Biopharmaceutical In Vitro Characterization of CPZEN-45, a Drug Candidate for Inhalation Therapy of Tuberculosis

• Muttil P , WangC, HickeyAJ. Inhaled drug delivery for tuberculosis therapy. Pharm. Res.26(11), 2401–2416 (2009).
   PubMed Web of Science ®Google Scholar
• McNerney R , MaeurerM, AbubakarIet al. Tuberculosis diagnostics and biomarkers: needs, challenges, recent advances, and opportunities. J. Infect. Dis. 205(Suppl. 2), S147–S158 (2012).
   PubMed Web of Science ®Google Scholar
• Pandey R , KhullerGK. Antitubercular inhaled therapy: opportunities, progress and challenges. J. Antimicrob. Chemother.55(4), 430–435 (2005).
   PubMed Web of Science ®Google Scholar
• Misra A , HickeyAJ, RossiCet al. Inhaled drug therapy for treatment of tuberculosis. Tuberculosis (Edinb). 91(1), 71–81 (2011).
   PubMed Web of Science ®Google Scholar
• Park JH , JinHE, KimDD, ChungSJ, ShimWS, ShimCK. Chitosan microspheres as an alveolar macrophage delivery system of ofloxacin via pulmonary inhalation. Int. J. Pharm.441(1–2), 562–569 (2013).
   PubMed Web of Science ®Google Scholar
• Gonzalez-Juarrero M , WoolhiserLK, BrooksE, DeGrooteMA, LenaertsAJ. Mouse model for efficacy testing of antituberculosis agents via intrapulmonary delivery. Antimicrob. Agents. Chemother.56(7), 3957–3959 (2012).
   PubMed Web of Science ®Google Scholar
• Hokey DA , MisraA. Aerosol vaccines for tuberculosis: a fine line between protection and pathology. Tuberculosis (Edinb).91(1), 82–85 (2011).
   PubMed Web of Science ®Google Scholar
• Igarashi M , NakagawaN, DoiN, HattoriS, NaganawaH, HamadaM. Caprazamycin B, a novel anti-tuberculosis antibiotics, from Streptomyces sp. J. Antibiot.56(6), 580–583 (2003).
   PubMed Web of Science ®Google Scholar
• Igarashi M , TakahashiY, ShitaraTet al. Caprazamycins, novel lipo-nucleoside antibiotics, from Streptomyces sp. II. Structure elucidation of caprazamycins. J. Antibiot. 58(5), 327–337 (2005).
   PubMed Web of Science ®Google Scholar
• Engohang-Ndong J . Antimycobacterial drugs currently in Phase II clinical trials and preclinical phase for tuberculosis treatment. Expert Opin. Investig. Drugs21(12), 1789–1800 (2012).
   PubMed Web of Science ®Google Scholar
• Koul A , ArnoultE, LounisN, GuillemontJ, AndriesK. The challenge of new drug discovery for tuberculosis. Nature469(7331), 483–490 (2011).
   PubMed Web of Science ®Google Scholar
• Forbes B , EhrhardtC. Human respiratory epithelial cell culture for drug delivery applications. Eur. J. Pharm. Biopharm.60(2), 193–205 (2005).
   PubMed Web of Science ®Google Scholar
• Sporty JL , HorálkováL, EhrhardtC. In vitro cell culture models for the assessment of pulmonary drug disposition. Expert Opin. Drug Metab. Toxicol.4(4), 333–345 (2008).
   PubMed Web of Science ®Google Scholar
• Salomon JJ , EhrhardtC. Organic cation transporters in the blood–air barrier: expression and implications for pulmonary drug delivery. Ther. Deliv.3(6), 735–747 (2012).
   PubMedGoogle Scholar
• Mehta R , KelleherD, PreeceA, HughesS, CraterG. Effect of verapamil on systemic exposure and safety of umeclidinium and vilanterol: a randomized and open-label study. Int. J. Chronic Obstr. Pulm. Dis.8, 159–167 (2013).
   PubMed Web of Science ®Google Scholar
• Demling N , EhrhardtC, KasperM, LaueM, KnelsL, RieberEP. Promotion of cell adherence and spreading: a novel function of RAGE, the highly selective differentiation marker of human alveolar epithelial type I cells. Cell. Tissue Res.323(3), 475–488 (2006).
   PubMed Web of Science ®Google Scholar
• Hamilton KO , BackstromG, YazdanianMA, AudusKL. P-glycoprotein efflux pump expression and activity in Calu-3 cells. J. Pharm. Sci.90(5), 647–658 (2001).
   PubMed Web of Science ®Google Scholar
• Salomon JJ , EndterS, TachonG, FalsonF, BuckleyST, EhrhardtC. Transport of the fluorescent organic cation 4-(4-(dimethylamino)styryl)-N-methylpyridinium iodide (ASP(+)) in human respiratory epithelial cells. Eur. J. Pharm. Biopharm.81(2), 351–359 (2012).
   PubMed Web of Science ®Google Scholar
• Gainanova GA , VagapovaGI, SyakaevVVet al. Self-assembling systems based on amphiphilic alkyltriphenyl phosphonium bromides: elucidation of the role of head group. J. Colloid Interface Sci. 367(1), 327–336 (2012).
   PubMedGoogle Scholar
• Baginski L , GobboOL, TewesFet al. In vitro and in vivo characterisation of PEG-lipid-based micellar complexes of salmon calcitonin for pulmonary delivery. Pharm. Res.29(6), 1425–1434 (2012).
   PubMed Web of Science ®Google Scholar
• Gumbleton M , Al-JayyoussiG, Crandon-LewisAet al. Spatial expression and functionality of drug transporters in the intact lung: objectives for further research. Adv. Drug Deliv. Rev. 63(1–2), 110–118 (2011).
   PubMed Web of Science ®Google Scholar
• Bosquillon C . Drug transporters in the lung – do they play a role in the biopharmaceutics of inhaled drugs? J. Pharm. Sci.99(5), 2240–2255 (2010).
   PubMed Web of Science ®Google Scholar
• Salomon JJ , EhrhardtC. Nanoparticles attenuate P-glycoprotein/MDR1 function in A549 human alveolar epithelial cells. Eur. J. Pharm. Biopharm.77(3), 392–397 (2011).
   PubMed Web of Science ®Google Scholar
• Endter S , BeckerU, DaumNet al. P-glycoprotein (MDR1) functional activity in human alveolar epithelial cell monolayers. Cell. Tissue Res. 328(1), 77–84 (2007).
   PubMed Web of Science ®Google Scholar
• Horvath G , SchmidN, FragosoMAet al. Epithelial organic cation transporters ensure pH-dependent drug absorption in the airway. Am. J. Respir. Cell Mol. Biol. 36(1), 53–60 (2007).
   PubMed Web of Science ®Google Scholar
• Smola M , VandammeT, SokolowskiA. Nanocarriers as pulmonary drug delivery systems to treat and to diagnose respiratory and non respiratory diseases. Int. J. Nanomedicine3(1), 1–19 (2008).
   PubMed Web of Science ®Google Scholar
• Craparo EF , TeresiG, BondiML, LicciardiM, CavallaroG. Phospholipid-polyaspartamide micelles for pulmonary delivery of corticosteroids. Int. J. Pharm.406(1–2), 135–144 (2011).
   PubMed Web of Science ®Google Scholar
• Torchilin VP . Micellar nanocarriers: pharmaceutical perspectives. Pharm. Res.24(1), 1–16 (2007).
   PubMed Web of Science ®Google Scholar
• Beresford B , SadoffJC. Update on research and development pipeline: tuberculosis vaccines. Clin. Infect. Dis.50(Suppl. 3), S178–S183 (2010).
   PubMed Web of Science ®Google Scholar
• Hanif SNM , DurhamP, RaghuvanshiD, HickeyAJ, Garcia Contreras LG. Pharmacokinetics of CPZEN-45, a novel anti-tuberculosis drug in male guinea pigs. J. Aerosol. Med. Pulm. Drug. Deliv.26(2), A18.
   Google Scholar

Patent

• Takahashi Y, Igarashi M, Okada M: 0237530 A1 (2011).
   Google Scholar

Website

• WHO Global Tuberculosis Report 2012. www.who.int/tb/publications/global_report/en
   Google Scholar