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Review

The Therapeutic Potential of Vaginal Drug Delivery in the Treatment of Cervical Cancer

Pages 559-570 | Published online: 22 May 2015

References

  • de Freitas AC Gurgel AP Chagas BS Coimbra EC do Amaral CM . Susceptibility to cervical cancer: an overview. Gynecol. Oncol.1269 (2), 304–311 (2012).
  • Franco EL Schlecht NF Saslow D . The epidemiology of cervical cancer. Cancer J.9 (5), 348–359 (2003).
  • Nour NM . Cervical cancer: a preventable death. Rev. Obstet. Gynecol.2 (4), 240–244 (2009).
  • Scarinci IC Garcia FA Kobetz E et al. Cervical cancer prevention: new tools and old barriers. Cancer116 (11), 2531–2542 (2010).
  • Sharma R . HPV vaccine: a breakthrough in prevention of cervical cancer. Apollo Medicine.9 (2), 87–90 (2012).
  • Denny L . Cytological screening for cervical cancer prevention. Best Pract. Res. Clin. Obstet. Gynaecol.26 (2), 189–196 (2012).
  • Schiffma M Castle PE Jeronimo J Rodriguez AC Wacholder S . Human papillomavirus and cervical cancer. Lancet370 (9590), 890–907 (2007).
  • Chien LN Adams EK Flowers LC . Treating cervical cancer: breast and cervical cancer prevention and treatment act patients. Am. J. Obstet. Gynecol.204 (6), 533–533 (2011).
  • Covens A Rosen B Murphy J et al. Changes in the demographics and perioperative care of stage Ia(2)/Ib(1) cervical cancer over the past 16 years. Gynecol. Oncol.81 (2), 133–137 (2001).
  • Gien LT Covens A . Fertility-sparing options for early stage cervical cancer. Gynecol. Oncol.117 (2), 350–357 (2010).
  • Speiser D Köhler C Schneider A Mangler M . Radical Vaginal Trachelectomy: a fertility-preserving procedure in early cervical cancer in young women. Dtsch. Arztebl. Int.110 (17), 289–295 (2013).
  • Cao DY Yang JX Wu XH et al. China Gynecologic Oncology Group. Comparisons of vaginal and abdominal radical trachelectomy for early-stage cervical cancer: preliminary results of a multi-center research in China. Br. J. Cancer109 (11), 2778–2782 (2013).
  • Roy M Plante M . Pregnancies after radical vaginal trachelectomy for early stage cervical cancer. Am. J. Obstet. Gynecol.179 (6 Pt 1), 1491–1496 (1998).
  • Mathevet P Laszlo de Kaszon E Dargent D . Fertility preservation in early cervical cancer. Gynecol. Obstet. Fertil.31 (9), 706–712 (2003) ( 2003).
  • Plante M Renaud MC Francois H Harel F . Vaginal radical trachelectomy: an oncologically safe fertility-preserving surgery. An update series of 72 cases and review of the literature. Gynecol. Oncol.94 (3), 614–623 (2004) ( 2004).
  • Nishio H Fujii T Kameyama K et al. Abdominal radical trachelectomy as a fertility-sparing procedure in women with early-stage cervical cancer in a series of 61 women. Gynecol. Oncol.115 (1), 51–55 (2009).
  • Rob L Pluta M Skapa P Robova H . Advanced in fertility-sparing surgery for cervical cancer. Expert Rev. Anticancer Ther.10 (7), 1101–1114 (2010).
  • Rob L Skapa P Robova H . Fertility-sparing surgery in patients with cervical cancer. Lancet Oncol.12 (2), 192–200 (2011).
  • Robova H Halaska M Pluta M et al. The role of neoadjuvant chemotherapy and surgery in cervical cancer. Int. J. Gynecol. Cancer20 (11 Suppl. 2), S42–46 (2010).
  • Robova H Rob L Halaska MJ et al. High-dose density neo-adjuvant chemotherapy in bulky IB cervical cancer. Gynecol. Oncol.128 (1), 49–53 (2013).
  • Benedetti-Panici P Greggi S Colombo A et al. Neoadjuvant chemotherapy and radical surgery versus exclusive radiotherapy in locally advanced squamous cellcervical cancer: result from the Italian multicentre randomized study. J. Clin. Oncol.20 (1), 179–188 (2002).
  • Wolinsky JB Colson YL Grinstaff MW . Local drug delivery strategies for cancer treatment: Gels, nanoparticles, polymeric films, rods, and wafers. J. Con. Rel.159 (1), 14–26 (2012).
  • Friend D . Intravaginal rings: controlled release systems for contraception and prevention of transmission of sexually transmitted infections. Drug Deliv. Transl. Res.1 (3), 185–193 (2011).
  • Loxley A Mitchnick M Okoh O et al. Ethylene vinyl acetate intravaginal rings for the simultaneous delivery of the antiretroviral UC781 and contraceptive levonorgestrel. Drug Deliv. Transl. Res.1 (3), 247–255 (2011).
  • Malcolm RK Woolfson AD Toner CF Morrow RJ McCullagh SD . Long-term, controlled release of the HIV microbicide TMC120 from silicone elastomer vaginal rings. J. Antimicrob. Chemother.56 (5), 954–956 (2005).
  • McConville C Major I Friend DR Clark MR Malcolm RM . Development of a UC781 releasing poly ethylene vinyl acetate vaginal ring. Drug Deliv. Transl. Res.2 (6) 489–497 (2012).
  • McConville C Friend DR Clark MR Malcolm K . Preformulation and development of a once-daily sustained-release tenofovir vaginal tablet containing a single excipient. J. Pharm. Sci.102 (6), 1859–1866 (2013).
  • Malcolm RM Forbes CJ Geer L et al. Pharmacokinetics and efficacy of a vaginally administered maraviroc gel in rhesus macaques. J. Antimicrob. Chemother.68 (3), 678–683 (2013).
  • Karim AQ Karim SSA Frohlich JA et al. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science329 (5996), 1168–1174 (2010).
  • Malcolm RK McCullagh SD Morrow RJ Woolfson AD . Vagina and uterus as drug-absorbing organs. In : Enhancement in Drug Delivery.TouitouEBarryBW ( Eds). CRC Press, Boca Raton, FL, USA, 395–431 (2006).
  • Woolfson AD Malcolm RK Gallagher R . Drug delivery by the intravaginal route. Crit. Rev. Ther. Drug Carrier Syst.17 (5), 509–555 (2000).
  • Woolfson AD McCafferty DF McCarron PA Price JH . A bioadhesive patch cervical drug delivery system for the administration of 5-fluorouracil to cervical tissue. J. Con. Rel.35 (1), 49–58 (1995).
  • Graham V Surwit ES Weiner S Meyskens FL . Phase II trial of beta-all-trans-retinoic acid for cervical intraepithelial neoplasia delivered via a collagen sponge and cervical cap. West. J. Med.145 (2), 192–195 (1986).
  • Kirwan P Naftalin NJ . Topical 5-fluorouracil in the treatment of vaginal intraepithelial neoplasia. Br. J. Obstet. Gynaecol.92 (3), 287–291 (1985).
  • Keskar V Mohanty PS Gemeinhart EJ Gemeinhart RA . Cervical cancer treatment with a locally insertable controlled release delivery system. J. Con. Rel.115 (3), 280–288 (2006).
  • Hodge LS Downs LS Chura LC et al. Localized delivery of chemotherapy to the cervix for radiosensitization. Gynecol. Oncol.127 (1), 121–125 (2012).
  • Bilensoy E Çırpanlı Y Şen M Doğan AL Çalış S . Thermosensitive mucoadhesive gel formulation loaded with 5-Fu: cyclodextrin complex for HPV-induced cervical cancer. J. Incl. Phenom. Macrocycl. Chem.57 (1–4), 363–370 (2007).
  • Cicinelli E DeZiegler D Morgese S et al. “First uterine pass effect” is observed when estradiol is placed in the upper but not lower third of the vagina. Fertil Steril.81, 1414–1416 (2004).
  • Debata PR Castellanos MR Fata JE et al. A novel curcumin-based vaginal cream Vacurin selectively eliminates apposed human cervical cancer cells. Gynecol. Oncol.129 (1), 145–153 (2013).
  • Snoeck R Noel JC Muller C De Clercq E Bossens M . Cidofovir. A new approach for the treatment of cervix intraepithelial neoplasia grade III (CIN III). J. Med. Virol.60 (2), 205–209 (2000).
  • Snoeck R Bossens M Parent D et al. Phase II double-blind, placebo-controlled study of the safety and efficacy of cidofovir topical gel for the treatment of patients with human papillomavirus infection. Clin. Infect. Dis.33 (5), 597–602 (2001).
  • Baffoe CS Nguyen N Boyd P Wang W Morris M McConville C . Disulfiram-loaded immediate and extended release vaginal tablets for the localised treatment of cervical cancer. J. Pharm. Pharmacol.67 (2), 189–198 (2015).
  • Wickström M Danielsson K Rickardson L et al. Pharmacological profiling of disulfiram using human tumor cell lines and human tumor cells from patients. Biochem. Pharmacol.73 (1), 25–33 (2006).
  • Yip NC Fombon IS Liu P et al. Disulfiram modulated ROS–MAPK and NFkB pathways and targeted breast cancer cells with cancer stem cell-like properties. Br. J. Cancer104 (10), 1564–1574 (2011).
  • Liu P Brown S Goktug T et al. Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells. Br. J. Cancer107 (9), 1488–1497 (2012).
  • Chen D Cui QC Yang H Dou QP . Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity. Cancer Res.66 (21), 10425–10433 (2006).
  • Iljin K Ketola K Vainio P et al. High-throughput cell-based screening of 4910 known drugs and drug-like small molecules identifies disulfiram as an inhibitor of prostate cancer cell growth. Clin. Cancer Res.15 (19), 6070–6078 (2009).
  • Ketola K Kallioniemi O Iljin K . Chemical biology drug sensitivity screen identifies sunitinib as synergistic agent with disulfiram in prostate cancer cells. PLoS ONE7, e51470 (2012).
  • Minagawa Y Kigawa J Itamochi H et al. Cisplatin-resistant HeLa cells are resistant to apoptosis via p53-dependent and -independent pathways. Jpn. J. Cancer Res.90 (12), 1373–1379 (1999).
  • Brar SS Grigg C Wilson KS et al. Disulfiram inhibits activating transcription factor/cyclic AMP-responsive element binding protein and human melanoma growth in a metal-dependent manner in vitro, in mice and in a patient with metastatic disease. Mol. Cancer Ther.3 (9), 1049–1060 (2004).
  • Dufour P Lang JM Giron C et al. Sodium ditiocarb as adjuvant immunotherapy for high risk breast cancer: A randomized study. Biotherapy6 (1), 9–12 (1993).
  • Verma S Stewart DJ Maroun JA Nair RC . A randomized Phase II study of cisplatin alone versus cisplatin plus disulfiram. Am. J. Clin. Oncol.13 (2), 119–124 (1990).
  • Pendekal MS Tegginamat PK . Hybrid drug delivery system for oropharyngeal, cervical and colorectal cancer–in vitro and in vivo evaluation. Saudi. Pharm. J.21 (2), 177–186 (2013).
  • Stefani C Liverani CA Bianco V et al. Spontaneous regression of low-grade cervical intraepithelial lesions is positively improved by topical bovine colostrum preparations (GINEDIE®). A multicentre, observational, Italian pilot study. Eur. Rev. Med. Pharmacol. Sci.18 (5), 728–733 (2014).
  • Shukla S Bharti AC Hussain S et al. Elimination of high-risk human papillomavirus type HPV16 infection by ‘Praneem’ polyherbal tablet in women with early cervical intraepithelial lesions. J. Cancer Res. Clin. Oncol.135 (12), 1701–1709 (2009).
  • Woolfson AD Elliott GRE Gilligan CA Passmore CM . Design of an intravaginal ring for the controlled delivery of 17beta-estradiol as its 3-acetate ester. J. Con. Rel.61 (3), 319–328 (1999).
  • Malcolm RK . Vaginal rings for controlled release drug delivery. In : Modified Release Drug Delivery Technology (2nd ed.).RathboneMJHadgraftJRobertsMSLaneME ( Eds). Informa Healthcare, New York, USA, 499–510 (2008).
  • Brucker C Karck U Merkle E . Cycle control, tolerability, efficacy and acceptability of the vaginal contraceptive ring, NuvaRing®: results of clinical experience in Germany. Eur. J. Contracept. Reprod. Health Care.13 (1), 31–38 (2008).
  • Woolfson AD Malcolm RK Gallagher RJ . Design of a silicone reservoir intravaginal ring for the delivery of oxybutynin. J. Con. Rel.91 (3) 465–476 (2003).
  • Ahrendt HJ Nisand I Bastianelli C et al. Efficacy, acceptability and tolerability of the combined contraceptive ring, NuvaRing, compared with an oral contraceptive containing 30 mg of ethinyl estradiol and 3 mg of drospirenone. Contraception74 (6), 451–457 (2006).
  • Chaplin S Peers T . NuvaRing: new combined hormonal contraceptive device. Prescriber20 (12), 17–20 (2009).
  • Henriksson L Stjernquist M Boquist L Cedergren I Selinus I . A one-year multicenter study of efficacy and safety of a continuous, low-dose, estradiol-releasing vaginal ring (Estring) in postmenopausal women with symptoms and signs of urogenital aging. Am. J. Obstet. Gynecol.74 (1 Pt 1), 85–92 (1996).
  • Boyd P Major I Wang W McConville C . Development of disulfiram-loaded vaginal rings for the localised treatment of cervical cancer. Eur. J. Pharm. Biopharm.88, 945–953 (2014).
  • Graham V Surwit ES Weiner S Meyskens FL . Phase II trial of beta-all-trans-retinoic acid for cervical intraepithelial neoplasia delivered via a collagen sponge and cervical cap. West J. Med.145 (2), 192–195 (1986).
  • Meyskens FL Surwit E Moon TE et al. Enhancement of regression of cervical intraepithelial neoplasia II (moderate dysplasia) with topically applied all-trans-retinoic acid: a randomized trial. J. Natl. Cancer Inst.86 (7), 539–543 (1994).
  • Ruffin MT Bailey JM Normolle DP et al. Low-dose topical delivery of all-trans retinoic acid for cervical intraepithelial neoplasia II and III. Cancer Epidemiol. Biomarkers Prev.13 (12), 2148–2152 (2004).
  • Hodge LS Downs LS Jr Chura JC et al. Localized delivery of chemotherapy to the cervix for radiosensitization. Gynecol Oncol.127 (1), 121–125 (2012).
  • McCarron PA Woolfson AD McCafferty DF Price JH Sidhub H Hickey GI . Cytotoxicity of 5-fluorouracil released from a bioadhesive patch into uterine cervical tissue. Int. J. Pharm.151 (1), 69–74 (1997).
  • Sidhu HK Price JH McCarron PA et al. A randomised controlled trial evaluating a novel cytotoxic drug delivery system for the treatment of cervical intraepithelial neoplasia. Br. J. Obstet. Gynaecol.104 (2), 145–149 (1997).
  • Donnelly RF McCarron PA Zawislak AA Woolfson AD . Design and physicochemical characterisation of a bioadhesive patch for dose-controlled topical delivery of imiquimod. Int. J. Pharm.307 (2), 318–325 (2006).
  • Hiorth M Liereng L Reinertsen R Tho I . Formulation of bioadhesive hexylaminolevulinate pellets intended for photodynamic therapy in the treatment of cervical cancer. Int. J. Pharm.441 (1–2), 544–554 (2013).
  • Ensign LM Cone R Hanes J . Nanoparticle-based drug delivery to the vagina: a review. J Control Release.190, 500–514 (2014).
  • Yang M Lai SK Wang YY et al. Biodegradable nanoparticles composed entirely of safe materials that rapidly penetrate human mucus. Angew Chem. Int. Ed. Engl.50 (11), 2597–2600 (2011).
  • Yang M Yu T Wang YY et al. Vaginal delivery of paclitaxel via nanoparticles with non-mucoadhesive surfaces suppresses cervical tumor growth. Adv. Healthc. Mater.3 (7), 1044–1052 (2014).
  • Zeng X Tao W Mei L Huang L Tan C Feng SS . Cholic acid-functionalized nanoparticles of star-shaped PLGA-vitamin E TPGS copolymer for docetaxel delivery to cervical cancer. Biomaterials34 (25), 6058–6067 (2013).
  • Saengkrit N Saesoo S Srinuanchai W Phunpee S Ruktanonchai UR . Influence of curcumin-loaded cationic liposome on anticancer activity for cervical cancer therapy. Colloids Surf. B Biointerfaces114, 349–356 (2014).
  • Chen MX Li BK Yin DK Liang J Li SS Peng DY . Layer-by-layer assembly of chitosan stabilized multilayered liposomes for paclitaxel delivery. Carbohydr. Polym.111, 298–304 (2014).
  • Gabizon AA . Selective tumor localization and improved therapeutic index of anthracyclines encapsulated in long-circulating liposomes. Cancer Res.52, 891–896 (1992).
  • Harrington KJ Mohammadtaghi S Uster PS et al. Effective targeting of solid tumors in patients with locally advanced cancers by radiolabeled pegylated liposomes. Clin. Cancer Res.7, 243–254 (2001).
  • Zheng J Jaffray D Allen C . Quantitative CT imaging of the spatial and temporal distribution of liposomes in a rabbit tumor model. Mol. Pharm.6, 571–580 (2009).
  • Dunne M Zheng J Rosenblat J Jaffray DA Allen C . APN/CD13-targeting as a strategy to alter the tumor accumulation of liposomes. J. Control. Release154, 298–305 (2011).
  • Stapleton S Allen C Pintilie M Jaffray DA . Tumor perfusion imaging predicts the intra-tumoral accumulation of liposomes. J. Control Release172 (1), 351–357 (2013).

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