Formulation Design for Topical Drug and Nanoparticle Treatment of Skin Disease

References

• Wiedersberg S Guy RH . Transdermal drug delivery: 30+ years of war and still fighting!J. Control. Release190, 150–156 (2014).
   PubMed Web of Science ®Google Scholar
• Prausnitz MR Langer R . Transdermal drug delivery. Nat. Biotechnol.26 (11), 1261–1268 (2008).
   PubMed Web of Science ®Google Scholar
• Padula C Nicoli S Aversa V et al. Bioadhesive film for dermal and transdermal drug delivery. Eur. J. Dermatol.17 (4), 309–312 (2007).
   PubMed Web of Science ®Google Scholar
• Thomas BJ Finnin BC . The transdermal revolution. Drug Discov. Today9 (16), 697–703 (2004).
   PubMed Web of Science ®Google Scholar
• Boonen J Veryser L Taevernier L et al. Risk evaluation of impurities in topical excipients: the acetol case. J. Pharm. Anal. (2014) ( In Press).
   PubMedGoogle Scholar
• Thiboutot D Del Rosso JQ . Acne vulgaris and the epidermal barrier: is acne vulgaris associated with inherent epidermal abnormalities that cause impairment of barrier functions? Do any topical acne therapies alter the structural and/or functional integrity of the epidermal barrier?J. Clin. Aesthet. Dermatol.6 (2), 18–24 (2013).
   PubMedGoogle Scholar
• Kurokawa I Danby FW Ju Q et al. New developments in our understanding of acne pathogenesis and treatment. Exp. Dermatol.18 (10), 821–832 (2009).
   PubMed Web of Science ®Google Scholar
• Bhate K Williams HC . Epidemiology of acne vulgaris. Br. J. Dermatol.168 (3), 474–485 (2013).
   PubMed Web of Science ®Google Scholar
• Nguyen SH Dang TP Maibach HI . Comedogenicity in rabbit: some cosmetic ingredients/vehicles. Cutan. Ocul. Toxicol.26 (4), 287–292 (2007).
   PubMed Web of Science ®Google Scholar
• Draelos ZD Dinardo JC . A re-evaluation of the comedogenicity concept. J. Am. Acad. Dermatol.54 (3), 507–512 (2006).
   PubMed Web of Science ®Google Scholar
• Galvin SA Gilbert R Baker M Guibal F Tuley MR . Comparative tolerance of adapalene 0.1% gel and six different tretinoin formulations. Br. J. Dermatol.139 (Suppl.) 52, 34–40 (1998).
   PubMedGoogle Scholar
• Hayashi N Kawashima M . Study of the usefulness of moisturizers on adherence of acne patients treated with adapalene. J. Dermatol.41 (7), 592–597 (2014).
   PubMed Web of Science ®Google Scholar
• Stinco G Bragadin G Trotter D Pillon B Patrone P . Relationship between sebostatic activity, tolerability and efficacy of three topical drugs to treat mild to moderate acne. J. Eur. Acad. Dermatol. Venereol.21 (3), 320–325 (2007).
   PubMed Web of Science ®Google Scholar
• Imokawa G Abe A Jin K Higaki Y Kawashima M Hidano A . Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin?J. Investig. Dermatol.96 (4), 523–526 (1991).
   PubMed Web of Science ®Google Scholar
• O'regan GM Sandilands A Mclean WH Irvine AD . Filaggrin in atopic dermatitis. J. Allergy. Clin. Immunol.122 (4), 689–693 (2008).
   PubMed Web of Science ®Google Scholar
• Miller DW Koch SB Yentzer BA et al. An over-the-counter moisturizer is as clinically effective as, and more cost-effective than, prescription barrier creams in the treatment of children with mild-to-moderate atopic dermatitis: a randomized, controlled trial. J. Drugs Dermatol.10 (5), 531–537 (2011).
   PubMed Web of Science ®Google Scholar
• Simpson E Bohling A Bielfeldt S Bosc C Kerrouche N . Improvement of skin barrier function in atopic dermatitis patients with a new moisturizer containing a ceramide precursor. J. Dermatolog. Treat.24 (2), 122–125 (2013).
   PubMed Web of Science ®Google Scholar
• Wiren K Nohlgard C Nyberg F et al. Treatment with a barrier-strengthening moisturizing cream delays relapse of atopic dermatitis: a prospective and randomized controlled clinical trial. J. Eur. Acad. Dermatol. Venereol.23 (11), 1267–1272 (2009).
   PubMed Web of Science ®Google Scholar
• Hon KL Pong NH Wang SS Lee VW Luk NM Leung TF . Acceptability and efficacy of an emollient containing ceramide-precursor lipids and moisturizing factors for atopic dermatitis in pediatric patients. Drugs in R&D13 (1), 37–42 (2013).
   PubMedGoogle Scholar
• Vergnanini AL Aoki V Takaoka R Madi J . Comparative effects of pimecrolimus cream vehicle and three commercially available moisturizers on skin hydration and transepidermal water loss. J. Dermatolog. Treat.21 (3), 126–129 (2010).
   PubMed Web of Science ®Google Scholar
• Billich A Aschauer H Aszodi A Stuetz A . Percutaneous absorption of drugs used in atopic eczema: pimecrolimus permeates less through skin than corticosteroids and tacrolimus. Int. J. Pharm.269 (1), 29–35 (2004).
   PubMed Web of Science ®Google Scholar
• Kerney DL Ford RO Gotz V . Self-reported participant experience with desonide hydrogel in the treatment of mild to moderate atopic dermatitis. Cutis88 (1 Suppl.), 18–24 (2011).
   PubMed Web of Science ®Google Scholar
• Yentzer BA Camacho FT Young T Fountain JM Clark AR Feldman SR . Good adherence and early efficacy using desonide hydrogel for atopic dermatitis: results from a program addressing patient compliance. J. Drugs Dermatol.9 (4), 324–329 (2010).
   PubMed Web of Science ®Google Scholar
• Benton EC Kerr OA Fisher A Fraser SJ Mccormack SK Tidman MJ . The changing face of dermatological practice: 25 years’ experience. Br. J. Dermatol.159 (2), 413–418 (2008).
   PubMed Web of Science ®Google Scholar
• Griffiths CE Barker JN . Pathogenesis and clinical features of psoriasis. Lancet370 (9583), 263–271 (2007).
   PubMed Web of Science ®Google Scholar
• Murphy M Kerr P Grant-Kels JM . The histopathologic spectrum of psoriasis. Clin. Dermatol.25 (6), 524–528 (2007).
   PubMed Web of Science ®Google Scholar
• Weinstein GD Krueger GG Lowe NJ et al. Tazarotene gel, a new retinoid, for topical therapy of psoriasis: vehicle-controlled study of safety, efficacy, and duration of therapeutic effect. J. Am. Acad. Dermatol.37 (1), 85–92 (1997).
   PubMed Web of Science ®Google Scholar
• Talpur R Cox K Duvic M . Efficacy and safety of topical tazarotene: a review. Expert Opin. Drug Metab. Toxicol.5 (2), 195–210 (2009).
   PubMed Web of Science ®Google Scholar
• Gollnick H Menter A . Combination therapy with tazarotene plus a topical corticosteroid for the treatment of plaque psoriasis. Br. J. Dermatol.140 (Suppl.) 54, 18–23 (1999).
   PubMedGoogle Scholar
• Tzung TY Wu JC Hsu NJ Chen YH Ger LP . Comparison of tazarotene 0.1% gel plus petrolatum once daily versus calcipotriol 0.005% ointment twice daily in the treatment of plaque psoriasis. Acta Derm. Venereol.85 (3), 236–239 (2005).
   PubMed Web of Science ®Google Scholar
• Krueger GG Drake LA Elias PM et al. The safety and efficacy of tazarotene gel, a topical acetylenic retinoid, in the treatment of psoriasis. Arch. Dermatol.134 (1), 57–60 (1998).
   PubMedGoogle Scholar
• Wheller L Lin LL Chai E Sinnya S Soyer HP Prow TW . Noninvasive methods for the assessment of photoageing. Australas. J. Dermatol.54 (4), 290–295 (2013).
   PubMed Web of Science ®Google Scholar
• Raphael AP Kelf TA Wurm EM Zvyagin AV Soyer HP Prow TW . Computational characterization of reflectance confocal microscopy features reveals potential for automated photoageing assessment. Exp. Dermatol.22 (7), 458–463 (2013).
   PubMed Web of Science ®Google Scholar
• Lebwohl M Swanson N Anderson LL Melgaard A Xu Z Berman B . Ingenol mebutate gel for actinic keratosis. N. Engl. J. Med.366 (11), 1010–1019 (2012).
   PubMed Web of Science ®Google Scholar
• Swanson N Abramovits W Berman B Kulp J Rigel DS Levy S . Imiquimod 2.5% and 3.75% for the treatment of actinic keratoses: results of two placebo-controlled studies of daily application to the face and balding scalp for two 2-week cycles. J. Am. Acad. Dermatol.62 (4), 582–590 (2010).
   PubMedGoogle Scholar
• El-Gohary M van Zuuren EJ Fedorowicz Z et al. Topical antifungal treatments for tinea cruris and tinea corporis. Cochrane Database Syst. Rev.8, CD009992 (2014).
   Web of Science ®Google Scholar
• Brasch J . Pathogenesis of tinea. J. Dtsch. Dermatol. Ges.8 (10), 780–786 (2010).
   PubMed Web of Science ®Google Scholar
• Ilkit M Durdu M . Tinea pedis: the etiology and global epidemiology of a common fungal infection. Crit. Rev. Microbiol. (2014) ( In Press).
   PubMed Web of Science ®Google Scholar
• Havlickova B Czaika VA Friedrich M . Epidemiological trends in skin mycoses worldwide. Mycoses51 (Suppl.) 4, 2–15 (2008).
   PubMedGoogle Scholar
• Lee WJ Kim JY Song CH et al. Disruption of barrier function in dermatophytosis and pityriasis versicolor. J. Dermatol.38 (11), 1049–1053 (2011).
   PubMed Web of Science ®Google Scholar
• Mcclellan KJ Wiseman LR Markham A . Terbinafine. An update of its use in superficial mycoses. Drugs58 (1), 179–202 (1999).
   PubMed Web of Science ®Google Scholar
• Alberti I Kalia YN Naik A Bonny J Guy RH . Effect of ethanol and isopropyl myristate on the availability of topical terbinafine in human stratum corneum, in vivo. Int. J. Pharm.219 (1–2), 11–19 (2001).
   PubMedGoogle Scholar
• Korting HC Kiencke P Nelles S Rychlik R . Comparable efficacy and safety of various topical formulations of terbinafine in tinea pedis irrespective of the treatment regimen: results of a meta-analysis. Am. J. Clin. Dermatol.8 (6), 357–364 (2007).
   PubMed Web of Science ®Google Scholar
• Ortonne JP Korting HC Viguie-Vallanet C Larnier C Savaluny E . Efficacy and safety of a new single-dose terbinafine 1% formulation in patients with tinea pedis (athlete's foot): a randomized, double-blind, placebo-controlled study. J. Eur. Acad. Dermatol. Venereol.20 (10), 1307–1313 (2006).
   PubMed Web of Science ®Google Scholar
• De Chauvin MF Viguie-Vallanet C Kienzler JL Larnier C . Novel, single-dose, topical treatment of tinea pedis using terbinafine: results of a dose-finding clinical trial. Mycoses51 (1), 1–6 (2008).
   PubMed Web of Science ®Google Scholar
• Gee CM Watkinson AC Nicolazzo JA Finnin BC . The effect of formulation excipients on the penetration and lateral diffusion of ibuprofen on and within the stratum corneum following topical application to humans. J. Pharm. Sci.103 (3), 909–919 (2014).
   PubMed Web of Science ®Google Scholar
• Gujjar M Banga AK . Vehicle influence on permeation through intact and compromised skin. Int. J. Pharm.472 (1–2), 362–368 (2014).
   PubMedGoogle Scholar
• Rosado C Cross SE Pugh WJ Roberts MS Hadgraft J . Effect of vehicle pretreatment on the flux, retention, and diffusion of topically applied penetrants in vitro. Pharm. Res.20 (9), 1502–1507 (2003).
   PubMed Web of Science ®Google Scholar
• Bronaugh RL Franz TJ . Vehicle effects on percutaneous absorption: in vivo and in vitro comparisons with human skin. Br. J. Dermatol.115 (1), 1–11 (1986).
   PubMed Web of Science ®Google Scholar
• Hilton J Woollen BH Scott RC Auton TR Trebilcock KL Wilks MF . Vehicle effects on in vitro percutaneous absorption through rat and human skin. Pharm. Res.11 (10), 1396–1400 (1994).
   PubMed Web of Science ®Google Scholar
• Bonina FP Carelli V Dicolo G Montenegro L Nannipieri E . Vehicle effects on in-vitro skin permeation of and stratum-corneum affinity for model-drugs caffeine and testosterone. Int. J. Pharm.100 (1–3), 41–47 (1993).
   Google Scholar
• Barry BW . Novel mechanisms and devices to enable successful transdermal drug delivery. Eur. J. Pharm. Sci.14 (2), 101–114 (2001).
   PubMed Web of Science ®Google Scholar
• Lane ME . Skin penetration enhancers. Int. J. Pharm.447 (1–2), 12–21 (2013).
   PubMed Web of Science ®Google Scholar
• Newton SJ . Chemical penetration enhancers. Int. J. Pharm. Compd.17 (5), 370–374 (2013).
   PubMedGoogle Scholar
• Wohlrab J Kreft B Tamke B . Skin tolerability of transdermal patches. Expert Opin. Drug Deliv.8 (7), 939–948 (2011).
   PubMed Web of Science ®Google Scholar
• Karande P Mitragotri S . Enhancement of transdermal drug delivery via synergistic action of chemicals. Biochim. Biophys. Acta1788 (11), 2362–2373 (2009).
   PubMed Web of Science ®Google Scholar
• Karande P Jain A Mitragotri S . Discovery of transdermal penetration enhancers by high-throughput screening. Nat. Biotechnol.22 (2), 192–197 (2004).
   PubMed Web of Science ®Google Scholar
• Kim YC Ludovice PJ Prausnitz MR . Optimization of transdermal delivery using magainin pore-forming peptide. J. Phys. Chem. Solids.69 (5–6), 1560–1563 (2008).
   PubMed Web of Science ®Google Scholar
• Kim Y-C Ludovice PJ Prausnitz MR . Transdermal delivery enhanced by antimicrobial peptides. J. Biomed. Nanotechnol.6 (5), 612–620 (2010).
   PubMed Web of Science ®Google Scholar
• Kogan A Garti N . Microemulsions as transdermal drug delivery vehicles. Adv. Colloid Interface Sci.123–126, 369–385 (2006).
   PubMed Web of Science ®Google Scholar
• Cevc G . Lipid vesicles and other colloids as drug carriers on the skin. Adv. Drug Delivery. Rev.56 (5), 675–711 (2004).
   PubMed Web of Science ®Google Scholar
• Schäfer-Korting M Mehnert W Korting H-C . Lipid nanoparticles for improved topical application of drugs for skin diseases. Adv. Drug Delivery. Rev.59 (6), 427–443 (2007).
   PubMed Web of Science ®Google Scholar
• Guterres SS Alves MP Pohlmann AR . Polymeric nanoparticles, nanospheres and nanocapsules, for cutaneous applications. Drug Target Insights2, 147–157 (2007).
   PubMedGoogle Scholar
• Prow TW Grice JE Lin LL et al. Nanoparticles and microparticles for skin drug delivery. Adv. Drug Delivery. Rev.63 (6), 470–491 (2011).
   PubMed Web of Science ®Google Scholar
• Lademann J Richter H Schanzer S et al. Penetration and storage of particles in human skin: perspectives and safety aspects. Eur. J. Pharm. Biopharm.77 (3), 465–468 (2011).
   PubMed Web of Science ®Google Scholar
• Raber AS Mittal A Schafer J et al. Quantification of nanoparticle uptake into hair follicles in pig ear and human forearm. J. Control. Release179, 25–32 (2014).
   PubMed Web of Science ®Google Scholar
• Patzelt A Lademann J . Drug delivery to hair follicles. Expert Opin. Drug Deliv.10 (6), 787–797 (2013).
   PubMed Web of Science ®Google Scholar
• Pardeike J Hommoss A Muller RH . Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products. Int. J. Pharm.366 (1–2), 170–184 (2009).
   PubMed Web of Science ®Google Scholar
• Saraceno R Chiricozzi A Gabellini M Chimenti S . Emerging applications of nanomedicine in dermatology. Skin Res. Technol.19 (1), e13–19 (2013).
   PubMed Web of Science ®Google Scholar
• Clinical Trials. ClinicalTrials.gov.
   Google Scholar
• Cevc G Vierl U . Nanotechnology and the transdermal route: a state of the art review and critical appraisal. J. Control. Release141 (3), 277–299 (2010).
   PubMed Web of Science ®Google Scholar
• Anton N Vandamme TF . Nano-emulsions and micro-emulsions: clarifications of the critical differences. Pharm. Res.28 (5), 978–985 (2011).
   PubMed Web of Science ®Google Scholar
• Tadros T Izquierdo P Esquena J Solans C . Formation and stability of nano-emulsions. Adv. Colloid Interface Sci.108–109, 303–318 (2004).
   PubMed Web of Science ®Google Scholar
• Bouchemal K Briançon S Perrier E Fessi H . Nano-emulsion formulation using spontaneous emulsification: solvent, oil and surfactant optimisation. Int. J. Pharm.280 (1–2), 241–251 (2004).
   PubMed Web of Science ®Google Scholar
• Wu Y Li Y-H Gao X-H Chen H-D . The application of nanoemulsion in dermatology: an overview. J. Drug Target.21 (4), 321–327 (2013).
   PubMed Web of Science ®Google Scholar
• Junyaprasert VB Teeranachaideekul V Souto EB Boonme P Müller RH . Q10-loaded NLC versus nanoemulsions: stability, rheology and in vitro skin permeation. Int. J. Pharm.377 (1–2), 207–214 (2009).
   PubMed Web of Science ®Google Scholar
• Butnariu MV Giuchici CV . The use of some nanoemulsions based on aqueous propolis and lycopene extract in the skin's protective mechanisms against UVA radiation. J. Nanobiotechnol.9 (1), 3 (2011).
   PubMedGoogle Scholar
• Bernardi DS Pereira TA Maciel NR et al. Formation and stability of oil-in-water nanoemulsions containing rice bran oil: in vitro and in vivo assessments. J. Nanobiotechnol.9 (1), 44 (2011).
   PubMedGoogle Scholar
• Yu M Ma H Lei M Li N Tan F . In vitro/in vivo characterization of nanoemulsion formulation of metronidazole with improved skin targeting and anti-rosacea properties. Eur. J. Pharm. Biopharm.88 (1), 92–103 (2014).
   PubMed Web of Science ®Google Scholar
• Guglielmini G . Nanostructured novel carrier for topical application. Clin. Dermatol.26 (4), 341–346 (2008).
   PubMed Web of Science ®Google Scholar
• Mehnert W Mäder K . Solid lipid nanoparticles: production, characterization and applications. Adv. Drug Delivery. Rev.47 (2–3), 165–196 (2001).
   PubMed Web of Science ®Google Scholar
• Keck CM Anantaworasakul P Patel M et al. A new concept for the treatment of atopic dermatitis: silver-nanolipid complex (sNLC). Int. J. Pharm.462 (1–2), 44–51 (2014).
   PubMedGoogle Scholar
• Shah KA Date AA Joshi MD Patravale VB . Solid lipid nanoparticles (SLN) of tretinoin: potential in topical delivery. Int. J. Pharm.345 (1–2), 163–171 (2007).
   PubMed Web of Science ®Google Scholar
• Joshi MD Müller RH . Lipid nanoparticles for parenteral delivery of actives. Eur. J. Pharm. Biopharm.71 (2), 161–172 (2009).
   PubMed Web of Science ®Google Scholar
• Alvarez-Román R Barré G Guy RH Fessi H . Biodegradable polymer nanocapsules containing a sunscreen agent: preparation and photoprotection. Eur. J. Pharm. Biopharm.52 (2), 191–195 (2001).
   PubMed Web of Science ®Google Scholar
• Alves MP Scarrone AL Santos M Pohlmann AR Guterres SS . Human skin penetration and distribution of nimesulide from hydrophilic gels containing nanocarriers. Int. J. Pharm.341 (1–2), 215–220 (2007).
   PubMedGoogle Scholar
• Bolzinger M-A Briançon S Chevalier Y . Nanoparticles through the skin: managing conflicting results of inorganic and organic particles in cosmetics and pharmaceutics. Wiley. Interdiscip. Rev. Nanomed. Nanobiotechnol.3 (5), 463–478 (2011).
   PubMed Web of Science ®Google Scholar
• Detoni CB Souto GD Da Silva ALM Pohlmann AR Guterres SS . Photostability and skin penetration of different E-resveratrol-loaded supramolecular structures. Photochem. Photobiol.88 (4), 913–921 (2012).
   PubMed Web of Science ®Google Scholar
• Labouta HI Liu DC Lin LL et al. Gold nanoparticle penetration and reduced metabolism in human skin by toluene. Pharm. Res.28 (11), 2931–2944 (2011).
   PubMed Web of Science ®Google Scholar
• Lin LL Grice JE Butler MK et al. Time-correlated single photon counting for simultaneous monitoring of zinc oxide nanoparticles and NAD(P)H in intact and barrier-disrupted volunteer skin. Pharm. Res.28 (11), 2920–2930 (2011).
   PubMed Web of Science ®Google Scholar
• Papakostas D Rancan F Sterry W Blume-Peytavi U Vogt A . Nanoparticles in dermatology. Arch. Dermatol. Res.303 (8), 533–550 (2011).
   PubMed Web of Science ®Google Scholar
• Raphael AP Sundh D Grice JE Roberts MS Soyer HP Prow TW . Zinc oxide nanoparticle removal from wounded human skin. Nanomed.8 (11), 1751–1761 (2013).
   PubMed Web of Science ®Google Scholar
• Choi MJ Maibach HI . Elastic vesicles as topical/transdermal drug delivery systems. Int. J. Cosmet. Sci.27 (4), 211–21 (2005).
   PubMedGoogle Scholar
• El Maghraby GM Barry BW Williams AC . Liposomes and skin: from drug delivery to model membranes. Eur. J. Pharm. Sci.34 (4–5), 203–222 (2008).
   PubMed Web of Science ®Google Scholar
• Honeywell-Nguyen PL Bouwstra JA . Vesicles as a tool for transdermal and dermal delivery. Drug. Discov. Today: Technol.2 (1), 67–74 (2005).
   PubMedGoogle Scholar
• Mura P Maestrelli F González-Rodríguez ML Michelacci I Ghelardini C Rabasco AM . Development, characterization and in vivo evaluation of benzocaine-loaded liposomes. Eur. J. Pharm. Biopharm.67 (1), 86–95 (2007).
   PubMed Web of Science ®Google Scholar
• Hafner A Lovrić J Pepić I Filipović-Grčić J . Lecithin/chitosan nanoparticles for transdermal delivery of melatonin. J. Microencapsul.28 (8), 807–815 (2011).
   PubMed Web of Science ®Google Scholar
• Gerelli Y Di Bari MT Deriu A et al. Structure and organization of phospholipid/polysaccharide nanoparticles. J. Phys.: Condes. Matter20 (10), 104211 (2008).
   Web of Science ®Google Scholar
• Manconi M Caddeo C Sinico C et al. Ex vivo skin delivery of diclofenac by transcutol containing liposomes and suggested mechanism of vesicle-skin interaction. Eur. J. Pharm. Biopharm.78 (1), 27–35 (2011).
   PubMed Web of Science ®Google Scholar
• Gratieri T Alberti I Lapteva M Kalia YN . Next generation intra- and transdermal therapeutic systems: using non- and minimally-invasive technologies to increase drug delivery into and across the skin. Eur. J. Pharm. Sci.50 (5), 609–622 (2013).
   PubMed Web of Science ®Google Scholar
• Guo XD Prausnitz MR . Microelectronic control of drug delivery. Expert Rev. Med. Devices9 (4), 323–326 (2012).
   PubMed Web of Science ®Google Scholar
• Sieg A Wascotte V . Diagnostic and therapeutic applications of iontophoresis. J. Drug Target.17 (9), 690–700 (2009).
   PubMed Web of Science ®Google Scholar
• Kalia YN Naik A Garrison J Guy RH . Iontophoretic drug delivery. Adv. Drug Delivery. Rev.56 (5), 619–658 (2004).
   PubMed Web of Science ®Google Scholar
• Dubey S Perozzo R Scapozza L Kalia YN . Noninvasive transdermal iontophoretic delivery of biologically active human basic fibroblast growth factor. Mol. Pharm.8 (4), 1322–1331 (2011).
   PubMed Web of Science ®Google Scholar
• Mitragotri S Kost J . Low-frequency sonophoresis: a review. Adv. Drug Delivery. Rev.56 (5), 589–601 (2004).
   PubMed Web of Science ®Google Scholar
• Gupta J Prausnitz MR . Recovery of skin barrier properties after sonication in human subjects. Ultrasound Med. Biol.35 (8), 1405–1408 (2009).
   PubMed Web of Science ®Google Scholar
• Rosim GC Barbieri CH Lanças FM Mazzer N . Diclofenac phonophoresis in human volunteers. Ultrasound Med. Biol.31 (3), 337–343 (2005).
   PubMed Web of Science ®Google Scholar
• Kim DK Choi SW Kwak YH . The effect of SonoPrep® on EMLA® cream application for pain relief prior to intravenous cannulation. Eur. J. Pediatr.171 (6), 985–988 (2012).
   PubMed Web of Science ®Google Scholar
• Raphael AP Meliga SC Chen X Fernando GJ Flaim C Kendall MA . Depth-resolved characterization of diffusion properties within and across minimally-perturbed skin layers. J. Control. Release166 (2), 87–94 (2013).
   PubMed Web of Science ®Google Scholar
• Raphael AP Prow TW Crichton ML Chen X Fernando GJ Kendall MA . Targeted, needle-free vaccinations in skin using multilayered, densely-packed dissolving microprojection arrays. Small6 (16), 1785–1793 (2010).
   PubMed Web of Science ®Google Scholar
• Prow TW Chen X Prow NA et al. Nanopatch-targeted skin vaccination against West Nile Virus and Chikungunya virus in mice. Small6 (16), 1776–1784 (2010).
   PubMed Web of Science ®Google Scholar
• van der Maaden K Trietsch SJ Kraan H et al. Novel hollow microneedle technology for depth-controlled microinjection-mediated dermal vaccination: a study with polio vaccine in rats. Pharm. Res.31 (7), 1846–1854 (2014).
   PubMed Web of Science ®Google Scholar
• Seok HY Suh H Baek S Kim YC . Microneedle applications for DNA vaccine delivery to the skin. Methods Mol. Biol.1143, 141–158 (2014).
   PubMedGoogle Scholar
• Norman JJ Arya JM Mcclain MA Frew PM Meltzer MI Prausnitz MR . Microneedle patches: usability and acceptability for self-vaccination against influenza. Vaccine32 (16), 1856–1862 (2014).
   PubMed Web of Science ®Google Scholar
• Chen X Fernando GJ Raphael AP et al. Rapid kinetics to peak serum antibodies is achieved following influenza vaccination by dry-coated densely packed microprojections to skin. J. Control. Release158 (1), 78–84 (2012).
   PubMed Web of Science ®Google Scholar
• Ito Y Nakahigashi T Yoshimoto N Ueda Y Hamasaki N Takada K . Transdermal insulin application system with dissolving microneedles. Diabetes Technol. Ther.14 (10), 891–899 (2012).
   PubMed Web of Science ®Google Scholar
• Hultstrom M Roxhed N Nordquist L . Intradermal insulin delivery: a promising future for diabetes management. J. Diabetes Sci. Technol.8 (3), 453–457 (2014).
   PubMedGoogle Scholar
• Gupta J Felner EI Prausnitz MR . Rapid pharmacokinetics of intradermal insulin administered using microneedles in Type 1 diabetes subjects. Diabetes Technol. Ther.13 (4), 451–456 (2011).
   PubMed Web of Science ®Google Scholar
• Gadkari R Nayak C . A split-face comparative study to evaluate efficacy of combined subcision and dermaroller against combined subcision and cryoroller in treatment of acne scars. J. Cosmet. Dermatol.13 (1), 38–43 (2014).
   PubMed Web of Science ®Google Scholar
• Raphael AP Primiero CA Lin LL et al. High aspect ratio elongated microparticles for enhanced topical drug delivery in human volunteers. Adv. Healthc. Mater.3 (6), 860–866 (2014).
   PubMed Web of Science ®Google Scholar
• Raphael AP Primiero CA Ansaldo AB Keates HL Soyer HP Prow TW . Elongate microparticles for enhanced drug delivery to ex vivo and in vivo pig skin. J. Control. Release172 (1), 96–104 (2013).
   PubMed Web of Science ®Google Scholar
• Raphael AP Sisney JP Liu DC Prow TW . Enhanced delivery of nano- and submicron particles using elongated microparticles. Curr. Drug Deliv. (2014) ( Epub ahead of print).
   Web of Science ®Google Scholar