27), 27861–27869 (2004).
- Lin YZ , YaoSY, VeachRA, TorgersonTR, HawigerJ. Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence. J. Biol. Chem.270(24), 14255–14258 (1995).
- May MJ , D‘acquistoF, MadgeLA, GlocknerJ, PoberJS, GhoshS. Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IκB kinase complex. Science289(5484), 1550–1554 (2000).
- Takada Y , SinghS, AggarwalBB. Identification of a p65 peptide that selectively inhibits NF-kappa B activation induced by various inflammatory stimuli and its role in down-regulation of NF-kappaB-mediated gene expression and up-regulation of apoptosis. J. Biol. Chem.279(15), 15096–15104 (2004).
- Yaron A , GonenH, AlkalayIet al. Inhibition of NF-kappa-B cellular function via specific targeting of the I-kappa-B-ubiquitin ligase. EMBO J. 16(21), 6486–6494 (1997).
- Bottger A , BottgerV, SparksA, LiuWL, HowardSF, LaneDP. Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo. Curr. Biol.7(11), 860–869 (1997).
- Friedler A , HanssonLO, VeprintsevDBet al. A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants. Proc. Natl Acad. Sci. USA 99(2), 937–942 (2002).
- Hupp TR , SparksA, LaneDP. Small peptides activate the latent sequence-specific DNA binding function of p53. Cell83(2), 237–245 (1995).
- Kanovsky M , RaffoA, DrewLet al. Peptides from the amino terminal mdm-2-binding domain of p53, designed from conformational analysis, are selectively cytotoxic to transformed cells. Proc. Natl Acad. Sci. USA 98(22), 12438–12443 (2001).
- Selivanova G , IotsovaV, OkanIet al. Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain. Nat. Med. 3(6), 632–638 (1997).
- Selivanova G , RyabchenkoL, JanssonE, IotsovaV, WimanKG. Reactivation of mutant p53 through interaction of a C-terminal peptide with the core domain. Mol. Cell. Biol.19(5), 3395–3402 (1999).
- Bidwell GL 3rd, Raucher D. Application of thermally responsive polypeptides directed against c-Myc transcriptional function for cancer therapy. Mol. Cancer Ther.4(7), 1076–1085 (2005).
- Bonfanti M , TavernaS, SalmonaM, D‘IncalciM, BrogginiM. p21WAF1-derived peptides linked to an internalization peptide inhibit human cancer cell growth. Cancer Res.57(8), 1442–1446 (1997).
- Massodi I , MoktanS, RawatA, BidwellGL 3rd, Raucher D. Inhibition of ovarian cancer cell proliferation by a cell cycle inhibitory peptide fused to a thermally responsive polypeptide carrier. Int. J. Cancer126(2), 533–544 (2010).
- Mutoh M , LungFD, LongYQ, RollerPP, SikorskiRS, O‘ConnorPM. A p21(Waf1/Cip1) carboxyl-terminal peptide exhibited cyclin-dependent kinase-inhibitory activity and cytotoxicity when introduced into human cells. Cancer Res.59(14), 3480–3488 (1999).
- Warbrick E , LaneDP, GloverDM, CoxLS. A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen. Curr. Biol.5(3), 275–282 (1995).
- Fahraeus R , ParamioJM, BallKL, LainS, LaneDP. Inhibition of pRb phosphorylation and cell-cycle progression by a 20-residue peptide derived from p16CDKN2/INK4A. Curr. Biol.6(1), 84–91 (1996).
- Andrews MJ , McinnesC, KontopidisGet al. Design, synthesis, biological activity and structural analysis of cyclic peptide inhibitors targeting the substrate recruitment site of cyclin-dependent kinase complexes. Org. Biomol. Chem. 2(19), 2735–2741 (2004).
- Gondeau C , Gerbal-ChaloinS, BelloP, Aldrian-HerradaG, MorrisMC, DivitaG. Design of a novel class of peptide inhibitors of cyclin-dependent kinase/cyclin activation. J. Biol. Chem.280(14), 13793–13800 (2005).
- Adams PD , LiX, SellersWRet al. Retinoblastoma protein contains a C-terminal motif that targets it for phosphorylation by cyclin-cdk complexes. Mol. Cell. Biol. 19(2), 1068–1080 (1999).
- Kashiwagi H , McdunnJE, GoedegebuurePSet al. TAT-Bim induces extensive apoptosis in cancer cells. Ann. Surg. Oncol. 14(5), 1763–1771 (2007).
- Polster BM , KinnallyKW, FiskumG. BH3 death domain peptide induces cell type-selective mitochondrial outer membrane permeability. J. Biol. Chem.276(41), 37887–37894 (2001).
- Sattler M , LiangH, NettesheimDet al. Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis. Science 275(5302), 983–986 (1997).
- Schimmer AD , HedleyDW, ChowSet al. The BH3 domain of BAD fused to the antennapedia peptide induces apoptosis via its alpha helical structure and independent of Bcl-2. Cell Death Differ. 8(7), 725–733 (2001).
- Chai J , DuC, WuJW, KyinS, WangX, ShiY. Structural and biochemical basis of apoptotic activation by Smac/DIABLO. Nature406(6798), 855–862 (2000).
- Mai JC , MiZ, KimSH, NgB, RobbinsPD. A proapoptotic peptide for the treatment of solid tumors. Cancer Res.61(21), 7709–7712 (2001).
- Leuschner C , HanselW. Membrane disrupting lytic peptides for cancer treatments. Curr. Pharm. Des.10(19), 2299–2310 (2004).
- Michl J , ScharfB, SchmidtAet al. PNC-28, a p53-derived peptide that is cytotoxic to cancer cells, blocks pancreatic cancer cell growth in vivo. Int. J. Cancer 119(7), 1577–1585 (2006).
- Bidwell GL , PerkinsE, RaucherD. A thermally targeted c-Myc inhibitory polypeptide inhibits breast tumor growth. Cancer Lett.319(2), 136–143 (2012).
- Hosotani R , MiyamotoY, FujimotoKet al. Trojan p16 peptide suppresses pancreatic cancer growth and prolongs survival in mice. Clin. Cancer Res. 8(4), 1271–1276 (2002).
- Fulda S , WickW, WellerM, DebatinKM. Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo. Nat. Med.8(8), 808–815 (2002).
- Chengalvala MV , PelletierJC, KopfGS. GnRH agonists and antagonists in cancer therapy. Curr. Med. Chem. Anti Cancer Agents3(6), 399–410 (2003).
- Cheer SM , PloskerGL, SimpsonD, WagstaffAJ. Goserelin: a review of its use in the treatment of early breast cancer in premenopausal and perimenopausal women. Drugs65(18), 2639–2655 (2005).
- Perez-Marrero R , TylerRC. A subcutaneous delivery system for the extended release of leuprolide acetate for the treatment of prostate cancer. Expert Opin. Pharmacother.5(2), 447–457 (2004).
- Pescarolo MP , BagnascoL, MalacarneDet al. A retro-inverso peptide homologous to helix 1 of c-Myc is a potent and specific inhibitor of proliferation in different cellular systems. FASEB J. 15(1), 31–33 (2001).
- Walensky LD , KungAL, EscherIet al. Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix. Science 305(5689), 1466–1470 (2004).
- Patch JA , BarronAE. Mimicry of bioactive peptides via non-natural, sequence-specific peptidomimetic oligomers. Curr. Opin. Chem. Biol.6(6), 872–877 (2002).
- Torchilin V . Tumor delivery of macromolecular drugs based on the EPR effect. Adv. Drug Deliv. Rev.63(3), 131–135 (2011).
- Greish K . Enhanced permeability and retention of macromolecular drugs in solid tumors: a royal gate for targeted anticancer nanomedicines. J. Drug Target.15(7–8), 457–464 (2007).
- Maeda H . The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. Adv. Enzyme. Regul.41, 189–207 (2001).
- Torchilin VP , LukyanovAN. Peptide and protein drug delivery to and into tumors: challenges and solutions. Drug Discov. Today8(6), 259–266 (2003).
- Sato AK , ViswanathanM, KentRB, WoodCR. Therapeutic peptides: technological advances driving peptides into development. Curr. Opin. Biotechnol.17(6), 638–642 (2006).
- Rosen O , MullerHJ, GokbugetNet al. PEGylated asparaginase in combination with high-dose methotrexate for consolidation in adult acute lymphoblastic leukaemia in first remission: a pilot study. Br. J. Haematol. 123(5), 836–841 (2003).
- Bottomley A , CoensC, SuciuSet al. Adjuvant therapy with pegylated interferon α-2b versus observation in resected stage III melanoma: a phase III randomized controlled trial of health-related quality of life and symptoms by the European Organisation for Research and Treatment of Cancer Melanoma Group. J. Clin. Oncol. 27(18), 2916–2923 (2009).
- Eggermont AM , SuciuS, SantinamiMet al. Adjuvant therapy with pegylated interferon α-2b versus observation alone in resected stage III melanoma: final results of EORTC 18991, a randomised phase III trial. Lancet 372(9633), 117–126 (2008).
- Van Der Auwera P , PlatzerE, XuZXet al. Pharmacodynamics and pharmacokinetics of single doses of subcutaneous PEGylated human G-CSF mutant (Ro 25–8315) in healthy volunteers: comparison with single and multiple daily doses of filgrastim. Am. J. Hematol. 66(4), 245–251 (2001).
- Bowen S , TareN, InoueTet al. Relationship between molecular mass and duration of activity of polyethylene glycol conjugated granulocyte colony-stimulating factor mutein. Exp. Hematol. 27(3), 425–432 (1999).
- Nie Y , ZhangX, WangX, ChenJ. Preparation and stability of N-terminal mono-PEGylated recombinant human endostatin. Bioconjug. Chem.17(4), 995–999 (2006).
- Zhu B , XuHM, ZhaoL, HuangX, ZhangF. Site-specific modification of anti-angiogenesis peptide HM-3 by polyethylene glycol molecular weight of 20 kDa. J. Biochem.148(3), 341–347 (2010).
- Zhang G , HanB, LinX, WuX, YanH. Modification of antimicrobial peptide with low molar mass poly(ethylene glycol). J. Biochem.144(6), 781–788 (2008).
- J⊘rgensen L , NielsenHM. Delivery Technologies for Biopharmaceuticals: Peptides, Proteins, Nucleic Acids and Vaccines. Wiley, Chichester, UK (2009).
- Wang J , ChowD, HeiatiH, ShenWC. Reversible lipidization for the oral delivery of salmon calcitonin. J. Control. Release88(3), 369–380 (2003).
- Wang J , HogenkampDJ, TranMet al. Reversible lipidization for the oral delivery of leu-enkephalin. J. Drug Target. 14(3), 127–136 (2006).
- Pardridge WM . Drug and gene delivery to the brain: the vascular route. Neuron36(4), 555–558 (2002).
- Duncan R . Polymer conjugates for tumour targeting and intracytoplasmic delivery. The EPR effect as a common gateway? Pharm. Sci. Technol. Today2(11), 441–449 (1999).
- Duvall CL , ConvertineAJ, BenoitDS, HoffmanAS, StaytonPS. Intracellular delivery of a proapoptotic peptide via conjugation to a RAFT synthesized endosomolytic polymer. Mol. Pharm.7(2), 468–476 (2010).
- Bidwell GL 3rd, Raucher D. Cell penetrating elastin-like polypeptides for therapeutic peptide delivery. Adv. Drug Deliv. Rev.62(15), 1486–1496 (2010).
- Meyer DE , ChilkotiA. Purification of recombinant proteins by fusion with thermally responsive polypeptides. Nat. Biotechnol.17, 1112–1115 (1999).
- Meyer DE , ChilkotiA. Genetically encoded synthesis of protein-based polymers with precisely specified molecular weight and sequence by recursive directional ligation: examples from the elastin-like polypeptide system. Biomacromolecules3(2), 357–367 (2002).
- Urry DW , Luan C-H, Parker TM et al. Temperature of polypeptide inverse temperature transition depends on mean residue hydrophobicity. J. Am. Chem. Soc.113, 4346–4348 (1991).
- Dreher MR , LiuW, MichelichCR, DewhirstMW, ChilkotiA. Thermal cycling enhances the accumulation of a temperature-sensitive biopolymer in solid tumors. Cancer Res.67(9), 4418–4424 (2007).
- Bidwell GL 3rd, Davis AN, Raucher D. Targeting a c-Myc inhibitory polypeptide to specific intracellular compartments using cell penetrating peptides. J. Control. Release135(1), 2–10 (2009).
- Massodi I , BidwellGL 3rd, Raucher D. Evaluation of cell penetrating peptides fused to elastin-like polypeptide for drug delivery. J. Control. Release108(2–3), 396–408 (2005).
- Massodi I , ThomasE, RaucherD. Application of thermally responsive elastin-like polypeptide fused to a lactoferrin-derived peptide for treatment of pancreatic cancer. Molecules14(6), 1999–2015 (2009).
- Bidwell GL 3rd, Whittom AA, Thomas E, Lyons D, Hebert MD, Raucher D. A thermally targeted peptide inhibitor of symmetrical dimethylation inhibits cancer-cell proliferation. Peptides31(5), 834–841 (2010).
- Pan H , SomanNR, SchlesingerPH, LanzaGM, WicklineSA. Cytolytic peptide nanoparticles (‘NanoBees‘) for cancer therapy. Nanomed. Nanobiotechnol.3(3), 318–327 (2011).
- Tosteson MT , HolmesSJ, RazinM, TostesonDC. Melittin lysis of red cells. J. Membr. Biol.87(1), 35–44 (1985).
- Bell HS , DufesC, O‘preyJet al. A p53-derived apoptotic peptide derepresses p73 to cause tumor regression in vivo. J. Clin. Invest. 117(4), 1008–1018 (2007).
- Noble CO , KirpotinDB, HayesMEet al. Development of ligand-targeted liposomes for cancer therapy. Expert Opin. Ther. Targets 8(4), 335–353 (2004).
- Torchilin VP , LevchenkoTS. TAT-liposomes: a novel intracellular drug carrier. Curr. Protein Pept. Sci.4(2), 133–140 (2003).
- Ducat E , DeprezJ, GilletAet al. Nuclear delivery of a therapeutic peptide by long circulating pH-sensitive liposomes: benefits over classical vesicles. Int. J. Pharm. 420(2), 319–332 (2011).
- Li C , ShenJ, WeiX, XieC, LuW. Targeted delivery of a novel palmitylated D-peptide for antiglioblastoma molecular therapy. J. Drug Target.20(3), 264–271 (2012).
- Kim SK , HuangL. Nanoparticle delivery of a peptide targeting EGFR signaling. J. Control. Release157(2), 279–286 (2012).
- Pasqualini R , KoivunenE, RuoslahtiE. Alpha v integrins as receptors for tumor targeting by circulating ligands. Nat. Biotechnol.15(6), 542–546 (1997).
- Ogris M , WalkerG, BlessingT, KircheisR, WolschekM, WagnerE. Tumor-targeted gene therapy: strategies for the preparation of ligand-polyethylene glycol-polyethylenimine/DNA complexes. J. Control. Release91(1–2), 173–181 (2003).
- Aina OH , SrokaTC, ChenML, LamKS. Therapeutic cancer targeting peptides. Biopolymers66(3), 184–199 (2002).
- Fay F , ScottCJ. Antibody-targeted nanoparticles for cancer therapy. Immunotherapy3(3), 381–394 (2011).
- Giorello L , ClericoL, PescaroloMPet al. Inhibition of cancer cell growth and c-Myc transcriptional activity by a c-Myc helix 1-type peptide fused to an internalization sequence. Cancer Res. 58(16), 3654–3659 (1998).
- Mae M , LangelU. Cell-penetrating peptides as vectors for peptide, protein and oligonucleotide delivery. Curr. Opin. Pharmacol.6(5), 509–514 (2006).
- Gupta B , LevchenkoTS, TorchilinVP. Intracellular delivery of large molecules and small particles by cell-penetrating proteins and peptides. Adv. Drug Deliv. Rev.57(4), 637–651 (2005).
- Rousselle C , ClairP, LefauconnierJM, KaczorekM, ScherrmannJM, TemsamaniJ. New advances in the transport of doxorubicin through the blood–brain barrier by a peptide vector-mediated strategy. Mol. Pharmacol.57(4), 679–686 (2000).
- Rousselle C , ClairP, SmirnovaMet al. Improved brain uptake and pharmacological activity of dalargin using a peptide-vector-mediated strategy. J. Pharmacol. Exp. Ther. 306(1), 371–376 (2003).
- Schwarze SR , HoA, Vocero-AkbaniA, DowdySF. In vivo protein transduction: delivery of a biologically active protein into the mouse. Science285(5433), 1569–1572 (1999).
- Aguilera TA , OlsonES, TimmersMM, JiangT, TsienRY. Systemic in vivo distribution of activatable cell penetrating peptides is superior to that of cell penetrating peptides. Integr. Biol. (Camb.)1(5–6), 371–381 (2009).
- Van Den Berg A , DowdySF. Protein transduction domain delivery of therapeutic macromolecules. Curr. Opin. Biotechnol.22(6), 888–893 (2011).
- Teesalu T , SugaharaKN, KotamrajuVR, RuoslahtiE. C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration. Proc. Natl Acad. Sci. USA106(38), 16157–16162 (2009).
- Sugahara KN , TeesaluT, KarmaliPPet al. Tissue-penetrating delivery of compounds and nanoparticles into tumors. Cancer Cell 16(6), 510–520 (2009).
- Sugahara KN , TeesaluT, KarmaliPPet al. Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs. Science 328(5981), 1031–1035 (2010).
- Agemy L , Friedmann-MorvinskiD, KotamrajuVRet al. Targeted nanoparticle enhanced proapoptotic peptide as potential therapy for glioblastoma. Proc. Natl Acad. Sci. USA 108(42), 17450–17455 (2011).
- Olson ES , AguileraTA, JiangTet al. In vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancer. Integr. Biol. (Camb.)1(5–6), 382–393 (2009).
- Olson ES , JiangT, AguileraTAet al. Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases. Proc. Natl Acad. Sci. USA 107(9), 4311–4316 (2010).